JPH0153424B2 - - Google Patents

Info

Publication number: JPH0153424B2
Authority: JP; Japan
Prior art keywords: protein; methylated; antigen; proteins; latex
Prior art date: 1981-10-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP15952881A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5861466A (ja

Inventor

Hiroko Koyanagi

Susumu Sofue

Iwao Sonezaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

YATORON KK

Original Assignee

YATORON KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-08

Filing date

1981-10-08

Publication date

1989-11-14

1981-10-08 Application filed by YATORON KK filed Critical YATORON KK

1981-10-08 Priority to JP15952881A priority Critical patent/JPS5861466A/ja

1983-04-12 Publication of JPS5861466A publication Critical patent/JPS5861466A/ja

1989-11-14 Publication of JPH0153424B2 publication Critical patent/JPH0153424B2/ja

Status Granted legal-status Critical Current

Links

102000036639 antigens Human genes 0.000 claims description 29
108091007433 antigens Proteins 0.000 claims description 29
238000000034 method Methods 0.000 claims description 28
239000000427 antigen Substances 0.000 claims description 22
239000004816 latex Substances 0.000 claims description 22
229920000126 latex Polymers 0.000 claims description 22
238000006243 chemical reaction Methods 0.000 claims description 12
108091005592 methylated proteins Proteins 0.000 claims description 12
239000000969 carrier Substances 0.000 claims description 9
230000004520 agglutination Effects 0.000 claims description 7
150000002632 lipids Chemical class 0.000 claims description 7
210000000601 blood cell Anatomy 0.000 claims description 6
150000004676 glycans Chemical class 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
229920001282 polysaccharide Polymers 0.000 claims description 4
239000005017 polysaccharide Substances 0.000 claims description 4
210000001124 body fluid Anatomy 0.000 claims description 2
239000010839 body fluid Substances 0.000 claims description 2
230000001900 immune effect Effects 0.000 claims description 2
150000007523 nucleic acids Chemical class 0.000 claims description 2
102000039446 nucleic acids Human genes 0.000 claims description 2
108020004707 nucleic acids Proteins 0.000 claims description 2
239000002245 particle Substances 0.000 claims description 2
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
102000009027 Albumins Human genes 0.000 claims 1
108010088751 Albumins Proteins 0.000 claims 1
229930186217 Glycolipid Natural products 0.000 claims 1
238000000354 decomposition reaction Methods 0.000 claims 1
235000018102 proteins Nutrition 0.000 description 39
102000004169 proteins and genes Human genes 0.000 description 39
108090000623 proteins and genes Proteins 0.000 description 39
238000001179 sorption measurement Methods 0.000 description 11
239000003153 chemical reaction reagent Substances 0.000 description 9
108091003079 Bovine Serum Albumin Proteins 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
229940098773 bovine serum albumin Drugs 0.000 description 6
210000002966 serum Anatomy 0.000 description 6
239000000126 substance Substances 0.000 description 6
239000000725 suspension Substances 0.000 description 6
108010058846 Ovalbumin Proteins 0.000 description 5
239000007853 buffer solution Substances 0.000 description 5
108010077055 methylated bovine serum albumin Proteins 0.000 description 5
244000005700 microbiome Species 0.000 description 5
229940092253 ovalbumin Drugs 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
238000003756 stirring Methods 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
239000004793 Polystyrene Substances 0.000 description 3
210000002421 cell wall Anatomy 0.000 description 3
230000000694 effects Effects 0.000 description 3
210000003677 hemocyte Anatomy 0.000 description 3
239000007788 liquid Substances 0.000 description 3
229920002223 polystyrene Polymers 0.000 description 3
208000023275 Autoimmune disease Diseases 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
230000003172 anti-dna Effects 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 description 2
108010074605 gamma-Globulins Proteins 0.000 description 2
230000008105 immune reaction Effects 0.000 description 2
230000000984 immunochemical effect Effects 0.000 description 2
230000011987 methylation Effects 0.000 description 2
238000007069 methylation reaction Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000243 solution Substances 0.000 description 2
208000006379 syphilis Diseases 0.000 description 2
201000000596 systemic lupus erythematosus Diseases 0.000 description 2
-1 urine Substances 0.000 description 2
JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
108010077805 Bacterial Proteins Proteins 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
108010064851 Plant Proteins Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000000274 adsorptive effect Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
235000021120 animal protein Nutrition 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
244000309466 calf Species 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
210000000038 chest Anatomy 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000000693 micelle Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
235000021118 plant-derived protein Nutrition 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000012216 screening Methods 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

JP15952881A 1981-10-08 1981-10-08 血清学的凝集反応による測定方法 Granted JPS5861466A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP15952881A JPS5861466A (ja)	1981-10-08	1981-10-08	血清学的凝集反応による測定方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15952881A JPS5861466A (ja)	1981-10-08	1981-10-08	血清学的凝集反応による測定方法

Publications (2)

Publication Number	Publication Date
JPS5861466A JPS5861466A (ja)	1983-04-12
JPH0153424B2 true JPH0153424B2 (fr)	1989-11-14

Family

ID=15695730

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP15952881A Granted JPS5861466A (ja)	1981-10-08	1981-10-08	血清学的凝集反応による測定方法

Country Status (1)

Country	Link
JP (1)	JPS5861466A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3640412A1 (de) *	1986-11-26	1988-06-09	Boehringer Mannheim Gmbh	Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
DE3804244A1 (de) *	1987-12-24	1989-07-06	Boehringer Mannheim Gmbh	Verfahren zur bestimmung einer immunologisch aktiven substanz

1981
- 1981-10-08 JP JP15952881A patent/JPS5861466A/ja active Granted

Also Published As

Publication number	Publication date
JPS5861466A (ja)	1983-04-12

Publication	Publication Date	Title
EP0406473B1 (fr)	1995-09-20	Réactifs pour la capture d'ions et méthodes pour effectuer des dépistages de liaison
CA1149277A (fr)	1983-07-05	Methode de dosage des complexes immuns
EP0201079B1 (fr)	1996-04-17	Essai immunologique retardé en phase solide
US4002532A (en)	1977-01-11	Enzyme conjugates
EP0496473B1 (fr)	1997-03-26	Procédé de production des réactifs biologiquement actifs à partir des polymères contenant succinimide, élément d'analyse et méthodes d'utilisation
EP0005271A2 (fr)	1979-11-14	Méthode et trousse pour essai immunologique enzymatique de substances biologiques
JP2599058B2 (ja)	1997-04-09	クラス特異的な免疫グロブリン抗体の免疫分析法
JP3105579B2 (ja)	2000-11-06	生物学的活性試薬ならびにその試薬の分析要素および使用方法
EP0064318B1 (fr)	1985-08-28	Procédé et trousse pour l'essai d'anticorps contre des antigènes solubles
EP0019277B1 (fr)	1986-01-29	Procédé de détection d'un antigène dans un échantillon
EP0450099A1 (fr)	1991-10-09	Excipient de liaison d'anticorps antiphospholipides, immuno-analyse utilisant cet excipient et kit associe
WO1997039736A1 (fr)	1997-10-30	Reactifs a base de liposomes pour dosages immunologiques
GB1571992A (en)	1980-07-23	Process for binding organic compounds containing carbohydrate moieties to solid supports
US4230683A (en)	1980-10-28	Hapten conjugated antibody for antibody or antigen detection
US4141965A (en)	1979-02-27	Assay of immune complexes
JP3327488B2 (ja)	2002-09-24	被検体の免疫化学的測定方法
Peterman et al.	1988	The immunochemistry of sandwich-ELISAs IV. The antigen capture capacity of antibody covalently attached to bromoacetyl surface-functionalized polystyrene
WO1991001368A1 (fr)	1991-02-07	Liaison d'affinite d'haptene/antihaptene dans la separation des cellules
JPS5861466A (ja)	1983-04-12	血清学的凝集反応による測定方法
JP2584924B2 (ja)	1997-02-26	免疫学的凝集反応粒子の製造方法
EP0370960A1 (fr)	1990-05-30	La néopterine comme marqueur dans un kit de dépistage pour la détection des affections rétrovirales
EP0569086A2 (fr)	1993-11-10	Procédé et trousse pour la fixation des composés sur des substrates carboxyles utilisant un sel d'uronium
RU2056057C1 (ru)	1996-03-10	Способ получения иммобилизованного иммуноглобулина на твердой фазе
JPH11304801A (ja)	1999-11-05	間接抗原固定化による自己抗体検出方法
JP2004184125A (ja)	2004-07-02	免疫学的検出試薬、該試薬を用いた検出方法及び該試薬の製造方法