JP5917522B2 - 生物医学的用途のマイクロデバイス及びその使用 - Google Patents

生物医学的用途のマイクロデバイス及びその使用 Download PDF

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JP5917522B2
JP5917522B2 JP2013529116A JP2013529116A JP5917522B2 JP 5917522 B2 JP5917522 B2 JP 5917522B2 JP 2013529116 A JP2013529116 A JP 2013529116A JP 2013529116 A JP2013529116 A JP 2013529116A JP 5917522 B2 JP5917522 B2 JP 5917522B2
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micro
microdevice
properties
mechanical
function
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JP2013539669A (ja
JP2013539669A5 (fr
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ユ、クリス、チャン
ユ、ヘ
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チャング ヘ バイオ−メディカル サイエンス（ヤンジョウ）カンパニー リミテッド
チャング ヘ バイオ−メディカル サイエンス（ヤンジョウ）カンパニー リミテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems ; Auxiliary parts of microstructural devices or systems
    • B81B7/02—Microstructural systems ; Auxiliary parts of microstructural devices or systems containing distinct electrical or optical devices of particular relevance for their function, e.g. microelectro-mechanical systems [MEMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00345—Micromachines, nanomachines, microsystems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013529116A 2010-09-17 2010-09-17 生物医学的用途のマイクロデバイス及びその使用 Expired - Fee Related JP5917522B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/049298 WO2012036697A1 (fr) 2010-09-17 2010-09-17 Applications biomédicales de micro-dispositifs et leurs utilisations

Publications (3)

Publication Number Publication Date
JP2013539669A JP2013539669A (ja) 2013-10-28
JP2013539669A5 JP2013539669A5 (fr) 2013-12-05
JP5917522B2 true JP5917522B2 (ja) 2016-05-18

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JP2013529116A Expired - Fee Related JP5917522B2 (ja) 2010-09-17 2010-09-17 生物医学的用途のマイクロデバイス及びその使用

Country Status (10)

Country Link
EP (1) EP2615968A4 (fr)
JP (1) JP5917522B2 (fr)
KR (1) KR101761259B1 (fr)
CN (2) CN103237492B (fr)
AU (2) AU2010360764A1 (fr)
BR (1) BR112013006299B8 (fr)
CA (1) CA2812189C (fr)
IL (1) IL225284B (fr)
WO (1) WO2012036697A1 (fr)
ZA (1) ZA201302375B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI711819B (zh) 2012-07-16 2020-12-01 大陸商昌和生物醫學科技（揚州）有限公司 增強疾病檢測與鑒定的器件與方法
AU2014231363A1 (en) 2013-03-15 2015-10-15 Anpac Bio-Medical Science (Lishui) Co., Ltd. Methods and apparatus for enhanced detection of diseases
EP3139166A4 (fr) * 2014-05-02 2017-04-19 Osaka Prefecture University Public Corporation Film de polymère pour détection de cellules cancéreuses et son procédé de fabrication, et dispositif de détection de cellules cancéreuses utilisant un tel film de polymère
CN104965002B (zh) * 2014-12-16 2018-04-17 湖南省茶叶研究所（湖南省茶叶检测中心） 降低触角电位仪背景噪音的装置及使用该装置检测触角的方法
FR3032106B1 (fr) * 2015-02-02 2020-07-31 Centre Nat Rech Scient Microdispositif pour la capture in vivo de biomarqueurs cellulaires circulants.
US11266344B2 (en) 2016-09-21 2022-03-08 Samsung Electronics Co., Ltd. Method for measuring skin condition and electronic device therefor
TWI636775B (zh) * 2017-10-27 2018-10-01 研能科技股份有限公司 微型泵浦
CN112023271B (zh) * 2020-09-22 2023-11-28 天津工业大学 亚毫米尺寸活体植入式多通道微磁刺激器
EP4288190A4 (fr) * 2021-02-02 2025-07-16 Delta S Energy Inc Membrane de diffusion thermique, dispositifs, systèmes et procédés
USD1053488S1 (en) * 2023-06-19 2024-12-03 Chengwen Zeng Screen cleaner
USD1060910S1 (en) * 2023-08-01 2025-02-04 Hangzhou Tanlink Technology Co., Ltd Screen cleaner

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663615A (en) * 1900-08-10 1900-12-11 Eugene J Gregory Pyrographical tool.
US6111520A (en) * 1997-04-18 2000-08-29 Georgia Tech Research Corp. System and method for the wireless sensing of physical properties
DE19717023C2 (de) * 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US6092530A (en) 1999-03-24 2000-07-25 The B.F. Goodrich Company Remotely interrogated implant device with sensor for detecting accretion of biological matter
US20020094515A1 (en) * 2000-11-30 2002-07-18 Erlach Julian Van Method and apparatus for attaching a microdevice or a nanodevice to a biological member
US6663615B1 (en) * 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
KR100417163B1 (ko) * 2001-11-12 2004-02-05 한국과학기술연구원 마이크로 캡슐형 로봇
US6682490B2 (en) * 2001-12-03 2004-01-27 The Cleveland Clinic Foundation Apparatus and method for monitoring a condition inside a body cavity
US20030216622A1 (en) * 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
JP2006512109A (ja) * 2002-08-01 2006-04-13 ザ ジョンズ ホプキンズ ユニバーシティ 蛍光発光を用いた、分子構造の特定技術、および身体内腔の内側に並ぶ細胞種の治療技術
JP3883001B2 (ja) * 2002-10-07 2007-02-21 国立循環器病センター総長 子宮内埋め込み型胎児モニタリング装置
US6936003B2 (en) * 2002-10-29 2005-08-30 Given Imaging Ltd In-vivo extendable element device and system, and method of use
US6922118B2 (en) 2002-11-01 2005-07-26 Hrl Laboratories, Llc Micro electrical mechanical system (MEMS) tuning using focused ion beams
CN1218756C (zh) * 2003-05-14 2005-09-14 厦门大学 无痛给药装置
US20050228313A1 (en) * 2003-12-04 2005-10-13 University Technologies International Inc. Fluid sampling, analysis and delivery system
JP4436707B2 (ja) 2004-03-25 2010-03-24 オリンパス株式会社 カプセル型医療装置及びカプセル型医療装置システム
US7857767B2 (en) * 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US7998060B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
ES2547220T3 (es) * 2004-04-20 2015-10-02 Dendritic Nanotechnologies, Inc. Polímeros dendríticos con amplificación y funcionalidad interior mejoradas
JP4746308B2 (ja) * 2004-11-29 2011-08-10 オリンパス株式会社 体内医療装置および体内医療システム
JP2007000177A (ja) 2005-06-21 2007-01-11 Konica Minolta Medical & Graphic Inc 医療用カプセル内視鏡
WO2007028035A2 (fr) * 2005-09-01 2007-03-08 Proteus Biomedical, Inc. Systeme de communications sans fil implantable
JP2008012094A (ja) * 2006-07-06 2008-01-24 Kenichi Katsu カプセル内視鏡
SG175681A1 (en) * 2006-10-25 2011-11-28 Proteus Biomedical Inc Controlled activation ingestible identifier
US20080241264A1 (en) * 2006-11-13 2008-10-02 Solomon Research Llc System and methods for collective nanorobotics for medical applications
CN100493451C (zh) * 2007-08-16 2009-06-03 上海交通大学 电磁式胃肠动力功能无创诊查系统
CN100534381C (zh) * 2007-09-06 2009-09-02 上海交通大学 胃肠道出血无创监测系统
FR2934949B1 (fr) * 2008-08-14 2010-09-10 Quidd Capsule autonome de detection destinee a etre introduite dans un conduit d'un corps humain ou animal
WO2010057082A2 (fr) * 2008-11-17 2010-05-20 Mayo Foundation For Medical Education And Research Capsules diagnostiques, systèmes de distribution/extraction, kits et procédés
EP2382463B1 (fr) * 2009-01-29 2016-05-25 Given Imaging Ltd. Dispositif, système et procédé de détection d'une hémorragie
US20100256518A1 (en) * 2009-04-01 2010-10-07 Yu Chris C Micro-Devices for Biomedical Applications and Method of Use of Same
CN101828907B (zh) * 2010-02-11 2012-06-20 上海交通大学 植入式微型生理参数检测系统

Also Published As

Publication number Publication date
CN105403690A (zh) 2016-03-16
JP2013539669A (ja) 2013-10-28
CA2812189C (fr) 2021-09-21
IL225284A0 (en) 2013-06-27
EP2615968A1 (fr) 2013-07-24
CA2812189A1 (fr) 2012-03-22
IL225284B (en) 2018-11-29
KR101761259B1 (ko) 2017-07-25
EP2615968A4 (fr) 2014-03-12
ZA201302375B (en) 2014-02-26
CN103237492A (zh) 2013-08-07
WO2012036697A1 (fr) 2012-03-22
AU2017200356A1 (en) 2017-02-02
AU2010360764A8 (en) 2013-04-18
BR112013006299B1 (pt) 2020-12-22
KR20130124484A (ko) 2013-11-14
AU2010360764A1 (en) 2013-04-11
BR112013006299A2 (pt) 2016-06-07
CN103237492B (zh) 2016-02-17
BR112013006299B8 (pt) 2021-07-27

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