JP5116428B2 - Moisturizer and external preparation for skin - Google Patents

Description

The present invention relates to a moisturizing agent and a skin external preparation containing a naturally derived component as an active ingredient. More particularly, to humectants and skin external preparation containing Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) plant or its extract.

  Conventionally, in order to provide a moisturizing ingredient that prevents the skin from drying and moisturizes the skin, various active ingredients have been studied. In particular, naturally-derived components are known to have various pharmacological and cosmetic effects, and so far, applications of extracts such as plants and fungi to humectants have been studied.

  For example, as a moisturizing agent excellent in moisturizing effect and safety, an extract of Julianidaceae plant (see Patent Document 1), an extract of Brassicaceae Pydium genus plant (see Patent Document 2), an extract of an Asteraceae genus Camelidae plant ( Patent Document 3), Maple plant extract (see Patent Document 4), Hyssop plant extract (see Patent Document 5), Novanoceae plant extract (see Patent Document 6), Amber plant extract (See Patent Document 7) and the like are known.

JP-A-11-209223 JP 2001-39854 A JP 2002-20262 A JP 2003-1113068 A JP 2004-262862 A JP 2006-69939 A JP 2007-77072 A

  Thus, various naturally-derived components have been applied so far. However, there are many naturally-derived ingredients whose effects are not yet known, and the development of an effective ingredient having an excellent moisturizing action has been expected.

The present inventors have made examined various components of natural origin, conventionally excellent moisturizing effect to the Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) plant or its extract its effect was not known The present invention was found out, and further studies were made to complete the present invention.

That is, the present invention relates to a humectant and Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) 1 or more kinds of plants or active ingredient the extract is selected from plant.

Another invention relates to an external preparation for skin characterized by containing one or more plants selected from the plants of the genus Liliaceae ( Cardiocrinum ) or an extract thereof.

According to the present invention, by the Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) 1 or more kinds of plants or active ingredient the extract is selected from plant, provides a moisturizing agent having an excellent effect be able to.

  By blending these moisturizing agents into the external preparation for skin, various compositions that prevent the skin from drying and moisturize the skin can be provided.

Liliaceae The (Liliaceae) cardiocrinum (Cardiocrinum) plant, perennial to put a large white flower, Ubayuri (Cardiocrinum cordatum var.cordatum) distributed in southwest Japan, distributed in northeastern Japan Ooubayuri (Cardiocrinum cordatum var.glehnii), Himalayan butterfly ( Cardioclinum giganteum ) distributed in China is known.

  These plants can be used alone or in combination of two or more.

The present invention is not particularly limited as long as Liliaceae cardiocrinum plants, from reasons such as availability is relatively easy, as appropriate, include Ooubayuri (Cardiocrinum cordatum var.glehnii) is.

  When using these liliaceae plants, there are no particular limitations on the site of use, and any part such as leaves, roots, stems, flowers, etc. can be used. A plurality of parts may be used in combination.

  They can be pulverized as they are, but it is preferable to use an extract from those parts.

  For the extraction, any part of the plant belonging to the genus Lilyaceae may be used, but whole plants, leaves, and flowers may be used for convenient use. In that case, you may make it obtain an extract using a some site | part. Further, two or more kinds of extracts extracted using different solvents may be mixed and used.

  In the extraction, the plant may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization.

  The extraction can be performed by immersing in an arbitrary extraction solvent for a predetermined time. The extraction solvent may be heated as necessary. Alternatively, extraction can be performed using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, stirring or homogenization in an extraction solvent may be performed. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 1 hour to 14 days.

  As an extraction solvent, in addition to water, lower alcohols such as methanol, ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethers such as ethyl ether and propyl ether Solvents such as esters; esters such as butyl acetate and ethyl acetate; ketones such as acetone and ethyl methyl ketone can be used. These may be used alone or in combination of any two or more. Saline, phosphate buffer, phosphate buffered saline, and the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical liquids and subcritical liquids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  The above-mentioned solvent extract of the genus Lilyaceae can be used as it is, but it may be left to mature for a certain period of time, or it may be used after aging and concentrating and drying the product again in water or a polar solvent. It can also be used by dissolving. Alternatively, it may be used after performing purification treatment such as decolorization, deodorization, desalting, etc., or fractionation treatment by column chromatography or the like, as long as these physiological functions are not impaired. The said extract of a lily family Ubayuri genus plant, its processed material, and a fraction can also be used after freeze-drying after each process and fractionation, and melt | dissolving in a solvent at the time of use. It can also be used by encapsulating in vesicles such as liposomes or microcapsules.

  The liliaceae genus Uliuri or its extract has an excellent moisturizing action and can be used as a moisturizing agent.

  A moisturizing agent comprising a lily family plant, or an extract thereof, as an active ingredient can give an excellent moisturizing effect to skin, hair, and the like.

  As long as the moisturizing agent of the present invention contains a plant belonging to the genus Liliaceae or an extract thereof as an active ingredient, the form and presence / absence of addition of other ingredients are not limited at all. As for the form, any form such as liquid, paste, gel, solid, powder, etc. can be selected according to its use and the like, vehicle (excipient), solvent, Other general additives (antioxidants, colorants, dispersants, etc.) can optionally be included.

  A lily family plant belonging to the genus Uberyuri or an extract thereof has an excellent moisturizing action, and by blending it, it is possible to provide an external preparation for skin which prevents drying of the skin and moisturizes the skin.

  Here, the external preparation for skin means all external compositions for external use on the skin or hair, such as cosmetics, quasi-drugs, and external medicines.

  The dosage form of the external preparation for skin is arbitrary, and can be provided, for example, as a solubilizing system such as lotion, a dispersion system such as calamine lotion, or an emulsifying system such as cream or emulsion. Further, it can be provided in various dosage forms such as an aerosol form, an ointment, and a poultice filled with a propellant.

  Specifically, various cosmetics such as emulsions, creams, lotions, lotions, packs, cosmetic liquids, cleaning agents, makeup cosmetics, etc .; liquids, ointments, powders, granules, aerosols, patches, poultices, etc. Various forms of cosmetics, quasi drugs, topical medicines, and the like can be exemplified.

  To provide a skin external preparation that prevents dryness of the skin and moisturizes the skin by blending a lily family plant belonging to the genus Uliuri, or an extract thereof, into a skin external preparation such as cosmetics, external medicines, and quasi drugs. it can. Therefore, for example, it can be preferably used as a skin external preparation for moisturizing.

  In addition to the liliaceae genus plant or extract thereof, the topical skin preparation is usually blended in pharmaceuticals, quasi drugs, skin cosmetics, hair cosmetics, and cleansing agents, etc. as necessary and necessary. Optional ingredients such as water, oily ingredients, powders, pigments, emulsifiers, solubilizers, gelling agents, detergents, UV absorbers, anti-inflammatory agents, thickeners, pH adjusters, chelating agents, drugs ( Medicinal components), fragrances, resins, fungicides, fungicides, antioxidants, alcohols, and the like can be appropriately blended. Furthermore, in the range which does not impair the effect of this invention, it is also possible to use together with other moisturizing agents or plants other than the liliaceae genus, or an extract thereof.

  The blending amount of the Lilyaceae plant or the extract thereof into the external preparation for skin can be adjusted depending on the type, purpose, etc., but from the viewpoint of the effect and stability, the total amount is 0.0001-10. 0.0 mass% is preferable, More preferably, it is 0.001-5 mass%, More preferably, it is 0.01-5 mass%, More preferably, it is 0.1-5 mass%.

Preparation follows Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) plant extracts, the test method for evaluating the moisturizing effect, described in more detail for prescription examples of the external preparation for skin, the technical scope of the present invention Is not limited in any way by this.

[Adjustment method 1]
To 100 g of dry ground pulverized leaves of Cardiocrinum cordatum var. Ghehnii, 2.0 kg of 50 mass% ethanol aqueous solution was added and extracted at room temperature for 2 hours with stirring. The extract was collected by filtration, concentrated under reduced pressure, and then lyophilized to obtain a Lilyaceae genus plant extract.

[Preparation Method 2]
100 g of purified water was added to 5 g of dried ground pulverized leaves of the green lily, and the mixture was extracted using an autoclave (120 ° C., 20 minutes). The extract was collected by filtration and freeze-dried to obtain a Lilyaceae genus plant extract.

[Preparation Method 3]
A supercritical extraction apparatus was charged with 100 g of dried ground lily leaves, and liquefied carbon dioxide was continuously poured with a pump, and extraction was performed using a supercritical fluid of carbon dioxide at 25 Mpa, 5 mL / min, 40 ° C. The extract was collected to obtain a lily family plant.

  Using the extract, the moisturizing effect was evaluated. Note that * and ** described in each evaluation result indicate that the significance probability P value in the t-test is less than 5% (P <0.05), and less than 1% significance (P <0.01). ) Is represented by **.

<Evaluation of moisturizing effect>
Evaluation of the moisturizing effect of the liliaceae plant was performed by the following method. As a sample, the Lilyaceae genus plant extract prepared by Preparation Method 1 and Preparation Method 2 was used.

A 1% by mass of Lilyaceae genus plant extract aqueous solution was prepared with distilled water to give Example 1 (Preparation Method 1) and Example 2 (Preparation Method 2). The examples were coated with 24 μL in the forearm area of 3 × 4 cm ² , and the keratin moisture content was measured before application, and after the application, 15, 30, 60, 120, and 180 minutes. The keratin water content was measured at 5 points from each application site using SKICON-200 (manufactured by IBI S Co., Ltd.). The average value of the five-point measured values is defined as the keratin moisture content, and the relative values are shown in Table 1 as the keratin moisture content 1 before application. As a control, the same amount of distilled water was applied, and the amount of stratum corneum was measured in the same manner.

  As is clear from the results in Table 1, a significant moisturizing effect was observed in the Lilyaceae genus plant extract of Examples 1 and 2. From this, it was found that the lily family genus plant extract has an excellent moisturizing action.

  Then, the formulation example of the skin external preparation which mix | blended the lily family genus plant extract obtained by each said preparation method is shown.

[Example 3] Emulsion (1) Squalane 10.0 (mass%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) 1,3-butylene glycol 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 100 (11) Arginine (1% by weight aqueous solution) 20.0
(12) Lilyaceae genus plant extract [Preparation method 1] 5.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification, cooling is started, and (11) and (12) are sequentially added and mixed uniformly.

[Example 4] Lotion (1) Ethanol 15.0 (mass%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 100 (5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Liliaceae plant extract [Preparation method 2] 1.0
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then sufficiently stirred, (9) is added and mixed uniformly.

[Example 5] Cream (1) Squalane 10.0 (mass%)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) 1,3-butylene glycol 5.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20 mass% aqueous solution) 15.0
(10) Remainder 100 (11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Lilyaceae genus plant extract [Preparation method 1] 5.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. (11) is added after completion | finish of emulsification, cooling is started, (12) is added at 40 degreeC, and it mixes uniformly.

[Example 6] Cosmetic liquid (1) The balance (mass%) of purified water 100
(2) Glycerin 10.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1% by weight aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (derived from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by mass aqueous solution) 2.0
(16) Lilyaceae genus plant extract [Preparation method 2] 3.0
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Cooling is started after completion of emulsification, and (15) is added at 50 ° C. Cool further to 40 ° C., add (16) and mix evenly.

[Example 7] Aqueous gel (1) Carboxyvinyl polymer 0.5 (mass%)
(2) The remainder (3) made into purified water 100 (3) Sodium hydroxide (10 mass% aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Liliaceae genus plant extract [Preparation method 2] 0.5
(8) Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (8) are added and stirred and mixed uniformly.

[Example 8] Cleansing fee (1) Squalane 81.0 (mass%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water 100 (4) Liliaceae genus plant extract [Preparation method 3] 1.0
Manufacturing method: (1) and (2) are uniformly dissolved. (3) and (4) are sequentially added to this and mixed uniformly.

[Example 9] Face-wash foam (1) Stearic acid 16.0 (mass%)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 25.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Residue remaining as 100 (8) Liliaceae genus plant extract [Preparation method 2] 0.1
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. Cooling is started, and (8) is added at 40 ° C. and mixed uniformly.

[Example 10] Make-up base cream (1) Squalane 10.2 (% by mass)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) The balance (100) of purified water 100 Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Lilyaceae genus plant extract [Preparation method 1] 3.0
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Example 11] Emulsion foundation (1) Methylpolysiloxane 2.0 (mass%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Remainder water 100 (11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Lilyaceae genus plant extract [Preparation method 1] 0.5
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the water phase components (7) to (10) are mixed, dissolved by heating at 75 ° C., the pigments (11) to (15) are added thereto, and the mixture is uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after the emulsification is completed, and components (16) and (17) are sequentially added at 40 ° C. and mixed uniformly.

[Example 12] Water-in-oil emollient cream (1) Liquid paraffin 34.0 (mass%)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Lilyaceae genus plant extract [Preparation method 2] 3.0
(11) The balance of 100 purified water (12) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (11) to 50 ° C., and gradually add to (4) heated to 50 ° C. with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (10) are added to the remainder of (11) heated and dissolved at 70 ° C. while stirring and emulsified with a homomixer. Cooling is started after completion of emulsification, and (12) is added at 40 ° C. and mixed uniformly.

[Example 13] Pack (1) The balance (mass%) of purified water 100
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 9.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Liliaceae genus plant extract [Preparation method 1] 1.0
(7) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After uniformly dissolving, add (4) and (5), and start cooling while stirring. Cool to 40 ° C, add (6) and (7) and mix uniformly.

[Example 14] Bath agent (1) Fragrance 0.3 (% by mass)
(2) Lilyaceae genus plant extract [Preparation method 1] 3.0
(3) Sodium bicarbonate 50.0
(4) Sodium sulfate 46.7
Production method: (1) to (4) are mixed uniformly.

[Example 15] Hair wax (1) Stearic acid 3.0 (mass%)
(2) Microcrystalline wax 2.0
(3) Cetyl alcohol 3.0
(4) Highly polymerized methylpolysiloxane 2.0
(5) Methylpolysiloxane 5.0
(6) Poly (oxyethylene / oxypropylene)
Methylpolysiloxane copolymer 1.0
(7) Methyl paraoxybenzoate 0.1
(8) 1,3-butylene glycol 7.5
(9) Arginine 0.7
(10) Remainder as purified water 100 (11) Liliumaceae plant extract [Preparation method 2] 2.0
(12) Fragrance 0.1
Production method: The oil phase components (1) to (6) are mixed and heated and dissolved at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 75 ° C., the oil phase component is added, and the mixture is emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Example 16] Hair artic (1) Ethanol 50.0 (mass%)
(2) Purified water 100 (3) Liliaceae genus plant extract [Preparation method 1] 3.0
(4) Fragrance 0.1
Production method: Components (1) to (4) are mixed and homogenized.

  The external preparations for skin of Examples 3 to 16 were compositions having a moisturizing effect that prevented the skin from drying and moisturized the skin.

Claims (2)

Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) 1 or more kinds of plants or humectant to the extract as an active ingredient selected from plants. Liliaceae (Liliaceae) cardiocrinum (Cardiocrinum) skin external agent characterized in that it contains one or more plants or extracts thereof selected from plants.