JP4528443B2 - 環状プロサポシン由来のペプチドおよびその使用 - Google Patents

環状プロサポシン由来のペプチドおよびその使用 Download PDF

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Publication number: JP4528443B2
Authority: JP; Japan
Prior art keywords: peptide; amino acid; acid; cyclic; peptides
Prior art date: 1998-08-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2000567569A

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English (en)

Japanese (ja)

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JP2002523518A (ja

JP2002523518A5 (pl

Inventor

デービッドイーライト

ジョンエスオーブライエン

Original Assignee

ミエロスコーポレーション

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-28

Filing date

1999-08-20

Publication date

2010-08-18

1999-08-20 Application filed by ミエロスコーポレーション filed Critical ミエロスコーポレーション

2002-07-30 Publication of JP2002523518A publication Critical patent/JP2002523518A/ja

2006-08-10 Publication of JP2002523518A5 publication Critical patent/JP2002523518A5/ja

2010-08-18 Application granted granted Critical

2010-08-18 Publication of JP4528443B2 publication Critical patent/JP4528443B2/ja

2019-08-20 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Toxicology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

JP2000567569A 1998-08-28 1999-08-20 環状プロサポシン由来のペプチドおよびその使用 Expired - Fee Related JP4528443B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9835998P	1998-08-28	1998-08-28
US60/098,359		1998-08-28
PCT/US1999/019378 WO2000012553A1 (en)	1998-08-28	1999-08-20	Cyclic prosaposin-derived peptides and uses thereof

Related Child Applications (1)

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JP2010034833A Division JP2010150272A (ja)	1998-08-28	2010-02-19	環状プロサポシン由来のペプチドおよびその使用

Publications (3)

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JP2002523518A JP2002523518A (ja)	2002-07-30
JP2002523518A5 JP2002523518A5 (pl)	2006-08-10
JP4528443B2 true JP4528443B2 (ja)	2010-08-18

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JP2000567569A Expired - Fee Related JP4528443B2 (ja)	1998-08-28	1999-08-20	環状プロサポシン由来のペプチドおよびその使用
JP2010034833A Pending JP2010150272A (ja)	1998-08-28	2010-02-19	環状プロサポシン由来のペプチドおよびその使用

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JP2010034833A Pending JP2010150272A (ja)	1998-08-28	2010-02-19	環状プロサポシン由来のペプチドおよびその使用

Country Status (13)

Country	Link
EP (1)	EP1105420A1 (pl)
JP (2)	JP4528443B2 (pl)
KR (1)	KR20010079695A (pl)
CN (1)	CN1324367A (pl)
AU (1)	AU751034B2 (pl)
BR (1)	BR9913490A (pl)
CA (1)	CA2341810A1 (pl)
CZ (1)	CZ2001655A3 (pl)
HU (1)	HUP0103265A3 (pl)
IL (1)	IL141586A0 (pl)
PL (1)	PL204359B1 (pl)
WO (1)	WO2000012553A1 (pl)
ZA (1)	ZA200102489B (pl)

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JP2010150272A (ja) *	1998-08-28	2010-07-08	Myelos Corp	環状プロサポシン由来のペプチドおよびその使用

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Publication number	Priority date	Publication date	Assignee	Title
US5571787A (en)	1993-07-30	1996-11-05	Myelos Corporation	Prosaposin as a neurotrophic factor
AUPQ084899A0 (en) *	1999-06-08	1999-07-01	University Of Melbourne, The	Neurotrophin agonists
IL137820A (en) *	2000-08-10	2009-06-15	S I S Shulov Inst For Science	Pharmaceutical composition for topical administration comprising an analgesic peptide
CN100366286C (zh) *	2003-04-28	2008-02-06	常州南云科技有限公司	Saposin C-DOPS:一种抗癌新药
JP5437790B2 (ja)	2006-04-28	2014-03-12	チルドレンズホスピタルメディカルセンター	膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
EP2081552A2 (en) *	2006-10-20	2009-07-29	Children's Hospital Medical Center	Spontaneously forming ellipsoidal phospholipid unilamellar vesicles
CN103275187B (zh) *	2013-06-14	2014-10-29	四川合泰新光生物科技有限公司	一种镇痛肽fi及其基因和应用
CA2982480C (en)	2015-04-23	2021-04-13	The Procter & Gamble Company	Delivery of surfactant soluble anti-dandruff agent
CN108697609A (zh)	2016-03-03	2018-10-23	宝洁公司	气溶胶去头皮屑组合物
EP3528896A1 (en)	2016-10-21	2019-08-28	The Procter & Gamble Company	Concentrated shampoo dosage of foam for providing hair care benefits
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EP3528894A1 (en)	2016-10-21	2019-08-28	The Procter and Gamble Company	Concentrated shampoo dosage of foam for providing hair care benefits
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US11141370B2 (en)	2017-06-06	2021-10-12	The Procter And Gamble Company	Hair compositions comprising a cationic polymer mixture and providing improved in-use wet feel
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JP7678101B2 (ja)	2020-11-23	2025-05-15	ザプロクターアンドギャンブルカンパニー	硫酸化界面活性剤を含まないパーソナルケア組成物
JP7768985B2 (ja)	2020-12-04	2025-11-12	ザプロクターアンドギャンブルカンパニー	悪臭低減物質を含むヘアケア組成物
US12409125B2 (en)	2021-05-14	2025-09-09	The Procter & Gamble Company	Shampoo compositions containing a sulfate-free surfactant system and sclerotium gum thickener
US11986543B2 (en)	2021-06-01	2024-05-21	The Procter & Gamble Company	Rinse-off compositions with a surfactant system that is substantially free of sulfate-based surfactants
WO2023108097A1 (en)	2021-12-09	2023-06-15	The Procter & Gamble Company	Sulfate free personal cleansing composition comprising effective preservation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL106106A0 (en) *	1993-06-22	1993-10-20	Interpharm Lab Ltd	Library of polymeric molecules and its preparation
US6271196B1 (en) *	1996-03-05	2001-08-07	Regents Of The University Of Ca	Methods of alleviating neuropathic pain using prosaposin-derived peptides
CA2341810A1 (en) *	1998-08-28	2000-03-09	Myelos Corporation	Cyclic prosaposin-derived peptides and uses thereof

1999
- 1999-08-20 CA CA002341810A patent/CA2341810A1/en not_active Abandoned
- 1999-08-20 JP JP2000567569A patent/JP4528443B2/ja not_active Expired - Fee Related
- 1999-08-20 PL PL346346A patent/PL204359B1/pl not_active IP Right Cessation
- 1999-08-20 CZ CZ2001655A patent/CZ2001655A3/cs unknown
- 1999-08-20 HU HU0103265A patent/HUP0103265A3/hu unknown
- 1999-08-20 BR BR9913490-0A patent/BR9913490A/pt not_active IP Right Cessation
- 1999-08-20 CN CN99812627A patent/CN1324367A/zh active Pending
- 1999-08-20 EP EP99943903A patent/EP1105420A1/en not_active Withdrawn
- 1999-08-20 IL IL14158699A patent/IL141586A0/xx not_active IP Right Cessation
- 1999-08-20 WO PCT/US1999/019378 patent/WO2000012553A1/en not_active Ceased
- 1999-08-20 AU AU56905/99A patent/AU751034B2/en not_active Ceased
- 1999-08-20 KR KR1020017002478A patent/KR20010079695A/ko not_active Withdrawn
2001
- 2001-03-27 ZA ZA200102489A patent/ZA200102489B/en unknown
2010
- 2010-02-19 JP JP2010034833A patent/JP2010150272A/ja active Pending

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010150272A (ja) *	1998-08-28	2010-07-08	Myelos Corp	環状プロサポシン由来のペプチドおよびその使用

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Publication number	Publication date
ZA200102489B (en)	2002-06-04
JP2002523518A (ja)	2002-07-30
BR9913490A (pt)	2001-09-25
JP2010150272A (ja)	2010-07-08
IL141586A0 (en)	2002-03-10
HUP0103265A2 (hu)	2002-02-28
WO2000012553A1 (en)	2000-03-09
AU751034B2 (en)	2002-08-08
PL204359B1 (pl)	2010-01-29
EP1105420A1 (en)	2001-06-13
CN1324367A (zh)	2001-11-28
CZ2001655A3 (cs)	2001-11-14
HUP0103265A3 (en)	2002-09-30
KR20010079695A (ko)	2001-08-22
PL346346A1 (en)	2002-02-11
CA2341810A1 (en)	2000-03-09
AU5690599A (en)	2000-03-21

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Publication	Publication Date	Title
JP4528443B2 (ja)	2010-08-18	環状プロサポシン由来のペプチドおよびその使用
DE69736712T2 (de)	2007-09-13	Verfahren zur milderung von neuropatischen schmerz mit prosaposin verwandten peptiden
JPH09503999A (ja)	1997-04-22	治療剤としてのプロサポシンおよびサイトカイン由来ペプチド
US6849602B1 (en)	2005-02-01	Compositions for alleviating neuropathic pain with prosaposin receptor agonists
US6458357B1 (en)	2002-10-01	Retro-inverso neurotrophic and analgesic peptides
WO1998039357A1 (en)	1998-09-11	Method of alleviating neuropathic pain
WO1998042746A9 (en)	1999-03-11	Synthetic saposin c-derived neurotrophic peptides
WO1998042746A2 (en)	1998-10-01	Synthetic saposin c-derived neurotrophic peptides
MXPA01001966A (en)	2003-11-07	Cyclic prosaposin-derived peptides and uses thereof
AU2002300005B2 (en)	2006-06-29	Method of alleviating neuropathic pain
AU4267297A (en)	1998-09-22	Method of alleviating neuropathic pain
US20020128193A1 (en)	2002-09-12	Retro-inverso prosaposin-derived peptides and use thereof

JP4528443B2 - 環状プロサポシン由来のペプチドおよびその使用 - Google Patents

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