JP2018523689A - ホスホイノシチド３−キナーゼ阻害剤および第二の抗増殖剤を含む組成物 - Google Patents

ホスホイノシチド３−キナーゼ阻害剤および第二の抗増殖剤を含む組成物 Download PDF

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Publication number
JP2018523689A
JP2018523689A JP2018508757A JP2018508757A JP2018523689A JP 2018523689 A JP2018523689 A JP 2018523689A JP 2018508757 A JP2018508757 A JP 2018508757A JP 2018508757 A JP2018508757 A JP 2018508757A JP 2018523689 A JP2018523689 A JP 2018523689A
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composition
kit
alkyl
agent
inhibitor
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JP2018508757A
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Japanese (ja)
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JP2018523689A5 (sr
Inventor
スティーブン ジョセフ シャトルワース，
スティーブン ジョセフ シャトルワース，
アンドリュー デイビッド ホエール，
アンドリュー デイビッド ホエール，
Original Assignee
カルス セラピューティクス リミテッド
カルス セラピューティクス リミテッド
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Publication of JP2018523689A publication Critical patent/JP2018523689A/ja
Publication of JP2018523689A5 publication Critical patent/JP2018523689A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018508757A 2015-08-19 2016-08-19 ホスホイノシチド３−キナーゼ阻害剤および第二の抗増殖剤を含む組成物 Withdrawn JP2018523689A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use
GB1514760.6 2015-08-19
PCT/GB2016/052575 WO2017029517A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent

Publications (2)

Publication Number Publication Date
JP2018523689A true JP2018523689A (ja) 2018-08-23
JP2018523689A5 JP2018523689A5 (sr) 2019-07-25

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JP2018508757A Withdrawn JP2018523689A (ja) 2015-08-19 2016-08-19 ホスホイノシチド３−キナーゼ阻害剤および第二の抗増殖剤を含む組成物

Country Status (22)

Country Link
US (3) US10668077B2 (sr)
EP (1) EP3337477B1 (sr)
JP (1) JP2018523689A (sr)
KR (1) KR20180064387A (sr)
CN (2) CN113786409B (sr)
AU (1) AU2016307885B2 (sr)
CA (1) CA2995898A1 (sr)
DK (1) DK3337477T3 (sr)
ES (1) ES2939815T3 (sr)
FI (1) FI3337477T3 (sr)
GB (1) GB201514760D0 (sr)
HR (1) HRP20230376T1 (sr)
HU (1) HUE061615T2 (sr)
IL (1) IL257499A (sr)
LT (1) LT3337477T (sr)
MX (1) MX2018001926A (sr)
PL (1) PL3337477T3 (sr)
PT (1) PT3337477T (sr)
RS (1) RS64095B1 (sr)
SI (1) SI3337477T1 (sr)
SM (1) SMT202300063T1 (sr)
WO (1) WO2017029517A1 (sr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020059705A1 (ja) * 2018-09-18 2021-08-30 株式会社ヤクルト本社 キノリンカルボキサミド誘導体を用いるがん併用療法
JP2022537925A (ja) * 2019-07-01 2022-08-31 カルス セラピューティクス リミテッド Ｂ細胞リンパ腫の療法に使用するためのｐｉ３ｋ阻害剤

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MX2012002059A (es) 2009-08-20 2012-04-19 Karus Therapeutics Ltd Compestos heterociclicos triciclicos como inhibidores de fosfoionositida 3-quinasa.
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GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
US10722527B2 (en) 2015-04-10 2020-07-28 Capsugel Belgium Nv Abiraterone acetate lipid formulations
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
CN113164466B (zh) * 2018-09-11 2025-07-08 柯瑞斯公司 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗
EP3930715B1 (en) * 2019-02-27 2024-05-08 Astrazeneca AB Saracatinib for use in the treatment of idiopathic pulmonary fibrosis
CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用
CN114533879B (zh) * 2020-11-19 2023-09-29 广州顺健生物医药科技有限公司 治疗癌症的联合疗法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020059705A1 (ja) * 2018-09-18 2021-08-30 株式会社ヤクルト本社 キノリンカルボキサミド誘導体を用いるがん併用療法
JP2022537925A (ja) * 2019-07-01 2022-08-31 カルス セラピューティクス リミテッド Ｂ細胞リンパ腫の療法に使用するためのｐｉ３ｋ阻害剤
JP7691939B2 (ja) 2019-07-01 2025-06-12 コンバライフ （シャンハイ） カンパニー リミテッド Ｂ細胞リンパ腫の療法に使用するためのｐｉ３ｋ阻害剤

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DK3337477T3 (en) 2023-02-20
US20180243313A1 (en) 2018-08-30
EP3337477A1 (en) 2018-06-27
ES2939815T3 (es) 2023-04-27
US10668077B2 (en) 2020-06-02
GB201514760D0 (en) 2015-09-30
CN108348505A (zh) 2018-07-31
LT3337477T (lt) 2023-03-10
AU2016307885A1 (en) 2018-03-08
PT3337477T (pt) 2023-03-20
PL3337477T3 (pl) 2023-07-03
HK1251467A1 (en) 2019-02-01
CA2995898A1 (en) 2017-02-23
AU2016307885B2 (en) 2019-07-25
US12257254B2 (en) 2025-03-25
FI3337477T3 (fi) 2023-04-27
CN108348505B (zh) 2021-10-12
IL257499A (en) 2018-07-31
RS64095B1 (sr) 2023-04-28
EP3337477B1 (en) 2023-02-01
HRP20230376T1 (hr) 2023-06-23
HUE061615T2 (hu) 2023-07-28
MX2018001926A (es) 2018-06-19
CN113786409A (zh) 2021-12-14
CN113786409B (zh) 2024-04-02
US20230066999A1 (en) 2023-03-02
WO2017029517A1 (en) 2017-02-23
US20210069200A1 (en) 2021-03-11
KR20180064387A (ko) 2018-06-14
US11291669B2 (en) 2022-04-05
SI3337477T1 (sl) 2023-04-28
SMT202300063T1 (it) 2023-03-17

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