JP5781941B2 - ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド - Google Patents

ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド Download PDF

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JP5781941B2
JP5781941B2 JP2011545744A JP2011545744A JP5781941B2 JP 5781941 B2 JP5781941 B2 JP 5781941B2 JP 2011545744 A JP2011545744 A JP 2011545744A JP 2011545744 A JP2011545744 A JP 2011545744A JP 5781941 B2 JP5781941 B2 JP 5781941B2
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sequence
protein
recombinant
amino acid
icha
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Japanese (ja)
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JP2013504301A (ja
JP2013504301A5 (2
Inventor
パトリス フィレーエ
パトリス フィレーエ
ヌーレディーヌ ラジー
ヌーレディーヌ ラジー
モレノ ガレーニ
モレノ ガレーニ
ベルナール タミニオー
ベルナール タミニオー
オリヴィエール ジョルワ
オリヴィエール ジョルワ
アルフレッド コーラル
アルフレッド コーラル
アラン ジャック
アラン ジャック
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Vrije Universiteit Brussel VUB
Universite Libre de Bruxelles ULB
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Vrije Universiteit Brussel VUB
Universite Libre de Bruxelles ULB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2011545744A 2009-01-19 2010-01-15 ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド Expired - Fee Related JP5781941B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09150888A EP2208787A1 (en) 2009-01-19 2009-01-19 A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted
EP09150888.7 2009-01-19
PCT/EP2010/050453 WO2010081875A1 (en) 2009-01-19 2010-01-15 A recombinant alpha-hemolysin polypeptide of staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted

Publications (3)

Publication Number Publication Date
JP2013504301A JP2013504301A (ja) 2013-02-07
JP2013504301A5 JP2013504301A5 (2) 2013-03-21
JP5781941B2 true JP5781941B2 (ja) 2015-09-24

Family

ID=40811673

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011545744A Expired - Fee Related JP5781941B2 (ja) 2009-01-19 2010-01-15 ステムドメインにおける欠失および挿入された異種配列を有する黄色ブドウ球菌の組換えα溶血素ポリペプチド

Country Status (7)

Country Link
US (1) US8545853B2 (2)
EP (2) EP2208787A1 (2)
JP (1) JP5781941B2 (2)
AU (1) AU2010205645B2 (2)
CA (1) CA2749862C (2)
ES (1) ES2483720T3 (2)
WO (1) WO2010081875A1 (2)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011010735A (es) 2009-04-14 2012-01-25 Novartis Ag Composiciones para inmunizacion contra staphylococcus aureus.
AU2012214677B2 (en) 2011-02-08 2016-11-10 Abvacc, Inc. Immunogenic composition comprising alpha-hemolysin oligopeptides
EP3470526A3 (en) * 2011-02-08 2019-07-17 Medimmune, LLC Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use
CN103648489A (zh) 2011-05-11 2014-03-19 儿童医疗中心有限公司 多抗原提呈免疫原性组合物及其方法和用途
WO2012178093A1 (en) 2011-06-24 2012-12-27 Electronic Biosciences Inc. High contrast signal to noise ratio device components
CN102977214B (zh) * 2012-09-29 2014-03-12 重庆原伦生物科技有限公司 用于耐甲氧西林金黄色葡萄球菌（mrsa）疫苗的重组蛋白hf2及制备方法和应用
WO2014100481A2 (en) 2012-12-20 2014-06-26 Electornic Biosciences Inc. Modified alpha hemolysin polypeptides and methods of use
JP6494527B2 (ja) 2013-02-07 2019-04-03 ザ チルドレンズ メディカル センター コーポレーション 肺炎球菌のコロニー形成および／または疾患からの保護を提供するタンパク質抗原
BE1022857A1 (fr) * 2014-03-26 2016-09-27 Glaxosmithkline Biologicals Sa Immunisation contre staphylococcus aureus
CA2962241A1 (en) * 2014-09-29 2016-04-07 Fujifilm Corporation Antibody-binding polypeptide, antibody-binding fusion polypeptide, and adsorption material
CN105641689B (zh) * 2016-01-21 2024-09-10 浙江海隆生物科技股份有限公司 一种奶牛金黄色葡萄球菌β-溶血素亚单位疫苗的制备方法及应用
US11414464B2 (en) 2016-07-22 2022-08-16 Evaxion Biotech A/S Chimeric proteins for inducing immunity towards infection with S. aureus
AU2018243910B2 (en) 2017-03-28 2025-04-10 The Children's Medical Center Corporation A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
WO2018237221A1 (en) 2017-06-23 2018-12-27 Nosocomial Vaccine Corporation IMMUNOGENIC COMPOSITIONS
TWI902669B (zh) 2018-07-24 2025-11-01 美商麥迪紐有限責任公司 抗金黃色葡萄球菌凝集因子a(clfa)之抗體
JP7535791B2 (ja) 2018-09-12 2024-08-19 ザ チルドレンズ メディカル センター コーポレーション 肺炎球菌融合タンパク質ワクチン
IL281204B2 (en) 2018-09-12 2025-07-01 Affinivax Inc Multivalent pneumococcal vaccines
CN113164602A (zh) 2018-10-09 2021-07-23 免疫医疗有限责任公司 抗金黄色葡萄球菌抗体的组合
IL326005A (en) 2021-09-09 2026-03-01 Affinivax Inc Multivalent pneumococcal vaccines
WO2024168197A2 (en) * 2023-02-08 2024-08-15 The Regents Of The University Of California Membrane translocation compositions and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005167A1 (en) * 1997-07-25 1999-02-04 University Of Massachusetts Designed protein pores as components for biosensors
AU6033299A (en) 1998-09-14 2000-04-03 Nabi Compositions of beta-glucans and specific igiv
US6849259B2 (en) 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy
CA2422867A1 (en) * 2000-09-15 2002-04-25 University Of Connecticut Health Center Improved formulations using heat shock/stress protein-peptide complexes
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP1524991A1 (en) * 2002-08-02 2005-04-27 GlaxoSmithKline Biologicals S.A. Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
KR20070058631A (ko) * 2004-09-22 2007-06-08 글락소스미스클라인 바이오로지칼즈 에스.에이. 면역원성 조성물
EP2043690A1 (en) 2006-06-12 2009-04-08 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections

Also Published As

Publication number Publication date
AU2010205645A1 (en) 2011-07-14
WO2010081875A1 (en) 2010-07-22
JP2013504301A (ja) 2013-02-07
EP2382316B1 (en) 2014-04-23
EP2208787A1 (en) 2010-07-21
US8545853B2 (en) 2013-10-01
AU2010205645B2 (en) 2014-09-04
CA2749862C (en) 2015-02-24
CA2749862A1 (en) 2010-07-22
US20120014983A1 (en) 2012-01-19
EP2382316A1 (en) 2011-11-02
ES2483720T3 (es) 2014-08-07

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