JP2952505B2 - 抗ウイルス性薬剤 - Google Patents

抗ウイルス性薬剤

Info

Publication number
JP2952505B2
JP2952505B2 JP2099445A JP9944590A JP2952505B2 JP 2952505 B2 JP2952505 B2 JP 2952505B2 JP 2099445 A JP2099445 A JP 2099445A JP 9944590 A JP9944590 A JP 9944590A JP 2952505 B2 JP2952505 B2 JP 2952505B2
Authority
JP
Japan
Prior art keywords
drug
ester
acid
azt
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2099445A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02304084A (ja
Inventor
デイビッド・フレデリック・ホロビン
ジョン・チャールス・マーシャル・スチュワート
マイケル・デイビッド・ウインザー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EFUAMORU Ltd
Original Assignee
EFUAMORU Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898908646A external-priority patent/GB8908646D0/en
Priority claimed from GB898921266A external-priority patent/GB8921266D0/en
Application filed by EFUAMORU Ltd filed Critical EFUAMORU Ltd
Publication of JPH02304084A publication Critical patent/JPH02304084A/ja
Application granted granted Critical
Publication of JP2952505B2 publication Critical patent/JP2952505B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2099445A 1989-04-17 1990-04-17 抗ウイルス性薬剤 Expired - Lifetime JP2952505B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898908646A GB8908646D0 (en) 1989-04-17 1989-04-17 Anti-viral agents
GB89/08646.6 1989-04-17
GB89/21266.6 1989-09-20
GB898921266A GB8921266D0 (en) 1989-09-20 1989-09-20 Anti-viral agents

Publications (2)

Publication Number Publication Date
JPH02304084A JPH02304084A (ja) 1990-12-17
JP2952505B2 true JP2952505B2 (ja) 1999-09-27

Family

ID=26295232

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2099445A Expired - Lifetime JP2952505B2 (ja) 1989-04-17 1990-04-17 抗ウイルス性薬剤

Country Status (15)

Country Link
US (2) US5216142A (de)
EP (2) EP0693498A1 (de)
JP (1) JP2952505B2 (de)
KR (1) KR100188616B1 (de)
AT (1) ATE155142T1 (de)
AU (1) AU637362B2 (de)
CA (1) CA2014662C (de)
DE (1) DE69031007T2 (de)
DK (1) DK0393920T3 (de)
ES (1) ES2108686T3 (de)
FI (1) FI901903A7 (de)
GR (1) GR3024835T3 (de)
IE (1) IE980216A1 (de)
NZ (1) NZ233297A (de)
TW (1) TW215417B (de)

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US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
KR927003044A (ko) * 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법
US6262241B1 (en) * 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
CA2220091C (en) * 1995-05-01 2011-01-04 Scotia Holdings Plc Nicotinic acid esters and pharmaceutical compositions containing them
US5639460A (en) * 1995-06-07 1997-06-17 Raymond; Hal C. Aqueous plant extract having antiviral activity
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US6673784B1 (en) * 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
US6054591A (en) * 1996-03-28 2000-04-25 Shionogi & Co., Ltd. Lymph-absorbable aryl substituted imidazole derivatives
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
WO1999026958A1 (en) * 1997-11-25 1999-06-03 Protarga, Inc. Nucleoside analog compositions and uses thereof
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
AU2002303164A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty amine drug conjugates
AU2002305099A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty alcohol drug conjugates
US20060122174A1 (en) * 2001-09-21 2006-06-08 Henderson Morley Research & Development Limited Antiviral treatment
CA2421026C (en) * 2001-10-16 2005-02-15 Avanir Pharmaceuticals Viral inhibition by n-docosanol
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CN1742018A (zh) * 2002-12-10 2006-03-01 弗·哈夫曼-拉罗切有限公司 抗病毒的核苷衍生物
AU2004314731B2 (en) * 2004-01-20 2011-07-07 The Board Of Regents Of The University Of Oklahoma Compositions and methods of treatment for inflammatory diseases
NO324263B1 (no) 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US20090111774A1 (en) * 2007-06-01 2009-04-30 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
MX2010003261A (es) 2007-09-26 2010-08-18 Sinai School Medicine Analogos de azacitidina y usos de los mismos.
US10463684B2 (en) 2014-01-29 2019-11-05 Board Of Regents, The Uneversety Of Texas System Nucleobase analogue derivatives and their applications

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2354288C2 (de) * 1973-10-30 1976-01-02 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Aminophenylalkyläthern
JPS5132573A (en) * 1974-09-11 1976-03-19 Asahi Chemical Ind Nn ashiruarabinonukureoshido no seizohoho
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
JPS5813394A (ja) * 1981-07-17 1983-01-25 Ajinomoto Co Inc １−β−Ｄ−リボフラノシル−４，５−置換イミダゾ−ルの製造法
EP0082668A1 (de) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenvinyl)-2'-Deoxyuridinderivate, Verfahren zu ihrer Herstellung, die sie enthaltende pharmazeutische Präparate und ihre Verwendung bei der Bekämpfung von viralen Infektionen
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
JPS6144897A (ja) * 1984-08-10 1986-03-04 Terumo Corp ５−フルオロウラシル誘導体およびこれを含有する医薬製剤
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
IE73219B1 (en) * 1985-03-16 1997-05-07 Wellcome Found Therapeutic nucleosides
IT1188654B (it) * 1985-04-15 1988-01-20 Toyo Jozo Kk Coniugato nucleo side-fosfolipide
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
EP0355131B1 (de) * 1987-10-28 1996-09-04 Pro-Neuron, Inc. Acyl deoxyribonukleosid-derivate und deren verwendungen
EP0339075B1 (de) * 1987-10-28 1993-08-18 Pro-Neuron, Inc. Acylatiertes uridin und cytidin und deren verwendungen
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，１９（５），１９７６，ｐ６５４〜６６２
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，１９（５），１９７６，ｐ６６３〜６６７
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，１９（５），１９７６，ｐ６６７〜６７４

Also Published As

Publication number Publication date
KR900015742A (ko) 1990-11-10
DK0393920T3 (da) 1997-09-22
EP0693498A1 (de) 1996-01-24
IE980216A1 (en) 2000-02-23
EP0393920A2 (de) 1990-10-24
DE69031007D1 (de) 1997-08-14
EP0393920A3 (de) 1991-07-03
FI901903A7 (fi) 1990-10-18
ES2108686T3 (es) 1998-01-01
US5216142A (en) 1993-06-01
AU5329090A (en) 1990-10-18
CA2014662C (en) 2002-09-17
US5276020A (en) 1994-01-04
DE69031007T2 (de) 1997-12-04
GR3024835T3 (en) 1998-01-30
AU637362B2 (en) 1993-05-27
HK1001003A1 (en) 1998-05-15
TW215417B (de) 1993-11-01
ATE155142T1 (de) 1997-07-15
JPH02304084A (ja) 1990-12-17
CA2014662A1 (en) 1990-10-17
NZ233297A (en) 1997-07-27
FI901903A0 (fi) 1990-04-12
KR100188616B1 (ko) 1999-06-01
EP0393920B1 (de) 1997-07-09

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