JPH02163043A - Feed additive for ruminant - Google Patents

Abstract

PURPOSE:To obtain the subject feed additive having improved acceptability of calcium salts of specified fatty acids and containing an enhanced bioactive substance by blending the bioactive substance, the calcium salts of the fatty acids and a hydrophobic substance having film-forming properties. CONSTITUTION:The objective feed additive is a granule consisting of a mixture composed of (A) <=10wt.% bioactive substance, (B) >=70wt.% calcium salts of one or more fatty acids selected from 6-14C saturated fatty acids and 12-24C unsaturated fatty acids or mixture composed of >=10wt.% above-mentioned calcium salts of the fatty acids and the residual part of a calcium salt of a 16-24C saturated fatty acid, (C) 5-28wt.% hydrophobic substance having film- forming properties and an additive added as necessary. As the component (C), higher fatty acids, higher alcohols, fatty esters, wax, hardened vegetable fats and oils and hardened animal fats and oils are exemplified and especially hardened vegetable fats and oils are preferably used.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a feed additive for ruminants, and more specifically to a feed containing a calcium salt of a fatty acid, a biologically active substance, hydrogenated oil, etc. Regarding additives.

The feed additive for ruminants of the present invention improves the palatability of calcium salts of fatty acids that are commercially available as cattle feed, and further enhances it by adding active substances such as amino acids. It is suitably used as a feed additive for ruminants.

[Conventional technology]

Peak milk production in dairy animals, especially humid cows, occurs several weeks before peak feed intake, resulting in substantial energy, amino acid and vitamin deficiencies during this time.

In order to supplement this energy deficiency, methods of adding fats and oils to feed have been considered, but in recent years, calcium salts of fatty acids have been developed that stably pass through the rumen of cows, and are beginning to be widely used. .

On the other hand, feed additives coated with fats and oils are becoming widely used to address deficiencies in amino acids and vitamins (H-gyo Kyosai Shimbun, April 4th issue, (19BB),
Deguija 8th, June issue, I'51. (1988
), etc.) [Problems to be solved by the invention] In order to replenish the insufficient energy during lactation of lactating animals,
The administration of fats and oils under consideration has not been adopted because it reduces the digestibility of feed in the rumen.

In addition, in order to compensate for this energy shortage, one dairy cow
200-500 g of calcium salts of fatty acids per day
In addition, to supplement amino acids, it is necessary to feed 50 to 100 g of oil-coated preparation per head per day.
Furthermore, they are required to ingest sufficient amounts of dry matter.

Salts of these fatty acids and fats and oils are fed to cows in early lactation who have no appetite, but calcium salts of fatty acids, which have an extremely strong soapy odor, are added to the feed in particular because of their large amounts. On the contrary, it causes a decrease in dry matter intake, which causes a decrease in milk yield and various problems.

An object of the present invention is to provide an animal feed additive that improves the palatability of the calcium salt of the fatty acid and is further enriched with biologically active substances such as amino acids and vitamins.

[Means for solving problems]

As a result of intensive research to achieve the above object, the present inventors have found that by creating a formulation in which a small amount of hydrogenated oil is added to a calcium salt of a fatty acid, the palatability of cattle is significantly improved, and furthermore, it is possible to improve the palatability of cattle. By adding biologically active substances that are easily degraded in the ruminal juice of another animal to the preparation, these biologically active substances bypass the rumen and are easily digested in the digestive tract from the abomasum onward. They discovered that it is eluted and absorbed, and completed the present invention.

The present invention provides the following components: Component A: Biologically active substance IO weight % or less Component B:
A calcium salt of at least one fatty acid selected from the group consisting of a saturated fatty acid having 6 to 14 carbon atoms and an unsaturated fatty acid having 12 to 24 carbon atoms, or containing 10% by weight or more of a calcium salt of the fatty acid with the remainder being carbon. Mixture of calcium salts of saturated fatty acids of numbers 16 to 24 7
0% by weight or more Component C: Hydrophobic substance with film-forming properties 5
~28% by weight This is an anti-separated animal feed additive characterized by consisting of a granular preparation of a mixture consisting of the above-mentioned components A, B, and C and optionally added additives.

In the present invention, the biologically active substance of component A is given to breeding animals such as cows and sheep to increase milk yield, improve milk quality, increase body weight, promote growth, prevent diseases, treat diseases, etc. It is a substance that shows activity. For example, amino acids such as methionine and lysine, N-acylaminoff1ti such as N-stearoylmethionine and N-oleylmethionine, calcium salts of N-hydroxymethionine, amino acid derivatives such as lysine hydrochloride, 2-hydroxy-4-methyl Hydroxy homologues of amino acids such as mercaptobutyric acid and its calcium salts, proteins such as feather powder, fish powder, casein, and potato protein, vitamin A5, vitamin A-acetate, and vitamin 7 mitate.

Vitamin D! , vitamin E, nicotinamide.

Vitamins such as calcium pantothenate and β-carotene and their derivatives, enzymes such as acid protease, carbohydrates such as glucose, antibiotics such as penicillin and tetracytalline, anthelmintic drugs such as Negfuon, etc. Examples include veterinary medicines.

Component B is a calcium salt of a saturated fatty acid having a straight chain or a branched chain having 6 to 14 carbon atoms, which may have a substituent, alone, or having a straight chain or a branched chain having 12 to 24 carbon atoms.
A single calcium salt of an unsaturated fatty acid which may have a group, a calcium salt of a mixed fatty acid containing two or more of the saturated fatty acids and unsaturated fatty acids, and at least one of the saturated fatty acids and unsaturated fatty acids. Any calcium salt of a mixed fatty acid consisting of 10% or more and the balance being a saturated fatty acid having 16 to 24 carbon atoms may be used, and preferably a calcium salt in which the saturated or unsaturated fatty acid is a monocarboxylic acid is used. . Calcium salts of several mixed fatty acids, saturated and unsaturated, which are commercially available, especially as feed additives for cattle, are more preferably used.

Component C is a hydrophobic substance having film-forming properties, and preferably a substance excellent in masking the soap odor of the calcium salts of fatty acids of Component B is used.

The film-forming hydrophobic substances of component C include higher fatty acids such as stearic acid, myristic acid, palmitic acid, hydrogenated castor oil fatty acids, hydrogenated sonolic acid), and higher alcohols such as stearyl alcohol. , fatty acid partial esters of polyhydric alcohols such as lauryl alcohol, myristyl alcohol, and cetyl alcohol, such as glycerin monostearate, glycerin distearate, etc., waxes such as rice wax, carnauba wax, beeswax, etc., hardened vegetable oils, For example, hydrogenated soybean oil, hydrogenated rapeseed oil, etc., hardened animal oils, such as hydrogenated beef tallow oil, hydrogenated lard oil, etc., and mixtures of two or more thereof may be mentioned, and hardened animal and vegetable oils are particularly preferably used.

Further, as additives that may be added as desired, inorganic compounds such as calcium carbonate, calcium phosphate, and talc, coloring agents, and the like may be added.

The anti-animal feed additive contains 210% by weight or less of the component A, 0% by weight or more of the component B, preferably component A/acid component (weight ratio) ≦3/20, and component C: 5 to 28% by weight.
Preferably, a granular preparation with a particle size of 100 μm or more is obtained by granulating a 7 to 25% by weight mixture using a known method such as extrusion granulation, stirring granulation, transfer granulation, or the like.

[For production]

As described above, the feed additive for reeling animals of the present invention comprises a biologically active substance (component A), a calcium salt of a fatty acid (component B), and a hydrophobic substance having film-forming properties (component C).
It is also characterized by being a granular preparation of a mixture consisting of additives added as desired.

In the present invention, component C acts as a binder during formulation and forms a film on the biologically active substance of component A and the calcium salt of the fatty acid of component B. This film is extremely stable against the weakly acidic to neutral rumen gastric fluid of rumen animals, and in the strongly acidic abomasum gastric fluid, the calcium salt of the fatty acid of component B reacts with the acid. The preparation swells or disintegrates due to the decomposition. As a result, the biologically active substance of component A present in this continuous phase is coated with component C, so it bypasses the rumen and is eluted in the digestive organs from the abomasum onward, with high efficiency. Absorbed.

Furthermore, the fatty acid produced by the decomposition of the calcium salt of the fatty acid of component B in the abomasum and beyond has better absorbability than when the fatty acid is directly administered as a nutritional source, and is absorbed as an energy source.

As the calcium salt of these fatty acids, calcium salts of mixed fatty acids, which are commercially available as nutritional sources for cattle, are more preferably used.

In addition, the film-forming hydrophobic substance used as component C masks the soap odor of the calcium salt of fatty acid of component B, and improves the palatability of the animal.

The biologically active substance of component A only needs to be provided in a small amount compared to the calcium salt of fatty acid of component B, which is an energy source, and although it varies depending on the type of biologically active substance, it is usually a component of component A/acid component ( Weight ratio) ≦3720 Su÷ is sufficient.

In addition, the amount of component C should be the minimum amount that can cover component A and component B (usually 5 to 28% by weight based on the entire formulation,
Preferably, 7 to 25% by weight is employed.

〔Example〕

The present invention will be explained in more detail with reference to Examples and Comparative Examples.

However, the scope of the present invention is not limited in any way by the following examples.

In addition, in the following examples, "parts" and "%" are based on weight unless otherwise specified.

(1) Manufacture of animal feed additive + al Sample A-1 Component A: 80 parts of methionine, component B: mixed fatty acids (saturated fatty acids: C- to C+a17.0%, CI, to Czt41
．． 1,520 parts of calcium salt of 4% unsaturated fatty acid (IC+S 35.6%) and 400 parts of component C: hardened beef tallow oil with a melting point of 59°C were mixed, and the average diameter was 3 mm using a single screw extruder.
A beret was prepared. The obtained pellets were crushed and sized to produce a feed additive for ruminant animals: Sample AI consisting of a 0.6 to 2.4 mm granular preparation.

(bl Sample A-2 Component A: 90 parts of methionine, Component B: 1,728 parts of calcium salt of mixed fatty acid (described above), and Component C: Melting point 59
182 parts of hardened beef tallow oil at a temperature of 182.degree.

IcI Sample A-3 Component A: 90 parts of methionine, Component B: 1,728 parts of calcium salt of mixed fatty acids (described above), and Component C: Melting point 69
182 parts of rapeseed hydrogenated oil was granulated using a Henschel mixer and sieved to produce a separate animal feed additive: Sample A-3 consisting of a granular preparation with a size of 0.6 to 2.4 mm.

[dl Sample A-4 Component A: 80 parts of lysine hydrochloride, Component B: 1,520 parts of a calcium salt of (N, syncytial fatty acid (described above)), and Component C: 400 parts of hydrogenated beef tallow oil with a melting point of 59°C. The mixture was granulated using a Henschel mixer and sieved to produce a separate animal feed additive: Sample A-4, which was a 0.6 to 2.4 mm granular preparation.

tel Sample A-5 Component A: 80 parts of methionine, Component B: 1,520 parts of calcium salt of mixed fatty acids (mentioned above), and Component C: Melting point 59
A feed additive for ruminants: Sample A-5 was prepared by granulating 400 parts of hydrogenated beef tallow oil at a temperature of 0.degree.

([1 Comparative Sample CA-1 Component A: 100 parts of methionine and 1.900 parts of calcium salt of mixed fat #I (described above) were mixed, and pellets with an average diameter of 8 mm were prepared using a single screw extruder. The obtained pellets had weak strength and were crushed in the same manner as in the production of sample A-1 to obtain a granular preparation. Table 1 shows the raw material compositions of each sample and comparative sample.

(Margin below) I couldn't do it.

(2) Elution test for biologically active substances For each sample and comparative sample prepared in Section 11 above, the following buffer solution (Mc solution) compatible with bovine ruminal fluid and CCL solution compatible with abomasal gastric fluid were used. A dissolution test of biologically active substances was conducted using

2g each of each sample and comparison sample was added to 200ml of Mc solution.
After shaking at 37° C. for 244 hours, the sample was taken out, the biologically active substance in the remaining liquid was quantified, and the elution rate of the biologically active substance into the Mc solution was determined.

Next, the sample taken out was immersed in CL solution 200mj+ again, shaken at 37°C for 4 hours, the sample was taken out, the biologically active substance in the remaining liquid was quantified, and the biologically active substance was eluted into the CL liquid. The rate was calculated.

Table 1 shows the elution rate of each sample and comparative sample into Mc solution and CL solution.

The specifications of the Mc liquid and CL liquid used in the test are shown below.

(Mc solution) Sodium hydrogen carbonate 9.8 g, potassium chloride 0.5
7g, calcium chloride 0.04g, phosphorus a22
Sodium dodecahydrate 9.30 g, sodium chloride 0
．． 47 g and magnesium sulfate heptahydrate 0.12 g
CCL solution] 0.2N hydrium chloride 50ml and 0.2N hydrochloric acid 10ml
, Om It with water to make the total volume 200 mA'. Balanced dissolution rate of active substances.

(3) Palatability test The feed additives for ruminants manufactured in the above (Section 11): Samples A to 1 and comparative sample CA-1 (powder) were mixed at 7.5% each into the compounded feed, and 4. It was fed to lactating dairy cows of !I by the cafeteria method.The number of feedings and the amount of feeding were observed for 20 minutes each over two days.

The observation results are shown in Table 2.

Table 2 As shown in Table 2, the animal feed additive of the present invention has significantly better palatability than the comparative sample that does not contain component C.

〔Effect of the invention〕

The present invention provides a granular preparation consisting of component A: a biologically active substance, component B: a calcium salt of a fatty acid, and component C: a hydrophobic substance having film-forming properties. , the biologically active substance has a low dissolution rate in the Mc fluid corresponding to the ruminal fluid of cattle, and has a low dissolution rate in the Mc fluid corresponding to the abomasal gastric fluid.
L? &, is a formulation that easily dissolves.

Therefore, biologically active substances that are easily degraded in the rumen of ruminant animals are useful as preparations that bypass the rumen and are absorbed in the digestive organs from the abomasum onward.

In addition, the palatability of cattle to the formulation of the present invention has been significantly improved compared to the conventional calcium implantation of fatty acids alone, and as a feed additive that provides calcium salts of fatty acids to breeding animals. Extremely excellent.

Furthermore, since it is made into a granular preparation, it can be administered by adding it to concentrated feed for breeding animals, making it suitable as a feed additive.

The present invention bypasses the rumen of the rumen, elutes biologically active substances in the digestive organs from the abomasum onwards, and efficiently supplies biologically active substances and fatty acids, which are an energy source, to the rumen. The present invention provides a feed additive for feed animals that can be absorbed in a well-balanced manner and is highly palatable to feed animals, and has extremely great industrial significance, including in the livestock field.

Claims (1)

[Claims] (1) Component A: Biologically active substance 10% by weight or less Component B: Saturated fatty acid with 6 to 14 carbon atoms and 12 carbon atoms
- Calcium salt of at least one fatty acid selected from the group consisting of 24 unsaturated fatty acids, or containing 10% by weight or more of the calcium salt of the fatty acid, with the balance having 16 to 16 carbon atoms
70% by weight or more of a mixture of calcium salts of 24 saturated fatty acids Component C: 5 to 28% by weight of a hydrophobic substance having film-forming properties A mixture consisting of the above components A, B, C and additives added as desired (2) A feed additive for ruminants characterized by comprising a granular preparation of (2) In claim (1), component C comprises higher fatty acids, higher alcohols,
A feed additive for ruminants characterized by being at least one selected from the group consisting of fatty acid esters, waxes, hardened vegetable oils and hardened animal oils (3) Claim No. (1) The feed additive for ruminants according to item or item (2), wherein component C is hydrogenated vegetable oil and/or animal oil.