JP6639656B2 - ミトコンドリア疾患を治療する新規化合物 - Google Patents

ミトコンドリア疾患を治療する新規化合物 Download PDF

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JP6639656B2
JP6639656B2 JP2018517211A JP2018517211A JP6639656B2 JP 6639656 B2 JP6639656 B2 JP 6639656B2 JP 2018517211 A JP2018517211 A JP 2018517211A JP 2018517211 A JP2018517211 A JP 2018517211A JP 6639656 B2 JP6639656 B2 JP 6639656B2
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cells
compound
mitochondrial
compounds
disease
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JP2018531250A6 (ja
JP2018531250A (ja
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ジュリアン デーヴィッド ベイラス，
ジュリアン デーヴィッド ベイラス，
ミーナ ペレグリーニ，
ミーナ ペレグリーニ，
ザンドボールト， ペトルス マリア ファン
ザンドボールト， ペトルス マリア ファン
ヨハネス アルベルトゥス マリア スメイティンク，
ヨハネス アルベルトゥス マリア スメイティンク，
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Khondrion IP BV
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    • C07—ORGANIC CHEMISTRY
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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JP2018517211A 2015-10-08 2016-10-07 ミトコンドリア疾患を治療する新規化合物 Active JP6639656B2 (ja)

Priority Applications (1)

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JP2019232983A JP6958979B2 (ja) 2015-10-08 2019-12-24 ミトコンドリア疾患を治療する新規化合物

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NL2015585 2015-10-08
NL2015585 2015-10-08
PCT/EP2016/074009 WO2017060432A1 (fr) 2015-10-08 2016-10-07 Nouveaux composés destinés au traitement de maladie mitochondriale

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JP2018531250A JP2018531250A (ja) 2018-10-25
JP2018531250A6 JP2018531250A6 (ja) 2018-12-13
JP6639656B2 true JP6639656B2 (ja) 2020-02-05

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US (2) US10815211B2 (fr)
EP (2) EP4553065A3 (fr)
JP (2) JP6639656B2 (fr)
ES (1) ES3033538T3 (fr)
WO (1) WO2017060432A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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WO2017106803A1 (fr) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Dérivés fluoroalkyle, fluoroalcoxy, phénoxy, hétéroaryloxy, alcoxy, et amine 1,4-benzoquinone pour le traitement de troubles du stress oxydatif
KR102660473B1 (ko) * 2017-04-05 2024-04-24 콘드리온 아이피 비.브이. 미토콘드리아 질환의 신규 치료
US11760733B2 (en) * 2017-04-23 2023-09-19 Washington University Small molecule regulators of mitochondrial fusion and methods of use thereof
CA3079483A1 (fr) * 2017-11-22 2019-05-31 Khondrion Ip B.V. Composes en tant qu'inhibiteurs de mpges-1
EP3713563B1 (fr) * 2017-11-22 2025-02-19 Khondrion Ip B.V. Dérivés amides de chromanyl ou chromanyl-quinones pour utilisation dans le traitement de la dépression et de la migraine
EP3917508A4 (fr) 2019-01-28 2022-12-21 Mitochondria Emotion, Inc. Activateurs de la mitofusine et leurs procédés d'utilisation
CA3127453A1 (fr) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Activateurs de derives trans-4-hydroxycyclohexylphenylamide de la mitofusine et leurs methodes d'utilisation
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease
NL2025730B1 (en) 2020-06-02 2022-01-20 Sulfateq Bv Compounds for treatment of sepsis
NL2026511B1 (en) 2020-09-21 2022-05-24 Sulfateq Bv Compounds for treatment of heart failure
NL2031091B1 (en) 2022-02-28 2023-09-07 Sulfateq Bv Chromanol compounds for treatment or prophylaxis of ageing and ageing-associated disorders
WO2025242849A1 (fr) 2024-05-24 2025-11-27 Khondrion Ip B.V. Dérivés de chromanyle destinés à être utilisés dans le traitement de troubles osseux
EP4729606A1 (fr) 2024-10-17 2026-04-22 Sulfateq B.V. Procédés de cryoconservation de cellules

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US5821247A (en) 1996-09-19 1998-10-13 Japan Energy Corporation Hydroquinone derivative and pharmaceutical use thereof
JP3093170B2 (ja) * 1996-09-19 2000-10-03 株式会社ジャパンエナジー ヒドロキノン誘導体及びその医薬用途
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
NZ513547A (en) 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
GB0204232D0 (en) 2002-02-22 2002-04-10 Isis Innovation Assay
EP1454627A1 (fr) * 2003-03-06 2004-09-08 MyoContract Ltd. Dérivés alpha-cétocarbonyliques comme inhibiteurs de la calpaine
EP2471530B1 (fr) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Produits therapeutiques actifs en reduction-oxydation destines au traitement de maladies mitochondriales et d'autres etats ainsi que la modulation de bio-marqueurs d'energie
WO2009061744A2 (fr) * 2007-11-06 2009-05-14 Edison Pharmaceuticals, Inc. Dérivés de 4-(p-quinolyl)-2-hydroxybutanamide pour le traitement de maladies mitochondriales
EP2262519A4 (fr) * 2008-03-05 2011-03-23 Edison Pharmaceuticals Inc Traitement des déficiences de l audition et de l équilibre avec des agents thérapeutiques à activité redox
EP2601168A4 (fr) 2010-08-06 2013-12-04 Ampere Life Sciences Inc Traitement de maladies mitochondriales par la vitamine k
EA201300215A1 (ru) 2010-08-06 2013-07-30 Эдисон Фармасьютикалз, Инк. Лечение митохондриальных болезней нафтохинонами
SG190472A1 (en) 2011-11-25 2013-06-28 Creative Tech Ltd A speaker apparatus suitable for use with a computer
HUE033757T2 (en) * 2012-07-12 2017-12-28 Khondrion Ip B V Chromanyl derivatives for treating mitochondrial disease
AU2014273891A1 (en) * 2013-05-31 2015-12-24 Bioelectron Technology Corporation Carboxylic acid derivatives for treatment of oxidative stress disorders

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JP6958979B2 (ja) 2021-11-02
EP4553065A2 (fr) 2025-05-14
HK1257665A1 (en) 2019-10-25
US11530190B2 (en) 2022-12-20
JP2018531250A (ja) 2018-10-25
WO2017060432A1 (fr) 2017-04-13
EP4553065A3 (fr) 2025-08-27
EP3359521B1 (fr) 2025-04-16
US20210024484A1 (en) 2021-01-28
EP3359521C0 (fr) 2025-04-16
US20180305328A1 (en) 2018-10-25
JP2020073524A (ja) 2020-05-14
EP3359521A1 (fr) 2018-08-15
ES3033538T3 (en) 2025-08-05
US10815211B2 (en) 2020-10-27

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