JP2019532092A5 - - Google Patents

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Publication number
JP2019532092A5
JP2019532092A5 JP2019522803A JP2019522803A JP2019532092A5 JP 2019532092 A5 JP2019532092 A5 JP 2019532092A5 JP 2019522803 A JP2019522803 A JP 2019522803A JP 2019522803 A JP2019522803 A JP 2019522803A JP 2019532092 A5 JP2019532092 A5 JP 2019532092A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
heteroatoms selected
substituted
alkoxy
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JP2019522803A
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English (en)
Japanese (ja)
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JP2019532092A (ja
JP7145850B2 (ja
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Priority claimed from PCT/US2017/058645 external-priority patent/WO2018081488A1/en
Publication of JP2019532092A publication Critical patent/JP2019532092A/ja
Publication of JP2019532092A5 publication Critical patent/JP2019532092A5/ja
Application granted granted Critical
Publication of JP7145850B2 publication Critical patent/JP7145850B2/ja
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JP2019522803A 2016-10-28 2017-10-27 Ｉｌ－１２、ｉｌ－２３および／またはｉｆｎアルファ応答の調節剤として有用なヘテロ二環化合物 Active JP7145850B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662414158P 2016-10-28 2016-10-28
US62/414,158 2016-10-28
PCT/US2017/058645 WO2018081488A1 (en) 2016-10-28 2017-10-27 Heterobicyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Publications (3)

Publication Number Publication Date
JP2019532092A JP2019532092A (ja) 2019-11-07
JP2019532092A5 true JP2019532092A5 (2) 2020-11-12
JP7145850B2 JP7145850B2 (ja) 2022-10-03

Family

ID=60263169

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019522803A Active JP7145850B2 (ja) 2016-10-28 2017-10-27 Ｉｌ－１２、ｉｌ－２３および／またはｉｆｎアルファ応答の調節剤として有用なヘテロ二環化合物

Country Status (8)

Country Link
US (1) US10781215B2 (2)
EP (1) EP3532473B1 (2)
JP (1) JP7145850B2 (2)
KR (1) KR102477063B1 (2)
CN (1) CN110114357B (2)
ES (1) ES2895107T3 (2)
MA (1) MA46620A (2)
WO (1) WO2018081488A1 (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3528816A4 (en) * 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
AR117177A1 (es) * 2018-12-10 2021-07-14 Lilly Co Eli DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa
CN111484480B (zh) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
CA3134814A1 (en) * 2019-03-26 2020-10-01 Ventyx Biosciences, Inc. Tyk2 pseudokinase ligands
SG11202112043PA (en) 2019-04-30 2021-11-29 Celgene Corp Combination therapies comprising apremilast and tyk2 inhibitors
JP7635228B2 (ja) 2019-11-08 2025-02-25 ベンティックス バイオサイエンシーズ，インク． Ｔｙｋ２偽キナーゼリガンド
US11697648B2 (en) * 2019-11-26 2023-07-11 Theravance Biopharma R&D Ip, Llc Fused pyrimidine pyridinone compounds as JAK inhibitors
CN116283993B (zh) * 2021-12-20 2024-05-03 艾立康药业股份有限公司 一种嘧啶类化合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
WO2008135232A1 (en) 2007-05-02 2008-11-13 Riccardo Cortese Use and compositions of purine derivatives for the treatment of proliferative disorders
ES2424977T3 (es) * 2007-08-08 2013-10-10 Glaxosmithkline Intellectual Property Development Limited Derivados de 2-[(2-{fenilamino}-1H-pirrolo[2,3-D]pirimidin-4-il)amino]benzamida como inhibidores de IGF-1R para el tratamiento del cáncer
MX2010010968A (es) 2008-04-07 2010-10-26 Irm Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
AU2009238590A1 (en) * 2008-04-22 2009-10-29 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
ES2648226T3 (es) * 2012-11-08 2017-12-29 Bristol-Myers Squibb Company Compuestos de pirimidina sustituidos con alquilamida útiles en la modulación de IL-12, IL-23 y/o IFN
TWI582077B (zh) 2013-11-07 2017-05-11 必治妥美雅史谷比公司 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物
ES2702126T3 (es) * 2013-12-10 2019-02-27 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
US9840520B2 (en) * 2014-05-14 2017-12-12 The Regents Of The University Of Colorado, A Body Corporate Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
EP3528816A4 (en) * 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF

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