JPH0156045B2 - - Google Patents
Info
- Publication number
- JPH0156045B2 JPH0156045B2 JP16152281A JP16152281A JPH0156045B2 JP H0156045 B2 JPH0156045 B2 JP H0156045B2 JP 16152281 A JP16152281 A JP 16152281A JP 16152281 A JP16152281 A JP 16152281A JP H0156045 B2 JPH0156045 B2 JP H0156045B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- dht
- scalp
- sodium
- testosterone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 claims description 8
- 239000002537 cosmetic Substances 0.000 claims description 8
- 230000003779 hair growth Effects 0.000 claims description 7
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims description 6
- 229960002218 sodium chlorite Drugs 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 125000005909 ethyl alcohol group Chemical group 0.000 claims 1
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 11
- 210000004209 hair Anatomy 0.000 description 11
- 210000004761 scalp Anatomy 0.000 description 11
- 239000007800 oxidant agent Substances 0.000 description 9
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 229960003604 testosterone Drugs 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 201000004384 Alopecia Diseases 0.000 description 4
- 230000003676 hair loss Effects 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000220645 Leonotis nepetifolia Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004641 brain development Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910001919 chlorite Inorganic materials 0.000 description 1
- 229910052619 chlorite group Inorganic materials 0.000 description 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003515 testosterones Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】
本発明は頭髪の発生および成長を促進させる頭
髪発毛育毛化粧料に係り、特に酸化剤を主成分と
する頭髪発毛育毛化粧料に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair growth cosmetic composition that promotes the generation and growth of hair, and more particularly to a hair growth cosmetic composition containing an oxidizing agent as a main component.
従来から典型禿の原因として遺伝的要素、食事
の傾向、頭蓋骨の張り、脳の発育不良、男性ホル
モンの過剰、頭皮が薄い等種々の説があげられて
きた。しかしながら、各種の原因がどのように作
用して禿るに到るのかというメカニズムが十分解
明されなかつたため、禿げた頭に頭髪を発生させ
ることは不可能であつた。 Various theories have been proposed for the causes of typical baldness, including genetic factors, dietary habits, skull tension, poor brain development, excess male hormones, and thin scalp. However, because the mechanism of how various causes interact to lead to baldness has not been fully elucidated, it has been impossible to generate hair on a bald head.
このような状況下において、近年男性ホルモン
の頭髪に対する作用機構が生化学的に研究され、
特にDorford、志田、安達、Hay、高安等は以下
に述べるような学説を発表するに至つている。即
ち、頭髪に作用するホルモンはテストステロンと
いう男性ホルモンであり、このテストステロンは
図面に示すように皮脂腺Ａおよび毛包部Ｂに存在
する還元作用を有する酵素5α―リダクターゼに
より5α―ジヒドロテストステロン（以下5α―
DHTと称する）に変化する。この5α―DHTは
毛包部Ａにおいて細胞分裂を抑制する機能を有
し、この部位における禿を生成する。 Under these circumstances, the mechanism of action of male hormones on hair has been studied biochemically in recent years.
In particular, Dorford, Shida, Adachi, Hay, Takayasu, and others have published the following theories. That is, the hormone that acts on hair is a male hormone called testosterone, and this testosterone is converted into 5α-dihydrotestosterone (hereinafter referred to as 5α-
(referred to as DHT). This 5α-DHT has the function of suppressing cell division in hair follicle area A, and produces baldness in this area.
上記のホルモン学説によれば、頭髪を回復する
には5α―DHTの機能を低下させるか、または5α
―DHTをテストステロンに転化すればよい訳で
ある。発明者は種々の研究の結果、次のような解
決法を発見するに到つた。即ち、5α―DHTは5α
―リダクターゼ酵素がテストステロンを還元する
ことにより形成されるものであるから、逆に5α
―DHTを酸化作用によりテストステロンに転化
することができるはずである。この酸化作用を直
接頭皮を通して与えれば5α―DHTの形成も抑制
することができ、禿た頭皮に頭髪を回復すること
が可能である。 According to the above hormone theory, in order to restore hair, it is necessary to reduce the function of 5α-DHT or to restore hair.
- All you have to do is convert DHT to testosterone. As a result of various studies, the inventor has discovered the following solution. In other words, 5α-DHT is 5α
-Since it is formed by the reductase enzyme reducing testosterone, on the contrary, 5α
- It should be possible to convert DHT to testosterone through oxidation. If this oxidation effect is applied directly to the scalp, it can also suppress the formation of 5α-DHT, making it possible to restore hair to bald scalps.
本発明者はまずオゾン（O3）を直接頭皮に照
射する実験を行つた。この結果充分な効果が得ら
れ、その事業化を通じて既に2000名以上の実績を
得るに至つた。さらに、各種の酸化薬剤を配合し
た化粧料を作製して実験を継続したところ、実に
良好な結果を得ることができた。 The inventor first conducted an experiment in which the scalp was directly irradiated with ozone (O 3 ). As a result, sufficient effects were obtained, and through its commercialization, more than 2,000 people have already gained experience. Furthermore, when we continued the experiment by creating cosmetics containing various oxidizing agents, we were able to obtain really good results.
また、酸化薬剤中、殺菌消毒作用（清浄化作
用）を有する酸化剤が最も効果が高いことが判明
した。この理由は、頭皮には皮脂からなる油成分
その他の老廃物、雑菌等が付着しているため、こ
れらの付着物を除去することが酸化剤の頭皮への
作用を強化促進することになるのである。この作
用を有する酸化剤のうち、特に亜塩素酸系酸化剤
およびクロラミンＴ（正式名はｐ―トルエンスル
ホニルクロルアミドナトリウム）が特に画期的な
効果を有することが解明された。 Furthermore, it has been found that among the oxidizing agents, an oxidizing agent having a sterilizing and disinfecting effect (cleaning effect) is the most effective. The reason for this is that the scalp is contaminated with oil components from sebum, other waste products, and bacteria, so removing these deposits will strengthen and promote the action of the oxidizing agent on the scalp. be. Among the oxidizing agents that have this effect, it has been found that chlorite-based oxidizing agents and chloramine T (official name: sodium p-toluenesulfonyl chloramide) have particularly groundbreaking effects.
実施例
物 質 重量％
亜塩素酸ナトリウム 0.1〜0.2％
クロラミンＴ 0.1％
エチルアルコール 20％
メチルセルロース 0.1％
精製水 残 量
本実施例中、亜塩素酸ナトリウムおよびクロラ
ミンＴは酸化剤として使用され、エチルアルコー
ルはこれら酸化剤の有機溶剤として使用されてい
る。メチルセルロースは粘性剤であり、化粧料に
粘性をもたせる成分である。この水溶液100c.c.を
常温で攪拌しながら調合を行う。この溶液を頭皮
に日に２〜３回よく擦り込む。１人当り使用され
る量は１月に約150c.c.である。Examples Materials Weight % Sodium chlorite 0.1-0.2% Chloramine T 0.1% Ethyl alcohol 20% Methyl cellulose 0.1% Purified water Remaining amount In this example, sodium chlorite and chloramine T are used as oxidizing agents, and ethyl alcohol is used as an organic solvent for these oxidizing agents. Methylcellulose is a viscosity agent and is an ingredient that gives cosmetics viscosity. 100 c.c. of this aqueous solution is mixed while stirring at room temperature. Rub this solution into your scalp well two to three times a day. The amount used per person is approximately 150 c.c. per month.
若禿の男性20名（20〜35才）を対象として実験
適用した結果平均的に一日当り0.2〜0.3ミリの硬
毛の成長（発毛および育毛）をみることが出来
た。頂頭禿（約５cm2）のケースでは、約２ケ月間
の実施で外観上全く目立たない状態にまで回復を
見ることができた。 As a result of experimenting with 20 young bald men (20 to 35 years old), we were able to see an average growth of 0.2 to 0.3 mm of terminal hair (hair growth and growth) per day. In a case of baldness on the top of the head (approximately 5 cm 2 ), it was possible to see recovery to a condition that was completely unnoticeable in appearance after about two months of treatment.
以上詳述したように、本発明にかかる頭髪発毛
育毛化粧料は、ｐ―トルエンスルホニルクロルア
ミドナトリウム、亜塩素酸ナトリウムおよびそれ
らの溶剤からなるので、これを頭皮に擦り込むこ
とで、皮脂腺および毛包部に存在する5α―DHT
をテストステロンに転化させ、以て、5α―DHT
の形成を抑制して禿げた頭皮に頭髪を回復させる
ことができる効果がある。 As detailed above, the hair growth cosmetic according to the present invention is composed of sodium p-toluenesulfonyl chloramide, sodium chlorite, and their solvents, so by rubbing it into the scalp, the hair growth cosmetic composition of the present invention stimulates the sebaceous glands and 5α-DHT present in hair follicles
Converts to testosterone, thereby producing 5α-DHT
It has the effect of suppressing the formation of hair on bald scalps and restoring hair.
そして、ｐ―トルエンスルホニルクロルアミド
ナトリウム及び亜塩素酸ナトリウムは、殺菌、消
毒作用を有するので、頭皮に皮脂からなる油成分
その他の老廃物、雑菌等が付着していても、これ
らの付着物を除去できることで、これらｐ―トル
エンスルホニルクロルアミドナトリウム及び亜塩
素酸ナトリウムの頭皮への浸透作用を促進でき、
以て5α―DHTの発生を抑制する効率が一層良く
なる効果もある。 Sodium p-toluenesulfonyl chloramide and sodium chlorite have bactericidal and disinfecting properties, so even if there is oil components from sebum, other waste products, or bacteria on the scalp, they can remove these deposits. By being able to remove them, it is possible to promote the permeation of these sodium p-toluenesulfonyl chloramide and sodium chlorite into the scalp,
This also has the effect of further improving the efficiency of suppressing the generation of 5α-DHT.
図面は皮脂腺Ａおよび毛包部Ｂの位置が判るよ
うに毛髪の構成を断面図に示したものである。
The drawing shows the structure of hair in a cross-sectional view so that the positions of sebaceous glands A and hair follicles B can be seen.
Claims (1)
ウム、亜塩素酸ナトリウムおよびそれらの溶剤か
らなることを特徴とする頭髪発毛育毛化粧料。 ２ 上記溶剤が、エチルアルコールまたは精製水
或いはその両方である特許請求の範囲第１項記載
の頭髪発毛育毛化粧料。[Scope of Claims] 1. A hair growth cosmetic comprising sodium p-toluenesulfonyl chloramide, sodium chlorite, and a solvent thereof. 2. The hair growth cosmetic composition according to claim 1, wherein the solvent is ethyl alcohol, purified water, or both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16152281A JPS5862107A (en) | 1981-10-10 | 1981-10-10 | Cosmetic for producing and growing hair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16152281A JPS5862107A (en) | 1981-10-10 | 1981-10-10 | Cosmetic for producing and growing hair |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5862107A JPS5862107A (en) | 1983-04-13 |
| JPH0156045B2 true JPH0156045B2 (en) | 1989-11-28 |
Family
ID=15736676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16152281A Granted JPS5862107A (en) | 1981-10-10 | 1981-10-10 | Cosmetic for producing and growing hair |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5862107A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5921610A (en) * | 1982-07-29 | 1984-02-03 | Inaba Heaa Res Kk | Agent for growing and nourishing hair |
| JPS58121206A (en) * | 1982-01-12 | 1983-07-19 | Kenichi Arakawa | Liquid agent for cultivating and nourishing hair |
| JPS59204121A (en) * | 1983-04-28 | 1984-11-19 | Masumi Inaba | Remedy for gray hair |
| JPH0753334A (en) * | 1993-08-13 | 1995-02-28 | Monamuule:Kk | Hair restoring and growing cosmetic |
-
1981
- 1981-10-10 JP JP16152281A patent/JPS5862107A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5862107A (en) | 1983-04-13 |
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