JPH0211510A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To obtain the subject excellent composition, containing an aluminosilicate and a compound selected from straight-chain and cyclic polyphosphates in combination as an active ingredient and capable of synergistically acting and suppressing formation of dental calculi. CONSTITUTION:A dentifrice composition containing one or two or more selected fron straight-chain polyphosphates expressed by formula I (M is Na or K; n is >=2) and cyclic polyphosphates expressed by formula II (n is >=3) and an aluminosilicate in combination as an active ingredient. The amount of the blended aluminosilicate is preferably 0.1-70%, especially 1-50% based on the total composition and the amount of the above-mentioned blended polyphosphates is preferably within the range of 0.1-10wt.%, especially 0.5-5wt.% based on the total composition. Straight-chain polyphosphates are preferred as the polyphosphates and, e.g., sodium pyrophosphate (n is 2) and potassium tripolyphosphate (n is 3), are cited.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a dentifrice composition that suppresses the formation of tartar.

[Prior art and problems to be solved by the invention] Dental calculus is a hard deposit with high mineral content that forms on the tooth surface.
It is a very important cause of gingivitis, periodontitis, etc. Therefore, suppressing the formation of tartar is an effective way to prevent periodontal disease.
This is a very effective treatment. In this case, regular brushing of the teeth can prevent the rapid accumulation of tartar, but this is not sufficient.

The formation of this dental calculus is thought to be due to amorphous or microcrystalline calcium phosphate depositing on the bacterial membrane system and interbacterial substances in dental plaque, and gradually becoming denser and changing into hydroxyapatite. It has been recognized that in order to suppress the formation of tartar, it is sufficient to inhibit the crystal growth of hydroxyapatite.

For this reason, various proposals have been made to prevent tartar. For example, Japanese Patent Publication No. 45-23637 and Japanese Patent Publication No. 49-27339 disclose many phosphonic acid type compounds and their compounds as tartar preventive agents. Pharmaceutically acceptable salts are disclosed. Also, rArch, 0
ra1. Biol, Vol.

15, p. 893-896 (1970), the effectiveness of soluble phosphates against dental calculus is shown. Further, JP-A No. 52-108029 discloses a method for preventing dental tartar using a combination of polyphosphate and polyvalent cations, and JP-A No. 54-80429 describes a method for preventing tartar using a combination of polyphosphates and polyvalent cations, and JP-A No. 54-80429 describes a method for preventing tartar using a combination of polyphosphates and polyvalent cations. JP-A No. 59-42311 discloses an oral composition containing pyrophosphate and has an anti-tartar effect; The publication proposes oral compositions that use a polyphosphate in combination with α-menthol and anethole.

It is known that polyphosphates are effective in inhibiting the formation of tartar.

However, the effect of the polyphosphate itself is still not sufficient, and there has been a demand for an oral composition that is biased towards preventing tartar.

[Means and effects for solving the problem] The present inventors,
As a result of intensive research on toothpaste compositions that achieve the above objectives, it was found that it is very effective to use aluminosilicate in combination with polyphosphate, and the following formulas (1) and (2) M, 4. Po03.4, -(1) (MPO,). ...(2) (However, M is N
Indicates a or K, and n is n≧2 in the case of formula (1), (2)
The present invention has been made based on the findings that when a polyphosphate represented by the formula (in the case of the formula n≧3) and an aluminosilicate are used together, these components act synergistically to suppress the formation of tartar. reached.

The present invention will be explained in more detail below.

The dentifrice composition according to the present invention contains a polyphosphate as an active ingredient for inhibiting the formation of tartar. or K and n≧2), i.e., sodium pyrophosphate or potassium pyrophosphate with a degree of polymerization n = 2, sodium tripolyphosphate or potassium tripolyphosphate with n = 3, tetrapolyphosphoric acid with n = 4 Linear polyphosphates such as sodium, potassium tetrapolyphosphate, high degree of polymerization sodium metaphosphate and potassium metaphosphate, and the following formula (2) % formula % (2) (However, M represents Na or K. , n≧3), i.e. sodium trimetaphosphate or potassium trimetaphosphate with a degree of polymerization n = 3, sodium tetrametaphosphate or potassium tetrametaphosphate with n = 4, n = 6
Cyclic polyphosphates such as sodium hexametaphosphate and potassium hexametaphosphate are used.

These polyphosphates can be used alone or in combination of two or more, but among these, linear polyphosphates are preferably used because they exhibit better tartar inhibiting effects. .

The amount of polyphosphate to be blended is not necessarily limited, but is preferably 0.1 to 10% (by weight, hereinafter the same), particularly 0.5 to 5%, based on the entire composition. When the amount is less than 0.1%, the synergistic effect of the combination with the aluminosilicate may not be sufficient, and when it is more than 10%, the taste of the oral composition may become bad.

Although the present invention uses the above-mentioned polyphosphate and aluminosilicate in combination, the aluminosilicate used in the present invention can be used in any of amorphous, partially crystalline, and crystalline forms.

Specifically, natural aluminosilicates such as analcite and chabazite, and zeolites A and X.

Synthetic zeolites designated by names such as Y are used. Among these, synthetic zeolite represented by the following formula (3), which contains few impurities and impurities, is preferred.

(M,0)x-An-Oy ・(SiO2)y' (
H2O)z -(3) (where M is an alkali or alkaline earth metal with a valence of n, X is 0.7 to 1,5, and y is 0.8
~10. z represents a number of 0 or more. ) Of the synthetic zeolites represented by the above formula (3),
Examples of the metal atom represented by M include sodium, potassium, calcium, magnesium, etc., but from the viewpoint of the ion exchange ability of Ca 2", which causes tartar formation, A where the metal atom is sodium or potassium Type zeolites are preferred.

Such aluminosilicates are commercially available, for example under the trade name ALU S I L N (Crosfield
ds company) ALUSIL AS (> ALUSIL ET () SI DENT P (Degussa company) Sa
sil (〃) Toyo Builder (Toyo Sodasha), etc. Moreover, zeolite for tooth brushing made by the method described in JP-A-55-24112 is also preferably used. The average particle size of the above aluminosilicate is 0
．． It can be set to 1 to 100μ, but from the viewpoint of feeling when used, 0.5 to 4oμ is particularly suitable.

In addition, the amount of aluminosilicate blended is 0.1 of the total composition.
It is preferable to set it as 70%, and it is especially preferable to set it as 1 to 50%.

In addition to the above-mentioned components, the dentifrice composition of the present invention may contain appropriately selected components such as binders, thickeners, surfactants, sweeteners, preservatives, and pigments depending on the type of the dentifrice composition. can do. In this case, in addition to the aluminosilicate, other abrasives, such as dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium pyrophosphate, calcium carbonate aluminum hydroxide, silicic anhydride, titanium oxide,
Insoluble sodium metaphosphate, synthetic resins such as urea-formaldehyde, etc. may be blended, and other active ingredients may also be blended in addition to the above-mentioned polyphosphate.

〔Effect of the invention〕

The dentifrice composition of the present invention is highly effective in preventing tartar due to the combination of the polyphosphate and aluminosilicate.

EXAMPLES Hereinafter, the present invention will be specifically explained by showing examples and comparative examples, but the present invention is not limited to the following examples.

[Example 1. Comparative example] A toothpaste having the following composition was manufactured by a conventional method.

Set - Example Comparative example Aluminosilicate 25.0% silicic anhydride
25.0% thickening silica propylene glycol 60% sodium sorbitol carboxymethyl cellulose 5.0 3.0 30.0 1.0 5.0 3.0 30.0 1.0 Sodium tripolyphosphate 1.0 Sodium lauryl sulfate 1. 5 1.5 Saccharin Sodium 0.1 0.1 Flavor
1.0 1.0 Paraben 0.3 0.3 total
100.0% 100.0% *Using Toyo Soda Co., Ltd.'s Toyo Builder (average particle size 1.5μ) Next, 40 panelists who were prone to tartar buildup were selected.

The lingual surfaces of six teeth from number 3 on the left to number 3 on the right in the lower jaw of each patient were scaled and polished to completely remove tartar. After that, the toothpaste of the comparative example was used for one month, and the status of tartar adhesion was measured using VM.
A dentist evaluated the score (Volpe-Manhold). [“Dental Hygiene Statistics” by Shimada and Maeda,
p. 28 (Ishiyaku Publishing)]. This result is considered to indicate the degree of susceptibility to tartar formation in each person, so based on this, the 40 people were divided into two groups so that there was no difference in the average value of the VM score between the two groups.

Scaling and polishing were performed again, and the test group received the toothpaste of Example 1, and the control group received the toothpaste of Comparative Example 2.
It was used for one month, and after two months, a dentist evaluated the state of tartar adhesion using the VM score. Based on the above results, Example 1
The test group that used this toothpaste for two months was found to be able to suppress tartar formation much better than the control group.

[Example 2] Dibasic calcium phosphate dihydrate 40.0% aluminosilicate *5.0 85% glycerin 20.0 Propylene glycol 4.0 Carboxymethylcellulose sodium tetrasodium pyrophosphate
1O hydrate 5.0 Sodium monofluorophosphate 0.76 Sodium lauryl sulfate Sodium saccharin Flavor Paraben Water meter * Use of Decyl manufactured by Degussa [Example 3] Silicic anhydride 60% Sorbitol propylene glycol Sodium carboxymethyl cellulose Sodium tripolyphosphate (n = 3.0) Sodium lauryl sulfate Sodium saccharin Flavor Paraben Water Total 1.5 0.1 1.2 0, 5 Remaining 100.0% 20.0% 25.0 4.0 1, 5 1.0 1, 2 0.1 1.0 0.3 Remaining 100.0% *Those described in JP-A-55-24112 (average particle size 2.0μ) [Example 4] Aluminum hydroxide 30.0% aluminosilicate Car 2.085
% Glycerin 20.0 Polyethylene glycol 400 5.0 Sodium carboxymethylcellulose 1.2 Sodium metaphosphate (n=36) 3.0 α-olefin sulfonate 1.0 Sodium saccharin
0.1 fragrance
1.2 Parabens
0.3 water
Remaining 100.0% Total * Using 5IDENT P manufactured by Degussa [Example 5] 60% sorbitol propylene glycol 20, 0 2.0 Sodium carboxymethyl cellulose Sodium metaphosphate (n=12) Sodium fluoride Sodium lauryl sulfate Sodium saccharin Flavor benzoin Acid 1.2 3.0 0, 23 1.0 0, 1 0.8 0, 5 Total 100.0% JP-A-55
-24112 publication (average particle size 1.6μ) [Example 6] Aluminosilicate * 32.0%
60% Sorbit 20.0 Thickening Silica 2.0 Hydroxyethyl Cellulose 1.2 Sodium Tetrapolyphosphate 1.5 Chlorhexidine Gluconate 0.025 Sodium Lauryl Sulfate
1.0 Satucalin Sodium
0.1 Fragrance Paraben Water 1.0 0.3 Total remaining 100.0% Toyo Soda Co., Ltd. Toyobuilder used (average particle size 1.5μ) [Example 7] Aluminosilicate * 15.
0%60% Sorbit 65.0
Propylene glycol 3.0 Sodium carboxymethylcellulose Sodium metaphosphate (n=58) 5.0 Dextranase
0.18 Sodium lauryl sulfate 1.2 Sodium saccharin
0.15 fragrance
1.2 Parabens
0.3 water
Remaining amount
100.0% Type A zeolite used (average particle size 15μ) [Example 8] Aluminosilicate * 85% Glycerin Propylene glycol Sodium carboxymethyl cellulose Sodium tripolyphosphate Potassium tripolyphosphate Tranexamic acid Sodium lauryl sulfate Sodium saccharin Fragrance Paraben total 100.0% *Using A-type zeolite (average particle size 5.5μ) [Example 9] Aluminosilicate Water 25.0%
Titanium dioxide 3.060
%Sorvit 23. .

Sodium carboxymethylcellulose Sodium trimetaphosphate Epsilon Dihydroxyaluminum aminocaproate Allantoin Sodium lauryl sulfate Sodium saccharin Flavor Paraben Total 100.0% Use of mA type zeolite (average particle size 8.0μ) [Example 1
0] Aluminosilicate car 45°60
%Sorvit 30゜Polyethylene glycol 400 5゜Sodium carboxymethylcellulose 1゜Sodium metaphosphate
2゜Potassium metaphosphate
2゜Glycyrrhizin
0゜Sodium lauryl sulfate
16 lauric acid diethanolamide saccharin sodium fragrance paraben book Uses Toyo Builder manufactured by Toyo Soda Co., Ltd. (average particle size 1.5μ)
) The dentifrice compositions of Examples 2 to 11 also have a good tartar formation inhibiting effect.

100.0% Meter Used by Degussa Zacil [Example 11] Aluminosilicate Book 60% Sorbitropropylene glycol Sodium carboxymethyl cellulose 1 Sodium helipolyphosphate (n=3.0) Sodium chloride Sodium lauryl sulfate Sodium saccharin Flavor Paraben

Claims (1)

[Claims] 1. Aluminosilicate and general formula (1) M_n_+_2P_nO_3_n_+_1...(1)
(However, M represents Na or K, and n≧2) and (MPO_3)_n...(2) (However, M represents Na or K, A dentifrice composition comprising one or more cyclic polyphosphates represented by n≧3.