JPH0126307B2 - - Google Patents
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- Publication number
- JPH0126307B2 JPH0126307B2 JP58192025A JP19202583A JPH0126307B2 JP H0126307 B2 JPH0126307 B2 JP H0126307B2 JP 58192025 A JP58192025 A JP 58192025A JP 19202583 A JP19202583 A JP 19202583A JP H0126307 B2 JPH0126307 B2 JP H0126307B2
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- Prior art keywords
- body fluid
- adsorbent particles
- present
- fluid treatment
- pores
- Prior art date
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Description
【発明の詳細な説明】
発明の背景
技術分野
本発明は改良された体液処理装置に関するもの
である。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improved body fluid treatment device.
さらに詳しくは、本発明は体液処理手段を収容
し、内部が減圧に保持された密閉容器からなり、
プライミング操作が容易な体液処理装置に関する
ものである。 More specifically, the present invention comprises a closed container containing a body fluid treatment means and whose interior is maintained at reduced pressure,
The present invention relates to a body fluid treatment device that allows easy priming operation.
本発明の装置は体液を浄化するための改良され
た装置として多方面に利用される。例えば人工腎
臓、人工肺、人工肝臓、血漿浄化装置、血漿分離
装置等として使用され、特に患者の血漿中から病
原物質を吸着除去することにより病気を治療する
血漿浄化装置として好適に使用される。 The device of the present invention has many uses as an improved device for purifying body fluids. For example, it is used as an artificial kidney, an artificial lung, an artificial liver, a plasma purification device, a plasma separation device, etc., and is particularly suitable as a plasma purification device for treating diseases by adsorbing and removing pathogenic substances from a patient's plasma.
先行技術
従来吸着剤粒子を使用する体液処理装置は、体
液流出入口を有し、吸着剤粒子を内部に充填した
容器からなつており、体液の処理は該容器に体液
を流入し、体液を吸着剤粒子と接触せしめ、除去
すべき物質を吸着剤に吸着せしめることによつて
実施されていた。ところが上記従来の装置におい
て吸着剤粒子が細孔を有するものである場合に
は、吸着剤粒子内の細孔に存在する空気に阻止さ
れて体液が細孔内に入り込むことができず、体液
が該粒子表面に接触できない為に吸着剤粒子の表
面積を有効に利用できない欠点があつた。また、
該粒子の脱泡操作も時間を要し、充分な脱泡は困
難であつた。この欠点を補うため、該吸着剤粒子
を予め蒸留水等の液体に浸漬した装置が知られて
いる。この装置においては、粒子細孔内の空気は
排除されているので体液は容易に細孔内に入り込
み、接触面積は所定の値を維持することができ
る。しかしながら、反面、浸漬させるための液体
の重量の分だけ装置が重くなり、装置の運搬や取
り扱いに不利である。また吸着剤粒子として担体
に蛋白を固定したものを使用する場合には液体へ
の浸漬により蛋白の安定性が悪くなつたり、オー
トクレーブ滅菌では蛋白の変質が生じるおそれが
ある為、装置内部に液体を充填しない状態で滅菌
し、製品として提供する必要があつた。Prior Art Conventional body fluid treatment devices using adsorbent particles consist of a container that has a body fluid inlet/outlet and is filled with adsorbent particles, and body fluid treatment involves flowing the body fluid into the container and adsorbing the body fluid. This was carried out by bringing the substance to be removed into contact with the adsorbent particles and causing the substance to be removed to be adsorbed onto the adsorbent. However, in the conventional device described above, when the adsorbent particles have pores, the body fluid cannot enter into the pores because the air present in the pores inside the adsorbent particles prevents the body fluid from entering the pores. There was a drawback that the surface area of the adsorbent particles could not be used effectively because the surface of the adsorbent particles could not be contacted. Also,
The defoaming operation of the particles also took time, and sufficient defoaming was difficult. In order to compensate for this drawback, an apparatus is known in which the adsorbent particles are immersed in a liquid such as distilled water in advance. In this device, since the air in the particle pores is excluded, body fluids can easily enter the pores and the contact area can be maintained at a predetermined value. However, on the other hand, the device becomes heavy due to the weight of the liquid used for immersion, which is disadvantageous in transporting and handling the device. Furthermore, when using adsorbent particles with proteins immobilized on a carrier, the stability of the protein may deteriorate due to immersion in a liquid, and the protein may be denatured when sterilized in an autoclave. It was necessary to sterilize the product without filling it and provide it as a product.
発明の目的
本発明は上記の欠点のない体液処理装置を提供
することを目的とする。 Object of the invention The object of the invention is to provide a body fluid treatment device that does not have the above-mentioned drawbacks.
即ち、本発明は体液と吸着剤粒子等の体液処理
手段との接触面積が大きく、処理能の優れた体液
処理装置を提供することを目的とする。 That is, an object of the present invention is to provide a body fluid treatment device that has a large contact area between body fluid and body fluid treatment means such as adsorbent particles, and has excellent treatment performance.
さらに本発明は、軽量で取り扱いの容易な体液
処理装置を提供することを目的とする。 A further object of the present invention is to provide a body fluid treatment device that is lightweight and easy to handle.
本発明はさらに、吸着剤粒子の安定性が優れた
体液処理装置を提供することを目的とする。 A further object of the present invention is to provide a body fluid treatment device in which adsorbent particles have excellent stability.
上記目的を達成するため、本発明の体液処理装
置は、開閉手段を備えた少くとも１つの体液流出
入口を有する密閉容器と、その内部に収容された
細孔を有する吸着剤粒子からなる体液処理手段と
を有し、前記密閉容器が使用前に減圧されてい
る。 In order to achieve the above object, the body fluid treatment device of the present invention comprises a closed container having at least one body fluid inlet and an opening/closing means, and adsorbent particles having pores housed inside the closed container. means, and the closed container is evacuated before use.
さらに本発明の体液処理装置は前記体液処理手
段が細孔を有する吸着剤粒子である。 Further, in the body fluid treatment device of the present invention, the body fluid treatment means is an adsorbent particle having pores.
さらに本発明の体液処理装置は前記細孔を有す
る吸着剤粒子が孔径40〜2200Åの貫通する多数の
孔をもち、表面積が10〜30m2／ｇである多孔性ビ
ーズである。 Furthermore, the body fluid treatment device of the present invention is a porous bead in which the adsorbent particles having pores have a large number of penetrating pores with a pore diameter of 40 to 2200 Å and a surface area of 10 to 30 m 2 /g.
さらに本発明の体液処理装置は前記密閉容器内
部が200〜１mmＨｇに減圧されている。 Further, in the body fluid treatment apparatus of the present invention, the pressure inside the sealed container is reduced to 200 to 1 mmHg.
本発明において体液処理装置とは、血液、血
漿、腹水等の体液を分離しまたは浄化処理する装
置をいい、その例として血液浄化装置、血漿分離
装置、人工腎臓、人工肺、人工肝臓等があげられ
る。 In the present invention, a body fluid treatment device refers to a device that separates or purifies body fluids such as blood, plasma, and ascites, and examples thereof include a blood purification device, a plasma separation device, an artificial kidney, an artificial lung, and an artificial liver. It will be done.
発明の具体的説明
以下本発明の構成を図面に示す実施例に基づい
て詳細に説明する。 DETAILED DESCRIPTION OF THE INVENTION The structure of the present invention will be described in detail below based on embodiments shown in the drawings.
図面に本発明の体液浄化装置の一実施例を示
す。 An embodiment of the body fluid purification device of the present invention is shown in the drawings.
この体液浄化装置は、コツク５を備えた体液流
出口３および体液流入口４を有する蓋体２で筒体
１の両端を螺嵌または嵌合してなる密閉容器と該
密閉容器の内部に収容された細孔を有する吸着剤
粒子６とからなり、該容器は減圧されている。吸
着剤粒子６は、流出防止のため筒体１の両端でフ
イルタ７により挾まれており、蓋体２はパツキン
グ８を介して液密に筒体１に螺嵌または嵌合して
いる。体液流出口３および体液流入口４には減圧
を完全に保持するため、および無菌状態を保持す
るためキヤツプ９が冠着している。吸着剤粒子６
は孔径40〜2200Åの貫通する多数の孔をもち、表
面積が10〜30m2／ｇである多孔性ビーズが適当で
ある。またビーズの粒子径は70〜200μmで材質は
ガラス、シリカ、プラスチツク等が用いられ、例
えばポリアミノスチレンが好ましい。尚、本発明
においてビーズとは球状体を意味する。装置内の
減圧度は、粒子細孔の大きさにもよるが略200〜
１mmＨｇ（266.65×102〜1.33×102Pa（Ｎ／m2））
である。本発明の装置を用いて体液を浄化するに
は、液体の浄化前の準備として該装置のプライミ
ング操作を行なう。プライミング操作とは該装置
内に生理食塩液等のプライミング液をしばらくの
間流し続け、該装置内の空気抜き及び洗浄を行な
う操作をいう。すなわち体液流入口４の先端に設
けられたキヤツプ９をはずした後、別に設けたプ
ライミング液の導入部と接続した後コツク５を開
いて体液流入口４からプライミング液を装置内に
吸い込ませ、プライミング液を吸着剤粒子６に充
分浸透させた後、体液流出口のコツク５を開いて
体液を装置外へ導出し、しばらくプライミング液
を流し続ける。装置内は減圧に保持されているの
でプライミング液は容易に吸着剤粒子の細孔内に
浸透し、該粒子表面の細孔内のプライミング液充
填及び洗浄が極めて短時間に行なわれる。 This body fluid purification device includes a closed container formed by screwing or fitting both ends of a cylindrical body 1 with a lid body 2 having a body fluid outflow port 3 and a body fluid inflow port 4 equipped with a cap 5, and a closed container housed inside the closed container. The container is under reduced pressure. The adsorbent particles 6 are sandwiched between filters 7 at both ends of the cylindrical body 1 to prevent them from flowing out, and the lid 2 is screwed or fitted into the cylindrical body 1 through a packing 8 in a fluid-tight manner. A cap 9 is attached to the body fluid outlet 3 and the body fluid inlet 4 in order to completely maintain a reduced pressure and to maintain a sterile state. Adsorbent particles 6
Porous beads having a large number of penetrating pores with a diameter of 40 to 2200 Å and a surface area of 10 to 30 m 2 /g are suitable. The particle diameter of the beads is 70 to 200 μm, and the material used is glass, silica, plastic, etc., and polyaminostyrene is preferred, for example. In the present invention, beads mean spherical bodies. The degree of vacuum inside the device is approximately 200~200, depending on the size of the particle pores.
1mmHg (266.65×10 2 ~1.33×10 2 Pa (N/m 2 ))
It is. To purify body fluids using the device of the present invention, the device is primed in preparation for purifying the liquid. The priming operation refers to an operation in which a priming solution such as physiological saline continues to flow into the device for a while to remove air from the device and clean it. That is, after removing the cap 9 provided at the tip of the body fluid inlet 4, and connecting it to the separately provided priming fluid inlet, the cap 5 is opened to suck the priming fluid into the device from the body fluid inlet 4, and the priming is performed. After the liquid has sufficiently penetrated into the adsorbent particles 6, the body fluid outflow port 5 is opened to lead the body fluid out of the device, and the priming liquid continues to flow for a while. Since the inside of the apparatus is maintained at a reduced pressure, the priming liquid easily penetrates into the pores of the adsorbent particles, and filling and cleaning of the pores on the surface of the particles with the priming liquid can be carried out in an extremely short time.
本発明の体液浄化装置は、特に血液や血漿を浄
化するための装置に適している。例えば吸着剤粒
子６として多孔性ビーズに１本鎖DNAまたは
IgGを固定させてなる抗体吸着剤を使用すること
により患者血漿から全身性エリテマトーデス因子
またはリウマチ因子を除去することができる。本
発明の装置においては吸着剤粒子は液体に浸され
ていないので、上記の如く吸着剤粒子に蛋白が固
定されている場合でもそれを変質させるおそれが
ない。本発明の装置を血漿浄化装置として使用す
る場合は、装置の材質に安全上の考慮を払う必要
がある。即ち、容器や吸着剤粒子等は有害物質を
溶出したり容易に破損するものであつてはなら
ず、また、エチレンオキサイドガスやガンマ線照
射による滅菌操作に耐えるものでなければならな
い。 The body fluid purification device of the present invention is particularly suitable as a device for purifying blood and plasma. For example, single-stranded DNA or
Systemic lupus erythematosus factor or rheumatoid factor can be removed from patient plasma by using an antibody adsorbent with immobilized IgG. In the apparatus of the present invention, the adsorbent particles are not immersed in liquid, so even if proteins are immobilized on the adsorbent particles as described above, there is no risk of deterioration of the protein. When using the device of the present invention as a plasma purification device, safety considerations must be given to the material of the device. That is, the container, adsorbent particles, etc. must not be able to elute harmful substances or be easily damaged, and must also be able to withstand sterilization operations using ethylene oxide gas or gamma ray irradiation.
以下に実験例を示して本発明をさらに具体的に
説明する。 The present invention will be explained in more detail with reference to experimental examples below.
実験例
図面に示す体液浄化装置を作成する。ここに、
筒体１、蓋体２、コツク５の材質はポリカーボネ
ートであり、筒体は内径30mm、外径36mm、長さ30
mmである。パツキング８はシリコーンゴム製Ｏリ
ング、フイルタ７はポリエチレン製で厚みは１mm
である。筒体内部には径500Åの連通した孔を有
する平均径100μのガラス粒子が充填されている。
このガラス粒子には抗アルブミン抗体がアミノプ
ロピル基を介して結合している。体液流出口３の
先端にチユーブを連結し、真空ポンプにつなげ、
容器内を20mmＨｇにまで減圧する。減圧されたと
きにコツクを閉じ、キヤツプ９をかぶせる。Experimental example Create a body fluid purification device as shown in the drawing. Here,
The material of the cylinder 1, lid 2, and pot 5 is polycarbonate, and the cylinder has an inner diameter of 30 mm, an outer diameter of 36 mm, and a length of 30 mm.
mm. Packing 8 is a silicone rubber O-ring, and filter 7 is made of polyethylene with a thickness of 1 mm.
It is. The inside of the cylinder is filled with glass particles with an average diameter of 100μ and having continuous pores with a diameter of 500Å.
Anti-albumin antibodies are bound to these glass particles via aminopropyl groups. Connect a tube to the tip of body fluid outflow port 3, connect it to a vacuum pump,
Reduce the pressure inside the container to 20 mmHg. When the pressure is reduced, close the pot and cover with cap 9.
次の実験によつて抗アルブミン抗体に吸着する
アルブミンを定量することにより吸着剤粒子の細
孔への体液の浸透を試験した。 The following experiment tested the penetration of body fluid into the pores of the adsorbent particles by quantifying the amount of albumin adsorbed to the anti-albumin antibody.
減圧状態にある装置の体液流入口４の先端に注
射針を連結し、針の先をアルブミンを含む生理食
塩水につける。その後コツク５を開いて液が流入
しなくなるまで装置に液を吸い込ませる。次いで
体液流出口３のコツク５も開いてしばらく同溶液
を流した後装置内を生理食塩液で十分洗浄する。
対照として同じ吸着剤粒子を詰め、減圧状態にし
なかつた装置を用いて上と同じ操作を行なう。両
装置にそれぞれ0.2Mグリシン緩衝液（PH2.5）を
流し、溶出液を1NNaOHでPH7.0に調整した後、
溶出液中のアルブミン量を測定する。その結果、
減圧しなかつた対照装置における吸着剤粒子への
アルブミン吸着量は45mgであるのに対して減圧し
た本発明装置の吸着剤粒子へのアルブミン吸着量
は350mgであつた。 A syringe needle is connected to the tip of the body fluid inlet 4 of the device under reduced pressure, and the tip of the needle is immersed in physiological saline containing albumin. After that, the pot 5 is opened and the liquid is sucked into the device until the liquid stops flowing. Next, the pot 5 of the body fluid outlet 3 is opened and the same solution is allowed to flow for a while, and then the inside of the device is sufficiently washed with physiological saline.
As a control, the same procedure as above is carried out using a device packed with the same adsorbent particles but not subjected to vacuum. After flowing 0.2M glycine buffer (PH2.5) into both devices and adjusting the eluate to pH7.0 with 1N NaOH,
Measure the amount of albumin in the eluate. the result,
The amount of albumin adsorbed onto the adsorbent particles in the control device without pressure reduction was 45 mg, whereas the amount of albumin adsorbed onto the adsorbent particles in the device of the present invention with reduced pressure was 350 mg.
この結果から、体液浄化装置内を減圧にするこ
とにより体液を吸着剤粒子の細孔内に十分しかも
容易に浸透させ、その表面積を有効に生かすこと
ができることが明らかである。尚、本発明の装置
内の減圧度は体液流出入口に圧力計を接続して容
易に測定することができる。 From this result, it is clear that by reducing the pressure inside the body fluid purification device, the body fluid can be sufficiently and easily penetrated into the pores of the adsorbent particles, and the surface area can be effectively utilized. Incidentally, the degree of reduced pressure inside the apparatus of the present invention can be easily measured by connecting a pressure gauge to the body fluid inlet.
発明の具体的作用効果
以上詳述した如く、本発明によれば体液と体液
処理手段との接触面積が大きく、浄化後の優れた
体液浄化装置が提供される。 Specific Effects of the Invention As described in detail above, the present invention provides a body fluid purification device that has a large contact area between body fluid and the body fluid treatment means and is excellent after purification.
本発明の装置は、容器内が減圧にされているの
で、吸着剤粒子の細孔に体液が容易に浸透し、プ
ライミング操作が極めて容易になるとともに体液
と吸着剤粒子との所定の有効接触面積の減少を防
止できる。 In the device of the present invention, since the inside of the container is under reduced pressure, the body fluid easily penetrates into the pores of the adsorbent particles, making the priming operation extremely easy and maintaining a predetermined effective contact area between the body fluid and the adsorbent particles. can prevent a decrease in
さらに本発明によれば、軽量で取り扱いの容易
な体液浄化装置が提供される。 Further, according to the present invention, a body fluid purification device that is lightweight and easy to handle is provided.
本発明の装置においては、吸着剤粒子は乾燥状
態においているので吸着剤が液体に浸漬されてい
る装置にくらべて軽量であり、運搬や取り扱いに
便利である。 In the apparatus of the present invention, since the adsorbent particles are in a dry state, it is lighter than an apparatus in which the adsorbent is immersed in a liquid, and is convenient to transport and handle.
さらに本発明によれば吸着剤粒子の安定性が優
れた体液浄化装置が提供される。 Further, according to the present invention, a body fluid purification device with excellent stability of adsorbent particles is provided.
血漿浄化等においては、吸着剤粒子に抗体等蛋
白を固定したものが使用されるが、その場合吸着
剤が液体に浸漬されていると蛋白が変質するおそ
れがある。しかし、本発明の装置においては上述
した如く、吸着剤粒子は乾燥状態に保持されてい
るのでそのようなおそれはない。従つて本発明の
装置は血漿浄化装置として特に適している。 In plasma purification and the like, adsorbent particles on which proteins such as antibodies are immobilized are used, but in this case, if the adsorbent is immersed in a liquid, there is a risk that the protein may be denatured. However, in the apparatus of the present invention, as described above, the adsorbent particles are kept in a dry state, so there is no such fear. The device of the invention is therefore particularly suitable as a plasma purification device.
尚、本発明は上記実験例に限られるものではな
く、前述のように人工腎臓、人工肺、人工肝臓、
血漿分離装置等に適用しても同様な効果が得られ
る。 It should be noted that the present invention is not limited to the above experimental examples, and as described above, artificial kidneys, artificial lungs, artificial livers,
A similar effect can be obtained when applied to a plasma separation device or the like.
図面は本発明の体液浄化装置の一実施例を示す
断面図である。
１…筒体、２…蓋体、３，４…体液流出入口、
５…コツク、６…吸着剤粒子、７…フイルタ、８
…パツキング、９…キヤツプ。
The drawing is a sectional view showing an embodiment of the body fluid purification device of the present invention. 1... Cylindrical body, 2... Lid body, 3, 4... Body fluid outflow inlet,
5... Kotoku, 6... Adsorbent particles, 7... Filter, 8
...Patzking, 9...Cap.
Claims (1)
を有する蓋体で筒体の両端を螺嵌または嵌合して
なる密閉容器と、その内部に収容された細孔を有
する吸着剤粒子からなる体液処理手段とを有し、
前記密閉容器内が使用前に減圧されていることを
特徴とする体液処理装置。 ２ 細孔を有する吸着剤粒子は、孔径40〜2200Å
の貫通する多数の孔をもち、表面積が10〜30m2／
ｇである多孔性ビーズである特許請求の範囲第１
項記載の体液処理装置。 ３ 密閉容器内が使用前に200〜１mmＨｇに減圧
されている特許請求の範囲第１項または第２項記
載の体液処理装置。[Scope of Claims] 1. A closed container formed by screwing or fitting both ends of a cylindrical body with a lid having a body fluid outlet or a body fluid inlet with a cap, and a pore housed inside the closed container. and a body fluid treatment means consisting of adsorbent particles,
A body fluid treatment device characterized in that the pressure inside the closed container is reduced before use. 2 Adsorbent particles with pores have a pore size of 40 to 2200 Å.
It has a large number of penetrating holes and has a surface area of 10 to 30 m 2 /
Claim 1, which is a porous bead of
The body fluid treatment device described in Section 1. 3. The body fluid treatment device according to claim 1 or 2, wherein the pressure inside the closed container is reduced to 200 to 1 mmHg before use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58192025A JPS6083666A (en) | 1983-10-14 | 1983-10-14 | Body fluids treating apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58192025A JPS6083666A (en) | 1983-10-14 | 1983-10-14 | Body fluids treating apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6083666A JPS6083666A (en) | 1985-05-11 |
| JPH0126307B2 true JPH0126307B2 (en) | 1989-05-23 |
Family
ID=16284340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58192025A Granted JPS6083666A (en) | 1983-10-14 | 1983-10-14 | Body fluids treating apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6083666A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0222307U (en) * | 1988-07-26 | 1990-02-14 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8206520L (en) * | 1982-11-16 | 1984-05-17 | Gambro Lundia Ab | COLUMN AND SYSTEM TO REMOVE SPECIFIC ANTIBODIES FROM A BODY WASTE |
-
1983
- 1983-10-14 JP JP58192025A patent/JPS6083666A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0222307U (en) * | 1988-07-26 | 1990-02-14 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6083666A (en) | 1985-05-11 |
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