JP2017532365A5 - - Google Patents
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- Publication number
- JP2017532365A5 JP2017532365A5 JP2017525311A JP2017525311A JP2017532365A5 JP 2017532365 A5 JP2017532365 A5 JP 2017532365A5 JP 2017525311 A JP2017525311 A JP 2017525311A JP 2017525311 A JP2017525311 A JP 2017525311A JP 2017532365 A5 JP2017532365 A5 JP 2017532365A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- pharmaceutical composition
- chain polypeptide
- protein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008186 Collagen Human genes 0.000 claims 26
- 108010035532 Collagen Proteins 0.000 claims 26
- 229920001436 collagen Polymers 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 150000001413 amino acids Chemical group 0.000 claims 12
- 102000002067 Protein Subunits Human genes 0.000 claims 9
- 108010001267 Protein Subunits Proteins 0.000 claims 9
- 208000003215 hereditary nephritis Diseases 0.000 claims 7
- 208000024985 Alport syndrome Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 4
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 208000006750 hematuria Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 201000001474 proteinuria Diseases 0.000 claims 3
- BJBUEDPLEOHJGE-IMJSIDKUSA-N trans-3-hydroxy-L-proline Chemical compound O[C@H]1CC[NH2+][C@@H]1C([O-])=O BJBUEDPLEOHJGE-IMJSIDKUSA-N 0.000 claims 3
- BJBUEDPLEOHJGE-UHFFFAOYSA-N (2R,3S)-3-Hydroxy-2-pyrolidinecarboxylic acid Natural products OC1CCNC1C(O)=O BJBUEDPLEOHJGE-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000025760 Benign familial haematuria Diseases 0.000 claims 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 2
- 208000032843 Hemorrhage Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000000523 end stage renal failure Diseases 0.000 claims 2
- 210000000585 glomerular basement membrane Anatomy 0.000 claims 2
- 229960002591 hydroxyproline Drugs 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 108010050451 2-oxoglutarate 3-dioxygenase proline Proteins 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 201000002431 Autosomal dominant Alport syndrome Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 208000029812 Cerebral Small Vessel disease Diseases 0.000 claims 1
- 208000032274 Encephalopathy Diseases 0.000 claims 1
- 208000002111 Eye Abnormalities Diseases 0.000 claims 1
- 208000028782 Hereditary disease Diseases 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 102000018399 Prolyl 3-hydroxylases Human genes 0.000 claims 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 claims 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 claims 1
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 claims 1
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 201000002429 X-linked Alport syndrome Diseases 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 201000002430 autosomal recessive Alport syndrome Diseases 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical group NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000009984 peri-natal effect Effects 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 210000004129 prosencephalon Anatomy 0.000 claims 1
- 238000001525 receptor binding assay Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029135P | 2014-07-25 | 2014-07-25 | |
| US62/029,135 | 2014-07-25 | ||
| US201462072490P | 2014-10-30 | 2014-10-30 | |
| US62/072,490 | 2014-10-30 | ||
| US201562128729P | 2015-03-05 | 2015-03-05 | |
| US62/128,729 | 2015-03-05 | ||
| PCT/US2015/041712 WO2016014781A1 (en) | 2014-07-25 | 2015-07-23 | Collagen iv replacement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532365A JP2017532365A (ja) | 2017-11-02 |
| JP2017532365A5 true JP2017532365A5 (2) | 2018-09-06 |
Family
ID=55163752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525311A Pending JP2017532365A (ja) | 2014-07-25 | 2015-07-23 | コラーゲンｉｖの置き換え |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180207240A1 (2) |
| EP (1) | EP3171889A4 (2) |
| JP (1) | JP2017532365A (2) |
| AU (1) | AU2015292582A1 (2) |
| CA (1) | CA2955481A1 (2) |
| WO (1) | WO2016014781A1 (2) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL264725B2 (en) * | 2016-08-11 | 2023-03-01 | Sulfilatec Inc | Preparations and methods for treating the disease |
| GB201717301D0 (en) * | 2017-10-20 | 2017-12-06 | Nordic Bioscience As | Type xvi collagen assay |
| JP2021532191A (ja) * | 2018-07-25 | 2021-11-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルポート症候群の治療に使用するためのエンパグリフロジン |
| EP4029514A4 (en) * | 2019-09-11 | 2023-10-11 | National University Corporation Kumamoto University | Drug for curative therapy of intractable hereditary renal alport syndrome |
| US12164185B2 (en) * | 2020-02-14 | 2024-12-10 | Tdk Corporation | Optical modulation element |
| GB202003618D0 (en) * | 2020-03-12 | 2020-04-29 | Univ Bristol | Gene Therapy |
| EP4255427B1 (en) * | 2020-12-03 | 2024-11-06 | Delta 4 GmbH | Clopidogrel for use in the treatment of focal segmental glomerulosclerosis (fsgs) |
| CN114149502A (zh) * | 2021-12-23 | 2022-03-08 | 杭州百凌生物科技有限公司 | 一种四型胶原蛋白ɑ3的抗体、检测试剂盒及其应用 |
| CN115960211B (zh) * | 2022-12-23 | 2023-11-21 | 江苏创健医疗科技股份有限公司 | 一种重组人源ⅵ型胶原蛋白及其制备方法和应用 |
| WO2025193938A1 (en) * | 2024-03-13 | 2025-09-18 | Oregon Health & Science University | Delivery of type iv collagen alpha chain using a split intein dual aav vector |
| CN119286901B (zh) * | 2024-11-21 | 2025-09-09 | 西安巨子生物基因技术股份有限公司 | 一种重组iv型胶原蛋白及其制备方法和应用 |
| CN120731923B (zh) * | 2025-09-05 | 2025-11-04 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | 一种Alport综合征小鼠NMD逃逸模型的构建方法及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440729B1 (en) * | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
| PT1064018E (pt) * | 1998-03-27 | 2004-12-31 | Univ Kansas Medical Center | Utilizacao de dominios isolados de colagenio de tipo iv para modificar interaccoes celulares e teciduais |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| CA2451942A1 (en) * | 2001-07-27 | 2003-02-13 | Munirathinam Sundaramoorthy | Crystallized structure of type iv collagen nc1 domain hexamer |
| US7183383B2 (en) * | 2002-03-20 | 2007-02-27 | The University Of Arkansas For Medical Sciences | Uses of collagen IV |
| US7608413B1 (en) * | 2005-03-25 | 2009-10-27 | Celera Corporation | Kidney disease targets and uses thereof |
| US20130116412A1 (en) * | 2010-04-02 | 2013-05-09 | Daniel M. Pinkas | Production of Post-Translationally Hydroxylated Recombinant Proteins in Bacteria |
| UA116639C2 (uk) * | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| US20180055913A1 (en) * | 2014-07-29 | 2018-03-01 | Vanderbilt University | Recombinant collagen iv surrogates and uses thereof |
-
2015
- 2015-07-23 WO PCT/US2015/041712 patent/WO2016014781A1/en not_active Ceased
- 2015-07-23 EP EP15824092.9A patent/EP3171889A4/en not_active Withdrawn
- 2015-07-23 AU AU2015292582A patent/AU2015292582A1/en not_active Abandoned
- 2015-07-23 CA CA2955481A patent/CA2955481A1/en not_active Abandoned
- 2015-07-23 US US15/328,215 patent/US20180207240A1/en not_active Abandoned
- 2015-07-23 JP JP2017525311A patent/JP2017532365A/ja active Pending
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