JP3678602B2 - Syringe fixed injection device - Google Patents
Syringe fixed injection device Download PDFInfo
- Publication number
- JP3678602B2 JP3678602B2 JP07122199A JP7122199A JP3678602B2 JP 3678602 B2 JP3678602 B2 JP 3678602B2 JP 07122199 A JP07122199 A JP 07122199A JP 7122199 A JP7122199 A JP 7122199A JP 3678602 B2 JP3678602 B2 JP 3678602B2
- Authority
- JP
- Japan
- Prior art keywords
- syringe
- injection device
- connecting plate
- main body
- pressurizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002347 injection Methods 0.000 title claims description 37
- 239000007924 injection Substances 0.000 title claims description 37
- 239000000243 solution Substances 0.000 claims description 24
- 239000000126 substance Substances 0.000 claims description 17
- 239000003106 tissue adhesive Substances 0.000 description 8
- 108010049003 Fibrinogen Proteins 0.000 description 7
- 102000008946 Fibrinogen Human genes 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229940012952 fibrinogen Drugs 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 108090000190 Thrombin Proteins 0.000 description 5
- 229960004072 thrombin Drugs 0.000 description 5
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229940075469 tissue adhesives Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、主に複数成分系製剤として適用される組織接着剤の注入装置に関するものであり、更に詳細には高濃度のフィブリノゲン溶液に対するトロンビン溶液の容積比を下げることによって高濃度のフィブリンを形成させ高い閉鎖効果を得るのに適する組織接着剤のシリンジ固定注入装置に関する。
【０００２】
【従来の技術】
繊維素原（フィブリノゲン）は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。同時に、幅広い臨床の現場で応用されている。近年、２本のシリンジ体に収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して、射出させた２液を霧状に噴霧して混合するスプレー塗布法が普及し始めている。このような器具の好適な例は、例えばＰＣＴ ＷＯ９４−０７４２０号公報に記載されている。しかしながらこのようなスプレー塗布法を用いても、大血管の処置や、肺のエアーリークの処置などの強い接着・閉鎖効果が求められる症例では、組織接着剤が十分な効果を発揮するまでにはなお克服するべき問題が存在した。
【０００３】
一方組織接着剤の効果を増強する方法としてフィブリノゲン溶液とトロンビン溶液との混合比を変更し、フィブリノゲン濃度を高めることが有効であることが確認された。
これらの組織接着剤に適用する装置、すなわちフィブリノゲン溶液とトロンビン溶液とを異なる容量で同時に注入するための装置としては特開昭６１−２９３４４３号公報、ＰＣＴ ＷＯ９７−３３６３３号公報に図３に示される断面積の異なる２本のシリンジを等長の有効ストロークとするものが示されている。しかしながら汎用のシリンジでは断面積が異なるもので有効ストロークが等しいものはなく、この用途専用に新たにシリンジを作製する必要があるため大量生産低価格であるシリンジ分野においてコストアップを免れなかった。
【０００４】
【発明が解決しようとする課題】
本発明は、従来のこのような問題点を解決することを目的とするもので、わざわざ特注の専用シリンジを作製せずとも汎用の低コストシリンジを使用して、かつ組織接着剤の効果を最大限に上げるために異なる容量の２液以上の薬液を常に一定の比率で同時に注入が可能な注入装置を提供するものである。
【０００５】
【課題を解決するための手段】
即ち本発明は、少なくとも２本以上の同じサイズのシリンジを固定し各々のシリンジより同時に薬液注入を行える装置において、常に一定の比率で異なる容量の注入が可能なシリンジ固定注入装置であって、各々のシリンジのプランジャー移動ストロークおよび移動速度がお互いに異なり、かつ一定の比率が保たれている装置であって、詳しくはバレルを固定する本体部と、複数のシリンジのプランジャーの末端に装着される加圧部と、本体部と複数の加圧部とを連結する連結板とからなり、薬液最少容量注入用シリンジ側の本体部の後端側に連結板の回転運動の中心となる接続部が設けられており、また加圧部には連結板の回転運動をプランジャーに伝達するためのスライド溝が設けられており、連結板において本体部の接続部と各々の加圧部との距離の比率が、各々のシリンジの異なる薬液注入量の比率と同じであるように設定されているシリンジ固定注入装置である。
【０００６】
【発明の実施の形態】
以下、図面をもとに本発明について詳細に説明する。図１は本発明の一実施例となるシリンジ固定注入装置の構造を示す立体斜視図で、図２は本発明の一実施例となるシリンジ固定注入装置の注入前と注入後の配置を示す側面図である。
【０００７】
本発明による非等量薬液注入用のシリンジ固定注入装置は、図１に示すように、複数の同サイズのシリンジ（２１）のバレル（２２）を保持する本体部（１）と、シリンジ（２１）のプランジャー（２３）の末端に装着された複数の加圧部（２）と、本体部（１）及び加圧部（２）双方をつなぎ止めるピン（９）、（１０）、（１１）が付設された連結板（３）とから基本的に構成されている。本体部（１）はシリンジ（２１）のバレル（２２）を保持する複数のバレル受け（４）と、バレル受け（４）の後端にはフランジ（２４）が嵌合固定されるフランジ受け（５）が設けられており、更に薬液最少容量注入用シリンジ側の本体部の後端側には連結板（３）のピン（９）が挿入され回転の中心となる接続部（６）が設けられている。加圧部（２）はプランジャー（２３）の末端のフランジ部が嵌合するＵ字溝部（７）が設けられ更に連結板（３）のピン（１０）、（１１）がシリンジ（２１）軸に対して直角方向に移動できるスライド溝部（８）が設けられている。連結板（３）は前述のごとくピン（９）、（１０）、（１１）が付設されており、本体部（１）挿入用のピン（９）と複数の加圧部（２）挿入用のピン（１０）、（１１）との距離関係は目的とする薬液の注入量に比例する関係にあり、例えば薬液の注入量の比率を１：３とする場合、ピン（９）から（１０）の距離とピン（９）から（１１）の距離との比率も１：３に設定されている。
【０００８】
本体部（１）、加圧部（２）、連結板（３）の材質及び成形方法はプラスチック等による射出成形等にて作製されるのが一般的であるが特に限定されるものではない。また決められた薬液注入比率で使用する限りにおいては連結板（３）とピン（９）〜（１１）を一体成形とすることがコスト的に安価となるが、注入比率を適宜変更して使用する場合においては、ピン（１０）、（１１）を別部品とし、連結板（３）には複数のピン取付部（１２）を予め設置しておけばユーザーにおいて薬液注入比率を変更して使用することも可能となるため望ましい実施例の一つである。
【０００９】
次に図２を用いて本発明による非等量薬液注入用のシリンジ固定注入装置の機構を説明する。図２（ａ）は薬液注入前の配置を示す側面図で、（ｂ）は薬液注入後の配置を示す側面図である。取り付けられた左右のシリンジ（１１）は容量が３ｍｌであり、３ｍｌと１ｍｌの注入例を示している。連結板（３）は本体部（１）の接続部（６）に嵌合したピン（９）を中心とする回転ができるように取り付けられており、図２（ａ）の配置より薬液注入が開始となり、加圧部（２ａ）を加圧することによりピン（１１）がスライド溝部（８ａ）内を左方向に移動するとともに連結板（３）がピン（９）を中心として回転する。そしてこの連結板（３）の回転にともないピン（１０）が加圧部（２ｂ）のスライド溝部（８ｂ）内を左方向に移動しながら加圧部（２ｂ）を押し進め薬液注入完了時は図２（ｂ）の配置となる。
原理的にはピン（９）→（１０）の距離をＡ、（９）→（１１）の距離をＢとするとそれぞれの距離Ａ：Ｂ＝１：３の場合、注入方向の距離も三角形の相似比に等しく、必ず薬液注入方向の距離Ｃ：Ｄ＝１：３の比率で薬液注入されることになる。
【００１０】
【発明の効果】
以上に述べた如く、本発明による非等量薬液注入用のシリンジ固定注入装置は複数の異なるプランジャーの進む量を常に一定の比率で進めることが可能な機構であるため、わざわざ特注の専用シリンジを作製せずとも汎用の低コストシリンジを使用して異なる薬液注入を行え、特に高濃度のフィブリンを形成させ高い閉鎖効果を得るのに適する組織接着剤の注入装置として有用である。
【図面の簡単な説明】
【図１】本発明の一実施例となる非等量薬液注入用シリンジ固定注入装置の構造を示す立体斜視図である。
【図２】本発明の一実施例となる非等量薬液注入用シリンジ固定注入装置の機構を示す図で（ａ）は薬液注入前で、（ｂ）は薬液注入後のそれぞれの配置を示す側面図である。
【図３】従来の非等量薬液注入用シリンジ固定注入装置の機構を示す側面図である。
【符号の説明】
１ 本体部
２ 加圧部
３ 連結板
４ バレル受け
５ フランジ受け
６ 接続部
７ Ｕ字溝部
８ スライド溝部
９ ピン（本体部取付用）
10 ピン（加圧部取付用）
11 ピン（加圧部取付用）
12 ピン取付部
21 シリンジ
22 バレル
23 プランジャー
24 フランジ[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a tissue adhesive injection device mainly applied as a multi-component preparation, and more specifically, forms high concentration fibrin by lowering the volume ratio of thrombin solution to high concentration fibrinogen solution. The present invention relates to a syringe-fixed injection device of a tissue adhesive suitable for obtaining a high closing effect.
[0002]
[Prior art]
Fibrinogen is a coagulation factor that plays a very important role in the final stage of the so-called blood coagulation cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes an important contribution to hemostasis and wound treatment, for example in the activation of the blood clotting system after injury. A tissue adhesive utilizing the principle of the final phase of blood coagulation has been developed and used in surgical operations as an adhesive for suturing a soft organ such as the liver or spleen, or as a suturing aid. At the same time, it is applied in a wide range of clinical settings. In recent years, a spray coating method in which a fibrinogen solution and a thrombin solution housed in two syringe bodies are simultaneously injected, and the two injected liquids are sprayed and mixed in a mist using aseptic gas has begun to spread. . A suitable example of such a device is described, for example, in PCT WO94-07420. However, even if such a spray coating method is used, in cases where a strong adhesion / closure effect such as treatment of large blood vessels or treatment of air leaks in the lung is required, until the tissue adhesive exhibits a sufficient effect There were still problems to overcome.
[0003]
On the other hand, as a method for enhancing the effect of the tissue adhesive, it was confirmed that it was effective to increase the fibrinogen concentration by changing the mixing ratio of the fibrinogen solution and the thrombin solution.
A device applied to these tissue adhesives, that is, a device for simultaneously injecting a fibrinogen solution and a thrombin solution in different volumes is shown in FIG. 3 in JP-A-61-293443 and PCT WO97-33633. It is shown that two syringes having different cross-sectional areas have an equal length effective stroke. However, there are no general-purpose syringes having different cross-sectional areas and equal effective strokes, and it is necessary to make a new syringe exclusively for this application, so it has been unavoidable to increase the cost in the syringe field where mass production is low-priced.
[0004]
[Problems to be solved by the invention]
The object of the present invention is to solve the conventional problems as described above. The purpose of the present invention is to use a general-purpose low-cost syringe without producing a special-purpose dedicated syringe and maximize the effect of the tissue adhesive. In order to raise the limit, it is an object of the present invention to provide an injection device capable of always injecting two or more liquids of different volumes at a constant ratio at the same time.
[0005]
[Means for Solving the Problems]
That is, the present invention is a device that can fix at least two or more syringes of the same size and can simultaneously inject a chemical solution from each syringe, and is a syringe fixed injection device that can always inject different volumes at a constant ratio, The plunger movement stroke and the movement speed of the syringe are different from each other and maintained at a constant ratio. Specifically, the syringe is attached to the main body for fixing the barrel and the plunger end of the plurality of syringes. And a connecting plate that connects the main body portion and the plurality of pressurizing portions, and serves as the center of the rotational movement of the connecting plate on the rear end side of the main body portion on the syringe side for injection of the minimum liquid volume The pressurizing part is provided with a slide groove for transmitting the rotational movement of the connecting plate to the plunger. The ratio of the distance between parts is a syringe fixed injection device is set to be the same as the ratio of the different liquid medicine injection amount of each syringe.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 is a three-dimensional perspective view showing the structure of a syringe fixed injection device according to one embodiment of the present invention, and FIG. 2 is a side view showing the arrangement before and after injection of the syringe fixed injection device according to one embodiment of the present invention. FIG.
[0007]
As shown in FIG. 1, a syringe fixed injection device for injecting a non-equal chemical solution according to the present invention includes a main body (1) that holds barrels (22) of a plurality of syringes (21) of the same size, and a syringe (21 ) Of a plurality of pressure parts (2) mounted on the end of the plunger (23), and pins (9), (10), (11) for securing both the main body part (1) and the pressure part (2). And a connecting plate (3) to which is attached. The main body (1) includes a plurality of barrel receivers (4) for holding the barrel (22) of the syringe (21), and a flange receiver (fitting a flange (24) to the rear end of the barrel receiver (4) ( 5) is provided, and a connecting portion (6) serving as the center of rotation is provided on the rear end side of the main body portion on the syringe side for injection of the minimum amount of the chemical solution by inserting the pin (9) of the connecting plate (3). It has been. The pressurizing part (2) is provided with a U-shaped groove part (7) into which the end flange part of the plunger (23) is fitted, and the pins (10) and (11) of the connecting plate (3) are syringes (21). A slide groove (8) is provided that can move in a direction perpendicular to the axis. As described above, the connecting plate (3) is provided with the pins (9), (10), (11), and the main body (1) for inserting the pin (9) and the plurality of pressure members (2) for inserting. The distance relationship between the pins (10) and (11) is proportional to the injection amount of the target chemical solution. For example, when the ratio of the injection amount of the chemical solution is 1: 3, the pin (9) to (10 ) And the distance between the pins (9) to (11) are also set to 1: 3.
[0008]
The material and molding method of the main body (1), the pressure unit (2), and the connecting plate (3) are generally produced by injection molding using plastic or the like, but are not particularly limited. In addition, as long as it is used at a predetermined chemical injection ratio, it is inexpensive to integrally form the connecting plate (3) and the pins (9) to (11). In this case, if the pins (10) and (11) are separate parts and the connecting plate (3) is provided with a plurality of pin mounting portions (12) in advance, the user can change the chemical injection ratio for use. This is one of the preferred embodiments.
[0009]
Next, the mechanism of the syringe fixed injection device for injecting a non-equal chemical solution according to the present invention will be described with reference to FIG. FIG. 2A is a side view showing an arrangement before chemical liquid injection, and FIG. 2B is a side view showing an arrangement after chemical liquid injection. The attached left and right syringes (11) have a capacity of 3 ml, and injecting examples of 3 ml and 1 ml are shown. The connecting plate (3) is attached so as to be able to rotate around the pin (9) fitted to the connecting portion (6) of the main body (1), and from the arrangement of FIG. At the start, by pressurizing the pressurizing portion (2a), the pin (11) moves in the left direction in the slide groove portion (8a) and the connecting plate (3) rotates around the pin (9). As the connecting plate (3) rotates, the pin (10) moves leftward within the slide groove (8b) of the pressurizing unit (2b) while pushing the pressurizing unit (2b), and when the injection of the chemical solution is completed, FIG. 2 (b).
In principle, if the distance of the pins (9) → (10) is A and the distance of (9) → (11) is B, the distance in the injection direction is also triangular when each distance A: B = 1: 3. It is equal to the similarity ratio, and the chemical solution is always injected at a ratio C: D = 1: 3 in the chemical solution injection direction.
[0010]
【The invention's effect】
As described above, the syringe-fixed injection device for injecting a non-equal chemical solution according to the present invention is a mechanism that can always advance a plurality of different plungers at a constant rate. Therefore, it is useful as a tissue adhesive injection device suitable for obtaining a high closing effect by forming a high concentration of fibrin.
[Brief description of the drawings]
FIG. 1 is a three-dimensional perspective view showing a structure of a syringe fixed injection device for non-equal drug solution injection according to an embodiment of the present invention.
FIGS. 2A and 2B are diagrams showing a mechanism of a syringe-fixed injection device for non-equal-volume drug solution injection according to an embodiment of the present invention, wherein FIG. 2A shows the arrangement before the solution injection, and FIG. 2B shows the arrangement after the solution injection. It is a side view.
FIG. 3 is a side view showing a mechanism of a conventional syringe fixed injection device for injecting a non-equal chemical solution.
[Explanation of symbols]
DESCRIPTION OF
10 pin (for mounting the pressure part)
11 pin (for mounting the pressure part)
12 pin mounting
21 syringe
22 barrels
23 Plunger
24 Flange
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07122199A JP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07122199A JP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000262525A JP2000262525A (en) | 2000-09-26 |
| JP3678602B2 true JP3678602B2 (en) | 2005-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP07122199A Expired - Fee Related JP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
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| Country | Link |
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| JP (1) | JP3678602B2 (en) |
Cited By (1)
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|---|---|---|---|---|
| CN109498911A (en) * | 2018-12-14 | 2019-03-22 | 王红玲 | Syringe for syringe |
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| US7732190B2 (en) | 2006-07-31 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
| US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
| US8741326B2 (en) | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US8192760B2 (en) | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
| US8535276B2 (en) * | 2008-06-26 | 2013-09-17 | Bellanovus Development Company Llc | Syringe-attached topical anesthetic dispenser |
| WO2012072553A1 (en) * | 2010-11-29 | 2012-06-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having a collar and a linkage component |
| CN103338799B (en) * | 2010-11-29 | 2016-01-13 | 赛诺菲-安万特德国有限公司 | Drug delivery device |
| JP5959528B2 (en) * | 2010-11-29 | 2016-08-02 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drug delivery device having collar and linkage member |
| IL217272A0 (en) * | 2011-12-29 | 2012-02-29 | Omrix Biopharmaceuticals | System for delivery of fluids and use thereof |
| US12409271B2 (en) * | 2022-04-25 | 2025-09-09 | Frank Levy | Apparatus and method for producing an enriched medical suspension |
-
1999
- 1999-03-17 JP JP07122199A patent/JP3678602B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498911A (en) * | 2018-12-14 | 2019-03-22 | 王红玲 | Syringe for syringe |
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| Publication number | Publication date |
|---|---|
| JP2000262525A (en) | 2000-09-26 |
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