JP6155193B2 - ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 - Google Patents

ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 Download PDF

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Publication number: JP6155193B2
Authority: JP; Japan
Prior art keywords: group; alkyl; hiv; nhc; compound
Prior art date: 2010-11-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2013540011A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013543003A5 (de

JP2013543003A (ja

Inventor

デイビッドシュピーゲル，

クリストファーパーカー

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Yale University

Original Assignee

Yale University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-18

Filing date

2011-11-17

Publication date

2017-06-28

2011-11-17 Application filed by Yale University filed Critical Yale University

2013-11-28 Publication of JP2013543003A publication Critical patent/JP2013543003A/ja

2014-03-13 Publication of JP2013543003A5 publication Critical patent/JP2013543003A5/ja

2017-06-28 Application granted granted Critical

2017-06-28 Publication of JP6155193B2 publication Critical patent/JP6155193B2/ja

Status Active legal-status Critical Current

2031-11-17 Anticipated expiration legal-status Critical

Links

0 C=*CC(C1=CCC=C1)=C1CCCC1 Chemical compound C=*CC(C1=CCC=C1)=C1CCCC1 0.000 description 7
CLEBWASNOBDPHJ-UHFFFAOYSA-N C1=C=NC=CN=C1 Chemical compound C1=C=NC=CN=C1 CLEBWASNOBDPHJ-UHFFFAOYSA-N 0.000 description 1
OYJWNEAVWJVJJB-UHFFFAOYSA-N CC1CC(C2)C2(C2)C2C1 Chemical compound CC1CC(C2)C2(C2)C2C1 OYJWNEAVWJVJJB-UHFFFAOYSA-N 0.000 description 1
GDOPTJXRTPNYNR-UHFFFAOYSA-N CC1CCCC1 Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N c1cncnc1 Chemical compound c1cncnc1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
PBMFSQRYOILNGV-UHFFFAOYSA-N c1cnncc1 Chemical compound c1cnncc1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
JIHQDMXYYFUGFV-UHFFFAOYSA-N c1ncncn1 Chemical compound c1ncncn1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 description 1

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

JP2013540011A 2010-11-18 2011-11-17 ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 Active JP6155193B2 (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US41497710P	2010-11-18	2010-11-18
US61/414,977		2010-11-18
US201161522518P	2011-08-11	2011-08-11
US61/522,518		2011-08-11
PCT/US2011/061174 WO2012068366A2 (en)	2010-11-18	2011-11-17	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2016215788A Division JP6567486B2 (ja)	2010-11-18	2016-11-04	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子

Publications (3)

Publication Number	Publication Date
JP2013543003A JP2013543003A (ja)	2013-11-28
JP2013543003A5 JP2013543003A5 (de)	2014-03-13
JP6155193B2 true JP6155193B2 (ja)	2017-06-28

Family

ID=46084646

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP2013540011A Active JP6155193B2 (ja)	2010-11-18	2011-11-17	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子
JP2016215788A Active JP6567486B2 (ja)	2010-11-18	2016-11-04	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP2016215788A Active JP6567486B2 (ja)	2010-11-18	2016-11-04	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子

Country Status (16)

Country	Link
US (5)	US9562038B2 (de)
EP (1)	EP2640720B1 (de)
JP (2)	JP6155193B2 (de)
KR (1)	KR20140000275A (de)
CN (2)	CN103402998B (de)
AU (1)	AU2011329829B2 (de)
BR (1)	BR112013012309A2 (de)
CA (1)	CA2818308A1 (de)
CL (1)	CL2013001429A1 (de)
CO (1)	CO6801635A2 (de)
EA (1)	EA201390726A1 (de)
IL (1)	IL226397B (de)
MX (1)	MX350974B (de)
PE (1)	PE20140406A1 (de)
SG (2)	SG10201510402WA (de)
WO (1)	WO2012068366A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2017052776A (ja) *	2010-11-18	2017-03-16	イェールユニバーシティーＹａｌｅＵｎｉｖｅｒｓｉｔｙ	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子

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EP2206702B1 (de)	2001-08-08	2011-12-28	Tobira Therapeutics, Inc.	Bizyklishe Verbindung, ihre Herstellung und Verwendung
US9181224B2 (en) *	2009-10-13	2015-11-10	Yale University	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
WO2013070688A1 (en)	2011-11-11	2013-05-16	Yale University	Reprogramming urokinase into an antibody-recruiting anticancer agent
EP4005600A1 (de)	2012-04-26	2022-06-01	Yale University	Gegen hiv gerichtete zytotoxische wirkstoffe freisetzende moleküle (cdm-hs), zytotoxische wirkung gegen das menschliche immunschwächevirus und verfahren zur verwendung
WO2013166110A1 (en)	2012-05-02	2013-11-07	Yale University	Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
ES2824026T3 (es)	2013-05-03	2021-05-11	Univ Yale	Compuestos miméticos de anticuerpos sintéticos (SyAM) dirigidos al cáncer, especialmente cáncer de próstata
BR112017013130A2 (pt) *	2014-12-23	2017-12-26	Tobira Therapeutics Inc	processo de fabricação de cenicriviroc e análogos relacionados
WO2017023994A1 (en)	2015-08-06	2017-02-09	Yale University	Small molecule based antibody-recruiting compounds for cancer treatment
JP6732915B2 (ja)	2015-12-15	2020-07-29	ギリアードサイエンシーズ，インコーポレイテッド	ヒト免疫不全ウイルス中和抗体
CA3017958C (en)	2016-03-18	2024-03-12	Rutgers, The State University Of New Jersey	Targeting tumor cells with chemotherapeutic agents conjugated to anti-matriptase antibodies by in vivo cleavable linking moieties
BR112018076449A2 (pt)	2016-06-21	2019-04-09	Tobira Therapeutics, Inc.	cenicriviroc purificado e intermediários purificados para fazer cenicriviroc
US10780084B2 (en)	2016-08-03	2020-09-22	Yale University	Antibody-recruiting molecules for the treatment of cancer
JP2019526628A (ja)	2016-08-31	2019-09-19	トビラセラピューティクス，インコーポレイテッド	セニクリビロクメシレートの固体形態及びセニクリビロクメシレートの固体形態を製造するプロセス
CN107056762B (zh) *	2016-12-22	2020-08-28	四川百利药业有限责任公司	一种用作抗流感病毒的双羰基类似物
AR112257A1 (es)	2017-06-21	2019-10-09	Gilead Sciences Inc	Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos
WO2021151391A1 (zh) *	2020-01-30	2021-08-05	沈阳福洋医药科技有限公司	异戊酰螺旋霉素类化合物及其组合物在制备抗病毒药物中的应用
CN111995622B (zh) *	2020-08-20	2022-04-15	复旦大学	化合物及其用途

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US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ZA893284B (en) *	1988-05-04	1990-03-28	Igen Inc	Peptide analogs and their use as haptens to elicit catalytic antibodies
EP0646019B9 (de) *	1992-06-09	2002-12-18	Neorx Corporation	Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren
JP3319073B2 (ja) *	1993-08-24	2002-08-26	和光純薬工業株式会社	免疫学的測定方法
US6140505A (en) *	1995-03-10	2000-10-31	G. D. Searle & Co.	Synthesis of benzo fused heterocyclic sulfonyl chlorides
US6469006B1 (en) *	1999-06-15	2002-10-22	Bristol-Myers Squibb Company	Antiviral indoleoxoacetyl piperazine derivatives
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US6573262B2 (en)	2000-07-10	2003-06-03	Bristol-Myers Sqibb Company	Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
US6825201B2 (en) *	2001-04-25	2004-11-30	Bristol-Myers Squibb Company	Indole, azaindole and related heterocyclic amidopiperazine derivatives
HUP0401523A3 (en) *	2004-07-29	2007-05-02	Richter Gedeon Vegyeszet	Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
DK2444807T3 (da) *	2006-11-01	2014-08-11	Ventana Med Syst Inc	Mono- og dinitropyrazolhaptenkonjugater
HRP20151367T1 (hr) *	2008-05-13	2016-01-29	Yale University	Kimerne male molekule za pojaäśanje odgovora protutijela na stanice raka
US20110177619A1 (en) *	2008-07-14	2011-07-21	Andrew Metters	In vitro diagnostic markers comprising carbon nanoparticles and kits
JP2012517447A (ja) *	2009-02-10	2012-08-02	ザスクリプスリサーチインスティチュート	化学的にプログラムされたワクチン接種法
US9181224B2 (en)	2009-10-13	2015-11-10	Yale University	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
WO2012019003A1 (en) *	2010-08-06	2012-02-09	Bristol-Myers Squibb Company	Substituted indole and azaindole oxoacetyl piperazinamide derivatives
SG10201510402WA (en)	2010-11-18	2016-01-28	Univ Yale	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus

2011
- 2011-11-17 SG SG10201510402WA patent/SG10201510402WA/en unknown
- 2011-11-17 PE PE2013001206A patent/PE20140406A1/es not_active Application Discontinuation
- 2011-11-17 WO PCT/US2011/061174 patent/WO2012068366A2/en not_active Ceased
- 2011-11-17 CN CN201180065404.3A patent/CN103402998B/zh active Active
- 2011-11-17 CA CA2818308A patent/CA2818308A1/en not_active Abandoned
- 2011-11-17 MX MX2013005462A patent/MX350974B/es active IP Right Grant
- 2011-11-17 EP EP11842404.3A patent/EP2640720B1/de active Active
- 2011-11-17 CN CN201611167953.2A patent/CN107011333B/zh active Active
- 2011-11-17 BR BR112013012309A patent/BR112013012309A2/pt not_active Application Discontinuation
- 2011-11-17 JP JP2013540011A patent/JP6155193B2/ja active Active
- 2011-11-17 US US13/988,251 patent/US9562038B2/en active Active
- 2011-11-17 AU AU2011329829A patent/AU2011329829B2/en active Active
- 2011-11-17 EA EA201390726A patent/EA201390726A1/ru unknown
- 2011-11-17 KR KR1020137015098A patent/KR20140000275A/ko not_active Ceased
- 2011-11-17 SG SG2013038344A patent/SG190829A1/en unknown
2013
- 2013-05-16 IL IL226397A patent/IL226397B/en active IP Right Grant
- 2013-05-17 CL CL2013001429A patent/CL2013001429A1/es unknown
- 2013-06-07 CO CO13138546A patent/CO6801635A2/es not_active Application Discontinuation
2016
- 2016-11-04 JP JP2016215788A patent/JP6567486B2/ja active Active
- 2016-12-15 US US15/379,969 patent/US10030008B2/en active Active
2018
- 2018-07-17 US US16/037,678 patent/US10703743B2/en active Active
2020
- 2020-06-05 US US16/894,362 patent/US11136316B2/en active Active
2021
- 2021-09-09 US US17/470,393 patent/US11858917B2/en active Active

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2017052776A (ja) *	2010-11-18	2017-03-16	イェールユニバーシティーＹａｌｅＵｎｉｖｅｒｓｉｔｙ	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子

Also Published As

Publication number	Publication date
JP6567486B2 (ja)	2019-08-28
MX350974B (es)	2017-09-27
KR20140000275A (ko)	2014-01-02
US20190002447A1 (en)	2019-01-03
MX2013005462A (es)	2014-02-03
EP2640720A2 (de)	2013-09-25
BR112013012309A2 (pt)	2016-08-23
CN107011333B (zh)	2021-03-19
JP2017052776A (ja)	2017-03-16
CN103402998A (zh)	2013-11-20
CA2818308A1 (en)	2012-05-24
PE20140406A1 (es)	2014-04-16
EA201390726A1 (ru)	2014-06-30
CL2013001429A1 (es)	2014-04-11
CN107011333A (zh)	2017-08-04
US20170096415A1 (en)	2017-04-06
SG10201510402WA (en)	2016-01-28
CN103402998B (zh)	2017-09-26
WO2012068366A2 (en)	2012-05-24
IL226397A0 (en)	2013-07-31
IL226397B (en)	2018-02-28
US20130245040A1 (en)	2013-09-19
US11858917B2 (en)	2024-01-02
US11136316B2 (en)	2021-10-05
US9562038B2 (en)	2017-02-07
SG190829A1 (en)	2013-07-31
JP2013543003A (ja)	2013-11-28
US10030008B2 (en)	2018-07-24
AU2011329829B2 (en)	2017-02-09
WO2012068366A3 (en)	2012-11-15
EP2640720A4 (de)	2014-05-28
US20220089579A1 (en)	2022-03-24
US10703743B2 (en)	2020-07-07
CO6801635A2 (es)	2013-11-29
WO2012068366A9 (en)	2013-07-18
EP2640720B1 (de)	2018-10-17
AU2011329829A1 (en)	2013-07-11
US20200392121A1 (en)	2020-12-17

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Publication	Publication Date	Title
JP6567486B2 (ja)	2019-08-28	ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子
US10188727B2 (en)	2019-01-29	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
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JP2021532154A (ja)	2021-11-25	抗ｈｉｖ化合物
JP2023508375A (ja)	2023-03-02	Ｔ細胞アクティベーターとして有用な置換ピペラジン誘導体
JP5599611B2 (ja)	2014-10-01	抗ウイルスプロテアーゼインヒビター
JP2024532362A (ja)	2024-09-05	細胞外タンパク質の分子分解誘導剤
HK1240932A1 (en)	2018-06-01	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
HK1240932B (zh)	2021-12-10	具有募集抗体并对人体免疫缺陷病毒进入有抑制活性的双功能分子
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JP6155193B2 - ヒト免疫不全ウイルスに対する抗体動員及び進入阻害活性を有する二官能性分子 - Google Patents

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