JP4428863B2 - リポ蛋白中のコレステロールの分別定量方法および定量用試薬 - Google Patents

リポ蛋白中のコレステロールの分別定量方法および定量用試薬 Download PDF

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Publication number: JP4428863B2
Authority: JP; Japan
Prior art keywords: cholesterol; reagent; group; salt; hdl
Prior art date: 1998-09-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP2000574287A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2000017388A1 (ja

Inventor

博幸杉内

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Minaris Medical Co Ltd

Original Assignee

Kyowa Medex Co Ltd

Hitachi Chemical Diagnostics Systems Co Ltd

Minaris Medical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-18

Filing date

1999-07-30

Publication date

2010-03-10

1999-07-30 Application filed by Kyowa Medex Co Ltd, Hitachi Chemical Diagnostics Systems Co Ltd, Minaris Medical Co Ltd filed Critical Kyowa Medex Co Ltd

2001-12-11 Publication of JPWO2000017388A1 publication Critical patent/JPWO2000017388A1/ja

2010-03-10 Application granted granted Critical

2010-03-10 Publication of JP4428863B2 publication Critical patent/JP4428863B2/ja

2019-07-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims abstract description 332
239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 176
235000012000 cholesterol Nutrition 0.000 title claims abstract description 166
238000000034 method Methods 0.000 title claims abstract description 74
102000004895 Lipoproteins Human genes 0.000 title claims description 58
108090001030 Lipoproteins Proteins 0.000 title claims description 58
108010010234 HDL Lipoproteins Proteins 0.000 claims abstract description 124
102000015779 HDL Lipoproteins Human genes 0.000 claims abstract description 124
102000004190 Enzymes Human genes 0.000 claims description 88
108090000790 Enzymes Proteins 0.000 claims description 88
238000008214 LDL Cholesterol Methods 0.000 claims description 82
-1 polyoxyethylene Polymers 0.000 claims description 63
150000003839 salts Chemical class 0.000 claims description 63
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 50
238000006243 chemical reaction Methods 0.000 claims description 49
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 37
238000011002 quantification Methods 0.000 claims description 29
239000002202 Polyethylene glycol Substances 0.000 claims description 25
229920001223 polyethylene glycol Polymers 0.000 claims description 25
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 22
102000000019 Sterol Esterase Human genes 0.000 claims description 21
108010055297 Sterol Esterase Proteins 0.000 claims description 21
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239000012472 biological sample Substances 0.000 claims description 19
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150000001346 alkyl aryl ethers Chemical class 0.000 claims description 15
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229910052751 metal Inorganic materials 0.000 claims description 10
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IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 claims description 10
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 9
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HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 9
108010023417 cholesterol dehydrogenase Proteins 0.000 claims description 6
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RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 27
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108040007629 peroxidase activity proteins Proteins 0.000 description 13
239000000523 sample Substances 0.000 description 13
DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 12
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SVLRFMQGKVFRTB-UHFFFAOYSA-M sodium;3-(3,5-dimethoxyanilino)-2-hydroxypropane-1-sulfonate Chemical compound [Na+].COC1=CC(NCC(O)CS([O-])(=O)=O)=CC(OC)=C1 SVLRFMQGKVFRTB-UHFFFAOYSA-M 0.000 description 10
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 9
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108010028554 LDL Cholesterol Proteins 0.000 description 8
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
210000002966 serum Anatomy 0.000 description 8
IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 description 7
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JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 4
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235000019341 magnesium sulphate Nutrition 0.000 description 4
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238000003759 clinical diagnosis Methods 0.000 description 3
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239000000758 substrate Substances 0.000 description 3
QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 description 2
BTIDJAQNJLWPTI-UHFFFAOYSA-N 3-(n-ethyl-3,5-dimethoxyanilino)-2-hydroxypropane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(O)CN(CC)C1=CC(OC)=CC(OC)=C1 BTIDJAQNJLWPTI-UHFFFAOYSA-N 0.000 description 2
NUFBIAUZAMHTSP-UHFFFAOYSA-N 3-(n-morpholino)-2-hydroxypropanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CN1CCOCC1 NUFBIAUZAMHTSP-UHFFFAOYSA-N 0.000 description 2
XCBLFURAFHFFJF-UHFFFAOYSA-N 3-[bis(2-hydroxyethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCCN(CCO)CC(O)CS(O)(=O)=O XCBLFURAFHFFJF-UHFFFAOYSA-N 0.000 description 2
GIAVHGFPMPSIFI-UHFFFAOYSA-N 3-hydroxy-2,4,6-triiodobenzoic acid Chemical compound OC(=O)C1=C(I)C=C(I)C(O)=C1I GIAVHGFPMPSIFI-UHFFFAOYSA-N 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
239000006173 Good's buffer Substances 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
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ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
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KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
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KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
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DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 2
YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
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VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 2
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125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
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230000002093 peripheral effect Effects 0.000 description 1
229960005222 phenazone Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
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229940051841 polyoxyethylene ether Drugs 0.000 description 1
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XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
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HDARHUHTZKLJET-UHFFFAOYSA-M sodium;3-(n-ethyl-3,5-dimethoxyanilino)-2-hydroxypropane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC(OC)=CC(OC)=C1 HDARHUHTZKLJET-UHFFFAOYSA-M 0.000 description 1
HLXGRHNZZSMNRX-UHFFFAOYSA-M sodium;3-(n-ethyl-3,5-dimethylanilino)-2-hydroxypropane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC(C)=CC(C)=C1 HLXGRHNZZSMNRX-UHFFFAOYSA-M 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
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WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1

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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol

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Engineering & Computer Science (AREA)
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Molecular Biology (AREA)
Immunology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
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JP2000574287A 1998-09-18 1999-07-30 リポ蛋白中のコレステロールの分別定量方法および定量用試薬 Expired - Lifetime JP4428863B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP26436798		1998-09-18
JP10-264367		1998-09-18
PCT/JP1999/004128 WO2000017388A1 (fr)	1998-09-18	1999-07-30	Dosage du cholesterol dans les lipoproteines et reactifs de quantification

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Publication Number	Publication Date
JPWO2000017388A1 JPWO2000017388A1 (ja)	2001-12-11
JP4428863B2 true JP4428863B2 (ja)	2010-03-10

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US (1)	US6794157B1 (de)
EP (1)	EP1114870B1 (de)
JP (1)	JP4428863B2 (de)
KR (1)	KR100607896B1 (de)
CN (2)	CN1544650A (de)
AT (1)	ATE278805T1 (de)
AU (1)	AU4932099A (de)
CA (1)	CA2344055C (de)
DE (1)	DE69920937T2 (de)
ES (1)	ES2226408T3 (de)
WO (1)	WO2000017388A1 (de)

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* Cited by examiner, † Cited by third party
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JP2017207505A (ja) *	2015-05-29	2017-11-24	シスメックス株式会社	リポタンパク質のコレステロール取り込み能を測定する方法及び試薬キット

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* Cited by examiner, † Cited by third party
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JP4456715B2 (ja) *	2000-02-28	2010-04-28	協和メデックス株式会社	レムナント様リポ蛋白中のコレステロールの測定方法および測定試薬
JP3686326B2 (ja) *	2000-11-08	2005-08-24	アークレイ株式会社	高密度リポタンパク質（ｈｄｌ）コレステロール測定用試験片
ATE384135T1 (de) *	2002-01-30	2008-02-15	Denka Seiken Kk	Verfahren zur quantifizierung von cholesterin in hd-(high density)-lipoprotein und reagenszusammensetzungen
AU2003301324A1 (en) *	2002-10-16	2004-05-04	Kyowa Medex Co., Ltd.	Method and reagent for measuring cholesterol in high-density lipoproteins
EP1555326B1 (de) *	2002-10-16	2009-11-25	Kyowa Medex Co., Ltd.	Verfahren und reagens zur messung von cholesterin in lipoproteinen hoher dichte
ATE505731T1 (de) *	2002-12-06	2011-04-15	Denka Seiken Kk	Verfahren zur quantifizierung von kleinen lipoproteinen mit geringer dichte
CN1748036B (zh) *	2002-12-13	2012-01-11	电化生研株式会社	低密度脂蛋白中胆固醇的多重定量方法
US20050032141A1 (en) *	2003-07-17	2005-02-10	Dimagno Theodore John	Dry analytical element for high-density lipoprotein cholesterol quantification
JP4643212B2 (ja) *	2003-11-28	2011-03-02	シスメックス株式会社	コレステロール脱水素酵素の安定化方法、コレステロール脱水素酵素含有組成物及びコレステロール測定試薬
KR20060127111A (ko) *	2004-01-29	2006-12-11	교와 메덱스 가부시키가이샤	초저밀도 지단백질 잔유물 (ｖｌｄｌ 잔유물) 중의콜레스테롤 정량 방법, 시약 및 키트
US7435577B2 (en) *	2004-02-03	2008-10-14	Polymer Technology Systems, Inc.	Direct measurement of chlolesterol from low density lipoprotein with test strip
JP4647927B2 (ja)	2004-03-31	2011-03-09	デンカ生研株式会社	低密度リポ蛋白中コレステロールのマルチ定量法
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- 1999-07-30 CA CA2344055A patent/CA2344055C/en not_active Expired - Lifetime
- 1999-07-30 DE DE69920937T patent/DE69920937T2/de not_active Expired - Lifetime
- 1999-07-30 KR KR1020017003452A patent/KR100607896B1/ko not_active Expired - Lifetime
- 1999-07-30 WO PCT/JP1999/004128 patent/WO2000017388A1/ja not_active Ceased
- 1999-07-30 CN CNA2004100067506A patent/CN1544650A/zh active Pending
- 1999-07-30 US US09/787,393 patent/US6794157B1/en not_active Expired - Lifetime
- 1999-07-30 AU AU49320/99A patent/AU4932099A/en not_active Abandoned
- 1999-07-30 EP EP99933203A patent/EP1114870B1/de not_active Expired - Lifetime
- 1999-07-30 ES ES99933203T patent/ES2226408T3/es not_active Expired - Lifetime
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- 1999-07-30 JP JP2000574287A patent/JP4428863B2/ja not_active Expired - Lifetime
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ATE278805T1 (de)	2004-10-15
CN1318107A (zh)	2001-10-17
US6794157B1 (en)	2004-09-21
CN1200113C (zh)	2005-05-04
EP1114870B1 (de)	2004-10-06
KR20010075176A (ko)	2001-08-09
CA2344055A1 (en)	2000-03-30
WO2000017388A1 (fr)	2000-03-30
EP1114870A4 (de)	2001-10-24
KR100607896B1 (ko)	2006-08-03
CN1544650A (zh)	2004-11-10
EP1114870A1 (de)	2001-07-11
DE69920937D1 (de)	2004-11-11
CA2344055C (en)	2010-08-17
AU4932099A (en)	2000-04-10
DE69920937T2 (de)	2006-02-23
ES2226408T3 (es)	2005-03-16

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Publication	Publication Date	Title
US6794157B1 (en)	2004-09-21	Methods for fractional quatification of cholesterol in lipoproteins and quantification reagents
JPWO2000017388A1 (ja)	2001-12-11	リポ蛋白中のコレステロールの分別定量方法および定量用試薬
US5888827A (en)	1999-03-30	Method for determination of cholesterol in low-density lipoprotein or very low-density lipoprotein
JP5548733B2 (ja)	2014-07-16	小粒子低比重リポ蛋白の定量方法および定量キット
JPWO1996029599A1 (ja)	1997-06-24	低密度リポ蛋白中または超低密度リポ蛋白中のコレステロールの定量法
JP4456715B2 (ja)	2010-04-28	レムナント様リポ蛋白中のコレステロールの測定方法および測定試薬
EP1849876B1 (de)	2011-08-24	Verfahren, reagens und kit zur quantifizierung von cholesterin in remnantartigem lipoprotein (rlp)
JP4690200B2 (ja)	2011-06-01	超低密度リポ蛋白レムナント（ｖｌｄｌレムナント）中のコレステロールの定量方法、試薬およびキット
JP5534644B2 (ja)	2014-07-02	レムナント様リポ蛋白中のコレステロール測定方法、試薬及びキット
JP5191236B2 (ja)	2013-05-08	低密度リポ蛋白中トリグリセリドの測定方法及び測定用キット
JPH08116996A (ja)	1996-05-14	血清または血漿中のｈｄｌ−コレステロールを測定する方法
EP3677688A1 (de)	2020-07-08	Verfahren zur messung von cholesterin in lipoprotein mit niedriger dichte, messreagenz und messkit
JP2007014201A (ja)	2007-01-25	レムナント様リポタンパク質中のコレステロールの測定方法
WO2019177093A1 (ja)	2019-09-19	高密度リポ蛋白質中のコレステロールの定量方法
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JPWO2000043537A1 (ja)	2002-05-21	リポ蛋白中のトリグリセライドの定量法

JP4428863B2 - リポ蛋白中のコレステロールの分別定量方法および定量用試薬 - Google Patents

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