JPH0117105B2 - - Google Patents
Info
- Publication number
- JPH0117105B2 JPH0117105B2 JP56046108A JP4610881A JPH0117105B2 JP H0117105 B2 JPH0117105 B2 JP H0117105B2 JP 56046108 A JP56046108 A JP 56046108A JP 4610881 A JP4610881 A JP 4610881A JP H0117105 B2 JPH0117105 B2 JP H0117105B2
- Authority
- JP
- Japan
- Prior art keywords
- measuring method
- sample
- lactamase
- item
- bla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 claims description 49
- 102000006635 beta-lactamase Human genes 0.000 claims description 42
- 108090000204 Dipeptidase 1 Proteins 0.000 claims description 37
- 238000012360 testing method Methods 0.000 claims description 36
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 35
- 239000003242 anti bacterial agent Substances 0.000 claims description 31
- 241000894006 Bacteria Species 0.000 claims description 26
- 229930182555 Penicillin Natural products 0.000 claims description 19
- 229940049954 penicillin Drugs 0.000 claims description 16
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 15
- 235000015097 nutrients Nutrition 0.000 claims description 14
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 14
- 229940124586 β-lactam antibiotics Drugs 0.000 claims description 14
- 238000011161 development Methods 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 241000193755 Bacillus cereus Species 0.000 claims description 7
- 238000000354 decomposition reaction Methods 0.000 claims description 7
- 230000002538 fungal effect Effects 0.000 claims description 6
- 210000004215 spore Anatomy 0.000 claims description 6
- OPEGYZAATHKDEM-HCWXCVPCSA-N (2r,4s)-2-[(r)-carboxy(formamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid Chemical group CC1(C)S[C@H]([C@H](NC=O)C(O)=O)N[C@H]1C(O)=O OPEGYZAATHKDEM-HCWXCVPCSA-N 0.000 claims description 5
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 5
- 229930186147 Cephalosporin Natural products 0.000 claims description 5
- 238000004458 analytical method Methods 0.000 claims description 5
- 229940124587 cephalosporin Drugs 0.000 claims description 5
- 150000001780 cephalosporins Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 239000007793 ph indicator Substances 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 2
- 210000004666 bacterial spore Anatomy 0.000 claims description 2
- 239000000047 product Substances 0.000 claims 4
- 238000005070 sampling Methods 0.000 claims 3
- 239000007857 degradation product Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 238000011534 incubation Methods 0.000 description 13
- 239000002609 medium Substances 0.000 description 13
- 235000013336 milk Nutrition 0.000 description 12
- 210000004080 milk Anatomy 0.000 description 12
- 229910052740 iodine Inorganic materials 0.000 description 10
- 239000011630 iodine Substances 0.000 description 10
- 239000008267 milk Substances 0.000 description 10
- 229940056360 penicillin g Drugs 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 230000001580 bacterial effect Effects 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 8
- 229930182566 Gentamicin Natural products 0.000 description 8
- 229960002518 gentamicin Drugs 0.000 description 8
- 235000019371 penicillin G benzathine Nutrition 0.000 description 8
- 229920001817 Agar Polymers 0.000 description 7
- 108010087702 Penicillinase Proteins 0.000 description 7
- 239000008272 agar Substances 0.000 description 7
- 229950009506 penicillinase Drugs 0.000 description 7
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 238000010998 test method Methods 0.000 description 6
- 108020004256 Beta-lactamase Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 238000000691 measurement method Methods 0.000 description 5
- 239000006916 nutrient agar Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000013048 microbiological method Methods 0.000 description 3
- 150000002960 penicillins Chemical class 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- -1 vaccines Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 229930195708 Penicillin V Natural products 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 229940126575 aminoglycoside Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000010170 biological method Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229940056367 penicillin v Drugs 0.000 description 2
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 229940040944 tetracyclines Drugs 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009640 blood culture Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- CZTQZXZIADLWOZ-CRAIPNDOSA-N cefaloridine Chemical compound O=C([C@@H](NC(=O)CC=1SC=CC=1)[C@H]1SC2)N1C(C(=O)[O-])=C2C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-CRAIPNDOSA-N 0.000 description 1
- 229960003866 cefaloridine Drugs 0.000 description 1
- XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 description 1
- 229960000603 cefalotin Drugs 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000011326 mechanical measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/04—Dairy products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2415/00—Assays, e.g. immunoassays or enzyme assays, involving penicillins or cephalosporins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/834—Bacillus cereus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Description
æ¬çºæã¯ããããã³åç©ã«å¯Ÿããå»è¬åãšããŠ
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL59723A IL59723A (en) | 1980-03-27 | 1980-03-27 | Determination of antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5719658A JPS5719658A (en) | 1982-02-01 |
| JPH0117105B2 true JPH0117105B2 (ja) | 1989-03-29 |
Family
ID=11051721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4610881A Granted JPS5719658A (en) | 1980-03-27 | 1981-03-27 | Measurement of beta-lactam antibiotics |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4381343A (ja) |
| EP (1) | EP0037932B1 (ja) |
| JP (1) | JPS5719658A (ja) |
| CA (1) | CA1176549A (ja) |
| DE (1) | DE3171976D1 (ja) |
| IL (1) | IL59723A (ja) |
| ZA (1) | ZA811960B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58179499A (ja) * | 1982-04-13 | 1983-10-20 | Wako Pure Chem Ind Ltd | 现èæåæ§è©Šéšãã£ã¹ã¯ |
| GB8305324D0 (en) * | 1983-02-25 | 1983-03-30 | Unilever Plc | Microbiological test processes |
| US4568637A (en) * | 1983-08-10 | 1986-02-04 | Whittaker M.A. Bioproducts, Inc. | Method of determining antibiotics in biological liquids |
| US4740459A (en) * | 1984-08-06 | 1988-04-26 | Washington Research Foundation | Fluorescence assay for microbial beta-lactamase |
| EP0266370A1 (en) * | 1986-03-26 | 1988-05-11 | Murex Corporation | Device and method for determining microbial resistance to antimicrobic agents |
| EP0576753B1 (en) * | 1986-06-24 | 1997-11-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Devices for carrying out a plurality of microbiological tests |
| DE3621563A1 (de) * | 1986-06-27 | 1988-01-07 | Boehringer Mannheim Gmbh | Verfahren zum nachweis von cephalosporin c-acylase |
| JPH07106018B2 (ja) * | 1986-11-06 | 1995-11-13 | æ¥æ°é»æ©æ ªåŒäŒç€Ÿ | 系統äºæ èšé²è£ 眮 |
| US5614375A (en) * | 1994-03-23 | 1997-03-25 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Method and test kit for the rapid detection of biotoxic contaminants |
| NZ260609A (en) * | 1994-05-26 | 1995-07-26 | Food Industry Research & Dev I | Detecting antimicrobial compound presence in a sample by growing a microorganism susceptible to the compound in media containing the sample and using an electrical parameter of the culture to indicate growth |
| US6153381A (en) * | 1997-08-28 | 2000-11-28 | Millennium Pharmaceuticals, Inc. | Screening for antibiotics |
| IL163821A0 (en) * | 2004-08-31 | 2005-12-18 | Ravgalai Ltd Rapax Consortium | Software for management of legal motions Methods and kits for the detection of biotoxic andantibiotic residues |
| US20110065595A1 (en) * | 2007-04-12 | 2011-03-17 | Nathan Citri | Method and Test Kit for the Rapid Identification and Characterization of Cells |
| EP2370812A2 (en) | 2008-12-08 | 2011-10-05 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods and kits for direct detection and susceptibility profiling of beta-lactam resistant bacteria |
| CN101571539B (zh) * | 2009-06-01 | 2013-10-30 | å京æå°çç©ææ¯æéå ¬åž | æ£æµå€Žå¢ç±»è¯ç©çé ¶èå ç«è¯åçåå ¶åºçš |
| WO2013053953A1 (en) * | 2011-10-14 | 2013-04-18 | Université de LiÚge | Method for measuring beta-lactam antibiotics |
| CN113009051A (zh) * | 2021-02-22 | 2021-06-22 | äžåœé£åè¯åæ£å®ç ç©¶é¢ | è éç æ¯71åç掻ç«èäžÎ²-å é °èºç±»æççŽ çæ£æµæ¹æ³ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2601350A (en) * | 1949-09-20 | 1952-06-24 | Welch Henry | Hydrolysis of beta lactam linkage by penicillinase |
| US3644177A (en) * | 1969-11-12 | 1972-02-22 | Yissum Res Dev Co | Monitoring penicillin in biological substances |
| BE789817A (fr) * | 1971-10-07 | 1973-04-06 | Glaxo Lab Ltd | Perfectionnements aux composes de cephalosporine |
| GB1467439A (en) * | 1973-05-31 | 1977-03-16 | Gist Brocades Nv | Method for determination of the presence of antibiotics |
| CA1108516A (en) * | 1977-11-21 | 1981-09-08 | Stanley E. Charm | Antibiotic detection method |
| US4239745A (en) * | 1978-11-22 | 1980-12-16 | Penicillin Assays, Inc. | Antibiotic detection method |
| US4234683A (en) * | 1978-11-24 | 1980-11-18 | Mcmillan William A | Beta-lactamase diagnostic product and method |
-
1980
- 1980-03-27 IL IL59723A patent/IL59723A/xx not_active IP Right Cessation
-
1981
- 1981-03-24 ZA ZA00811960A patent/ZA811960B/xx unknown
- 1981-03-25 DE DE8181102218T patent/DE3171976D1/de not_active Expired
- 1981-03-25 EP EP81102218A patent/EP0037932B1/en not_active Expired
- 1981-03-26 CA CA000373953A patent/CA1176549A/en not_active Expired
- 1981-03-27 US US06/248,408 patent/US4381343A/en not_active Expired - Fee Related
- 1981-03-27 JP JP4610881A patent/JPS5719658A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0037932A1 (en) | 1981-10-21 |
| IL59723A0 (en) | 1980-06-30 |
| ZA811960B (en) | 1982-05-26 |
| DE3171976D1 (en) | 1985-10-03 |
| IL59723A (en) | 1983-05-15 |
| EP0037932B1 (en) | 1985-08-28 |
| US4381343A (en) | 1983-04-26 |
| JPS5719658A (en) | 1982-02-01 |
| CA1176549A (en) | 1984-10-23 |
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