JP3714978B2 - ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体 - Google Patents

ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体 Download PDF

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Publication number: JP3714978B2
Authority: JP; Japan
Prior art keywords: methoxy; compound; cdcl; hexane; ethyl acetate
Prior art date: 1993-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP23682494A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0873404A (ja

Inventor

光昭大谷

利幸加藤

洋三堀

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shionogi and Co Ltd

Original Assignee

Shionogi and Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-01

Filing date

1994-09-30

Publication date

2005-11-09

1994-09-30 Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd

1994-09-30 Priority to JP23682494A priority Critical patent/JP3714978B2/ja

1996-03-19 Publication of JPH0873404A publication Critical patent/JPH0873404A/ja

2005-11-09 Application granted granted Critical

2005-11-09 Publication of JP3714978B2 publication Critical patent/JP3714978B2/ja

2020-11-09 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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0 Cc1c(*)c(OC)c(C)c(*c(c(OC)c2C)c(C)c(*)c2OCCCCCCSc(cc2)ccc2F)c1C Chemical compound Cc1c(*)c(OC)c(C)c(*c(c(OC)c2C)c(C)c(*)c2OCCCCCCSc(cc2)ccc2F)c1C 0.000 description 6
VOHRIBRQYLSFCF-UHFFFAOYSA-N BrCCCOc1cc2ccccc2cc1 Chemical compound BrCCCOc1cc2ccccc2cc1 VOHRIBRQYLSFCF-UHFFFAOYSA-N 0.000 description 1
ZXLYYQUMYFHCLQ-UHFFFAOYSA-N CN(C(c1c2cccc1)=O)C2=O Chemical compound CN(C(c1c2cccc1)=O)C2=O ZXLYYQUMYFHCLQ-UHFFFAOYSA-N 0.000 description 1
DDIIAJRLFATEEE-UHFFFAOYSA-N CN(C(c1c2cccc1)=O)S2(=O)=O Chemical compound CN(C(c1c2cccc1)=O)S2(=O)=O DDIIAJRLFATEEE-UHFFFAOYSA-N 0.000 description 1
HUNUAFNLLYVTQD-UHFFFAOYSA-N COC(c1ccccc1S(Cl)(=O)=O)=O Chemical compound COC(c1ccccc1S(Cl)(=O)=O)=O HUNUAFNLLYVTQD-UHFFFAOYSA-N 0.000 description 1
VKNUENLPKPOOPS-UHFFFAOYSA-N Fc(cc1)ccc1OCCCBr Chemical compound Fc(cc1)ccc1OCCCBr VKNUENLPKPOOPS-UHFFFAOYSA-N 0.000 description 1
PYPCIOWTSGJQHX-UHFFFAOYSA-N Fc(cc1)ccc1SCCCCCCBr Chemical compound Fc(cc1)ccc1SCCCCCCBr PYPCIOWTSGJQHX-UHFFFAOYSA-N 0.000 description 1
LGRFSURHDFAFJT-UHFFFAOYSA-N O=C(c1c2cccc1)OC2=O Chemical compound O=C(c1c2cccc1)OC2=O LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
RHMPLDJJXGPMEX-UHFFFAOYSA-N Oc(cc1)ccc1F Chemical compound Oc(cc1)ccc1F RHMPLDJJXGPMEX-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
- C07C233/92—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/03—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Quinoline Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Pyrane Compounds (AREA)
Hydrogenated Pyridines (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

JP23682494A 1993-10-01 1994-09-30 ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体 Expired - Fee Related JP3714978B2 (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP23682494A JP3714978B2 (ja)	1993-10-01	1994-09-30	ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP5-246732		1993-10-01
JP24673293		1993-10-01
JP6-154937		1994-07-06
JP15493794		1994-07-06
JP23682494A JP3714978B2 (ja)	1993-10-01	1994-09-30	ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体

Publications (2)

Publication Number	Publication Date
JPH0873404A JPH0873404A (ja)	1996-03-19
JP3714978B2 true JP3714978B2 (ja)	2005-11-09

Family

ID=26483074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP23682494A Expired - Fee Related JP3714978B2 (ja)	1993-10-01	1994-09-30	ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体

Country Status (12)

Country	Link
US (1)	US5534533A (2)
EP (1)	EP0646569B1 (2)
JP (1)	JP3714978B2 (2)
CN (1)	CN1071738C (2)
AT (1)	ATE161820T1 (2)
AU (1)	AU674779B2 (2)
CA (1)	CA2133115A1 (2)
DE (1)	DE69407709T2 (2)
DK (1)	DK0646569T3 (2)
ES (1)	ES2112489T3 (2)
GR (1)	GR3025911T3 (2)
TW (1)	TW307757B (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4323409A1 (de) *	1993-07-13	1995-01-19	Boehringer Mannheim Gmbh	Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel
AU2652397A (en) *	1996-05-13	1997-12-05	Nippon Shinyaku Co. Ltd.	Substituted ethylene compounds and drugs
US5888721A (en) *	1996-07-03	1999-03-30	Millennium Pharmaceuticals, Inc.	Antibacterial compounds
CA2301586A1 (en) *	1997-08-28	1999-03-04	William Louis Macias	Method for treatment of non-rheumatoid arthritis
US6861448B2 (en) *	1998-01-14	2005-03-01	Virtual Drug Development, Inc.	NAD synthetase inhibitors and uses thereof
JP4775259B2 (ja) *	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
DE112022004333T5 (de)	2021-09-09	2024-07-04	Asahi Kasei Kabushiki Kaisha	Substrat mit aufgebrachter haftschicht, laminat und beschichtungsmaterialzusammensetzung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL45396A0 (en) *	1973-08-23	1974-11-29	Beecham Group Ltd	Pharmaceutical compositions containing aryl aralkyl ether and thioether derivatives,certain such novel compounds and their preparation
US4067892A (en) *	1973-08-23	1978-01-10	Beecham Group Limited	Substituted (4-carboxyphenoxy) phenyl alkane compounds
KR100233343B1 (ko) *	1991-07-03	1999-12-01	시오노 요시히코	포스포리파제 a2 저해물질

1994
- 1994-09-28 CA CA002133115A patent/CA2133115A1/en not_active Abandoned
- 1994-09-28 AU AU74285/94A patent/AU674779B2/en not_active Ceased
- 1994-09-28 US US08/313,890 patent/US5534533A/en not_active Expired - Lifetime
- 1994-09-29 ES ES94307136T patent/ES2112489T3/es not_active Expired - Lifetime
- 1994-09-29 DK DK94307136.5T patent/DK0646569T3/da active
- 1994-09-29 DE DE69407709T patent/DE69407709T2/de not_active Expired - Fee Related
- 1994-09-29 EP EP94307136A patent/EP0646569B1/en not_active Expired - Lifetime
- 1994-09-29 TW TW083109006A patent/TW307757B/zh active
- 1994-09-29 AT AT94307136T patent/ATE161820T1/de not_active IP Right Cessation
- 1994-09-30 CN CN94118648A patent/CN1071738C/zh not_active Expired - Fee Related
- 1994-09-30 JP JP23682494A patent/JP3714978B2/ja not_active Expired - Fee Related
1998
- 1998-01-15 GR GR980400079T patent/GR3025911T3/el unknown

Also Published As

Publication number	Publication date
GR3025911T3 (en)	1998-04-30
EP0646569B1 (en)	1998-01-07
AU7428594A (en)	1995-04-13
DK0646569T3 (da)	1998-02-09
AU674779B2 (en)	1997-01-09
EP0646569A1 (en)	1995-04-05
DE69407709D1 (de)	1998-02-12
ATE161820T1 (de)	1998-01-15
CA2133115A1 (en)	1995-04-02
ES2112489T3 (es)	1998-04-01
CN1071738C (zh)	2001-09-26
CN1107137A (zh)	1995-08-23
TW307757B (2)	1997-06-11
DE69407709T2 (de)	1998-04-23
JPH0873404A (ja)	1996-03-19
US5534533A (en)	1996-07-09

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2005-08-03	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20050802
2005-09-01	A61	First payment of annual fees (during grant procedure)	Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20050824
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2008-09-02	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
US6316503B1 (en)	2001-11-13	LXR modulators
US4258058A (en)	1981-03-24	Phenoxyalkylcarboxylic acid compounds and thrombocyte-aggregation inhibition
DE69624262T2 (de)	2003-09-11	Sulfonamidinhibitoren von matrix metalloproteinasen
US6214877B1 (en)	2001-04-10	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
EP0261254B1 (en)	1990-02-07	3,4-dihydro-4-oxo-2h-1-benzopyranyloxy alkanoic acid derivatives
JPH0123462B2 (2)	1989-05-02
US6414179B1 (en)	2002-07-02	Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors
US6890932B2 (en)	2005-05-10	Anthranilic acid derivative
JPH0710827B2 (ja)	1995-02-08	新規のスルホニル―フェニルアルキルアミン、及びこれを含有する、高められた血小板凝集又は腎臓機能の病理学的変化に基づく疾病の治療剤
BG63940B1 (bg)	2003-07-31	Бифенилсулфонамидни инхибитори на металопротеиназата на матрикса
JP3004678B2 (ja)	2000-01-31	置換（キノリン―２―イル―メトキシ）フエニル―アシル―スルホンアミド類及び―シアナミド類
US20040002493A1 (en)	2004-01-01	Benzoic acid derivatives and pharmaceutical agents comprising the same as active ingredient
JPH0819040B2 (ja)	1996-02-28	フェニルアルカン（ケン）酸
JP3714978B2 (ja)	2005-11-09	ホスホリパーゼａ２阻害活性を有する新規カルボン酸誘導体
CS271469B2 (en)	1990-10-12	Method of phenoxyalkylcarboxyl acid's derivatives production
SU664561A3 (ru)	1979-05-25	Способ получени производных 2-/4(ациламиноалкил)-фенокси/-алкилкарбоновой кислоты или их солей
JP3933244B2 (ja)	2007-06-20	アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
JPH0610174B2 (ja)	1994-02-09	アミノフエノ−ル誘導体
US4999345A (en)	1991-03-12	Sulfonamide derivatives and drugs obtained therefrom
CA2202704A1 (en)	1997-10-18	Benzyloxy-substituted phenylglycinolamides
US7419974B2 (en)	2008-09-02	Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
US4657916A (en)	1987-04-14	Quinoline-N-oxide derivative and pharmaceutical composition
RU2103261C1 (ru)	1998-01-27	Изобутилзамещенные амиды метансульфонилхинолилметоксифенилциклоалкилуксусной кислоты или их фармацевтически приемлемые соли
KR100362789B1 (ko)	2002-11-30	5-리폭시게네이즈 저해제를 제조하기 위한 방법 및 중간체
ES2391265T3 (es)	2012-11-22	Derivados del ácido butírico