JP2017524668A5 - - Google Patents
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- JP2017524668A5 JP2017524668A5 JP2016573017A JP2016573017A JP2017524668A5 JP 2017524668 A5 JP2017524668 A5 JP 2017524668A5 JP 2016573017 A JP2016573017 A JP 2016573017A JP 2016573017 A JP2016573017 A JP 2016573017A JP 2017524668 A5 JP2017524668 A5 JP 2017524668A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methoxy
- quinolyl
- substituents
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14382230 | 2014-06-16 | ||
| EP14382230.2 | 2014-06-16 | ||
| PCT/EP2015/056860 WO2015192981A1 (en) | 2014-06-16 | 2015-03-30 | Novel compounds as dual inhibitors of histone methyltransferases and dna methyltransferases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524668A JP2017524668A (ja) | 2017-08-31 |
| JP2017524668A5 true JP2017524668A5 (2) | 2018-04-12 |
| JP6527534B2 JP6527534B2 (ja) | 2019-06-05 |
Family
ID=51136403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016573017A Active JP6527534B2 (ja) | 2014-06-16 | 2015-03-30 | ヒストンメチルトランスフェラーゼ及びｄｎａメチルトランスフェラーゼの二重阻害剤としての新規化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9840500B2 (2) |
| EP (1) | EP3154957B1 (2) |
| JP (1) | JP6527534B2 (2) |
| CN (1) | CN106536509B (2) |
| AU (1) | AU2015276537B2 (2) |
| CA (1) | CA2987978C (2) |
| DK (1) | DK3154957T3 (2) |
| ES (1) | ES2769648T3 (2) |
| WO (1) | WO2015192981A1 (2) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190127354A1 (en) * | 2015-12-14 | 2019-05-02 | Fundación Para La Investigación Médica Aplicada | 2,4,6,7-tetrasubstituted quinoline compounds as inhibitors of dna methyltransferases |
| PL3442947T3 (pl) * | 2016-04-15 | 2023-10-02 | Epizyme, Inc. | Związki arylowe lub heteroarylowe podstawione aminą jako inhibitory ehmt1 i ehmt2 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| US11278550B2 (en) | 2016-05-17 | 2022-03-22 | Duke University | Compositions and methods for the treatment of Prader-Willi syndrome |
| WO2018049000A1 (en) * | 2016-09-08 | 2018-03-15 | The General Hospital Corporation | Treatment of cancers having alterations within the swi/snf chromatin remodeling complex |
| JP7091336B2 (ja) * | 2016-12-22 | 2022-06-27 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヒストンメチルトランスフェラーゼ阻害剤 |
| US11103549B2 (en) | 2016-12-22 | 2021-08-31 | Asddr, Llc | Use of histone methyltransferase inhibitors and histone deacetylase inhibitors for therapy of Phelan-McDermid Syndrome |
| US20200113901A1 (en) * | 2017-03-31 | 2020-04-16 | Epizyme, Inc. | Methods of using ehmt2 inhibitors |
| CN110621316B (zh) | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| WO2018226998A1 (en) | 2017-06-09 | 2018-12-13 | Global Blood Therapeutics, Inc. | Azaindole compounds as histone methyltransferase inhibitors |
| WO2018229139A1 (en) | 2017-06-14 | 2018-12-20 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cancer |
| EP3668863B1 (en) | 2017-08-15 | 2025-03-19 | Global Blood Therapeutics, Inc. | Tricyclic compounds as histone methyl-transferase inhibitors |
| US11584734B2 (en) | 2017-08-15 | 2023-02-21 | Global Blood Therapeutics, Inc. | Tricyclic compounds as histone methyltransferase inhibitors |
| JP2021500326A (ja) * | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | 血液障害の予防又は処置にｅｈｍｔ２阻害剤を使用する方法 |
| JP2021500334A (ja) * | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法 |
| EP3807248A4 (en) * | 2018-05-29 | 2021-10-27 | Council of Scientific and Industrial Research | BICYCLIC TOPOISOMERASE I INHIBITOR COMPOUNDS, THEIR PREPARATION AND USE |
| WO2019243236A1 (en) | 2018-06-18 | 2019-12-26 | Fundación Para La Investigación Médica Aplicada | New anticancer drug combinations |
| CN112390791B (zh) * | 2019-08-14 | 2023-08-01 | 复旦大学 | 一类dna甲基转移酶1荧光探针及其用途 |
| JP2023533016A (ja) | 2020-07-11 | 2023-08-01 | ファイザー・インク | 抗ウイルス性ヘテロアリールケトン誘導体 |
| CA3188260A1 (en) * | 2020-08-07 | 2022-02-10 | Dimitrios Iliopoulos | Small molecules for the treatment of autoimmune diseases and cancer |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| CN115160294B (zh) * | 2022-06-27 | 2023-09-29 | 中山大学 | 一种G9a/GLP共价抑制剂及其制备方法及应用 |
| CN120965666B (zh) * | 2025-10-21 | 2026-02-17 | 四川大学华西医院 | 一种喹啉类化合物、制备方法和用途及其药物组合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001154A1 (en) | 1997-07-03 | 1999-01-14 | University Of Iowa Research Foundation | Method for inhibiting immunostimulatory dna associated responses |
| EP1377554A1 (en) | 1999-06-16 | 2004-01-07 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
| EP1088818B1 (en) * | 1999-10-01 | 2004-11-03 | F. Hoffmann-La Roche Ag | Quinolin-4-yl derivatives |
| US6440995B1 (en) * | 1999-10-01 | 2002-08-27 | Hoffman-La Roche Inc. | Quinolin-4-yl derivatives |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| AU2003297460A1 (en) * | 2002-12-19 | 2004-07-14 | Scios, Inc. | TREATMENT OF OBESITY AND ASSOCIATED CONDITIONS WITH TGF-Beta INHIBITORS |
| ES2389258T3 (es) * | 2003-06-17 | 2012-10-24 | Millennium Pharmaceuticals, Inc. | Composiciones y métodos para inhibir TGF-s |
| CN101535295A (zh) * | 2006-10-12 | 2009-09-16 | 休普基因公司 | 用于调节dna甲基化的喹啉衍生物 |
| WO2008046085A2 (en) * | 2006-10-12 | 2008-04-17 | Supergen, Inc. | Quinoline derivatives for modulating dna methylation |
| US7790746B2 (en) * | 2007-10-12 | 2010-09-07 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
| CN102625799A (zh) * | 2009-06-25 | 2012-08-01 | 安姆根有限公司 | 杂环化合物及其用途 |
| WO2011019092A1 (en) * | 2009-08-12 | 2011-02-17 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
| EP2496234A1 (en) * | 2009-11-07 | 2012-09-12 | Merck Patent GmbH | Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors |
| WO2013062943A1 (en) | 2011-10-24 | 2013-05-02 | Glaxosmithkline Intellectual Property Development Limited | New compounds |
| AU2013237226A1 (en) | 2012-03-19 | 2014-10-09 | Emory University | Quinazoline compounds and their use in therapy |
| EP2730558A1 (en) | 2012-11-08 | 2014-05-14 | Ikerchem, S.L. | Indole derivatives, pharmaceutical compositions containing such indoles and their use as DNA methylation modulators |
| US9264060B2 (en) * | 2012-11-09 | 2016-02-16 | St-Ericsson Sa | Analog to digital conversion method with offset tracking and correction and analog to digital converter implementing the same |
| ES2635016T3 (es) * | 2013-03-01 | 2017-10-02 | Fundación Para La Investigación Médica Aplicada | Nuevos compuestos como inhibidores duales de fosfodiesterasas e histonas deacetilasas |
-
2015
- 2015-03-30 CN CN201580034131.4A patent/CN106536509B/zh active Active
- 2015-03-30 US US15/315,326 patent/US9840500B2/en active Active
- 2015-03-30 JP JP2016573017A patent/JP6527534B2/ja active Active
- 2015-03-30 EP EP15714185.4A patent/EP3154957B1/en active Active
- 2015-03-30 AU AU2015276537A patent/AU2015276537B2/en active Active
- 2015-03-30 WO PCT/EP2015/056860 patent/WO2015192981A1/en not_active Ceased
- 2015-03-30 DK DK15714185.4T patent/DK3154957T3/da active
- 2015-03-30 CA CA2987978A patent/CA2987978C/en active Active
- 2015-03-30 ES ES15714185T patent/ES2769648T3/es active Active
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