JP4969016B2 - 抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物 - Google Patents

抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物 Download PDF

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Publication number: JP4969016B2
Authority: JP; Japan
Prior art keywords: combination; alkyl; estrogen; acid; growth
Prior art date: 2001-02-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP2002563936A

Other languages

English (en)

Japanese (ja)

Other versions

JP2004517960A (ja

Inventor

エンド，デイビツド・ウイリアム

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-15

Filing date

2002-02-06

Publication date

2012-07-04

2002-02-06 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2004-06-17 Publication of JP2004517960A publication Critical patent/JP2004517960A/ja

2012-07-04 Application granted granted Critical

2012-07-04 Publication of JP4969016B2 publication Critical patent/JP4969016B2/ja

2022-02-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Oncology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Detergent Compositions (AREA)

JP2002563936A 2001-02-15 2002-02-06 抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物 Expired - Lifetime JP4969016B2 (ja)

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Application Number	Priority Date	Filing Date	Title
US26883901P	2001-02-15	2001-02-15
US60/268,839		2001-02-15
PCT/EP2002/001248 WO2002064142A1 (en)	2001-02-15	2002-02-06	Farnesyl protein transferase inhibitor combinations with antiestrogen agents

Related Child Applications (1)

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JP2009236573A Division JP4865027B2 (ja)	2001-02-15	2009-10-13	抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物

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JP2004517960A JP2004517960A (ja)	2004-06-17
JP4969016B2 true JP4969016B2 (ja)	2012-07-04

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Application Number	Title	Priority Date	Filing Date
JP2002563936A Expired - Lifetime JP4969016B2 (ja)	2001-02-15	2002-02-06	抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物
JP2009236573A Expired - Lifetime JP4865027B2 (ja)	2001-02-15	2009-10-13	抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物

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JP2009236573A Expired - Lifetime JP4865027B2 (ja)	2001-02-15	2009-10-13	抗エストロゲン剤とファルネシルプロテイントランスフェラーゼ阻害剤の組み合わせ物

Country Status (7)

Country	Link
US (4)	US20040110769A1 (de)
EP (1)	EP1365763B1 (de)
JP (2)	JP4969016B2 (de)
AT (1)	ATE415161T1 (de)
DE (1)	DE60230017D1 (de)
ES (1)	ES2318000T3 (de)
WO (1)	WO2002064142A1 (de)

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WO2002064142A1 (en) *	2001-02-15	2002-08-22	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitor combinations with antiestrogen agents
AU2003272964A1 (en) *	2002-10-09	2004-05-04	Kyowa Hakko Kogyo Co., Ltd.	Remedy for hormone-dependent cancer
US7838531B2 (en) *	2002-10-18	2010-11-23	The United States Of America As Represented By The Department Of Health And Human Services	Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis
WO2004035753A2 (en)	2002-10-18	2004-04-29	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Lmna gene and its involvement in hutchinson-gilford progeria syndrome (hgps) and arteriosclerosis
BRPI0416316A (pt) *	2003-11-06	2007-01-09	Schering Corp	combinação de um inibidor da farnesil transferase com um agente anti-hormonal para o tratamento de cáncer de mama
AU2006331542A1 (en)	2005-12-23	2007-07-05	Link Medicine Corporation	Treatment of synucleinopathies
HK1213887A1 (zh)	2012-10-16	2016-07-15	Janssen Pharmaceutica N.V.	RORγt的苯基连接的喹啉基调节剂
WO2014062655A1 (en)	2012-10-16	2014-04-24	Janssen Pharmaceutica Nv	HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
CA2927182A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Quinolinyl modulators of ror.gamma.t
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
CA2926339A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of roryt
PL3137078T3 (pl) *	2014-05-01	2019-08-30	Eiger Biopharmaceuticals, Inc.	Leczenie zakażenia wirusem zapalenia wątroby typu delta
US10076512B2 (en)	2014-05-01	2018-09-18	Eiger Biopharmaceuticals, Inc.	Treatment of hepatitis delta virus infection
US11311519B2 (en)	2014-05-01	2022-04-26	Eiger Biopharmaceuticals, Inc.	Treatment of hepatitis delta virus infection
HUE054068T2 (hu)	2015-04-21	2021-08-30	Eiger Biopharmaceuticals Inc	Lonafarnibot és Ritonavirt tartalmazó gyógyszerkészítmények
US10471055B2 (en)	2015-08-17	2019-11-12	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
HRP20210544T1 (hr)	2016-11-03	2021-08-20	Kura Oncology, Inc.	Inhibitori farneziltransferaze za uporabu u liječenju raka

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JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
TW349948B (en) *	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
DE69635966T2 (de) *	1995-12-08	2006-11-30	Janssen Pharmaceutica N.V.	(Imidazol-5-yl)Methyl-2-Chinolinonderivate als Farnesyl Protein transferase Inhibitoren
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
SK146199A3 (en) *	1997-04-25	2000-06-12	Janssen Pharmaceutica Nv	Farnesyltransferase inhibiting quinazolinones
CN1275911A (zh) *	1997-08-15	2000-12-06	杜克大学	一种预防或治疗雌激素依赖性疾病及失调的方法
PT1041985E (pt) *	1997-12-22	2006-07-31	Schering Corp	Combinacao de compostos benzociclo-heptapiridina e farmacos antineoplasicos para tratar doencas proliferativas
DE19826213A1 (de) *	1998-06-09	1999-12-16	Schering Ag	Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
AU1230100A (en) *	1998-10-29	2000-05-22	Merck & Co., Inc.	A method of treating endometriosis
PT1140935E (pt) *	1998-12-23	2003-10-31	Janssen Pharmaceutica Nv	Derivados da quinolina 1,2-ciclizada
PT1255537E (pt) *	2000-02-04	2006-09-29	Janssen Pharmaceutica Nv	Inibidores da proteina farnesil transferase para tratar cancro da mama
JP2003523381A (ja) *	2000-02-24	2003-08-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	投与レジメン
WO2002024683A1 (en) *	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derivatives
WO2002064142A1 (en) *	2001-02-15	2002-08-22	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitor combinations with antiestrogen agents

2002
- 2002-02-06 WO PCT/EP2002/001248 patent/WO2002064142A1/en not_active Ceased
- 2002-02-06 DE DE60230017T patent/DE60230017D1/de not_active Expired - Lifetime
- 2002-02-06 AT AT02719776T patent/ATE415161T1/de not_active IP Right Cessation
- 2002-02-06 ES ES02719776T patent/ES2318000T3/es not_active Expired - Lifetime
- 2002-02-06 JP JP2002563936A patent/JP4969016B2/ja not_active Expired - Lifetime
- 2002-02-06 US US10/468,162 patent/US20040110769A1/en not_active Abandoned
- 2002-02-06 EP EP02719776A patent/EP1365763B1/de not_active Expired - Lifetime
2008
- 2008-09-29 US US12/240,075 patent/US20090023776A1/en not_active Abandoned
2009
- 2009-10-13 JP JP2009236573A patent/JP4865027B2/ja not_active Expired - Lifetime
2011
- 2011-01-07 US US12/986,351 patent/US20110105557A1/en not_active Abandoned
2012
- 2012-01-04 US US13/343,125 patent/US20120108634A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2002064142A1 (en)	2002-08-22
JP2010047589A (ja)	2010-03-04
US20120108634A1 (en)	2012-05-03
JP4865027B2 (ja)	2012-02-01
US20040110769A1 (en)	2004-06-10
US20110105557A1 (en)	2011-05-05
US20090023776A1 (en)	2009-01-22
ATE415161T1 (de)	2008-12-15
EP1365763A1 (de)	2003-12-03
JP2004517960A (ja)	2004-06-17
EP1365763B1 (de)	2008-11-26
DE60230017D1 (de)	2009-01-08
ES2318000T3 (es)	2009-05-01

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