JPH01203312A - External agent for skin and hair - Google Patents

Abstract

PURPOSE:To obtain the present external agent containing highly purified acetic acid liquid lanolin and/or acetic acid lanolin, reduced in color and odor and having excellent safeness. CONSTITUTION:Liquid lanolin or lanolin is acetylated using 0.1-0.3pt.wt. acetic anhydride based on 1pt.wt. lanolin and then the acetylated lanolin is treated with an absorbent such as silica gel, active alumina, active clay or magnesium silicate to afford a purified product having <=1% polar ingredient content, which is then blended with a cosmetic such as cream, emulsion or lip color or hair cosmetic such as hair cream.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention provides a highly purified acetic acid liquid lanolin and/or acetic acid lanolin containing acetic acid lanolin, which has less color, less odor, and is highly safe for the skin and/or ) provides a hair external preparation.

(Prior Art) Since ancient times, lanolin has been incorporated into cosmetics such as creams, whey, and lipsticks because it has excellent affinity, adhesion, and wettability to the skin, and also has water-holding power. In recent years, liquid lanolin, which is obtained by removing the waxy ester portion with a high melting point from lanolin by solvent fractionation, has been developed in order to improve skin permeability and diffusivity, and is widely used in cosmetics.

However, lanolin has been reported to cause allergic reactions in some cases, and the main cause is said to be the polar components in lanolin (free lanolin alcohol, lanolin fatty acids, and other polar substances). Liquid lanolin contains more polar components than lanolin due to its manufacturing process and has the same allergy issues as lanolin. It also has a unique animal odor, so care must be taken when adding it to cosmetics.

Since the main cause of allergies is free alcohol and other polar components with hydroxyl groups, acetic acid lanolin, which is made hypoallergenic by acetylation using acetic anhydride, is used. Furthermore, lanolin is dissolved in mineral oil and used in baby oil and the like, but due to its hydrophilic nature, it has the disadvantage of becoming cloudy or precipitating over time. Lanolin acetate has been improved by acetylating properties thought to be caused by such hydroxyl groups. Also, acetic acid liquid lanolin has recently been used for the same purpose.

However, since the polar components in lanolin include not only alcohol components with hydroxyl groups, but also free fatty acids and other polar components whose composition is unknown, it is difficult to reduce the polar components to less than 1% in a normal acetylation reaction. Possible and already commercially available acetic acid vinolin and acetic acid liquid lanolin usually contain 2 to 5% of polar components. Furthermore, although the characteristic animal odor of lanolin has decreased, it is still strong, and care must be taken when incorporating it into cosmetics.

(Solution Means) As a result of intensive studies to improve the above-mentioned drawbacks of acetic acid lanolin and acetic acid liquid lanolin, the present invention has been developed by acetylating lanolin or liquid lanolin, and then using silica gel, activated alumina, activated clay, and silicic acid. We have completed the present invention by discovering that by treating with an adsorbent such as magnesium, it is possible to adsorb and remove extremely small amounts of polar components, and to remove animal odor to the point where it is almost odorless.

Acetylation can be easily carried out by reacting lanolin or liquid lanolin with acetic anhydride.

The ratio of acetic anhydride to lanolin or liquid lanolin is 0.1 part of acetic anhydride to 1 part of lanolin or liquid lanolin.
~0.3 part is sufficient and can be obtained by reacting at 100 to 130°C for 1 to 3 hours. After the reaction, wash with warm water until neutral.

After washing with water, adsorbents such as silica gel, activated alumina, activated clay, and magnesium silicate are added to perform adsorption treatment.
Polar components can be easily removed (polar components can be easily removed by dissolving the acetylated product in a non-polar organic solvent such as n-hexane, and then passing the solution through a column packed with an adsorbent. The treated acetic acid lanolin and acetic acid liquid lanolin can be used in creams, emulsions, lipsticks, etc., and it is possible to obtain cosmetics with an unprecedented feeling of use, color, and little odor.In addition, it can be used in creams, emulsions, lipsticks, etc. When used in hair cosmetics, it is possible to obtain an excellent hair cosmetic that has excellent gloss, is easy to comb, and gives a moist feel to the hair.There are no particular restrictions on the amount of the compound in creams. No, but - 0.1 for boat fishing.
~30% (weight%) can be blended.

Production Example 1 As shown in Table 1, acetic anhydride is added to lanolin or liquid lanolin, acetylated at 110°C for 1 hour, and then washed with warm water until it becomes neutral.

As shown in Table 2, the obtained acetylated products range from 2.8 to 5.
Contains 5% polar components. Add and dissolve 3 parts of n-hexane to 1 part of acetic acid lanolin obtained in Test No. 1. After this n-hexane solution was passed through a column packed with 3 parts of activated alumina, 3 parts of n-hexane was passed through it, and the resulting eluate was taken into a flask. A yellow paste was obtained, the yield was
It was 65.8%. The yield of acetylated products and the content of polar components obtained by similarly processing Test Nos. 2 to 4 are shown in Table 3.

Table-1 Table-2 Table-3 As shown in Table-2 and Table-3, suck am! By applying L2, the polar component decreases to 1% or less.

The polar components in Tables 2 and 3 were determined by IATROScan.

Figures 1 and 2 show spots (b) showing the positions of polar components.
) is the polar component, and spot (a) is the main component of acetic acid lanolin and acetic acid liquid lanolin.

Example 1 Next, a cream was formulated using the purified acetylated products of Test Nos. 91 to 4 according to the formulation shown in Table 4, and 20 panelists evaluated the feel and smell of the cream.

For comparison, commercially available lanolin acetate and liquid lanolin acetate were similarly formulated into creams and 1 scoop was added. The results are shown in Table-5.

Table-4 Table-'5 As is clear from the results in Table-6, formulation No. L 2 containing purified acetic acid lanolin and purified acetic acid liquid lanolin in which the polar component in the acetylated product used was 1% or less had a flattening effect. There is no smell and the animal odor is less.

Prescription example-1 Emollient cream beeswax 6.0 weight x
6.0 weight 2 Setano II
5.0 5.0 Purified acetic acid lanolin 8.0 8. O
IPM 17.5
13.5 Sukuran 10
,0 10.0Flow n@Rough-in 10.0 10.0I
Leaf oil 4.0
4.0 Lipophilic monostearic acid lycerin 4.0 0 lyophilic monostearic acid monostearic acid monoste? Phosphoric acid ester (20EO)
4.0 Preservatives Appropriate amount of purified water
35.5 Formulation example-2 Emulsion microcrystalline wax
1.0 Mitsu 0 U
2.0 Purified Acetic Acid Liquid Lanoli S/2.0 Liquid I Biraffin
3050 Crane Seven Tanse λ Key [Eight
4.0 〇Rioxiech [
Sol and 1 tan monooleate (20EO)
1.0 stearic acid 1luminium
0.2 preservative
Appropriate amount” 17t rin
8.0 Purified water
51.8 Prescription example-3 hair cream beeswax
! , 0 heavy tX fluid ha 0 rough: /
35. OIPM

10.0 Purified acetic acid liquid lanolin 5.0
Todoroki Hitensesto [-]
2.2 1st batch Solvent (20EO) 2.0 Preservative
Appropriate amount of purified water
44.8 The emollient cream of Formulation-1 and the milky lotion of Formulation Example-2 were almost odorless, did not give a sticky feeling after use, and were excellent in giving a moist feel to the skin. The hair cream of Formulation Example 3 had excellent usability, such as being almost odorless, easy to comb, and giving shine to the hair.

[Brief explanation of the drawing]

Figure 1 shows Iatroscan chromatographs of currently commercially available lanolin acetate and liquid lanolin acetate, and Figure 2
1 is an Iatroscan chromatograph of purified acetic acid lanolin and purified acetic acid liquid lanolin according to the present invention. (a) Main component of lanolin acetate and liquid lanolin acetate (I) Polar component dish 2-plate lanolin acetate Liquid lanolin acetate Iatoroscan Measurement conditions Stationary phase Chromarod 5i11 (silica gel)
Exhibit 51I Solvent Chloroform di-produced purified acetic acid lanolin Purified acetic acid liquid lanolin (Test No, l)
(Test No. 3) IatroScan Measuring conditions Stationary phase Chromarod SII+ (silica gel) developing solvent Chloroform Procedure amendment September 1988 Coni Date 1, Incident indication 1988 Patent application No. 25089 2, Title of the invention Skin and hair external preparations 3. Relationship with the case of the person making the amendment Patent applicant address 1-37 Tokuimachi, Higashi-ku, Osaka Name Clodagh Japan Co., Ltd. May 31, 1988 (Shipping port) 5. Subject of amendment 6 , Contents of amendments A, r application” (1) In accordance with the partial amendments to the Patent Act etc. that came into effect on January 1, 1988, “(patent application pursuant to the proviso to Article 38 of the Patent Act)” is deleted. (2) In accordance with the partial amendments to the Patent Act, etc. that came into effect on January 1, 1988, the "number of inventions stated in the scope of claims" will be amended to "the number of claims." (3) The title of the invention is amended to "External preparation for skin and hair." B, r Specification” (1) Delete the date on the second line of the first page. (2) The title of the invention is amended to "External preparation for skin and hair." Description 1, Name of the invention Skin and hair external preparation 2, Claims A skin and hair product characterized by containing purified acetic acid liquid lanolin and/or purified acetic acid lanolin with a polar component content of 1% or less or) topical hair preparation. 3. Detailed Description of the Invention (Industrial Application Field) The present invention provides a highly purified acetic acid liquid lanolin and/or acetic acid lanolin containing acetic acid lanolin, which has less color, less odor, and is highly safe for the skin and/or ) provides a hair external preparation. (Conventional technology)

Claims (1)

[Claims] A skin and/or hair external preparation characterized by containing purified acetic acid liquid lanolin and/or purified acetic acid lanolin with a polar component content of 1% or less.