JPH02102658A - ポリウレタンプラグとその製造法とそれを使用する避妊法 - Google Patents

ポリウレタンプラグとその製造法とそれを使用する避妊法

Info

Publication number: JPH02102658A
Authority: JP; Japan
Prior art keywords: formula; plug; polyurethane; prepolymer; tables
Prior art date: 1988-09-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP63239092A

Other languages

English (en)

Japanese (ja)

Inventor

Seisai Cho

趙　生オ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-26

Filing date

1988-09-26

Publication date

1990-04-16

1988-09-22 Priority to IN793/CAL/88A priority Critical patent/IN170057B/en

1988-09-26 Application filed by Individual filed Critical Individual

1988-09-26 Priority to JP63239092A priority patent/JPH02102658A/ja

1990-04-16 Publication of JPH02102658A publication Critical patent/JPH02102658A/ja

Status Pending legal-status Critical Current

Links

239000004814 polyurethane Substances 0.000 title claims abstract description 59
229920002635 polyurethane Polymers 0.000 title claims abstract description 58
238000004519 manufacturing process Methods 0.000 title claims description 29
238000000034 method Methods 0.000 title claims description 14
230000002254 contraceptive effect Effects 0.000 title description 5
239000003433 contraceptive agent Substances 0.000 title description 4
239000003960 organic solvent Substances 0.000 claims abstract description 20
150000007524 organic acids Chemical class 0.000 claims abstract description 13
239000003377 acid catalyst Substances 0.000 claims abstract description 12
229920000642 polymer Polymers 0.000 claims abstract description 7
229910052736 halogen Inorganic materials 0.000 claims abstract 3
150000002367 halogens Chemical class 0.000 claims abstract 3
150000002431 hydrogen Chemical class 0.000 claims abstract 3
229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
239000001257 hydrogen Substances 0.000 claims abstract 3
210000001177 vas deferen Anatomy 0.000 claims description 31
239000004970 Chain extender Substances 0.000 claims description 27
239000000126 substance Substances 0.000 claims description 9
238000002347 injection Methods 0.000 claims description 3
239000007924 injection Substances 0.000 claims description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 16
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract description 15
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 12
239000002904 solvent Substances 0.000 abstract description 11
125000003277 amino group Chemical group 0.000 abstract description 10
-1 and for catalyzer Chemical compound 0.000 abstract description 9
239000004014 plasticizer Substances 0.000 abstract description 8
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract description 6
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract description 6
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract description 6
239000005642 Oleic acid Substances 0.000 abstract description 6
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract description 6
229960000583 acetic acid Drugs 0.000 abstract description 6
239000003795 chemical substances by application Substances 0.000 abstract description 6
239000012362 glacial acetic acid Substances 0.000 abstract description 6
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract description 6
238000002156 mixing Methods 0.000 abstract description 6
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract description 6
OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical group N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 abstract description 3
230000000903 blocking effect Effects 0.000 abstract description 3
238000006116 polymerization reaction Methods 0.000 abstract description 3
239000013530 defoamer Substances 0.000 abstract 1
239000000463 material Substances 0.000 description 15
239000002518 antifoaming agent Substances 0.000 description 10
150000001875 compounds Chemical class 0.000 description 7
238000012360 testing method Methods 0.000 description 7
241001465754 Metazoa Species 0.000 description 6
125000005442 diisocyanate group Chemical group 0.000 description 6
230000000694 effects Effects 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
239000000284 extract Substances 0.000 description 6
IBOFVQJTBBUKMU-UHFFFAOYSA-N 4,4'-methylene-bis-(2-chloroaniline) Chemical compound C1=C(Cl)C(N)=CC=C1CC1=CC=C(N)C(Cl)=C1 IBOFVQJTBBUKMU-UHFFFAOYSA-N 0.000 description 5
241000283973 Oryctolagus cuniculus Species 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
239000003708 ampul Substances 0.000 description 5
239000003054 catalyst Substances 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
230000035558 fertility Effects 0.000 description 5
239000013641 positive control Substances 0.000 description 5
239000000376 reactant Substances 0.000 description 5
229920002545 silicone oil Polymers 0.000 description 5
241001112258 Moca Species 0.000 description 4
230000008520 organization Effects 0.000 description 4
230000002441 reversible effect Effects 0.000 description 4
239000000243 solution Substances 0.000 description 4
DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical group CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
241000699666 Mus <mouse, genus> Species 0.000 description 3
239000000460 chlorine Substances 0.000 description 3
229910052801 chlorine Inorganic materials 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 3
239000013642 negative control Substances 0.000 description 3
238000011160 research Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
239000002253 acid Substances 0.000 description 2
XLJMAIOERFSOGZ-UHFFFAOYSA-N anhydrous cyanic acid Natural products OC#N XLJMAIOERFSOGZ-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000037396 body weight Effects 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
230000015271 coagulation Effects 0.000 description 2
238000005345 coagulation Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
238000002513 implantation Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000011344 liquid material Substances 0.000 description 2
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
230000035935 pregnancy Effects 0.000 description 2
210000000582 semen Anatomy 0.000 description 2
238000010953 Ames test Methods 0.000 description 1
231100000039 Ames test Toxicity 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
239000004606 Fillers/Extenders Substances 0.000 description 1
244000043261 Hevea brasiliensis Species 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
229920001730 Moisture cure polyurethane Polymers 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
206010065805 Spermatic cord obstruction Diseases 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
231100000899 acute systemic toxicity Toxicity 0.000 description 1
OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical group NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
210000002798 bone marrow cell Anatomy 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000007799 cork Substances 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
231100000263 cytotoxicity test Toxicity 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
150000002009 diols Chemical class 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000036512 infertility Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
230000036244 malformation Effects 0.000 description 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N methyl monoether Natural products COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
239000011259 mixed solution Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
231100000219 mutagenic Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 1
229920003052 natural elastomer Polymers 0.000 description 1
229920001194 natural rubber Polymers 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
239000002245 particle Substances 0.000 description 1
231100000915 pathological change Toxicity 0.000 description 1
230000036285 pathological change Effects 0.000 description 1
210000003899 penis Anatomy 0.000 description 1
150000003022 phthalic acids Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003225 polyurethane elastomer Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000010926 purge Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
238000007789 sealing Methods 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1

Landscapes

Materials For Medical Uses (AREA)
Orthopedics, Nursing, And Contraception (AREA)

JP63239092A 1988-09-26 1988-09-26 ポリウレタンプラグとその製造法とそれを使用する避妊法 Pending JPH02102658A (ja)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IN793/CAL/88A IN170057B (2)	1988-09-26	1988-09-22
JP63239092A JPH02102658A (ja)	1988-09-26	1988-09-26	ポリウレタンプラグとその製造法とそれを使用する避妊法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP63239092A JPH02102658A (ja)	1988-09-26	1988-09-26	ポリウレタンプラグとその製造法とそれを使用する避妊法

Publications (1)

Publication Number	Publication Date
JPH02102658A true JPH02102658A (ja)	1990-04-16

Family

ID=17039695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP63239092A Pending JPH02102658A (ja)	1988-09-26	1988-09-26	ポリウレタンプラグとその製造法とそれを使用する避妊法

Country Status (2)

Country	Link
JP (1)	JPH02102658A (2)
IN (1)	IN170057B (2)

1988
- 1988-09-22 IN IN793/CAL/88A patent/IN170057B/en unknown
- 1988-09-26 JP JP63239092A patent/JPH02102658A/ja active Pending

Also Published As

Publication number	Publication date
IN170057B (2)	1992-02-01

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