JP5208510B2 - 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 - Google Patents
呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 Download PDFInfo
- Publication number
- JP5208510B2 JP5208510B2 JP2007542103A JP2007542103A JP5208510B2 JP 5208510 B2 JP5208510 B2 JP 5208510B2 JP 2007542103 A JP2007542103 A JP 2007542103A JP 2007542103 A JP2007542103 A JP 2007542103A JP 5208510 B2 JP5208510 B2 JP 5208510B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenoxy
- piperazinyl
- chloro
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- GVKHWAUYRBBHEC-UHFFFAOYSA-N C(C1)C11N2C1C2 Chemical compound C(C1)C11N2C1C2 GVKHWAUYRBBHEC-UHFFFAOYSA-N 0.000 description 1
- JTNMVEBSCUDNMB-UHFFFAOYSA-N CC(C1)N(Cc(cc(cc2)Cl)c2OCC(O)=O)CC(C)N1C(Cc1ccccc1)=O Chemical compound CC(C1)N(Cc(cc(cc2)Cl)c2OCC(O)=O)CC(C)N1C(Cc1ccccc1)=O JTNMVEBSCUDNMB-UHFFFAOYSA-N 0.000 description 1
- VOJBLZYFOKEFOL-UHFFFAOYSA-N CC(c1cc(Cl)ccc1OCC(O)=O)N(CC1)CCN1Sc1ccccc1 Chemical compound CC(c1cc(Cl)ccc1OCC(O)=O)N(CC1)CCN1Sc1ccccc1 VOJBLZYFOKEFOL-UHFFFAOYSA-N 0.000 description 1
- SYNYMOOIHRQYQN-UHFFFAOYSA-N COc1ccc(CC(N2CCN(Cc(cc(cc3)Cl)c3OCC(O)=O)CC2)=O)cc1 Chemical compound COc1ccc(CC(N2CCN(Cc(cc(cc3)Cl)c3OCC(O)=O)CC2)=O)cc1 SYNYMOOIHRQYQN-UHFFFAOYSA-N 0.000 description 1
- SNMDUARWLPWWOD-INIZCTEOSA-N C[C@@H](CN(Cc1cc(Cl)ccc1OC(C)(C)C(O)=O)CC1)N1S(c1ccccc1)(=O)=O Chemical compound C[C@@H](CN(Cc1cc(Cl)ccc1OC(C)(C)C(O)=O)CC1)N1S(c1ccccc1)(=O)=O SNMDUARWLPWWOD-INIZCTEOSA-N 0.000 description 1
- GMFBGMFMMAVODH-MRXNPFEDSA-N C[C@H](CN(Cc(cc(cc1)Cl)c1OCC(O)=O)CC1)N1C(Cc1ccccc1)=O Chemical compound C[C@H](CN(Cc(cc(cc1)Cl)c1OCC(O)=O)CC1)N1C(Cc1ccccc1)=O GMFBGMFMMAVODH-MRXNPFEDSA-N 0.000 description 1
- SVKSSVSQZRWBMW-UHFFFAOYSA-N OC(COc(c(CN(CC1)CCN1S(Cc1ncccc1)(=O)=O)c1)ccc1Cl)=O Chemical compound OC(COc(c(CN(CC1)CCN1S(Cc1ncccc1)(=O)=O)c1)ccc1Cl)=O SVKSSVSQZRWBMW-UHFFFAOYSA-N 0.000 description 1
- JQOOWJRHEJTXRT-UHFFFAOYSA-O OC(COc(c(N(CC1)CCN1[S+](Cc1ccccc1)O)c1)ccc1Cl)=O Chemical compound OC(COc(c(N(CC1)CCN1[S+](Cc1ccccc1)O)c1)ccc1Cl)=O JQOOWJRHEJTXRT-UHFFFAOYSA-O 0.000 description 1
- VEDPQGGGGHKSLY-UHFFFAOYSA-N OC(COc(cc1)c(CN(CC2)CCN2S(c2ccccc2)(=O)=O)cc1Cl)=O Chemical compound OC(COc(cc1)c(CN(CC2)CCN2S(c2ccccc2)(=O)=O)cc1Cl)=O VEDPQGGGGHKSLY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0425673.1 | 2004-11-23 | ||
| GB0425673A GB0425673D0 (en) | 2004-11-23 | 2004-11-23 | Novel compounds |
| GB0508923A GB0508923D0 (en) | 2005-04-30 | 2005-04-30 | Novel compounds |
| GB0508923.0 | 2005-04-30 | ||
| PCT/GB2005/004464 WO2006056752A1 (en) | 2004-11-23 | 2005-11-22 | Phenoxyacetic acid derivatives useful for treating respiratory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012280027A Division JP2013082729A (ja) | 2004-11-23 | 2012-12-21 | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520637A JP2008520637A (ja) | 2008-06-19 |
| JP2008520637A5 JP2008520637A5 (2) | 2009-01-15 |
| JP5208510B2 true JP5208510B2 (ja) | 2013-06-12 |
Family
ID=35589515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542103A Expired - Fee Related JP5208510B2 (ja) | 2004-11-23 | 2005-11-22 | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| JP2012280027A Pending JP2013082729A (ja) | 2004-11-23 | 2012-12-21 | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012280027A Pending JP2013082729A (ja) | 2004-11-23 | 2012-12-21 | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8524715B2 (2) |
| EP (1) | EP1817282B1 (2) |
| JP (2) | JP5208510B2 (2) |
| AR (1) | AR051966A1 (2) |
| AT (1) | ATE517085T1 (2) |
| CY (1) | CY1112115T1 (2) |
| DK (1) | DK1817282T3 (2) |
| PL (1) | PL1817282T3 (2) |
| PT (1) | PT1817282E (2) |
| SA (1) | SA05260362B1 (2) |
| SI (1) | SI1817282T1 (2) |
| TW (1) | TW200630336A (2) |
| UY (1) | UY29223A1 (2) |
| WO (1) | WO2006056752A1 (2) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013082729A (ja) * | 2004-11-23 | 2013-05-09 | Astrazeneca Ab | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| EP2407459A1 (en) | 2005-09-27 | 2012-01-18 | Shionogi & Co., Ltd. | Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity |
| DK1928457T3 (da) * | 2005-09-30 | 2013-02-04 | Pulmagen Therapeutics Asthma Ltd | Quinoliner og deres terapeutiske anvendelse |
| EP1937632A1 (en) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| EP1948630A2 (en) * | 2005-11-05 | 2008-07-30 | AstraZeneca AB | Novel compounds |
| TW200732296A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Novel compounds |
| UA100983C2 (ru) * | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| DK2229358T3 (da) | 2007-12-14 | 2011-07-04 | Pulmagen Therapeutics Asthma Ltd | Indoler og deres terapeutiske anvendelse |
| CA2746422A1 (en) * | 2008-12-09 | 2010-06-17 | University Of Florida Research Foundation, Inc. | Kinase inhibitor compounds |
| WO2010083314A2 (en) | 2009-01-14 | 2010-07-22 | Dow Agrosciences Llc | Fungicidal compositions including hydrazone derivatives and copper |
| CN102958914B (zh) | 2010-07-05 | 2015-05-27 | 埃科特莱茵药品有限公司 | 1-苯基取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| SG11201402796SA (en) | 2011-12-16 | 2014-06-27 | Atopix Therapeutics Ltd | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| TW201331179A (zh) | 2011-12-21 | 2013-08-01 | Actelion Pharmaceuticals Ltd | 雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途 |
| CA2876808A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| US10307355B2 (en) | 2015-04-28 | 2019-06-04 | Conopco, Inc. | N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same |
| WO2016173817A1 (en) | 2015-04-28 | 2016-11-03 | Unilever Plc | N-aralkylcarbonyl-piperazine and -homopiperazine compounds and personal care compositions comprising the same |
| WO2017209272A1 (ja) * | 2016-06-03 | 2017-12-07 | 国立大学法人東京大学 | がん転移阻害剤 |
| BR112021025637A2 (pt) | 2019-06-19 | 2022-02-01 | Nmd Pharma As | Compostos para o tratamento de doenças neuromusculares |
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2005
- 2005-11-22 UY UY29223A patent/UY29223A1/es not_active Application Discontinuation
- 2005-11-22 SI SI200531361T patent/SI1817282T1/sl unknown
- 2005-11-22 AT AT05807437T patent/ATE517085T1/de active
- 2005-11-22 EP EP05807437A patent/EP1817282B1/en not_active Expired - Lifetime
- 2005-11-22 AR ARP050104896A patent/AR051966A1/es unknown
- 2005-11-22 PT PT05807437T patent/PT1817282E/pt unknown
- 2005-11-22 PL PL05807437T patent/PL1817282T3/pl unknown
- 2005-11-22 US US11/719,832 patent/US8524715B2/en not_active Expired - Fee Related
- 2005-11-22 WO PCT/GB2005/004464 patent/WO2006056752A1/en not_active Ceased
- 2005-11-22 JP JP2007542103A patent/JP5208510B2/ja not_active Expired - Fee Related
- 2005-11-22 DK DK05807437.8T patent/DK1817282T3/da active
- 2005-11-23 TW TW094141046A patent/TW200630336A/zh unknown
- 2005-11-23 SA SA05260362A patent/SA05260362B1/ar unknown
-
2011
- 2011-09-15 CY CY20111100891T patent/CY1112115T1/el unknown
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2012
- 2012-12-21 JP JP2012280027A patent/JP2013082729A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013082729A (ja) * | 2004-11-23 | 2013-05-09 | Astrazeneca Ab | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200630336A (en) | 2006-09-01 |
| EP1817282B1 (en) | 2011-07-20 |
| CY1112115T1 (el) | 2015-11-04 |
| PT1817282E (pt) | 2011-09-19 |
| JP2013082729A (ja) | 2013-05-09 |
| US8524715B2 (en) | 2013-09-03 |
| US20090149448A1 (en) | 2009-06-11 |
| EP1817282A1 (en) | 2007-08-15 |
| PL1817282T3 (pl) | 2011-11-30 |
| UY29223A1 (es) | 2006-06-30 |
| DK1817282T3 (da) | 2011-10-10 |
| SI1817282T1 (sl) | 2011-10-28 |
| SA05260362B1 (ar) | 2009-04-18 |
| WO2006056752A1 (en) | 2006-06-01 |
| JP2008520637A (ja) | 2008-06-19 |
| AR051966A1 (es) | 2007-02-21 |
| ATE517085T1 (de) | 2011-08-15 |
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