JPH0155302B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides stable silicone-water emulsion compositions particularly useful for cosmetic and pharmaceutical applications and stable silicone-water emulsions of volatile cyclic polysiloxanes without the need for kneading or homogenization. The present invention relates to a method for manufacturing.

The silicone-water emulsion compositions of the present invention are epidermal enhancing agents.
It is particularly suitable to serve as a vehicle for applications. The term "epidermal performance enhancer" refers to a composition that has properties that are generally considered beneficial when applied to areas of the human body. For example, such enhancers include a wide range of cosmetic and pharmaceutical compounds.

There are many types of products in the cosmetic category that can be beneficially applied to the skin in the form of silicone emulsions. For example, such cosmetics include creams, eye shadows, foundations, blushes, lip glosses, mascaras and eyeliners, cover-up compositions and anti-wrinkle creams, moisturizers, acne concealers, hair removers and This would include epidermis removers and the like.

Such emulsions can also be used for cleansing purposes and can take the form of shampoos, soaps, conditioners and moisturizers. Furthermore, hair dye is also made of silicone.
It can be applied and used in a water emulsion vehicle.

Other cosmetic uses include application to the human body as perfumes, colognes and perfumes. Among the particularly useful applications are deodorants and antiperspirants.

Among the many medical uses of such emulsion vehicles are first aid applications, such as burn ointments and antiseptic applications. Additionally, corn, wart and callus removers, for example, may also be used in such silicone-water emulsion vehicles for satisfactory application to the skin.

Of course, the consistency of the silicone-water emulsion of the present invention can vary over a wide range from a lotion-like consistency, through a cold cream-like paste, to a gel-type ointment or a salve on the order of petroleum jelly.

Silicones are typically synthetic polymers commercially made from chlorosilane monomers and are available in liquid, resin, and rubber forms. Silicone polymers of particular interest in the cosmetic manufacturing industry are those prepared into compositions such as emulsions, greases, pastes, and the like. A wide variety of materials may be used with silicones in these compositions.

Monomeric chlorosilane is a highly reactive volatile material that readily reacts with moisture to form silicone and hydrochloric acid as a by-product. Therefore, in the presence of moisture, monomeric chlorosilane is considered a corrosive material and must be handled with care as it may have harmful properties. However, after being processed into silicone polymers, these materials become mild, inert materials. Silicones can be further mixed with other materials to produce a variety of end-use compositions, and the physiological properties of the final composition are often determined by the nature of the non-silicone components.

The toxicological properties of silicones have been extensively studied, and polymeric silicone fluids and resins are classified as a group with very low toxicity. From a practical point of view, the steepness they pose is extremely small.
Silicone liquid polymers were found to be safe when subjected to skin irritation and sensitization patch tests.
This low toxicity of silicone materials has further led to safe and satisfactory use of silicone fluids in medical and dental applications.

Silicone fluids generally provide excellent protection against waterborne irritants such as harsh detergents and other household cleaning products. The primary reason silicone fluids are effective in protecting against dermatitis is that they are chemically inert and have excellent water repellency. Silicones also act as emollients, providing a pleasant, non-stick "feel." Silicone liquids can be used to make excellent tanning lotions and creams because they are carriers for sunscreening agents and are resistant to washing off by bathing or sweating.

Volatile silicone cyclic polysiloxane-containing emulsions have previously been produced using emulsifiers such as dodecylbenzenesulfonic acid, but these systems require kneading or homogenization to emulsify the immiscible phases. . Only compositions of this type containing volatile cyclic polysiloxanes in concentrations up to about 55% can be emulsified, and emulsions of this type often involve emulsion polymerization of cyclic polysiloxanes such as octamethyltetrasiloxane. used to carry out.

The present invention provides a method that allows emulsification of cyclic polysiloxanes at high concentrations while simultaneously eliminating the need for kneading or homogenization. Furthermore, the present invention provides that the concentration of volatile cyclic polysiloxane is 80%.
% or even more, cyclic polysiloxane emulsions provide stable emulsions that generally do not "break" under normal storage and use conditions. This is a particularly useful property for consumer products, since these emulsions can therefore be ideally used as vehicles for delivering epidermal performance enhancers onto the user's skin in an advantageous manner. .

Additionally, the present invention provides a system for the emulsification of volatile cyclic polysiloxanes that provides opaque to transparent materials that can be readily incorporated into a number of consumer products, particularly antiperspirants and deodorizers. It can be prepared as an agent, etc. Other potential uses for aqueous cyclic polysiloxane emulsions are skin care products such as hand lotions, skin fresheners, hair preparations and other care aids. As mentioned above, the method of the present invention provides a means to selectively vary the consistency of these emulsions depending on the end use of the product.

An additional advantage of the present invention is that these silicone-
The point is that the water emulsion is composed of a relatively volatile cyclic polysiloxane component such that the emulsion vehicle base will eventually evaporate from the skin, leaving only the beneficial skin performance enhancer on the skin. It is in.

The present invention provides a silicone-water emulsion, its preparation and use, which emulsion comprises (A) 100 parts by weight of the general formula: (In the formula, n is an integer from 3 to 10, and R is -
CH ₃ , −(CH ₂ ) _z CH ₃ , −CH ₂ CH ₂ CF ₃ , −CH=
( _B ) a cyclic _polysiloxane or _a mixture thereof; z is an integer from 1 to 10; 0.7 to 666 parts by weight of an emulsifier; and (C) 5.0 to 960 parts by weight of water; It consists of stirring under moderate heat until an emulsion forms.

As described above, the present invention is based on the general formula: (In the formula, n is an integer of 3 to 10, R is _-CH3 ,
-( _CH2 ) _{zCH3 , -CH2CH2CF3} , -CH= _CH2 or _-C6H5 or _a mixture _thereof to provide _a silicone-water emulsion mainly composed of 100 parts by weight. be. Polysiloxanes represented by this formula are known as volatile cyclic silicones and this volatility imparts advantageous properties to emulsion compositions. Particularly useful volatile cyclic silicones are octamethyltetrasiloxane and decamethylpentasiloxane.

The volatile cyclic polysiloxane is mixed with an emulsifier and water to form a silicone-water emulsion. Although the order of mixing the components is not critical, particularly satisfactory results are obtained when the emulsifier and water are mixed together to form a premix to which the volatile cyclic polysiloxane is added.

Preferably, the cyclic polysiloxane is added to a premix of about 50 to 200 parts by weight of water mixed with 100 parts by weight of one or more emulsifiers and the mixture is heated until a homogeneous mixture is obtained.

This premix is suitable for making paste-like silicone-water emulsions, but up to 2000 parts of water per 100 parts of emulsifier may be used if a more liquid-like or lotion-like consistency is desired. Emulsifiers can be nonionic, anionic, cationic or amphoteric, but of particular interest are highly ethoxylated nonionic emulsifiers. Best results are obtained using ethoxylated fatty acids, ethoxylated and non-ethoxylated sorbitan esters, ethoxylated alkylphenols and ethoxylated ethers.

Examples of emulsifiers that can be used to prepare the silicone-water emulsions of the present invention include, but are not limited to:

(1) Ethoxylated fatty acids such as polyoxyethylene 8 stearate polyoxyethylene 40 stearate polyoxyethylene 50 stearate (2) Sorbitan esters such as sorbitan monolaurate sorbitan monopalmitate sorbitan monostearate sorbitan tristearate Sorbitan monooleate Sorbitan trioleate (3) Ethoxylated sorbitan esters such as polyoxyethylene (20) Sorbitan monolaurate polyoxyethylene (4) Sorbitan monolaurate polyoxyethylene (20) Sorbitan monopalmitate polyoxyethylene (20 ) Sorbitan Monostearate Polyoxyethylene 20 Sorbitan Tristearate Polyoxyethylene 20 Sorbitan Monooleate Polyoxyethylene 5 Sorbitan Monooleate Polyoxyethylene 20 Sorbitan Triolate (4) Ethoxylated ethers, such as polyoxyethylene 4 lauryl ether polyoxyethylene 23 lauryl ether polyoxyethylene 20 cetyl ether polyoxyethylene 10 stearyl ether polyoxyethylene 20 oleyl ether (5) Ethoxylated alkyl phenols, such as (alkyl phenoxy polyoxyethylene glycol) (C ₈ H ₁₇ C ₆ H ₄ ) (OCH ₂ CH ₂ ) _o OH CAS#9036-19-5 (C ₉ H ₁₉ C ₆ H ₄ ) (OCH ₂ CH ₂ ) _o OH CAS#26-27-38-3 Paste silicone - water If an emulsion is desired, about 15 to 50 parts by weight of the emulsifier-water premix are added per 100 parts by weight of the cyclic polysiloxane.

per 100 parts by weight of volatile cyclic polysiloxane to provide a low viscosity lotion-like product.
Up to 1000 parts by weight of this premix can be added.

The consistency of the product can be influenced by adjusting various process parameters such as the content of volatile cyclic polysiloxane, emulsifier and water, as well as the degree of mixing. Silicone-water emulsions can be prepared in the form of paste or cream-like consistency and lotions, and also in the form of more viscous forms, such as ointments, salves or gels. Each of these consistencies will of course be selected in relation to the desired end use of the product.

The silicone-water emulsion of this invention is useful as a vehicle for applying 0.1 to 20,000 parts by weight of one or more epidermal performance enhancers per 100 parts by weight of the emulsion.

This wide dosage range is intended to encompass products consisting of nearly pure silicone-water emulsions with small amounts of skin performance enhancers to other products containing small amounts of silicone-water emulsions. . Epidermal performance enhancers refer to cosmetic or medicinal additives that are generally considered to provide beneficial results when applied externally to the skin of a user. Silicone of the present invention
Water emulsions are particularly suitable for use as vehicles for applying deodorants or antiperspirants to the human body.

A premixed water-emulsifier mixture is obtained by stirring water and emulsifier under moderate heating until a homogeneous mixture is obtained, to which is added the cyclic polysiloxane, and milled or milled. The desired silicone-water emulsion can be obtained by slow mixing without the need for homogenization. Of course, kneading and homogenization processes can be used if desired, and the term "mixing" is intended to include these methods as well as simple stirring. The term "mixing" is therefore intended to include continuous methods, such as using a Wener-Pfleiderer type, in which each stream of the formulation components is metered into a two-screw processor.
Similarly, Henschel type high speed mixers, sonolater homogenizers with vibrating reeds, and simple vessels fitted with mechanical agitator turbine blades all give satisfactory results. The silicone-water-emulsifier mixture is then vigorously stirred at a temperature of 20 DEG to 80 DEG C. until an emulsion with the desired consistency is obtained. If desired, antimicrobial agents such as formalin can be added.

Water and emulsifier are added together to two stainless steel beakers fitted with a hot plate, mechanical air stirrer and thermometer and heated to about 20-80°C, preferably 65°C.
Premix by heating to ~75°C and stir to obtain a homogeneous mixture when all solids have melted. A volatile cyclic polysiloxane, which may be octamethyltetrasiloxane or decamethylpentasiloxane or mixtures thereof or other cyclic polysiloxanes, is then slowly added to the aqueous premix and heated to about 30-80°C.
Stir vigorously until a homogeneous grease-like emulsion forms, preferably at a temperature of 50-60°C. When the product becomes homogeneous a small amount of formalin can be added to prevent bacterial action. Unlike many conventional silicone emulsions, colloidal milling or homogenization processes are not required to make these emulsions, although these means can be used if desired.

The consistency of the emulsion can be controlled by the amount of water added. At water contents of 15-20%, the emulsion has a grease-like consistency, but adding additional amounts of water reduces the viscosity of the system to a lotion-like consistency, and adding even more water produces a lower viscosity emulsion. be able to. The silicone-water emulsion of the present invention is completely dispersible in water.

Furthermore, the consistency of the composition can be further varied by the amount of cyclic polysiloxane added. In other words, as the amount of cyclic polysiloxane added increases, the emulsion will become thicker and more grease-like. A lower proportion of cyclic polysiloxane added will result in a more dilute emulsion.

The emulsifier itself influences the consistency of the product. Solid emulsifiers such as polyoxyethylene 40 stearate will make the emulsion thicker and more greasy. On the other hand, a more liquid emulsifier will give a lotion-like product.

A wide range of emulsion compositions can be prepared by varying any of the process parameters mentioned above, such as water concentration, cyclic polysiloxane concentration or emulsifier concentration and emulsifier type - solid or liquid. It is clear that it is possible to produce

Example 1 200g of water in a stainless steel beaker with a capacity of 2,
82 g of polyoxyethylene 40 stearate and 67 g of sorbitan monostearate were added and the mixture was heated under stirring to a temperature of 65-75 DEG C. until all solids were melted and a homogeneous mixture was obtained. Next, add decamethylpentasiloxane 900 to this aqueous system.
g was slowly added and stirred vigorously at 50-60°C to form a uniform grease-like emulsion. When the product became homogeneous, 2 g of formalin was added to inhibit bacterial activity. The emulsion was formed without any colloidal mixing or homogenization treatment and a stable, thick paste-like emulsion was obtained. This was suitable to serve as a vehicle for the application of epidermal performance enhancers such as deodorants or antiperspirants for direct application to the skin.

Example 2 The procedure of Example 1 is repeated with the addition of an additional 11% by weight of polyoxyethylene 20 sorbitan monooleate to produce an emulsion with the consistency of a lotion containing about 64% by weight of pentasiloxane. Obtained. This was suitable for use in cosmetics.

Example 3 Polyoxyethylene 40 according to the method of Example 1
A water-emulsifier premix was prepared containing 135 g of stearate and 100 g of sorbitan monostearate with 300 g of water. To this was added 1300 g of decamethylpentasiloxane to obtain a grease-like emulsion. Formalin was added as an antibacterial agent.

Example 4 An emulsifier premix consisting of 255 g of water, 82 g of polyoxyethylene 40 stearate and 67 g of sorbitan monostearate was prepared according to the method of Example 1, and this premix was added to 900 g of octamethyltetrasiloxane to form a paste. A similar emulsion was produced.

Example 5 A 50-50 cyclic silicone mixture consisting of 450 g of octamethyltetrasiloxane and 450 g of decamethylpentasiloxane was mixed with 82 g of polyoxyethylene 40 stearate and 57 g of sorbitan monostearate.
An emulsion was prepared by blending with an emulsifier-water premix consisting of 280 g of water and 280 g of water. A silicone-water emulsion was formed with a grease-like consistency.

Example 6 900 g of decamethylpentasiloxane, 60 g of sorbitan monostearate, 200 g of 70% octylphenoxy polyethoxy 39 ethanol, and 200 g of water.
A premix consisting of: A silicone-water emulsion with a soft paste-like consistency was obtained according to the method described in Example 1.

Example 7 The silicone-water emulsion paste of Example 4 was prevented by mixing 100 g with 20 g of aluminum chlorohydrate in the form of Micro-Dry Ultrafine (trademark of Releis Co.). Manufactured a sweating agent.

Example 8 A skin freshener was prepared by mixing 100 g of the silicone-water emulsion paste of Example 6 with 0.25% fragrance.

Example 9 100 g of the silicone-water emulsion lotion of Example 2 was mixed with 3% homosalate.
and 0.25% fragrance.

Claims (1)

[Claims] 1 (A) General formula: (In the formula, n is an integer of 3 to 10, R is _-CH3 , -
(CH ₂ ) _z A group selected from the group consisting of CH ₃ , -CH ₂ CH ₂ CF ₃ , -CH=CH ₂ and -C ₆ H ₅ and mixed groups thereof, and z represents an integer from 1 to 10) 100 cyclic polysiloxanes or mixtures thereof with
A silicone-water emulsion comprising: (B) 0.7 to 666 parts by weight of an emulsifier; and (C) 5.0 to 960 parts by weight of water. 2. The composition according to claim 1, wherein 100 parts by weight of a cyclic polysiloxane is added to 15 to 1000 parts by weight of a premix of water and an emulsifier. 3. The premixed water and emulsifier mixture contains (i) 100 parts by weight of one or more emulsifiers selected from the group consisting of ethoxylated fatty acids, ethoxylated or non-ethoxylated sorbitan esters, ethoxylated alkylphenols and ethoxylated ethers; and (ii) 50 to 2000 parts by weight of water. 4 Claim 1 further containing an antibacterial agent
Silicone-water emulsion as described in Section. 5. The composition of claim 1, wherein the silicone-water emulsion is a lotion. 6. The composition according to claim 1, wherein the silicone-water emulsion is a cream or paste. 7. The composition according to claim 1, wherein the silicone-water emulsion is an ointment or a gel. 8. The silicone-water emulsion according to claim 1, further comprising 0.1 to 20,000 parts by weight of one or more skin performance enhancers per 100 parts by weight of the emulsion. 9. The composition according to claim 8, wherein the epidermal performance enhancer is a cosmetic or a medicine. 10. The composition according to claim 8, wherein the epidermal performance enhancer is a deodorant or an antiperspirant. 11 (A) 0.1 to 20,000 parts by weight of one or more epidermal performance enhancers contained in the vehicle described below;
and (B)(i) general formula: (In the formula, n is an integer of 3 to 10, R is _-CH3 , -
(CH ₂ ) _z group selected from the group consisting of CH ₃ , -CH ₂ CH ₂ CF ₃ , -CH=CH ₂ and -C ₆ H ₅ and mixed groups thereof, z is an integer from 1 to 10) cyclic polysiloxane or mixtures thereof with
100 parts by weight; (ii) 0.7 to 666 parts by weight of an emulsifier; and (iii) a vehicle comprising 100 parts by weight of a silicone-water emulsion comprising 5.0 to 960 parts by weight of water. 12 Water and emulsifier, (i) 100 parts by weight of one or more emulsifiers selected from the group consisting of ethoxylated fatty acids, ethoxylated and non-ethoxylated sorbitan esters, ethoxylated alkylphenols and ethoxylated ethers; and (ii) water. 50～
A composition according to claim 11 in the form of a premix consisting of 2000 parts by weight. 13. The composition according to claim 11, wherein the epidermal performance enhancer is a cosmetic. 14. The composition according to claim 11, wherein the epidermal performance enhancer is a pharmaceutical. 15. The composition according to claim 11, wherein the epidermal performance enhancer is an antiperspirant. 16. The composition according to claim 11, wherein the epidermal performance enhancer is a deodorant. 17. The composition of claim 11, wherein the epidermal performance enhancer is applied in the form of a lotion. 18. A composition according to claim 11, wherein the epidermal performance enhancer is applied in the form of a paste. 19. A composition according to claim 11, wherein the epidermal performance enhancer is applied in the form of a cream. 20. The composition of claim 11, wherein the epidermal performance enhancer is applied in the form of an ointment or gel. 21 (A) General formula: (In the formula, n is an integer of 3 to 10, R is _-CH3 , -
(CH ₂ ) _z is a group selected from the group consisting of CH ₃ , -CH ₂ CH ₂ CF ₃ , -CH=CH ₂ and -C ₆ H ₅ and mixed groups thereof, and z is an integer from 1 to 10. be)
cyclic polysiloxane or mixtures thereof with
(B) 0.7 to 666 parts by weight of emulsifier; and (C) 5.0 to 960 parts by weight of water; and stirring the mixture under moderate heat until an emulsion with the desired consistency is formed. A method for producing a silicone-water emulsion consisting of. 22. The method of claim 21, wherein 100 parts by weight of the cyclic polysiloxane is added to 15 to 1000 parts by weight of the premix of water and emulsifier. 23 Add the premixed water and emulsifier mixture to approx.
23. The manufacturing method according to claim 22, which comprises heating to ~80°C. 24 The premixed water and emulsifier mixture is
(A) 100 parts by weight of one or more emulsifiers selected from the group consisting of ethoxylated fatty acids, ethoxylated or non-ethoxylated sorbitan esters, ethoxylated alkylphenols and ethoxylated ethers; and (B) 50 to 2000 parts by weight of water. 23. The method of claim 22, wherein the mixture is heated to about 20 DEG to 80 DEG C. until a homogeneous mixture is formed. 25. The manufacturing method according to claim 24, further comprising the step of adding an antibacterial agent.