JP5297817B2 - オキシントモジュリン誘導体 - Google Patents

オキシントモジュリン誘導体 Download PDF

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Publication number
JP5297817B2
JP5297817B2 JP2008556379A JP2008556379A JP5297817B2 JP 5297817 B2 JP5297817 B2 JP 5297817B2 JP 2008556379 A JP2008556379 A JP 2008556379A JP 2008556379 A JP2008556379 A JP 2008556379A JP 5297817 B2 JP5297817 B2 JP 5297817B2
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JP
Japan
Prior art keywords
cys
mpeg
peptide
oxm
kda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2008556379A
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English (en)
Japanese (ja)
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JP2009527558A (ja
Inventor
ロイ，ラナビール，シンハ
ビアンキ，エリザベッタ
ペッシ，アントネッロ
インガリネッラ，パオロ
マーシュ，ドナルド，ジェイ
アイエルマン，ジョージ，ジェイ
ムー，インチュン
チョウ，ユン，ピン
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of JP2009527558A publication Critical patent/JP2009527558A/ja
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Publication of JP5297817B2 publication Critical patent/JP5297817B2/ja
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008556379A 2006-02-22 2007-02-16 オキシントモジュリン誘導体 Expired - Fee Related JP5297817B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77554406P 2006-02-22 2006-02-22
US60/775,544 2006-02-22
US83445206P 2006-07-31 2006-07-31
US60/834,452 2006-07-31
PCT/US2007/004306 WO2007100535A2 (fr) 2006-02-22 2007-02-16 Dérivés d'oxyntomoduline

Publications (2)

Publication Number Publication Date
JP2009527558A JP2009527558A (ja) 2009-07-30
JP5297817B2 true JP5297817B2 (ja) 2013-09-25

Family

ID=38309987

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008556379A Expired - Fee Related JP5297817B2 (ja) 2006-02-22 2007-02-16 オキシントモジュリン誘導体

Country Status (7)

Country Link
US (2) US7928058B2 (fr)
EP (3) EP1991574B1 (fr)
JP (1) JP5297817B2 (fr)
CN (1) CN101389648B (fr)
AU (1) AU2007221366B2 (fr)
CA (1) CA2638800A1 (fr)
WO (1) WO2007100535A2 (fr)

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* Cited by examiner, † Cited by third party
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CN101389648A (zh) 2009-03-18
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WO2007100535A3 (fr) 2008-03-20
EP2471811A1 (fr) 2012-07-04
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CN101389648B (zh) 2013-07-17
AU2007221366A1 (en) 2007-09-07
EP1991574A2 (fr) 2008-11-19
EP2471811B1 (fr) 2015-09-16
CA2638800A1 (fr) 2007-09-07
US7928058B2 (en) 2011-04-19
AU2007221366A8 (en) 2012-06-07
WO2007100535A2 (fr) 2007-09-07
US8268779B2 (en) 2012-09-18
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US20110183902A1 (en) 2011-07-28
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