JP4361275B2 - ジペプチジル・ペプチダーゼｉｖの２，１−オキサゾリンおよび１，２−ピラゾリンに基づくインヒビターおよび方法 - Google Patents

ジペプチジル・ペプチダーゼｉｖの２，１−オキサゾリンおよび１，２−ピラゾリンに基づくインヒビターおよび方法 Download PDF

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Publication number: JP4361275B2
Authority: JP; Japan
Prior art keywords: compound; formula; alkyl; cycloalkyl; mmol
Prior art date: 2001-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP2002580932A

Other languages

English (en)

Japanese (ja)

Other versions

JP2004532220A (ja

Inventor

リチャード・ビー・サルスキー

ジェフリー・エイ・ローブル

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-05

Publication date

2009-11-11

2002-04-05 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-10-21 Publication of JP2004532220A publication Critical patent/JP2004532220A/ja

2009-11-11 Application granted granted Critical

2009-11-11 Publication of JP4361275B2 publication Critical patent/JP4361275B2/ja

2022-04-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

0 C*1NC(*)C*1 Chemical compound C*1NC(*)C*1 0.000 description 8
GWBSVOPPSNSUGB-UHFFFAOYSA-N C1=COC2C=CC=CC12 Chemical compound C1=COC2C=CC=CC12 GWBSVOPPSNSUGB-UHFFFAOYSA-N 0.000 description 1
KNSFHYOYXKDWMY-UHFFFAOYSA-N C1=NC2C=CC=CC2O1 Chemical compound C1=NC2C=CC=CC2O1 KNSFHYOYXKDWMY-UHFFFAOYSA-N 0.000 description 1
CPEQAIMOKLKVOS-UHFFFAOYSA-N C1C(CCC=C2)=C2OC1 Chemical compound C1C(CCC=C2)=C2OC1 CPEQAIMOKLKVOS-UHFFFAOYSA-N 0.000 description 1
FCZWMPQUJUCBGL-UHFFFAOYSA-N C1C=C(C=CC#C2)C2=NC1 Chemical compound C1C=C(C=CC#C2)C2=NC1 FCZWMPQUJUCBGL-UHFFFAOYSA-N 0.000 description 1
HRCMXYXVAWHBTH-UHFFFAOYSA-N C1Oc(cccc2)c2N1 Chemical compound C1Oc(cccc2)c2N1 HRCMXYXVAWHBTH-UHFFFAOYSA-N 0.000 description 1
KURJFDVIHICSIW-UHFFFAOYSA-N C1SC=Nc2c1cccc2 Chemical compound C1SC=Nc2c1cccc2 KURJFDVIHICSIW-UHFFFAOYSA-N 0.000 description 1
SHBIAFCRGMIRGC-UHFFFAOYSA-N CC(C1)C=Cc2c1[nH]cn2 Chemical compound CC(C1)C=Cc2c1[nH]cn2 SHBIAFCRGMIRGC-UHFFFAOYSA-N 0.000 description 1
ASSKVPFEZFQQNQ-UHFFFAOYSA-N O=C1Oc(cccc2)c2N1 Chemical compound O=C1Oc(cccc2)c2N1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Immunology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Obesity (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Virology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
Neurology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pregnancy & Childbirth (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)

JP2002580932A 2001-04-12 2002-04-05 ジペプチジル・ペプチダーゼｉｖの２，１−オキサゾリンおよび１，２−ピラゾリンに基づくインヒビターおよび方法 Expired - Lifetime JP4361275B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28343801P	2001-04-12	2001-04-12
PCT/US2002/010936 WO2002083128A1 (en)	2001-04-12	2002-04-05	2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase iv and method

Publications (2)

Publication Number	Publication Date
JP2004532220A JP2004532220A (ja)	2004-10-21
JP4361275B2 true JP4361275B2 (ja)	2009-11-11

Family

ID=23086067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2002580932A Expired - Lifetime JP4361275B2 (ja)	2001-04-12	2002-04-05	ジペプチジル・ペプチダーゼｉｖの２，１−オキサゾリンおよび１，２−ピラゾリンに基づくインヒビターおよび方法

Country Status (10)

Country	Link
US (1)	US6573287B2 (de)
EP (1)	EP1377288B1 (de)
JP (1)	JP4361275B2 (de)
AT (1)	ATE443517T1 (de)
AU (1)	AU2002254557B2 (de)
CA (1)	CA2444465A1 (de)
DE (1)	DE60233785D1 (de)
ES (1)	ES2331352T3 (de)
HU (1)	HUP0401423A3 (de)
WO (1)	WO2002083128A1 (de)

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US20020183367A1 (en)	2002-12-05
EP1377288B1 (de)	2009-09-23
DE60233785D1 (de)	2009-11-05
JP2004532220A (ja)	2004-10-21
AU2002254557B2 (en)	2007-01-18
HUP0401423A2 (hu)	2004-11-29
HUP0401423A3 (en)	2008-03-28
CA2444465A1 (en)	2002-10-24
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US6573287B2 (en)	2003-06-03
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