JP2026501931A - ステロール修飾されたリン脂質を含む脂質ナノ粒子 - Google Patents

ステロール修飾されたリン脂質を含む脂質ナノ粒子

Info

Publication number
JP2026501931A
JP2026501931A JP2025536815A JP2025536815A JP2026501931A JP 2026501931 A JP2026501931 A JP 2026501931A JP 2025536815 A JP2025536815 A JP 2025536815A JP 2025536815 A JP2025536815 A JP 2025536815A JP 2026501931 A JP2026501931 A JP 2026501931A
Authority
JP
Japan
Prior art keywords
lipid
lnp
independently
group
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025536815A
Other languages
English (en)
Japanese (ja)
Inventor
ダンダン・リン
ジアンシウ・シュエ
ジェリー・シー・ジャン
ボ・イン
Original Assignee
スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド filed Critical スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド
Publication of JP2026501931A publication Critical patent/JP2026501931A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2025536815A 2022-12-21 2023-12-20 ステロール修飾されたリン脂質を含む脂質ナノ粒子 Pending JP2026501931A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2022/140569 2022-12-21
CN2022140569 2022-12-21
PCT/CN2023/140052 WO2024131810A1 (fr) 2022-12-21 2023-12-20 Nanoparticules lipidiques comprenant des phospholipides modifiés par stérol

Publications (1)

Publication Number Publication Date
JP2026501931A true JP2026501931A (ja) 2026-01-19

Family

ID=91587685

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2025536815A Pending JP2026501931A (ja) 2022-12-21 2023-12-20 ステロール修飾されたリン脂質を含む脂質ナノ粒子

Country Status (4)

Country Link
EP (1) EP4637718A1 (fr)
JP (1) JP2026501931A (fr)
CN (1) CN119095585A (fr)
WO (1) WO2024131810A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119264001A (zh) * 2024-04-03 2025-01-07 上海蓝鹊生物医药有限公司 含氮链状化合物、制备方法、包含其的组合物和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101766408B1 (ko) * 2009-06-10 2017-08-10 알닐람 파마슈티칼스 인코포레이티드 향상된 지질 조성물
JP6948313B6 (ja) * 2015-09-17 2022-01-14 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物および組成物
HRP20230209T1 (hr) * 2015-10-28 2023-04-14 Acuitas Therapeutics Inc. Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
EP3532103B1 (fr) * 2016-10-26 2025-12-03 Acuitas Therapeutics, Inc. Formulations de nanoparticules lipidiques
WO2019089828A1 (fr) * 2017-10-31 2019-05-09 Acuitas Therapeutics, Inc. Nanoparticules lipidiques lamellaires
CA3088485A1 (fr) * 2018-01-18 2019-07-25 Etherna Immunotherapies Nv Nanoparticules lipidiques
EP3959314A4 (fr) * 2019-04-26 2023-02-08 Genevant Sciences Gmbh Nanoparticules lipidiques
US20220280639A1 (en) * 2019-07-31 2022-09-08 Modernatx, Inc. Compositions and methods for delivery of rna interference agents to immune cells
CN114901253A (zh) * 2019-08-14 2022-08-12 爱康泰生治疗公司 用于递送核酸的改进的脂质纳米颗粒
US20240261381A1 (en) * 2020-06-11 2024-08-08 Etherna Immunotherapies Nv Lipid nanoparticles
WO2022112855A1 (fr) * 2020-11-27 2022-06-02 Guangzhou Ribobio Co., Ltd Composé lipidique et sa composition
WO2022152109A2 (fr) * 2021-01-14 2022-07-21 Suzhou Abogen Biosciences Co., Ltd. Composés lipidiques et compositions de nanoparticules lipidiques
US20240398933A1 (en) * 2021-09-03 2024-12-05 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
US20240398940A1 (en) * 2021-09-03 2024-12-05 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids

Also Published As

Publication number Publication date
EP4637718A1 (fr) 2025-10-29
CN119095585A (zh) 2024-12-06
WO2024131810A1 (fr) 2024-06-27

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