JPH01149703A - Repellent for house mite - Google Patents

Abstract

PURPOSE:To obtain a repellent for house mite such as dust mite or acarid, having extremely low toxicity, exhibiting remarkable miticidal activity and effective at a low concentration, by using l-menthone which is a monoterpene compound used in cosmetics, flavors, etc., as an active component. CONSTITUTION:The objective house mite repellent contains l-menthone as an active component (preferably in an amount of about >=32wt.%). The obtained miticidal repellent for house mite has extremely strong miticidal activity against house mites belonging to Acaridiae, Cheyletoidae or Dermatophagoidae such as Dermatophagoides farinae or Dermatophagoides pteronyssinus to which conventional miticide is ineffective. The mite repellent exhibits miticidal effect by applying to TATAMI mat, carpet, food container and human body. Accordingly, the bite, bloodsucking and allergic diseases caused by mite can be surely avoided.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to an exterminator for house dust mites, white mites, and black mites that occur in residences and are particularly harmful, and to a method for using the same.

In recent years, as housing environments have improved, large numbers of indoor mites have been occurring, and it has been reported that they cause skin disorders in young children.

The indoor mite repellent of the present invention has extremely low toxicity and can effectively exterminate dust mites, white mites, black mites, etc. at low concentrations, so it is greatly beneficial to a healthy life.

(b) Conventional technology and problems Takaoka et al. have reported that wood essential oils such as seed oil have a breeding suppressive effect on Dermatophagoides mites (Nichiei Shi, Vol. 42, 224. (19, 87) ). It has also been reported that linalool is effective in exterminating spider mites, which are agricultural pests (Japanese Unexamined Patent Publication No. 61-83103). However, even when these agents were tested for exterminating indoor mites, their extermination effects were not satisfactory.

House dust mites have long been well known as indoor mites that cause significant damage to humans.

However, as times have changed, the damage caused by dust mites has decreased, and new types of mite damage have begun to attract attention. Until now, it was thought that mites were harmless, but dust mites and dust mites that live in houses, as well as the black mites that prey on these mites, have caused problems such as allergies and cavities, and now mite damage has become an advanced problem. As the country enters a new phase, these problems are increasing year by year and tend to become more and more serious. Organophosphorus insecticides, carbamate insecticides, pyrethroids, etc., which have traditionally been used to control pests, have been tried to control these mites, but none of them have been recognized as effective in controlling them. The current situation is that there is no such thing. Furthermore, the use of organic phosphorus and carbamate insecticides is regulated due to problems such as residual accumulation and environmental pollution, and some of them are no longer practical. Furthermore, the safety of insecticides for ticks has become a problem, with acute toxicity caused by insecticides for ticks (deaths of infants, decreased vision of family members, confusion of consciousness, etc.), and complaints of sore throats caused by sheets for ticks. etc. are happening. Pyrethroid insecticides are increasingly used due to their relatively high safety, but resistant mites and other disorders have emerged in some cases, so insecticides that are practically effective against white mites and house dust mites are currently being used. Currently, no drugs are approved. Under these circumstances, there is a demand for the development of new acaricides that have excellent acaricidal properties and are safe for humans, livestock, and fish.

(c) Means, Action, and Effect for Solving the Problems The present inventors conducted an intensive search for a low-toxicity drug that can effectively exterminate indoor mites, and discovered that it has a low toxicity and is effective against indoor mites. I learned that it has an exterminating effect.

Thus, according to the present invention, an indoor mite repellent containing a-menthone as an active ingredient is provided.

E-menthone used in the present invention is the most naturally occurring isomer among the four optically active forms of menthone. The active ingredient of the present invention only needs to substantially contain ρ-menthone. Substantially contains at least about 10%
(by weight), preferably about 25% or more, more preferably 32% or more. Therefore, other isomers of menthone may be included in addition to Q-menthone.

In addition, a-menthone can be used as
aarvensis L, var, piperasce
ns Holmes) and Mentha (Ment
ha Piperfta L.), beniroyal oil, dementholized oil [also known as menthone oil (12-menthol content:
0%) or white oil (30% Q-menthol content)
It can be used in the form of

The active ingredient of the present invention belongs to monoterpene compounds, which are generally used in cosmetics, flavors, etc., and have been confirmed to be safe in terms of skin irritation, oral toxicity, etc. It is significantly safer for humans and livestock than conventional insecticides.

The indoor mite repellent of the present invention has properties that are extremely safe for humans, livestock, and fish, and in particular, it has been found to be extremely safe for humans, livestock, and fish, and is particularly effective against mites, mites, mites, mites, mites, and mites. It has extremely strong acaricidal activity against mites that occur in houses belonging to the dust mite family, such as mites.

Therefore, by applying the acaricide of the present invention to tatami mats, carpets, etc. in the home, food storage areas, and the human body, it is possible to reliably kill various mites living or parasitic in these places. It exhibits a mite-killing effect, and can also accurately prevent mite bites, blood-sucking, and allergic diseases.

When actually applying the active ingredient of the present invention, it can be used alone without adding other ingredients, but in order to make it easier to use as a pesticidal agent, it is formulated with a carrier and diluted as necessary. It is applied as follows.

For example, it can be prepared into any dosage form such as an aerosol, an oil solution, a heated fumigation agent, a sheet, a powder, a granule, a fine granule, a microcapsule, and a wettable powder. The preparation method may be based on the fact that the active ingredient of the present invention is liquid and soluble in various organic solvents, and techniques known in the art may be used in consideration of its properties. For example, to prepare microcapsules, e-menthon may be added to a solution of cyclodextrin or other clathrate forming agent, and the solvent may be removed. In addition, the spray agent is prepared by diluting e-menthone with a small amount of organic solvent as necessary.
This can be made using a liquefied gas propellant such as dichlorofluoromethane.

These preparations are selectively used depending on the place of use and purpose.

The usage amount of the acaricide of the present invention is e.g.
- Menthone is about 0.1zQ.

(D) Examples Next, as examples of the present invention, test examples and formulation examples of acaricides that illustrate the effect as an excellent acaricide will be explained, but the present invention is limited to the following examples. Needless to say, many modifications and modification methods not exemplified here may be employed.

Example 1 Acaricidal activity against mites and Dermatophagoides mites (acaricidal activity test method) An acrylic resin plate (length 5 am, width 2.6 CI 11% thickness 3) with a hole in the center (outer diameter 1.5 cm, inner diameter 1 cm)
CI11) Sandwich a sheet of Japanese paper between two sheets, and place food and mites (Tyrophagus putre) on top of the Japanese paper.
scentiae.

Dermatophagoides pt.
eronyssinus.

Dermatophagoides farinae)
After adding 20 to 50 fish, cover with a slide glass,
Stop everything with a clip.

Plastic petri dish (diameter 14cm, height 1.6cm)
).Insert the acrylic resin plate with the above-mentioned mites in it.

Also, in order to maintain the humidity in the petri dish at 70 to 80% or higher, a container containing 2xQ saturated potassium chloride solution is placed in the petri dish. 20 μe of each test compound was placed on a watch glass.

Add 5 μQ and 1 μe, put it in a petri dish, seal it with parafilm, put it in a 4-cell container at 25°C, and observe it with a microscope after 24.48 hours. The acrylic resin plate containing the cells was taken out, left open for one day, and then observed again under a microscope. If all cells were killed, it was determined that the cells were active. ++ indicates activity in 24 hours, + indicates activity in 48 hours
Closed. Those in which no activity was observed were marked -.

The results shown in Table 1 show that the active ingredient of the present invention exhibits remarkable acaricidal activity, particularly against Dermatophagoides mites, which was ineffective with conventional acaricides such as pyrethroids. Ta. It was also found that the compound of the present invention has far superior acaricidal activity than linalool and seed oil.

Formulation example 1. Aerosol agent ρ-menthone 40 parts by weight Dichlorofluoromethane 500 parts by weight Formulation example 2. Sheet agent Pharmacopoeia peppermint oil is included in cyclodextrin □
After that, the clathrate compound is kneaded into PP, PE, and EVA and formed into a sheet.

Formulation example 3. Unglazed material body Q-Menthone IO part Unglazed material plate (pore volume 0.53 cc/g, water absorption rate approximately 20%) 15
0 parts The former is diluted with 8 lθ times alcohol, and the latter is immersed in this solution for 10 minutes, then taken out and dried as much as possible.

The various preparations of the present invention thus obtained can be used to reliably kill various mites living or parasitic in these places when used on mites, carpets, food storage areas, and human and animal bodies in the home. The tick effect is exerted.

Claims (1)

[Claims] 1. An indoor mite repellent containing l-menthone as an active ingredient.