JPH01500515A - Ｂ型肝炎ウィルス表面抗原のプレｓ領域のｔ及びｂ細胞エピトープ - Google Patents

Ｂ型肝炎ウィルス表面抗原のプレｓ領域のｔ及びｂ細胞エピトープ

Info

Publication number
JPH01500515A
JPH01500515A JP62504116A JP50411687A JPH01500515A JP H01500515 A JPH01500515 A JP H01500515A JP 62504116 A JP62504116 A JP 62504116A JP 50411687 A JP50411687 A JP 50411687A JP H01500515 A JPH01500515 A JP H01500515A
Authority
JP
Japan
Prior art keywords
polypeptide
region
hbsag
cell
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62504116A
Other languages
English (en)
Japanese (ja)
Inventor
ミリッチ　ディヴィッド　アール
ソーントン　ジョージ　ビー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of JPH01500515A publication Critical patent/JPH01500515A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP62504116A 1986-06-20 1987-06-18 Ｂ型肝炎ウィルス表面抗原のプレｓ領域のｔ及びｂ細胞エピトープ Pending JPH01500515A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87702086A 1986-06-20 1986-06-20
US877,020 1986-06-20
US6021487A 1987-06-10 1987-06-10
US060,214 1987-06-10

Publications (1)

Publication Number Publication Date
JPH01500515A true JPH01500515A (ja) 1989-02-23

Family

ID=26739692

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62504116A Pending JPH01500515A (ja) 1986-06-20 1987-06-18 Ｂ型肝炎ウィルス表面抗原のプレｓ領域のｔ及びｂ細胞エピトープ

Country Status (9)

Country Link
EP (1) EP0250253A3 (da)
JP (1) JPH01500515A (da)
CN (1) CN87105411A (da)
AU (1) AU617292B2 (da)
DK (1) DK88988A (da)
FI (1) FI880802A7 (da)
NZ (2) NZ232438A (da)
PT (1) PT85137B (da)
WO (1) WO1987007896A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532115A (ja) * 1998-12-19 2002-10-02 エムエル ラボラトリーズ ピーエルシー 異種移植片に対する寛容の改善

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126399A (en) * 1986-04-30 1992-06-30 Board Of Regents, The University Of Texas System Methods and compositions for the preparation and use of site-directed immunologic reagents
EP1088830A3 (en) * 1987-06-22 2004-04-07 Medeva Holdings B.V. Hepatitis b surface antigen particles
AU619753B2 (en) * 1987-06-22 1992-02-06 Medeva Holdings B.V. Hepatitis b surface antigen vaccine
EP0300213A1 (en) * 1987-06-22 1989-01-25 Hexal-Pharma Gentechnik GmbH & Co. KG Hepatitis a viral peptide particle immunogens
PT97632A (pt) * 1990-05-11 1992-03-31 Scripps Clinic Res Processo de obtencao de polipeptidos relacionados com a proteina do antigenio de superficie do virus da hepatite b e de vacinas que os contem
EP0491077A1 (en) * 1990-12-19 1992-06-24 Medeva Holdings B.V. A composition used as a therapeutic agent against chronic viral hepatic diseases
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
US5929220A (en) * 1995-07-21 1999-07-27 The General Hospital Corporation Hepadnavirus receptor
EP2298900A1 (en) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
EP1281761A1 (en) * 2001-07-27 2003-02-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Hepatitis B virus pre-S1 derived synthetic polypeptides and their use thereof.
GB0326416D0 (en) 2003-11-12 2003-12-17 Karolinska Innovations Ab Methods and means relating to hepatitis B infection
JP4486647B2 (ja) * 2003-11-12 2010-06-23 エイチビーヴイ セラノスティカ アクチエボラーグ Ｂ型肝炎感染症に関連する方法及び手段
ES2728243T3 (es) 2012-11-12 2019-10-23 Univ Heidelberg Ruprecht Karls Lipopéptidos para su uso en el tratamiento de enfermedades hepáticas y enfermedades cardiovasculares
JP7629649B2 (ja) * 2019-09-11 2025-02-14 ザ ロックフェラー ユニバーシティー Ｂ型肝炎に対するヒト中和抗体に関連する組成物及び方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480779B2 (fr) * 1979-08-30 1986-07-18 Anvar Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
US4847080A (en) * 1984-03-07 1989-07-11 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers
US4599231A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
AU579148B2 (en) * 1984-03-09 1988-11-17 Scripps Clinic And Research Foundation Synthetic hepatitis b virus vaccine including both t cell and b cell determinants
US4599230A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532115A (ja) * 1998-12-19 2002-10-02 エムエル ラボラトリーズ ピーエルシー 異種移植片に対する寛容の改善

Also Published As

Publication number Publication date
DK88988D0 (da) 1988-02-19
WO1987007896A1 (en) 1987-12-30
CN87105411A (zh) 1988-08-24
FI880802L (fi) 1988-02-19
PT85137B (pt) 1990-03-08
FI880802A0 (fi) 1988-02-19
EP0250253A3 (en) 1989-03-22
FI880802A7 (fi) 1988-02-19
PT85137A (en) 1987-07-01
NZ220803A (en) 1990-03-27
EP0250253A2 (en) 1987-12-23
AU617292B2 (en) 1991-11-28
AU7640587A (en) 1988-01-12
DK88988A (da) 1988-04-20
NZ232438A (en) 1991-07-26

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