JP5734981B2 - 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖ阻害剤としてのアミノテトラヒドロピラン - Google Patents
糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖ阻害剤としてのアミノテトラヒドロピラン Download PDFInfo
- Publication number
- JP5734981B2 JP5734981B2 JP2012527901A JP2012527901A JP5734981B2 JP 5734981 B2 JP5734981 B2 JP 5734981B2 JP 2012527901 A JP2012527901 A JP 2012527901A JP 2012527901 A JP2012527901 A JP 2012527901A JP 5734981 B2 JP5734981 B2 JP 5734981B2
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- Japan
- Prior art keywords
- alkyl
- group
- pharmaceutically acceptable
- substituted
- dpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CN1Cc2n[n](*)cc2C1 Chemical compound CN1Cc2n[n](*)cc2C1 0.000 description 2
- NWYGPOJAEHFCFJ-UHFFFAOYSA-N CC(C)(C[n]1nc(CN(C2)C(CC3N)COC3c(cc(cc3)[I]=C)c3F)c2c1)O Chemical compound CC(C)(C[n]1nc(CN(C2)C(CC3N)COC3c(cc(cc3)[I]=C)c3F)c2c1)O NWYGPOJAEHFCFJ-UHFFFAOYSA-N 0.000 description 1
- PEXPXTIKHASWFI-FBCCYDICSA-N C[C@H](C[C@@H]1N)CO[C@@H]1[AlH2] Chemical compound C[C@H](C[C@@H]1N)CO[C@@H]1[AlH2] PEXPXTIKHASWFI-FBCCYDICSA-N 0.000 description 1
- GIXWEPLPCQAKSD-IKQUFJDSSA-N N[C@@H](C1)[C@@H](c(cc(cc2)F)c2F)OCC1N1Cc2n[n](CC(O)=O)cc2C1 Chemical compound N[C@@H](C1)[C@@H](c(cc(cc2)F)c2F)OCC1N1Cc2n[n](CC(O)=O)cc2C1 GIXWEPLPCQAKSD-IKQUFJDSSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23924209P | 2009-09-02 | 2009-09-02 | |
| US61/239,242 | 2009-09-02 | ||
| US26227809P | 2009-11-18 | 2009-11-18 | |
| US61/262,278 | 2009-11-18 | ||
| PCT/US2010/046270 WO2011028455A1 (en) | 2009-09-02 | 2010-08-23 | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503864A JP2013503864A (ja) | 2013-02-04 |
| JP5734981B2 true JP5734981B2 (ja) | 2015-06-17 |
Family
ID=43649576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527901A Expired - Fee Related JP5734981B2 (ja) | 2009-09-02 | 2010-08-23 | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖ阻害剤としてのアミノテトラヒドロピラン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455533B2 (2) |
| EP (1) | EP2473047B1 (2) |
| JP (1) | JP5734981B2 (2) |
| KR (1) | KR20120092096A (2) |
| CN (1) | CN102595897A (2) |
| AU (1) | AU2010289871B2 (2) |
| BR (1) | BR112012004335A8 (2) |
| CA (1) | CA2771352A1 (2) |
| IN (1) | IN2012DN00721A (2) |
| MX (1) | MX2012002633A (2) |
| RU (1) | RU2550508C2 (2) |
| WO (1) | WO2011028455A1 (2) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853212B2 (en) | 2010-02-22 | 2014-10-07 | Merck Sharp & Dohme Corp | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
| US8980929B2 (en) | 2010-05-21 | 2015-03-17 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2012078448A1 (en) | 2010-12-06 | 2012-06-14 | Schering Corporation | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| SG192941A1 (en) | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| CA2836487A1 (en) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of gpr-119 |
| TWI574965B (zh) * | 2011-06-29 | 2017-03-21 | 默沙東藥廠 | 二肽基肽酶－ｉｖ抑制劑之新穎結晶型 |
| EP2729468A4 (en) | 2011-07-05 | 2015-03-18 | Merck Sharp & Dohme | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| WO2013122920A1 (en) | 2012-02-17 | 2013-08-22 | Merck Sharp & Dohme Corp. | Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US9156848B2 (en) | 2012-07-23 | 2015-10-13 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-IV inhibitors |
| EP2874622A4 (en) | 2012-07-23 | 2015-12-30 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
| TWI500613B (zh) | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
| CN105085528A (zh) * | 2014-05-15 | 2015-11-25 | 成都贝斯凯瑞生物科技有限公司 | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 |
| PT3159344T (pt) | 2014-06-17 | 2023-11-30 | Sichuan Haisco Pharmaceutical Co Ltd | Derivado em anel aminopiranoide e sua composição e utilização |
| JP6574474B2 (ja) | 2014-07-21 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の製造方法 |
| CN105985357A (zh) * | 2015-02-12 | 2016-10-05 | 北京赛林泰医药技术有限公司 | 取代的氨基六元饱和杂脂环类长效dpp-iv抑制剂 |
| TWI681962B (zh) * | 2015-08-26 | 2020-01-11 | 大陸商四川海思科製藥有限公司 | 胺基六員環類衍生物及其在醫藥上的應用 |
| US10562896B2 (en) | 2017-05-31 | 2020-02-18 | Chemocentryx, Inc. | 6-5 fused rings as C5a inhibitors |
| CN107459501B (zh) * | 2017-08-22 | 2020-06-09 | 钟桂发 | 一种奥格列汀的手性中间体的制备方法 |
| WO2019126424A1 (en) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
| JP7150862B2 (ja) * | 2018-02-06 | 2022-10-11 | スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド | アミノピラン誘導体の組成物 |
| BR112020019822A2 (pt) | 2018-04-02 | 2021-03-16 | Chemocentryx, Inc. | Profármacos de antagonistas bicíclicos fundidos de c5ar |
| KR102131359B1 (ko) * | 2018-09-07 | 2020-07-07 | 오토텔릭바이오 주식회사 | 안정성이 향상된 의약 조성물 |
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-
2010
- 2010-08-23 BR BR112012004335A patent/BR112012004335A8/pt not_active IP Right Cessation
- 2010-08-23 CN CN2010800391645A patent/CN102595897A/zh active Pending
- 2010-08-23 IN IN721DEN2012 patent/IN2012DN00721A/en unknown
- 2010-08-23 US US13/390,538 patent/US8455533B2/en active Active
- 2010-08-23 KR KR1020127005395A patent/KR20120092096A/ko not_active Withdrawn
- 2010-08-23 RU RU2012112471/04A patent/RU2550508C2/ru not_active IP Right Cessation
- 2010-08-23 WO PCT/US2010/046270 patent/WO2011028455A1/en not_active Ceased
- 2010-08-23 AU AU2010289871A patent/AU2010289871B2/en not_active Ceased
- 2010-08-23 MX MX2012002633A patent/MX2012002633A/es active IP Right Grant
- 2010-08-23 JP JP2012527901A patent/JP5734981B2/ja not_active Expired - Fee Related
- 2010-08-23 CA CA2771352A patent/CA2771352A1/en not_active Abandoned
- 2010-08-23 EP EP10814188.8A patent/EP2473047B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2473047B1 (en) | 2014-08-13 |
| AU2010289871B2 (en) | 2014-07-10 |
| IN2012DN00721A (2) | 2015-06-19 |
| US8455533B2 (en) | 2013-06-04 |
| KR20120092096A (ko) | 2012-08-20 |
| JP2013503864A (ja) | 2013-02-04 |
| BR112012004335A2 (pt) | 2015-09-08 |
| EP2473047A4 (en) | 2013-02-13 |
| BR112012004335A8 (pt) | 2016-06-21 |
| MX2012002633A (es) | 2012-04-20 |
| WO2011028455A1 (en) | 2011-03-10 |
| AU2010289871A1 (en) | 2012-04-26 |
| RU2550508C2 (ru) | 2015-05-10 |
| CN102595897A (zh) | 2012-07-18 |
| RU2012112471A (ru) | 2013-10-10 |
| CA2771352A1 (en) | 2011-03-10 |
| US20120149734A1 (en) | 2012-06-14 |
| EP2473047A1 (en) | 2012-07-11 |
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