JP7106340B2 - 血液脳関門保護剤 - Google Patents

血液脳関門保護剤 Download PDF

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Publication number
JP7106340B2
JP7106340B2 JP2018090144A JP2018090144A JP7106340B2 JP 7106340 B2 JP7106340 B2 JP 7106340B2 JP 2018090144 A JP2018090144 A JP 2018090144A JP 2018090144 A JP2018090144 A JP 2018090144A JP 7106340 B2 JP7106340 B2 JP 7106340B2
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Japan
Prior art keywords
acid
mass
chlorogenic acids
expression
salts
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JP2018090144A
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English (en)
Japanese (ja)
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JP2019178129A (ja
Inventor
瞳 西村
征輝 山本
幸一 三澤
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Kao Corp
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Kao Corp
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2018090144A 2017-05-12 2018-05-08 血液脳関門保護剤 Active JP7106340B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2017095637 2017-05-12
JP2017095637 2017-05-12
JP2018073637 2018-04-06
JP2018073637 2018-04-06

Publications (2)

Publication Number Publication Date
JP2019178129A JP2019178129A (ja) 2019-10-17
JP7106340B2 true JP7106340B2 (ja) 2022-07-26

Family

ID=64105098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018090144A Active JP7106340B2 (ja) 2017-05-12 2018-05-08 血液脳関門保護剤

Country Status (2)

Country Link
JP (1) JP7106340B2 (fr)
WO (1) WO2018207792A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3096579B1 (fr) * 2019-05-27 2023-05-05 Organes Tissus Regeneration Reparation Remplacement composition pour la protection et la reparation de la barriere hematoencephalique (BHE)
JP7634648B2 (ja) * 2021-03-26 2025-02-21 デンカ株式会社 蛍光体粒子、複合体および発光装置

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HELMS, H.C. et al.，Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood-Brain Barri，The AAPS Journal，2010年，Vol.12, No.4，p.759-770，ISSN 1550-7416
LEE, C.H. et al.，Chlorogenig Acid Attenuates High Mobility Group Box 1(HMGB1) and Enhances Host Defense Mechanisms in，Molecular Medicine，2012年，Vol.18，p.1437-1448，ISSN 1528-3658
LEE, K. et al.，Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 i，European Journal of Pharmacology，2012年，Vol.689，p.89-95，ISSN 0014-2999
OKUMA, Y. et al.，Anti-High Mobility Group Box-1 Antibody therapy for Traumatic Brain Injury，Annals of Neurology，2012年，Vol.72，p.373-384，ISSN 1531-8249
SHIN, J.Y. et al.，Chlorogenic Acid Decreases Retinal Vascular Hyperpermeability in Diabetic Rat Model，J Korean Med Sci，2013年，Vol.28，p.608-613，ISSN 1011-8934
YUN, N. et al.，Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular e，Journal of Nutritional Biochemistry，2012年，Vol.23，p.1249-1255，ISSN 0955-2863

Also Published As

Publication number Publication date
WO2018207792A1 (fr) 2018-11-15
JP2019178129A (ja) 2019-10-17

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