JP2017534644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017534644A5 JP2017534644A5 JP2017525007A JP2017525007A JP2017534644A5 JP 2017534644 A5 JP2017534644 A5 JP 2017534644A5 JP 2017525007 A JP2017525007 A JP 2017525007A JP 2017525007 A JP2017525007 A JP 2017525007A JP 2017534644 A5 JP2017534644 A5 JP 2017534644A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acid sequence
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14192524 | 2014-11-10 | ||
| EP14192524.8 | 2014-11-10 | ||
| PCT/EP2015/075876 WO2016075035A1 (en) | 2014-11-10 | 2015-11-06 | Anti-ang2 antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205947A Division JP2021050229A (ja) | 2014-11-10 | 2020-12-11 | 抗ａｎｇ２抗体及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017534644A JP2017534644A (ja) | 2017-11-24 |
| JP2017534644A5 true JP2017534644A5 (2) | 2018-12-06 |
Family
ID=51868115
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525007A Pending JP2017534644A (ja) | 2014-11-10 | 2015-11-06 | 抗ａｎｇ２抗体及び使用方法 |
| JP2020205947A Pending JP2021050229A (ja) | 2014-11-10 | 2020-12-11 | 抗ａｎｇ２抗体及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205947A Pending JP2021050229A (ja) | 2014-11-10 | 2020-12-11 | 抗ａｎｇ２抗体及び使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10538585B2 (2) |
| EP (1) | EP3218398A1 (2) |
| JP (2) | JP2017534644A (2) |
| KR (1) | KR20170082594A (2) |
| CN (1) | CN107001456A (2) |
| AR (1) | AR102595A1 (2) |
| AU (1) | AU2015345321A1 (2) |
| BR (1) | BR112017009790A2 (2) |
| CA (1) | CA2963606A1 (2) |
| IL (1) | IL251477A0 (2) |
| MX (1) | MX2017005642A (2) |
| SG (1) | SG11201703458UA (2) |
| TW (1) | TW201630935A (2) |
| WO (1) | WO2016075035A1 (2) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5616428B2 (ja) | 2009-04-07 | 2014-10-29 | ロシュ グリクアート アクチェンゲゼルシャフト | 三価の二重特異性抗体 |
| AU2015345323A1 (en) | 2014-11-10 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies and methods of use in ophthalmology |
| CN107148429B (zh) | 2014-11-10 | 2021-12-03 | 豪夫迈·罗氏有限公司 | 抗-pdgf-b抗体和使用方法 |
| EP3218402A1 (en) | 2014-11-10 | 2017-09-20 | F. Hoffmann-La Roche AG | Anti-il-1beta antibodies and methods of use |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| CN111491951B (zh) * | 2017-12-22 | 2024-05-24 | 豪夫迈·罗氏有限公司 | 通过疏水相互作用色谱法耗尽轻链错配的抗体变体 |
| KR102497171B1 (ko) | 2018-02-20 | 2023-02-08 | 기초과학연구원 | 항-안지오포이에틴-2(Ang2) 항체 및 그의 용도 |
| WO2019164219A1 (en) * | 2018-02-20 | 2019-08-29 | Institute For Basic Science | Anti-angiopoietin-2 antibodies and uses thereof |
| JP2023530187A (ja) | 2020-06-22 | 2023-07-13 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 抗ａｎｇ－２抗体とその用途 |
| US20230312698A1 (en) * | 2020-08-07 | 2023-10-05 | Nanjing GenScript Biotech Co., Ltd. | Antibodies against human angiopoietin-2 and uses thereof |
| CN116209765B (zh) * | 2020-08-19 | 2025-11-07 | 药物抗体公司 | 经修饰抗体及其制备方法 |
| CN115772544B (zh) * | 2021-09-06 | 2024-04-26 | 合肥星眸生物科技有限公司 | 抗vegf-a和ang-2的aav载体 |
| CN116925234B (zh) * | 2022-04-02 | 2024-05-31 | 合肥星眸生物科技有限公司 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| CN117820490A (zh) * | 2022-09-28 | 2024-04-05 | 科兴生物制药股份有限公司 | Vegf和ang-2双特异性抗体及其应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935343A (en) | 1986-08-08 | 1990-06-19 | Syntex (U.S.A.) Inc. | Monoclonal antibodies for interleukin-1β |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| EP1481010A2 (en) | 2002-02-28 | 2004-12-01 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
| ES2263984T3 (es) * | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| EP1590369B1 (en) | 2003-01-24 | 2016-03-16 | Applied Molecular Evolution, Inc. | Human il-1 beta antagonists |
| US20050282233A1 (en) | 2004-03-05 | 2005-12-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for VEGF/PDGF family of growth factors |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| EP2068925A4 (en) | 2007-05-07 | 2011-08-31 | Medimmune Llc | ANTI-ICOS ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER, TRANSPLANTATIONS AND AUTOIMMUNE DISEASES |
| US20090162359A1 (en) * | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| JO2913B1 (en) * | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| ES2398693T3 (es) | 2008-06-06 | 2013-03-21 | Xoma Technology Ltd. | Métodos para el tratamiento de la artritis reumatoide |
| RU2368359C1 (ru) | 2008-07-22 | 2009-09-27 | Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) | Способ лечения возрастной макулярной дегенерации |
| US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8133979B2 (en) * | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| TWI426920B (zh) | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗－ｖｅｇｆ／抗－ａｎｇ－２抗體 |
| RU2013110844A (ru) | 2010-08-13 | 2014-09-20 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ |
| JP5866130B2 (ja) | 2010-09-10 | 2016-02-17 | アペクシジェン， インコーポレイテッド | 抗ＩＬ−１β抗体およびその使用方法 |
| EP2686345B1 (en) * | 2011-03-16 | 2018-04-25 | Amgen Inc. | Fc variants |
| MX358726B (es) * | 2011-06-29 | 2018-09-03 | Amgen Inc | Biomarcador predictivo de supervivencia en el tratamiento de carcinoma de celulas renales. |
| CA2877584A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| LT3495387T (lt) * | 2012-07-13 | 2021-11-25 | Roche Glycart Ag | Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti |
| CN104661679A (zh) * | 2012-09-28 | 2015-05-27 | 勃林格殷格翰国际有限公司 | 包含双重血管生成素-2/Dll4结合物和抗VEGF药剂的药物组合 |
| JP2015532272A (ja) * | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重アンジオポエチン−２／Ｄｌｌ４結合剤および抗ＶＥＧＦ−Ｒ剤を含む薬学的組み合わせ |
| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| HK1216428A1 (zh) | 2012-11-09 | 2016-11-11 | 辉瑞公司 | 血小板衍生生长因子b之特异性抗体及其组合物和用途 |
| JO3405B1 (ar) | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
| KR20210094669A (ko) * | 2013-04-29 | 2021-07-29 | 에프. 호프만-라 로슈 아게 | 인간 fcrn-결합 변형된 항체 및 사용 방법 |
| KR20160085888A (ko) * | 2013-12-20 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 항-ang2 항체 및 cd40 작용제를 사용한 조합 요법 |
| RU2727639C2 (ru) * | 2014-01-15 | 2020-07-22 | Ф.Хоффманн-Ля Рош Аг | Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а |
| CN107148429B (zh) | 2014-11-10 | 2021-12-03 | 豪夫迈·罗氏有限公司 | 抗-pdgf-b抗体和使用方法 |
| EP3218402A1 (en) | 2014-11-10 | 2017-09-20 | F. Hoffmann-La Roche AG | Anti-il-1beta antibodies and methods of use |
| AU2015345323A1 (en) * | 2014-11-10 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies and methods of use in ophthalmology |
| WO2016209972A1 (en) * | 2015-06-26 | 2016-12-29 | Amgen Inc. | Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor |
| MX2019014199A (es) * | 2017-06-02 | 2020-01-23 | Boehringer Ingelheim Int | Tratamiento de combinacion antineoplasico. |
-
2015
- 2015-11-06 CA CA2963606A patent/CA2963606A1/en not_active Abandoned
- 2015-11-06 AU AU2015345321A patent/AU2015345321A1/en not_active Abandoned
- 2015-11-06 SG SG11201703458UA patent/SG11201703458UA/en unknown
- 2015-11-06 KR KR1020177015610A patent/KR20170082594A/ko not_active Withdrawn
- 2015-11-06 BR BR112017009790A patent/BR112017009790A2/pt not_active Application Discontinuation
- 2015-11-06 JP JP2017525007A patent/JP2017534644A/ja active Pending
- 2015-11-06 MX MX2017005642A patent/MX2017005642A/es unknown
- 2015-11-06 WO PCT/EP2015/075876 patent/WO2016075035A1/en not_active Ceased
- 2015-11-06 EP EP15790575.3A patent/EP3218398A1/en not_active Withdrawn
- 2015-11-06 CN CN201580060787.3A patent/CN107001456A/zh active Pending
- 2015-11-09 AR ARP150103648A patent/AR102595A1/es unknown
- 2015-11-09 TW TW104136927A patent/TW201630935A/zh unknown
-
2017
- 2017-03-30 IL IL251477A patent/IL251477A0/en unknown
- 2017-05-10 US US15/591,600 patent/US10538585B2/en not_active Expired - Fee Related
-
2020
- 2020-12-11 JP JP2020205947A patent/JP2021050229A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017534644A5 (2) | ||
| JP2017534646A5 (2) | ||
| JP2017534645A5 (2) | ||
| JP2020062036A5 (2) | ||
| JP2017537896A5 (2) | ||
| RU2017120360A (ru) | Биспецифические антитела и способы их применения в офтальмологии | |
| JP2020500538A5 (2) | ||
| JP2021525087A5 (2) | ||
| JP2017504566A5 (2) | ||
| HRP20191584T1 (hr) | Anti-cd79b protutijela i načini uporabe | |
| RU2020124153A (ru) | Гуманизированные антитела к cd19 человека и способы их применения | |
| JP2018522541A5 (2) | ||
| JP2018537966A5 (2) | ||
| JP2017528476A5 (2) | ||
| JP2018108086A5 (2) | ||
| JP2019502712A5 (2) | ||
| JP2018035138A5 (2) | ||
| HRP20200384T1 (hr) | Humanizirana anti-tau(ps422) protutijela i načini uporabe | |
| JP2018521638A5 (2) | ||
| JP2021533159A5 (2) | ||
| HRP20211528T1 (hr) | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije | |
| HRP20231134T1 (hr) | Humanizirana i afinitetno zrela protutijela na fcrh5 i postupci za uporabu | |
| JP2016503413A5 (2) | ||
| JP2019534277A5 (2) | ||
| RU2017119543A (ru) | Анти-tim3 антитела и способы их применения |