JP2019107018A5 - - Google Patents
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- JP2019107018A5 JP2019107018A5 JP2019036646A JP2019036646A JP2019107018A5 JP 2019107018 A5 JP2019107018 A5 JP 2019107018A5 JP 2019036646 A JP2019036646 A JP 2019036646A JP 2019036646 A JP2019036646 A JP 2019036646A JP 2019107018 A5 JP2019107018 A5 JP 2019107018A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 34
- 239000012634 fragment Substances 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000043321 human CTLA4 Human genes 0.000 claims 3
- 230000008629 immune suppression Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410377352.9 | 2014-08-01 | ||
| CN201410377352.9A CN105296433B (zh) | 2014-08-01 | 2014-08-01 | 一种ctla4抗体、其药物组合物及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Division JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019107018A JP2019107018A (ja) | 2019-07-04 |
| JP2019107018A5 true JP2019107018A5 (2) | 2019-09-19 |
| JP6783886B2 JP6783886B2 (ja) | 2020-11-11 |
Family
ID=55194268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Active JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
| JP2019036646A Active JP6783886B2 (ja) | 2014-08-01 | 2019-02-28 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Active JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US10449251B2 (2) |
| EP (2) | EP3858861A1 (2) |
| JP (2) | JP6514774B2 (2) |
| KR (1) | KR102017396B1 (2) |
| CN (3) | CN105296433B (2) |
| AP (1) | AP2017009762A0 (2) |
| AU (2) | AU2015295936C1 (2) |
| CA (1) | CA2956000C (2) |
| CL (1) | CL2017000250A1 (2) |
| CO (1) | CO2017000754A2 (2) |
| CR (1) | CR20170033A (2) |
| CY (1) | CY1124190T1 (2) |
| DK (1) | DK3176181T3 (2) |
| DO (1) | DOP2017000031A (2) |
| EA (1) | EA036396B1 (2) |
| EC (1) | ECSP17012781A (2) |
| ES (1) | ES2857509T3 (2) |
| GE (2) | GEAP202014437A (2) |
| HR (1) | HRP20210448T1 (2) |
| HU (1) | HUE053719T2 (2) |
| IL (1) | IL250321B (2) |
| LT (1) | LT3176181T (2) |
| MA (2) | MA55868A (2) |
| MD (1) | MD4795C1 (2) |
| MX (2) | MX387685B (2) |
| MY (1) | MY192822A (2) |
| NI (1) | NI201700008A (2) |
| NZ (1) | NZ729158A (2) |
| PE (1) | PE20170772A1 (2) |
| PH (1) | PH12017500190B1 (2) |
| PL (1) | PL3176181T3 (2) |
| PT (1) | PT3176181T (2) |
| RS (1) | RS61590B1 (2) |
| SG (1) | SG11201700819QA (2) |
| SI (1) | SI3176181T1 (2) |
| TN (1) | TN2017000010A1 (2) |
| UA (1) | UA119570C2 (2) |
| WO (1) | WO2016015675A1 (2) |
| ZA (1) | ZA201700528B (2) |
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| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
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| CA2986765A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
| EP3344656A1 (en) | 2015-09-01 | 2018-07-11 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
| EP3433275A1 (en) | 2016-03-24 | 2019-01-30 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| CN107400166A (zh) | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | 针对ctla4的单域抗体及其衍生蛋白 |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| CN106967172B (zh) * | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
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