JP6430949B2 - Ｇｍ−ｃｓｆとｉｌ−４のコンジュゲート、組成物、ならびにそれに関連する方法 - Google Patents

Ｇｍ−ｃｓｆとｉｌ−４のコンジュゲート、組成物、ならびにそれに関連する方法 Download PDF

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JP6430949B2
JP6430949B2 JP2015538149A JP2015538149A JP6430949B2 JP 6430949 B2 JP6430949 B2 JP 6430949B2 JP 2015538149 A JP2015538149 A JP 2015538149A JP 2015538149 A JP2015538149 A JP 2015538149A JP 6430949 B2 JP6430949 B2 JP 6430949B2
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cells
gift4
cell
csf
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JP2015533376A5 (2
JP2015533376A (ja
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ガリポー，ジャック
デン，ジウシェン
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Childrens Healthcare of Atlanta Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/1034—Isolating an individual clone by screening libraries
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JP2015538149A 2012-10-23 2013-10-23 Ｇｍ−ｃｓｆとｉｌ−４のコンジュゲート、組成物、ならびにそれに関連する方法 Expired - Fee Related JP6430949B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717129P 2012-10-23 2012-10-23
US61/717,129 2012-10-23
PCT/US2013/066261 WO2014066443A1 (en) 2012-10-23 2013-10-23 Gm-csf and il-4 conjugates, compositions, and methods related thereto

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JP2015533376A JP2015533376A (ja) 2015-11-24
JP2015533376A5 JP2015533376A5 (2) 2016-12-08
JP6430949B2 true JP6430949B2 (ja) 2018-11-28

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US (4) US9657076B2 (2)
EP (2) EP3587455A1 (2)
JP (1) JP6430949B2 (2)
CN (2) CN109134640A (2)
WO (1) WO2014066443A1 (2)

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CA2855675C (en) 2011-11-14 2020-11-03 Emory University Conjugates of gm-csf and il-7, compositions and methods related thereto
EP3587455A1 (en) 2012-10-23 2020-01-01 Emory University Gm-csf and il-4 conjugates, compositions, and methods related thereto
US10072058B2 (en) 2015-04-29 2018-09-11 Emory University Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates
US20190000943A1 (en) * 2015-08-13 2019-01-03 Aavet Therapeutics, Llc Aav6 vectors for immunotherapy
CN105647970A (zh) * 2016-02-22 2016-06-08 河北利同康生物科技有限公司 前列腺癌特异性pap-gm-csf-il-6基因重组融合蛋白及其制备方法
CN109312364A (zh) * 2016-03-18 2019-02-05 河谷细胞有限公司 用于感染树突状细胞的多模式载体
EP3634487A4 (en) 2017-06-09 2021-03-24 The Regents Of The University Of Colorado, A Body Corporate, A Colorado Non-Profit GM-CSF MIMETICS AND PROCESSES FOR THE PRODUCTION AND USE OF THEM
CN109735566B (zh) * 2018-12-13 2023-02-28 中国科学院广州生物医药与健康研究院 一种增强腺病毒载体生物制品感染靶细胞的方法
WO2020212598A1 (en) 2019-04-19 2020-10-22 Synerkine Pharma B.V. A fusion protein comprising il13
EP4121095A4 (en) * 2020-03-20 2024-04-03 The Regents of the University of Colorado, a body corporate METHODS AND COMPOSITIONS FOR TREATING VIRUS DISEASES WITH GRANULOCYTE MACROPHAGE COLONIA STIMULATING FACTOR (GM-CSF)
WO2023072863A1 (en) * 2021-10-25 2023-05-04 Ellennbe Gmbh Pharmaceutical composition and kit comprising an immunomodulatory substance for treating diseases
EP4622660A1 (en) * 2022-11-21 2025-10-01 Wisconsin Alumni Research Foundation Synthetic il6-il1 beta fusion cytokine for promoting t cell cytotoxic function, t cell proliferation, and tumoricidal activity

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US20170226173A1 (en) 2017-08-10
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US20210277083A1 (en) 2021-09-09
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US9657076B2 (en) 2017-05-23
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