JP2020506178A5 - - Google Patents
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- JP2020506178A5 JP2020506178A5 JP2019539774A JP2019539774A JP2020506178A5 JP 2020506178 A5 JP2020506178 A5 JP 2020506178A5 JP 2019539774 A JP2019539774 A JP 2019539774A JP 2019539774 A JP2019539774 A JP 2019539774A JP 2020506178 A5 JP2020506178 A5 JP 2020506178A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- heterocycle
- membered
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000623 heterocyclic group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 22
- 239000012453 solvate Substances 0.000 claims 22
- 229940002612 prodrug Drugs 0.000 claims 21
- 239000000651 prodrug Substances 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000002950 monocyclic group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 125000003367 polycyclic group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 4
- 125000004585 polycyclic heterocycle group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- -1 C 6 alkyne Chemical class 0.000 claims 1
- 208000005101 LEOPARD Syndrome Diseases 0.000 claims 1
- 206010062901 Multiple lentigines syndrome Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010029748 Noonan syndrome Diseases 0.000 claims 1
- 208000010708 Noonan syndrome with multiple lentigines Diseases 0.000 claims 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187881A JP2023018095A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449530P | 2017-01-23 | 2017-01-23 | |
| US62/449,530 | 2017-01-23 | ||
| PCT/US2018/013023 WO2018136265A1 (en) | 2017-01-23 | 2018-01-09 | Bicyclic compounds as allosteric shp2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187881A Division JP2023018095A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506178A JP2020506178A (ja) | 2020-02-27 |
| JP2020506178A5 true JP2020506178A5 (2) | 2021-02-12 |
| JP7240319B2 JP7240319B2 (ja) | 2023-03-15 |
Family
ID=61054566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539774A Active JP7240319B2 (ja) | 2017-01-23 | 2018-01-09 | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| JP2022187881A Pending JP2023018095A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187881A Pending JP2023018095A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11739093B2 (2) |
| EP (1) | EP3571199B1 (2) |
| JP (2) | JP7240319B2 (2) |
| KR (1) | KR102665763B1 (2) |
| CN (2) | CN117327075A (2) |
| AR (1) | AR110740A1 (2) |
| AU (2) | AU2018210770B2 (2) |
| BR (1) | BR112019015075A2 (2) |
| CA (1) | CA3051206A1 (2) |
| IL (2) | IL296456A (2) |
| MX (2) | MX2019008695A (2) |
| SG (1) | SG11201906209SA (2) |
| TW (1) | TWI820013B (2) |
| WO (1) | WO2018136265A1 (2) |
Families Citing this family (121)
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| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| WO2017210134A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Heterocyclic inhibitors of ptpn11 |
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| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
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| RU2020133727A (ru) | 2018-03-21 | 2022-04-21 | Сучжоу Пухе Биофарма Ко., Лтд. | Ингибиторы shp2 и их применение |
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| MX2020011565A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor. |
| IL312291A (en) | 2018-05-01 | 2024-06-01 | Revolution Medicines Inc | C-26-linked rapamycin analogs as MTOR inhibitors |
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| JP2022508651A (ja) | 2018-10-08 | 2022-01-19 | レヴォリューション・メディスンズ，インコーポレイテッド | 癌を処置するためのｓｈｐ２阻害剤組成物および方法 |
| JP2022506887A (ja) | 2018-11-07 | 2022-01-17 | シャンハイ リンジーン バイオファーマ カンパニー リミテッド | 窒素含有縮合複素環系ｓｈｐ２阻害剤化合物、製造方法及び使用 |
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| US20220073521A1 (en) | 2018-11-30 | 2022-03-10 | Tuojie Biotech (Shanghai) Co., Ltd. | Pyrimidine and five-membered nitrogen heterocycle derivative, preparation method therefor, and medical uses thereof |
| EP3889153A4 (en) | 2018-11-30 | 2022-09-07 | Tuojie Biotech (Shanghai) Co., Ltd. | PYRIMIDINE AND FIVE-MEMBERED HETEROCYCLIC NITROGEN DERIVATIVE, METHOD OF MANUFACTURE THEREOF AND MEDICAL USES THEREOF |
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2018
- 2018-01-09 JP JP2019539774A patent/JP7240319B2/ja active Active
- 2018-01-09 CA CA3051206A patent/CA3051206A1/en active Pending
- 2018-01-09 TW TW107100769A patent/TWI820013B/zh not_active IP Right Cessation
- 2018-01-09 SG SG11201906209SA patent/SG11201906209SA/en unknown
- 2018-01-09 KR KR1020197024604A patent/KR102665763B1/ko active Active
- 2018-01-09 WO PCT/US2018/013023 patent/WO2018136265A1/en not_active Ceased
- 2018-01-09 CN CN202311080113.2A patent/CN117327075A/zh active Pending
- 2018-01-09 CN CN201880018606.4A patent/CN110446709B/zh active Active
- 2018-01-09 BR BR112019015075-7A patent/BR112019015075A2/pt not_active Application Discontinuation
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- 2018-01-09 EP EP18701883.3A patent/EP3571199B1/en active Active
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2023
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2025
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