JPH01242524A - Syrup agent - Google Patents
Syrup agentInfo
- Publication number
- JPH01242524A JPH01242524A JP6903788A JP6903788A JPH01242524A JP H01242524 A JPH01242524 A JP H01242524A JP 6903788 A JP6903788 A JP 6903788A JP 6903788 A JP6903788 A JP 6903788A JP H01242524 A JPH01242524 A JP H01242524A
- Authority
- JP
- Japan
- Prior art keywords
- added
- cimetizine
- agent
- syrup
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006188 syrup Substances 0.000 title claims abstract description 21
- 235000020357 syrup Nutrition 0.000 title claims abstract description 21
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 13
- 229960001380 cimetidine Drugs 0.000 claims description 13
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 8
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 7
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 7
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 7
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 7
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 7
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 abstract description 11
- 239000003765 sweetening agent Substances 0.000 abstract description 11
- 235000019658 bitter taste Nutrition 0.000 abstract description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 8
- 239000008213 purified water Substances 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract description 5
- -1 antiseptic Substances 0.000 abstract description 5
- 229960002920 sorbitol Drugs 0.000 abstract description 5
- 239000003086 colorant Substances 0.000 abstract description 4
- 239000000654 additive Substances 0.000 abstract description 3
- 235000000346 sugar Nutrition 0.000 abstract description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 abstract description 2
- 229940085605 saccharin sodium Drugs 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 abstract 3
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 abstract 3
- 229960003720 enoxolone Drugs 0.000 abstract 3
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003205 fragrance Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 5
- 241000220223 Fragaria Species 0.000 description 3
- 235000016623 Fragaria vesca Nutrition 0.000 description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 3
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 239000008371 vanilla flavor Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
この発明はシメチジンのシロップ剤、さらに詳しくは、
シメチジンおよびグリチルリチン酸またはその塩を含有
するシロップ剤に関するものであり、医療の分野で利用
される。[Detailed Description of the Invention] [Industrial Application Field] This invention provides a cimetidine syrup, more specifically,
The present invention relates to a syrup containing cimetidine and glycyrrhizic acid or its salt, and is used in the medical field.
［従来技術］
従来、シロップ剤を製造する際の甘味剤としては、ショ
糖、Ｄ−ソルビトール、サッカリンナトリウムなどが汎
用きれている。[Prior Art] Conventionally, sucrose, D-sorbitol, sodium saccharin, and the like have been widely used as sweeteners for producing syrups.
し発明が解決しようとする問題点コ
ノメチシンは下記の化学構造を有する抗潰瘍剤であり、
その儂れた薬効のため広く用いられているが、強い苦味
を有するために、これを内服用の液剤とする場合には、
その苦味を防止することが必要である。Problems to be Solved by the Invention Conomethicin is an anti-ulcer agent having the following chemical structure:
Although it is widely used for its medicinal properties, it has a strong bitter taste, so when it is made into a liquid preparation for internal use,
It is necessary to prevent that bitter taste.
そのためにはシロップ剤とすることが最も好ましいが、
従来シロップ剤を製造するために用いられている前記の
甘味剤を添加するだけでは、それらをシロップ剤に添加
し得る最大量を加えても、甘味が持続せず、後にシメチ
ジンの苦味が残るためシロップ剤として満足できるもの
ではなかった。For this purpose, it is most preferable to make it into a syrup, but
Simply adding the above-mentioned sweeteners, which are conventionally used to produce syrups, does not maintain the sweetness even if they are added in the maximum amount that can be added to the syrup, and the bitterness of cimetidine remains afterwards. It was not satisfactory as a syrup.
［問題点を解決するための手段］
この発明の発明者らは、上記の問題点を解決するために
鋭意検討した結果、従来より食品などのオ味剤として用
いられているグリチルリチン酸またはその塩を加えてシ
ロップ剤を調製すると、シメチジンの苦味を防止でき、
甘味が持続することを見出してこの発明を完成した。[Means for Solving the Problems] As a result of intensive studies to solve the above problems, the inventors of the present invention found that glycyrrhizic acid or its salt, which has been conventionally used as a flavoring agent for foods, etc. The bitter taste of cimetidine can be prevented by preparing syrup by adding
This invention was completed after discovering that the sweetness lasts.
この発明で用いられるグリチルリチン酸の塩としては、
ナトリウム塩、カリウム塩などのアルカリ金属塩、アン
モニウム塩などが挙げられる。The glycyrrhizic acid salts used in this invention include:
Examples include alkali metal salts such as sodium salts and potassium salts, and ammonium salts.
グリチルリチン酸およびその塩はそれぞれ単独で用いて
もよく、また両者を組み合わせて用いてもよく、あるい
は従来の甘味剤と併用してもよい。Glycyrrhizic acid and its salts may be used alone, in combination, or in combination with conventional sweeteners.
シロップ剤中のグリチルリチン酸またはその塩の添加量
は、シメチジンの配合量によって適宜法めることができ
るが、従来の甘味剤を併用する場合、通常０．０５〜１
％程度が好ましい。The amount of glycyrrhizic acid or its salt added to the syrup can be adjusted as appropriate depending on the amount of cimetidine added, but when conventional sweeteners are used together, it is usually 0.05 to 1.
% is preferable.
グリチルリチン酸またはその塩と併用きれる甘味剤とし
ては、例えばシｇ糖、ブドウ糖、果糖、麦芽糖、乳糖な
どの糖類、Ｄ−ソルビトール、マンニトール、キシリト
ールなどの糖アルコール類、サッカリンナトリウムなど
が挙げられ、これらの甘味剤は２種以上組み合わせて用
いてもよい。これらの甘味剤の総添加量は、シメチジン
の配合量によって適宜法めることができるが、通常２０
〜６０％程度が好ましい。Examples of sweeteners that can be used in combination with glycyrrhizic acid or its salts include sugars such as sigose, glucose, fructose, maltose, and lactose, sugar alcohols such as D-sorbitol, mannitol, and xylitol, and sodium saccharin. Two or more sweeteners may be used in combination. The total amount of these sweeteners added can be adjusted as appropriate depending on the amount of cimetidine added, but usually 20
About 60% is preferable.
この発明のシロップ剤には、甘味剤のほかに例えば酸味
剤（例えばクエン酸、酒石酸、リンゴ酸、乳酸などの有
機酸またはそのアルカリ金属塩など）、香料（例えばス
トロベリーフレーバー、オレンジフレーバー、バニラフ
レーバーなどの天然または合成フレーバーなど）、着色
剤（黄色５号などの合成色素、カラメルなどの天然色素
など）、防腐剤（例えば安息香酸、安息香酸ナトリウム
、パラベン類など）、増粘剤（メチルセルロースなど）
、可溶化剤、安定化剤などシロップ剤に通常用いられる
添加剤を適宜加えてもよい。In addition to sweeteners, the syrup of this invention includes, for example, acidulants (for example, organic acids such as citric acid, tartaric acid, malic acid, lactic acid, etc. or alkali metal salts thereof), flavoring agents (for example, strawberry flavor, orange flavor, vanilla flavor). (e.g., natural or synthetic flavors), colorants (synthetic colors such as Yellow No. 5, natural colors such as caramel, etc.), preservatives (e.g. benzoic acid, sodium benzoate, parabens, etc.), thickeners (e.g. methylcellulose, etc.) )
, solubilizers, stabilizers, and other additives commonly used in syrups may be added as appropriate.
この発明のシロップ剤は、常法により製造することがで
きるが、その−例を示せば、まず精製水にシメチジンを
加え、次いで塩酸を加えてシメチジンを溶解したのち、
グリチルリチン酸およびその塩などからなる甘味剤なら
びにその他の添加剤を適宜加えて攪拌することにより製
造することができる。The syrup of the present invention can be produced by a conventional method; for example, first, cimetidine is added to purified water, then hydrochloric acid is added to dissolve the cimetidine, and then,
It can be produced by appropriately adding a sweetener such as glycyrrhizic acid and its salt and other additives and stirring.
Ｃ効果］ 以下、この発明の効果を試験例により説明する。C effect] The effects of this invention will be explained below using test examples.
宣ｔｋ’を恥
５名のパネル員により、一対比較法の官能試験で、この
発明による後記実施例１のシロップ剤と、対照の後記参
考例１のシロップ剤の味を比較した。Five panel members compared the taste of the syrup of Example 1 according to the present invention and the control syrup of Reference Example 1 of the following in a paired comparison method sensory test.
赫
対照のシロップ剤については５名全員が、最初寸みを感
じたもののその甘味は持続せず、すぐに苦味を感したの
に対して、この発明のシロップ剤については、５名全員
が、甘味を持続して感じ、苦味はほとんど感じなかった
。Regarding the control syrup, all five people felt that it had a bitter taste at first, but the sweet taste did not last long, and they immediately felt a bitter taste, whereas for the syrup of this invention, all five people felt The sweetness lasted, and there was almost no bitterness.
参考例１
精製水（４０＋ｎｌｌ ）にシメチジン（２，０ｇ）お
よび特級塩酸（０，６３８ｍ１１ ）を加えてシメチジ
ンを溶解した後、ショ糖（３０ｇ）、Ｄ−ソルビトール
（２０ｇ）、サッカリンナトリウム（０，３ｇ）、クエ
ン酸ナトリウム（０，３ｇ）、安息香酸ナトリウム（０
，２ｇ）およびストロベリーフレーバー（０，１ｍＡ
）を加えて攪拌し、精製水で全量を１００ ｍＱにして
シロップ剤を得る。Reference Example 1 Cimetidine (2.0 g) and special grade hydrochloric acid (0,638 ml) were added to purified water (40+nll) to dissolve cimetidine, and then sucrose (30 g), D-sorbitol (20 g), and saccharin sodium (0.3 g ), sodium citrate (0,3g), sodium benzoate (0
,2g) and strawberry flavor (0,1mA
), stir, and make a total volume of 100 mQ with purified water to obtain a syrup.
［実施例］ 以下、この発明を実施例により説明する。[Example] This invention will be explained below with reference to Examples.
犬及堡ユ
精製水（４０ｍＱ）にシメチジン（２，０ｇ）および特
級塩酸（０，６３８ｍ１！ ）を加えてシメチジンを溶
解した後、ン９糖（３０ｇ）、Ｄ−ソルビトール（２０
ｇ）、サッカリンナトリウム（０，３ｇ）、グリチルリ
チン酸ジカリウム塩（０，１８ｇ）、クエン酸ナトリウ
ム（０，３ｇ）、安息香酸ナトリウム（０，２ｇ）おヨ
ヒストロベリーフレーハ−（Ｑ、１ｍＱ ） ヲ加ニー
ｒ攪拌し、精製水で含量を１００ｍＱにして、シロップ
剤を得る。Cimetidine (2.0 g) and special grade hydrochloric acid (0,638 ml!) were added to Inuyobayu purified water (40 mQ) to dissolve cimetidine, and then N9 sugar (30 g) and D-sorbitol (20
g), Sodium saccharin (0.3g), Dipotassium glycyrrhizinate (0.18g), Sodium citrate (0.3g), Sodium benzoate (0.2g), Strawberry Fleher (Q, 1mQ) Stir with a kneader and adjust the content to 100 mQ with purified water to obtain a syrup.
Claims (1)
することを特徴とするシロップ剤。A syrup containing cimetidine and glycyrrhizic acid or a salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63069037A JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63069037A JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01242524A true JPH01242524A (en) | 1989-09-27 |
| JP2643260B2 JP2643260B2 (en) | 1997-08-20 |
Family
ID=13390982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63069037A Expired - Lifetime JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2643260B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999059588A1 (en) * | 1998-05-21 | 1999-11-25 | Sumitomo Pharmaceuticals Co., Ltd. | Medicinal composition reduced in bitterness |
| US6517870B1 (en) | 1998-04-29 | 2003-02-11 | Sumitomo Pharmaceuticals Company, Limited | Oral formulation comprising biguanide and an organic acid |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54132280A (en) * | 1977-11-25 | 1979-10-15 | Macandrews & Forbes Co | Sweetening composition |
| JPS6019472A (en) * | 1983-07-13 | 1985-01-31 | ジエネラル・フ−ヅ・コ−ポレ−シヨン | Food containing sweetness modifier |
| JPS6019473A (en) * | 1983-07-13 | 1985-01-31 | ジエネラル・フ−ヅ・コ−ポレ−シヨン | Food containing sweetness modifier |
| JPS61500223A (en) * | 1983-10-10 | 1986-02-06 | スミス・クライン・ダウエルスベルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | pharmaceutical composition |
-
1988
- 1988-03-22 JP JP63069037A patent/JP2643260B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54132280A (en) * | 1977-11-25 | 1979-10-15 | Macandrews & Forbes Co | Sweetening composition |
| JPS6019472A (en) * | 1983-07-13 | 1985-01-31 | ジエネラル・フ−ヅ・コ−ポレ−シヨン | Food containing sweetness modifier |
| JPS6019473A (en) * | 1983-07-13 | 1985-01-31 | ジエネラル・フ−ヅ・コ−ポレ−シヨン | Food containing sweetness modifier |
| JPS61500223A (en) * | 1983-10-10 | 1986-02-06 | スミス・クライン・ダウエルスベルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | pharmaceutical composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6517870B1 (en) | 1998-04-29 | 2003-02-11 | Sumitomo Pharmaceuticals Company, Limited | Oral formulation comprising biguanide and an organic acid |
| WO1999059588A1 (en) * | 1998-05-21 | 1999-11-25 | Sumitomo Pharmaceuticals Co., Ltd. | Medicinal composition reduced in bitterness |
| JP4493847B2 (en) * | 1998-05-21 | 2010-06-30 | ユセベ ファルシム ソシエテ アノニム | Pharmaceutical composition with reduced bitterness |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2643260B2 (en) | 1997-08-20 |
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