JP2018526033A5 - - Google Patents

Download PDF

Info

Publication number
JP2018526033A5
JP2018526033A5 JP2018532485A JP2018532485A JP2018526033A5 JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5 JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5
Authority
JP
Japan
Prior art keywords
receptor
cancer
cell
dysfunctional
chimeric antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018532485A
Other languages
English (en)
Japanese (ja)
Other versions
JP6957471B2 (ja
JP2018526033A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/AU2016/050851 external-priority patent/WO2017041143A1/en
Publication of JP2018526033A publication Critical patent/JP2018526033A/ja
Publication of JP2018526033A5 publication Critical patent/JP2018526033A5/ja
Priority to JP2021164222A priority Critical patent/JP7253020B2/ja
Application granted granted Critical
Publication of JP6957471B2 publication Critical patent/JP6957471B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018532485A 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用 Active JP6957471B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021164222A JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903719A AU2015903719A0 (en) 2015-09-11 Chimeric antigen receptor and uses thereof
AU2015903719 2015-09-11
PCT/AU2016/050851 WO2017041143A1 (en) 2015-09-11 2016-09-10 Chimeric antigen receptors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021164222A Division JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Publications (3)

Publication Number Publication Date
JP2018526033A JP2018526033A (ja) 2018-09-13
JP2018526033A5 true JP2018526033A5 (2) 2020-09-10
JP6957471B2 JP6957471B2 (ja) 2021-11-02

Family

ID=58240468

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018532485A Active JP6957471B2 (ja) 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Active JP7822340B2 (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Active JP7822340B2 (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Country Status (8)

Country Link
US (3) US12121539B2 (2)
EP (2) EP3816294A1 (2)
JP (4) JP6957471B2 (2)
KR (2) KR20250058773A (2)
CN (2) CN114891116A (2)
AU (4) AU2016318230B2 (2)
ES (1) ES2848478T3 (2)
WO (1) WO2017041143A1 (2)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3226897T1 (sl) 2014-12-05 2021-08-31 Memorial Sloan Kettering Cancer Center Protitelesa, ki ciljajo na B-celični maturacijski antigen, in postopki uporabe
US12121539B2 (en) * 2015-09-11 2024-10-22 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors and uses thereof
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
PT3703750T (pt) 2017-11-01 2025-01-17 Memorial Sloan Kettering Cancer Center Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes
MX2020004568A (es) 2017-11-06 2020-10-05 Juno Therapeutics Inc Combinación de una terapia celular y un inhibidor de gamma secretasa.
CN119193493A (zh) 2017-12-08 2024-12-27 朱诺治疗学股份有限公司 生产工程化t细胞组合物的过程
EP3735265A4 (en) 2018-01-03 2021-11-10 Qu Biologics Inc. INNATE TARGETING OF ADOPTIVE CELL THERAPIES
JP2021514648A (ja) * 2018-03-01 2021-06-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 新規の標的抗原結合部分のための特異性アッセイ
CN112955184A (zh) * 2018-03-15 2021-06-11 基本解决方案公司 可编程免疫细胞受体复合物系统
CN112166193A (zh) * 2018-05-21 2021-01-01 生物权威(英国)有限公司 具有经修饰的接头结构域的嵌合抗原受体及其用途
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
MA54078A (fr) 2018-11-01 2021-09-15 Juno Therapeutics Inc Méthodes pour le traitement au moyen de récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b
CN114173811A (zh) * 2019-07-26 2022-03-11 生物权威(澳大利亚)有限责任公司 P2x7受体靶向治疗
EP4304610A4 (en) * 2021-03-11 2025-03-05 Biosceptre (Aust) Pty Ltd Novel cell therapy system
US20240368282A1 (en) * 2021-09-01 2024-11-07 Biosceptre (Aust) Pty Ltd Methods and compositions for stimulating immune activity
CN120187461A (zh) * 2022-09-14 2025-06-20 生物权威(澳大利亚)有限责任公司 免疫细胞的体内检测
CN120166997A (zh) * 2022-09-14 2025-06-17 生物权威(澳大利亚)有限责任公司 检测免疫细胞的方法
JP2025531675A (ja) * 2022-09-14 2025-09-25 バイオセプター (オースト) プロプライエタリー・リミテッド 操作された免疫細胞の富化
WO2025054416A1 (en) * 2023-09-06 2025-03-13 The Regents Of The University Of California Methods for treating cancer

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4940661A (en) 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US5512483A (en) 1993-05-21 1996-04-30 Mcgill University Expression vectors responsive to steroid hormones
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
PL323587A1 (en) 1995-05-26 1998-04-14 Zeneca Ltd Gene changing-over system including edisone receptor
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
AUPP991199A0 (en) 1999-04-21 1999-05-13 University Of Sydney, The Methods for diagnosing pre-cancerous and cancerous conditions
AU4533300A (en) 1999-09-16 2001-04-17 Liangqi Zhang A pressure-reducing diaphragm of carburettor
AUPQ968700A0 (en) 2000-08-28 2000-09-21 Intreat Pty Limited Treatment of urinary incontinence
AUPR201500A0 (en) 2000-12-11 2001-01-11 Biosceptre Pty Ltd Methods for identifying pre-neoplastic and neoplastic states in mammals
JP4384852B2 (ja) 2001-01-17 2009-12-16 イントリート ピーティーワイ リミテッド 非機能性p2x7レセプター抗体、癌及びその他の容態の診断及び処置
US20030203411A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Methods of minicell-based delivery
CN100497386C (zh) 2001-09-03 2009-06-10 因特里特有限公司 非功能性p2x7受体的抗体及其应用
CA2402930A1 (en) * 2002-09-19 2004-03-19 William Herman Targeted ligands
JP2008511286A (ja) 2004-06-02 2008-04-17 ダイアテック・ピーティワイ・リミテッド サメ類のIgNARドメインに基づく結合成分
WO2008043146A1 (en) 2006-10-10 2008-04-17 Biosceptre International Limited Antibodies against non functional p2x7 receptor
JP2010505426A (ja) 2006-10-10 2010-02-25 バイオスセプター インターナショナル リミテッド 非機能性p2x7受容体に対する抗体を産生するハイブリドーマ
JP2010536341A (ja) * 2007-08-15 2010-12-02 アムニクス, インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
ES2619681T3 (es) 2007-09-14 2017-06-26 Biosceptre (Aust) Pty Ltd Novedosos epítopos P2X7
ATE542139T1 (de) 2007-09-14 2012-02-15 Biosceptre Int Ltd Purinerge (p2x)-rezeptoren in extrazellulärer körperflüssigkeit
US8840186B2 (en) 2007-11-07 2014-09-23 L&P Swiss Holding Ag Support assembly and corresponding seat structure
CN102143978B (zh) 2008-07-04 2015-02-18 生物权威国际有限公司 抗p2x7肽和表位
JP5164806B2 (ja) 2008-11-12 2013-03-21 サンデン株式会社 車両用通信制御装置
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
EP2467404B1 (en) 2009-08-20 2015-09-30 Biosceptre International Limited Anti p2x7 receptor antibodies and fragments thereof
WO2011075789A1 (en) 2009-12-24 2011-06-30 Biosceptre International Limited Antibodies to non-functional oligomeric p2x7 receptors
EP2613808B1 (en) 2010-09-10 2017-11-08 Biosceptre (Aust) Pty Ltd Companion animal cancer treatments with an anti p2x7 antibody
EP2646461A2 (en) 2010-12-03 2013-10-09 Cyclogenix Ltd VARIANTS OF igNAR
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9233125B2 (en) * 2010-12-14 2016-01-12 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer
MX349321B (es) 2011-07-01 2017-07-21 Biosceptre (Aust) Pty Ltd Terapia combinada.
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
KR102558502B1 (ko) 2014-12-05 2023-07-20 시티 오브 호프 Cs1 표적화된 키메라 항원 수용체-변형된 t 세포
WO2016123143A1 (en) 2015-01-26 2016-08-04 The University Of Chicago CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2
US20180037650A1 (en) 2015-04-02 2018-02-08 Biosceptre (Uk) Limited Pain Treatment
US12121539B2 (en) 2015-09-11 2024-10-22 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors and uses thereof
WO2017181001A1 (en) 2016-04-15 2017-10-19 Trustees Of Dartmouth College High affinity b7-h6 antibodies and antibody fragments
WO2018017649A1 (en) 2016-07-19 2018-01-25 Unum Therapeutics Inc. Use of antibody-coupled t cell receptor (actr) with multiple anti-cancer antibodies in cancer treatment
US20190263928A1 (en) 2016-09-30 2019-08-29 Baylor College Of Medicine Adaptive chimeric antigen receptor t-cell design
MX2019004410A (es) 2016-10-21 2019-09-26 Biosceptre Uk Ltd Particulas citotoxicas.
CN112166193A (zh) 2018-05-21 2021-01-01 生物权威(英国)有限公司 具有经修饰的接头结构域的嵌合抗原受体及其用途
CN114173811A (zh) 2019-07-26 2022-03-11 生物权威(澳大利亚)有限责任公司 P2x7受体靶向治疗

Similar Documents

Publication Publication Date Title
JP2018526033A5 (2)
JP7737440B2 (ja) 抗ヒトパピローマウイルス(hpv)抗原結合性タンパク質およびその使用方法
CN108884164B (zh) 用于免疫疗法的经修饰细胞
EP3472205B1 (en) Chimeric antigen receptor
CN109069537B (zh) 共刺激结构域中具有重复结合基序的car
CN112368298A (zh) 嵌合跨膜蛋白及其用途
JP2018529327A5 (2)
CN113646335A (zh) 使用对b细胞成熟抗原具有特异性的嵌合抗原受体的治疗的方法
CN114391021B (zh) TGF-β受体和使用方法
CN115916833B (zh) 靶向b7h3的抗原结合多肽及其应用
WO2022247795A1 (zh) 靶向Claudin18.2的纳米抗体及其用途
US12331315B2 (en) Chimeric antigen receptor
CN110678480A (zh) 嵌合多肽和改变它们的在细胞膜中的定位的方法
JP2025536940A (ja) 新規cd19バインダー、それを含むcar-t構造体、およびその使用方法
TWI849430B (zh) Gpc3結合分子
KR20230124656A (ko) 전립선암 키메라 항원 수용체
US20250297282A1 (en) Viral-binding protein and related reagents, articles, and methods of use
CN112279915A (zh) Icos抗体、基因、载体、宿主细胞和icos拮抗剂
HK40072388A (zh) TGF-β受体和使用方法
WO2024210072A1 (ja) キメラタンパク質、核酸、ベクター、t細胞又はnk細胞、医薬組成物、組み合わせ物、組み合わせ医薬、及び標的抗原結合タンパク質
JP2025539151A (ja) Lilrb4を特異的に結合する合成t細胞受容体抗原受容体およびその使用
HK40121523A (zh) 多特异性蛋白及相关方法
CN117586411A (zh) 一种结合tnfr2和ccr8的双特异性抗体
CN120225549A (zh) 对b细胞成熟抗原(bcma)和/或跨膜激活剂和caml相互作用因子(taci)具有特异性的嵌合抗原受体
HK40013683A (en) Chimeric polypeptides and methods of altering their localisation in the cell membrane