JPH02115111A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic, containing ethylglycoside and capable of keeping the skin in a healthy state or repairing the skin by accelerating the water holding function essential to the skin, imparting moistness, flexibility, resiliency and gloss to the skin and having excellent skin beautifying effects. CONSTITUTION:A skin cosmetic containing ethylglycoside (e.g., ethylglucose, ethylgalactose, ethylmannose, ethylallose or ethylaltrose). The amount thereof blended is preferably within the range of about 0.1-10wt.% based on the total amount of the composition. The about-mentioned cosmetic is applicable to, e.g., lotions, milky lotions or creams.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a skin cosmetic containing ethyl glycoside that enhances the moisture retention function of the skin and exhibits a beautifying effect.

(Prior art and problems to be solved by the invention) In order to maintain healthy skin, hydrophilic skin moisturizers and oily skin softeners that provide appropriate moisture and oil content to the skin have traditionally been used as skin cosmetics. It is being blended into

Skin moisturizers include glycerin, propylene glycol,
Polyethylene glycol, pyrrolidone carboxylate, etc. are used, but these can absorb moisture from the stratum corneum, the outermost layer of the skin, and cause the skin to lose moisture. Skin cosmetics that contain a large amount of these substances are not always satisfactory, as they give an unpleasant feeling such as stickiness.

In addition, liquid paraffin, petrolatum, olive oil, squalane, lanolin, synthetic ester oil, etc. are used as skin softeners, but these are also included in skin-in cosmetics to the extent that they sufficiently prevent water evaporation from the epidermis. When urging,
It has drawbacks such as inhibiting the normal metabolism of the skin.

The present invention provides skin protection. Rather than relying only on the ability of formulations to replenish moisture to the epidermis or prevent water evaporation from the epidermis, as with skin softeners and skin softeners, they can maintain healthy skin by enhancing the skin's natural moisture retention function. hold in condition,
Alternatively, it is an object of the present invention to provide a skin cosmetic having an excellent skin beautifying effect.

(Means for Solving the Problems) The present invention is a skin cosmetic characterized by containing ethyl glycoside.

Moisture in the skin is transferred from the dermis to the basal cell layer of the epidermis and then to the stratum corneum (always moves from the inside of the skin to the outer layer along the gradient of water content V, which decreases as it goes toward the layer,
Water evaporates to the outside through I, but this water evaporation is mainly controlled by the I31 function (barrier function), which consists of a dense cell tissue that extends from the lamellar granules at the top of the granular layer to the stratum granulosum. Transpiration rate (Transpid)
er+eal WaLer 1oss ) value (hereinafter, ]
``WL value'' is, for example, 0 in the normal state of healthy skin; 0.2 to 0 on the skin surface of one arm.
, 3 mg/crn”/hr range,
It is usually maintained at about 0.25 mg/cm''/br or less.

On the other hand, in the case of normal dryness l15 (dry skin) or dry skin seen in aging skin, the 'Fw1- value will be the upper limit (1^
It is recognized that the moisture retention function of the skin is below 1 level.This means that in the case of dry skin, the normal control limit of the protective function of the stratum corneum has been exceeded. This may be due to the fact that the defense function is in a weakened state.

Therefore, if we can make the MU weave of the stratum corneum and lamellar granules more delicate and activate its defense function, this will impair the moisture retention function of the skin, maintain the skin in a healthy state, and further dry it out. This makes it possible to improve or repair the skin.

Therefore, the present inventors have found that the cosmetic of the present invention containing the above-mentioned ethyl glycoside normalizes the &Il structure from the N temporary granules at the top of the granular layer to the stratum corneum, and by regressing the moisture retention function of the skin itself. It is known to have beautifying effects that improve dry skin, maintain the skin in a healthy state and prevent aging, and give the skin moisture (moistness), flexibility (smoothness! 8), elasticity, and luster. I found it.

In the case of the skin cosmetics of the present invention, unlike conventional skin cosmetics, it is not necessary to incorporate a large amount of the above-mentioned skin moisturizers and skin softeners, and there is no risk of interfering with the normal physiological functions of the skin, which is very significant. It is something.

The ethyl glycoside used in the present invention is ethyl glucose,
Ethylgalactose, ethylmannose.

Ethyl allose, ethyl aldrose, ethylg 11-
Although these substances are known, such as ethyl crose, ethyl xylose, and ethyl arabinose, they are not commercially available, and can be obtained by the synthesis method described in the literature Rocznik Chesi, Vol. 49, No. 12, pp. 2113-2115, 1975. Can be done. The blended type of ethyl glycoside is approximately 0.0% based on the total amount of the skin cosmetic (composition).
A range of I to lQwL% is suitable. The mixing tank is approximately 0.
If it is less than lwL%, the effect will not be sufficiently achieved, and on the other hand, even if it exceeds approximately IQwt%, the effect cannot be expected to be commensurate with the increase.

The skin cosmetics of the present invention include, for example, lotions, milky lotions,
It can be applied to creams, punctures, etc.

In addition, in addition to the above, the cutaneous tjL family of the present invention also contains pigments and fragrances.
Preservatives, surfactants, pigments, antioxidants, etc. can be appropriately added within the scope of achieving the objective of the present invention.

The present invention will be explained in detail below based on Examples and Test Examples.

In addition, TWL value, TWL value ratio change rate of plasma cells? /, +1
The method for measuring or evaluating the separation characteristics is shown below.

+11 TWL value A method was used to measure the humidity change in the air above the sealed skin surface over a certain period of time using electrical resistance.

That is, the test subject's skin surface is sealed in a measurement cell, forced dry air is vented into the cell to sufficiently replace the inside of the cell with dry air, and then the ventilation of dry air is stopped and the cell is closed at that point. Find the relative humidity RII s (%) inside the cell, then leave it for 10 minutes, measure the relative humidity R141° (%) again, and from the humidity change at this time, 1' W +,
The value was calculated.

However, Dt: Density of saturated water vapor in the air at the measurement temperature (t'c) (m B / II) ■ = Volume of the cell i) S Near 5Ill constant plane JR (Cm") (21T W L ratio change The TWL values were obtained before and after applying the test Fl (skin cosmetic) to the skin, and the rate of change was calculated using the following formula to evaluate the TWL reduction effect (moisture retention function enhancement effect). .

Table 1: Corneocytes 7. 'r W L (a:
Ding wL.

TWL value after application of sample (skin cosmetic); TWL
.

(3) Peeling properties of keratinocytes Scotch tape (Tiban mending tape) was applied to the skin, and this was peeled off to allow the keratinocytes on the skin surface to adhere to the tape. Next, the condition of the keratinocytes was observed in detail using a scanning electron microscope, and the exfoliation characteristics of the keratinocytes were classified based on the criteria shown in Table 1, and their indices were determined.

(Margins below) This exfoliation property of corneocytes serves as an index for determining the structural properties of the horny In layer, and -i is dry skin;
It has been confirmed that in aging skin, the index increases by 1 because the intercellular bonding force is weak and the density of the structure is also low.

Examples 1 to 3 Comparative Example 1 [Skin cream] Examples 1 to 3 of the present invention containing ethyl glycoside and skin cream of Comparative Example 1 containing propylene glycol instead of ethyl glycoside were prepared and various tests were conducted. carried out.

(Left below) +21! Jl manufacturing method Component (8) and component (B) were each heated and melted at 80°C, then mixed, and cooled to 30°C with stirring to prepare each skin cream.

Test Example 1 When applying the skin cream of the present invention of Examples 1 to 3 and the skin cream of Comparative Example 1, their T W L
4a and the effect on keratinocyte 7 release properties were investigated.

+11 Test method 60 healthy back skin test subjects (age 20-25)
．． ) were divided into 3 groups (groups 8, C, and E), and 60 subjects (females aged 20 to 25 years old) with normal dry skin were divided into 3 groups (groups 8, C, and E). They were divided into groups (BD and F groups).

Prior to the test, the left and right 11 of all test subjects H; T on the skin surface of the i arm.
W L 4. σ was measured, and the average i1α was calculated for each group. Next, the skin cream of Comparative Example I was applied to the skin surface of the forearm of the test subjects for all the test subjects on the left forearm, and the skin cream of Example 1 and C was applied to the right forearm of each group for each group. The skin cream of Example 2 was applied to Group D and the skin cream of Example 3 was applied to Groups E and F twice a day (in the morning,
Evening) Apply the cream continuously for one month, and on the next day after the final application, the skin surface area of the left and right arms [i] of the left and right arms where the cream was applied for all subjects. , values were measured, and the characteristics of more than 111 corneocytes were evaluated.

Furthermore, after the completion of the application test, the results of a diagnosis by a doctor revealed that there was no abnormality in the skin of the forearm or physical condition of all the test subjects.

(2) Results T W L values before and after application of skin cream, T W L 4fL change rate and corneocytes determined from these TWL values! Table 2 shows the releasability index (all (lrE is the average value of 20 people in each group).

(See below:) 1) As is clear from the results in Table 2, the effects of the skin creams of Examples 1.2 and 3 of the present invention were observed as described below.

■ In the healthy, conventional skin of groups A, C, and E, the moisture retention function of the skin is originally maintained in a normal state. ) Although the effect of coating is difficult to become apparent, a slight improvement is still observed compared to Comparative Example 1.

■ +1. For dry skin in groups D and F, the skin surface of the right forearm to which the skin cream of the present invention (Examples 1.2 and 3) was applied, and the skin surface of the left forearm (skin cream of Comparative Example 1) In comparison, a remarkable improvement in the i'WL value was observed, and the clay was equal to or close to that of healthy skin. When comparing the creams of the present invention, Example 3 had the highest moisture retention function improvement effect, followed by Example 2.1. Furthermore, horny 140
Similar results were obtained for the cell peeling test.

That is, the skin creams of Examples 1.2 and 3 of the present invention exhibited the effect of maintaining healthy skin in A, C, and 1 digroups, and B.

In the ot and F groups, it is clear that it has the effect of bringing the skin closer to normal skin.

From these results, it was found that Neel 1-Le Glycosy 1' contained in the skin creams of Examples 1 to 3 of the present invention effectively acts on epidermal cells, improves the intercellular bonding ability of the stratum corneum, and tightens this structure. and enhance the skin's moisture retention function,
It can be seen that it is highly safe and does not interfere with the physiological functions of healthy skin in any way.

Examples 4-5. Comparative Example 2 [Skin lotion (two-layer type)] Examples 4 and 5 of the present invention, in which ethyl glycode was added in the same manner as in Example 1, and Comparative Example 2, in which glycerin was added in place of ethyl glycode; -Nron-yong was manufactured by JJIL and various tests were conducted.

(Margins below) (2) Preparation method After uniformly dissolving the (A) component and (B) component, (A)
Components ) and (I3) were combined by stirring for 11 minutes, and then filled into a container.

When using, shake and disperse the contents evenly and apply to the skin.

Test Example 2 Skin Lawn Thin of Comparative Example 2 and Examples 4 to 5 was applied 102 times (morning and evening) continuously for one month to 30 test subjects (females aged 26 to 34 years old) complaining of dry skin. did. As a result of the diagnosis by the doctor, no abnormality was observed in the skin+a or physical condition of all the test subjects.

Next, Table 3 shows the results of a 3Jrn survey of all the test subjects on the effect of applying Skin Loan Thin on the skin's six components: moisture (moistness), softness (smoothness), elasticity, and shine. It was shown to.

As is clear from the results in Table 3, Examples 4 to 4 of the present invention
All of the skin lotions of Example 5 show better results than Comparative Example 2, but especially the skin lotion of Example 5 shows a remarkable skin modification effect.

(Effect of the invention) The skin cosmetic containing ethyl glycoside of the present invention maintains or repairs the skin in a healthy state and moisturizes the skin by enhancing the skin's inherent moisture retention function. It has the same properties as skin care products, which provide softness, elasticity, luster, and have a beautifying effect.

Claims (1)

[Claims] A skin cosmetic containing ethyl glycoside.