JPH0148244B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dental cream for promoting oral hygiene. Traditionally, dental creams have been used that contain unilateral F-supplying agents such as sodium fluoride, stannous fluoride, and sodium monofluorophosphate (commercially available sodium monofluorophosphate is thought to contain small amounts of NaF). ). Recently, Beach Yam Group's British patent 1435624
Oral health promoting dental creams containing two separately added F-providing agents, sodium fluoride and sodium monofluorophosphate, are described, as in US Pat. However, two such F-supplying agents and a compound containing a small amount of bonded alumina
Dental creams containing Si abrasives are not described. A first object of the present invention is to provide a dental cream containing sodium fluoride and sodium monofluorophosphate which promotes oral hygiene, for example by reducing caries formation and achieving tooth remineralization. A second objective of the present invention is to produce a silica abrasive-containing dental cream with high F stability. The opaque dental cream of the present invention has a
wt% opacifier and binary F providing about 750-1225 ppm F from sodium monofluorophosphate and about 50-1000 ppm F from sodium fluoride.
It consists of a feed system and about 15-20% by weight of an abrasive consisting essentially of synthetic precipitated silica (with up to about 1% by weight alumina interconnected therewith). Sodium monofluorophosphate is used in an amount to provide about 750 to 1225 ppm F in the dental cream. This corresponds to about 0.5-1% by weight of sodium monofluorophosphate in dental creams.
A preferred amount is about 0.76% to provide about 1000 ppm F in the dental cream. Sodium monofluorophosphate _{( Na2PO3F} )
is commercially available, but its purity varies considerably. Any suitable purity can be used provided that impurities do not adversely affect the desired properties. Generally, a purity of at least 80% is desirable. For best results, sodium monofluorophosphate should be at least 85% by weight;
Preferably it should be at least 90%, with the remainder being primarily impurities or by-products such as sodium fluoride, water-soluble sodium phosphate salts. Stated otherwise, the sodium monofluorophosphate used has a total F content of more than 12%, preferably more than 12.7%, and a free F content of no more than 1.5%, preferably no more than 1.2%.
The sodium monofluorophosphate content should be at least 12%, preferably at least 12.1% (all calculated as F). Sodium fluoride is about 50 to 1000 ppm (e.g. 50
~100 ppm) is added separately to provide an additional amount of F.
This corresponds to approximately 0.01-0.2% sodium fluoride. The abrasive is a synthetic precipitated silica having up to about 1% by weight alumina interconnected therewith. Such abrasives may be considered aluminosilicates, particularly sodium aluminosilicates. A typical example is Colgate.
Palmolive's US Patent No. 3906090 and JM
Huber US patent 4015996,
It is described in the specifications of Nos. 4105757 and 4122160. A commercially available example of these materials is Hoover's ZEO49.
ZEO49B, TIXOSIL 53 from Sifrance. Abrasives are used in amounts of about 15-20% by weight. If desired, a small amount (eg, about 0.5-1%) of dicalcium phosphate may be present as an additional abrasive. The dental cream of the present invention is opaque. Since abrasives have a refractive index close to that of humectants such as glycerin and sorbit, which are commonly used in dental creams, an opacifying agent such as about 0.5 to 2% titanium dioxide or its equivalent is used. Use. Dental creams of the present invention typically contain about 50-80% by weight humectants, such as about 20-30% glycerin and about 30-60% sorbitol.
(70% solution). Other opacifying agents such as zinc oxide, which do not cause adverse effects by reacting with other ingredients of the dental cream, may also be used in orally acceptable amounts. Water may also be present in small amounts, such as about 2-7% by weight. If it is desired to color the dental cream, a coloring pigment may be dissolved in this water. Dental creams of the invention also typically include:
Contains natural or synthetic gums or gummy substances such as gelling agents such as iris gum, gum tragacanth, sodium carboxymethylcellulose, polyvinylpyrrolidone, and starch. Sodium carboxymethylcellulose is preferred. The content of gelling agent is typically about 0.1-5% by weight, preferably about 0.1-0.5%. This gelling effect can be supplemented with fillers such as about 7-8% pyrogenic silica, silica aerogels. ZEOSYL200 from JM Hoover is a preferred silica-based filler. “ZEOSYL” is a trademark name. Any suitable surfactant or detergent can be included in the dentifrice compositions of the present invention. Such formulations, depending on their type, desirably provide additional cleaning, foaming, and antimicrobial properties and are similarly selected. These detergents are typically water-soluble compounds and may be anionic, nonionic, or cationic. It is usually preferred to use water-soluble non-soap or synthetic organic detergents. Suitable cleaning agents are known, such as water-soluble salts of higher fatty acid monoglyceride monosulfates (e.g. sodium coconut fatty acid monoglyceride monosulfate), water-soluble salts of higher alkyl sulfates (e.g. sodium lauryl sulfate), alkylaryl sulfonates. (eg, sodium dodecylbenzenesulfonate), higher fatty acid esters of 1,2-dihydroxypropanesulfonic acid, and the like. Other surfactants are substantially saturated higher aliphatic acylamides of lower amino acid detergents, such as those having 12 to 16 Cs in the acyl group. The amino acid moiety is generally derived from lower aliphatic saturated monoaminocarboxylic acids (usually monocarboxylic acid compounds) having about 2 to 6 C's. Suitable compounds are fatty acid amides of glycine, sarcosine, alanine, 3-aminopropanoic acid, and valine, in which the acyl group has about 12 to 16 Cs. It is preferred to use N-lauroyl, myristoyl, palmitoyl sarcoside compounds for optimum effectiveness. The amide compound can be used in the free acid form or, preferably, as its water-soluble salt (eg, alkali metal, ammonium, amine, alkylolamine salt). Particular examples thereof are sodium or calcium N-lauroyl, myristoyl or palmitoyl sarcoside, ammonium or ethanolamine N-lauroyl sarcoside, N-lauroyl sarcosine, sodium N-lauroylglyside, alanine. Surfactants are typically used in amounts of about 1-5% by weight, preferably about 1-3% sodium lauryl sulfate. Any suitable flavoring or sweetening agent may be used in the flavor formulation of the compositions of this invention. Examples of suitable flavoring ingredients are fragrances such as spearmint oil,
These are peppermint oil, wintergreen oil, satsafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, orange oil, and methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol,
Sodium cyclamate, soluble saccharin. Soluble saccharin is preferred. Flavoring agents are typically present in an amount of about 0.5-15%, preferably about 1% by weight, and sweeteners are present in an amount of about 0.1-0.2%. If desired, visible particles of pearly flakes, such as titanium dioxide coated mica flakes, may be distributed in the dental cream, typically in an amount of about 0.1 to 0.3% by weight. Similarly, dental creams may be striped. Dental creams can be placed in conventional tubes, such as lined or unlined aluminum tubes or wax-lined lead tubes. The dental cream of the present invention must have a practical pH. A PH range of about 5-10 is particularly desirable. this
PH was measured directly with dental cream. The following examples are illustrative of the present invention. All weights are by weight unless otherwise specified. Example 1 The following dental cream was manufactured in a conventional manner. Ingredients Glycerin 25.00 Sorbit (70%) 42.31 Sodium carboxymethyl 0.18 Cellulose 0.17 Soluble saccharin 0.82 Sodium monofluorophosphate 0.02 Sodium fluoride 3.0 Water 0.5 Titanium dioxide 17.0 Silicon dioxide - low (approximately 1%) alumina 7.0 Zeosil 200 Diphosphate Calcium dihydrate 1.0 Sodium lauryl sulfate 2.0 Flavor 1.0 Example 2 The formulation of Example 1 was added with 0.25 parts of titanium dioxide-coated mica flakes, and the water content was reduced by the same amount instead, and separated again in the usual manner. manufactured dental cream. The following table shows formulation examples of three types of dental creams manufactured by conventional methods, and Example 3 is according to the present invention. During the test period, the formulation example of Example 3 had a higher amount of F and higher
The retention rate is clearly shown. The F content is determined by the British Cosmetic Chemists' Association Journal (The
Journal of the Society of Cosmetic Chemists
It was measured using the following standard method described by Cropper and Puttnam in vol. 21 (1970), p. 533 of Great Britain. This method determines the total dissolved fluorine as fluorine ions in sodium fluoride and sodium monofluorophosphate in dental cream. Fluorine ions are converted to trimethylfluorosilane in an acidic solution, and this silane derivative is extracted with a solvent and analyzed by gas chromatography (filling material: 80
~100 meshes of 10% Silicone OVI at 60°C using nitrogen gas as a carrier). 【table】

Claims (1)

[Claims] 1. 0.5 to 2% by weight of an opacifying agent; from about 750% to 2% by weight of sodium monofluorophosphate
50~ from 1225ppm fluorine and sodium fluoride
a binary fluorine supply system providing 1000 ppm of fluorine; and 15 to 20% by weight of an abrasive consisting essentially of synthetic silica with about 1
opaque dental cream consisting of up to % alumina); 2. The dental cream according to claim 1, wherein the opacifying agent is titanium dioxide. 3. The dental cream according to claim 1 or 2, wherein the sodium fluoride supplies 50 to 100 ppm of F. 4. Dental cream according to any one of claims 1 to 3, comprising about 0.5 to 1% by weight of dicalcium phosphate. 5. The dental cream according to any one of claims 1 to 4, comprising about 0.1 to 0.3% by weight of pearl flakes.