JPH02189131A - Pressure reducing blood collecting tube - Google Patents
Pressure reducing blood collecting tubeInfo
- Publication number
- JPH02189131A JPH02189131A JP1338379A JP33837989A JPH02189131A JP H02189131 A JPH02189131 A JP H02189131A JP 1338379 A JP1338379 A JP 1338379A JP 33837989 A JP33837989 A JP 33837989A JP H02189131 A JPH02189131 A JP H02189131A
- Authority
- JP
- Japan
- Prior art keywords
- blood collection
- collecting tube
- collection tube
- blood collecting
- sealed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008280 blood Substances 0.000 title claims abstract description 67
- 210000004369 blood Anatomy 0.000 title claims abstract description 67
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 15
- 239000000057 synthetic resin Substances 0.000 claims abstract description 15
- 229910001873 dinitrogen Inorganic materials 0.000 claims abstract description 14
- 239000012298 atmosphere Substances 0.000 claims abstract description 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 13
- 229920005549 butyl rubber Polymers 0.000 abstract description 13
- 229910052760 oxygen Inorganic materials 0.000 abstract description 13
- 239000001301 oxygen Substances 0.000 abstract description 13
- 239000007789 gas Substances 0.000 abstract description 12
- 229920002725 thermoplastic elastomer Polymers 0.000 abstract description 7
- 229920002367 Polyisobutene Polymers 0.000 abstract description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract description 6
- 239000004926 polymethyl methacrylate Substances 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 5
- 229940123973 Oxygen scavenger Drugs 0.000 abstract description 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 2
- 239000004831 Hot glue Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 description 12
- 238000004806 packaging method and process Methods 0.000 description 11
- 239000006096 absorbing agent Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 6
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 5
- -1 Polyethylene terephthalate Polymers 0.000 description 5
- 238000010241 blood sampling Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 229920001971 elastomer Polymers 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 239000005062 Polybutadiene Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 2
- 229920006378 biaxially oriented polypropylene Polymers 0.000 description 2
- 239000011127 biaxially oriented polypropylene Substances 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000012943 hotmelt Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 229920002857 polybutadiene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 229920003048 styrene butadiene rubber Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920000181 Ethylene propylene rubber Polymers 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical class C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 229910001567 cementite Inorganic materials 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 229940087654 iron carbonyl Drugs 0.000 description 1
- XWHPIFXRKKHEKR-UHFFFAOYSA-N iron silicon Chemical compound [Si].[Fe] XWHPIFXRKKHEKR-UHFFFAOYSA-N 0.000 description 1
- 229910021506 iron(II) hydroxide Inorganic materials 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000005987 sulfurization reaction Methods 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
【発明の詳細な説明】 ■１発明の背景 技術分野 本発明は、合成樹脂製減圧採血管に関するものである。[Detailed description of the invention] ■1 Background of the invention Technical field The present invention relates to a vacuum blood collection tube made of synthetic resin.
詳しく述べると、減圧度の長期維持が可能な合成樹脂製
減圧採血管に関するものである。More specifically, the present invention relates to a vacuum blood collection tube made of synthetic resin that can maintain the degree of vacuum for a long period of time.
先行技術
減圧採血方式は溶血や凝血が小さく、また汚染や水分蒸
散が少ない検体が得られ、また効率面では採血準備や器
具の管理が単純化できるので広く使用されている。しか
して、このような減圧採血方式において使用される減圧
採血管は、管状容器と穿刺可能な密封用ゴム栓とからな
り、その密封容器内は減圧されており、採血針の一端を
血管に穿刺後、他端を前記ゴム栓に穿刺して密封容器内
部と連通させることにより該容器内の負圧により白液が
流入して採血されものである。このような減圧採血管と
しては、従来、管状容器としてガス透過性がなくかつ透
明性の良好なものとしてガラス製管状容器、また止栓と
してガス透過性が低くかつ穿刺可能なものとしてブチル
ゴム製栓よりなるものが使用されてきた。The prior art vacuum blood collection method is widely used because it produces samples with less hemolysis and coagulation, less contamination and water evaporation, and simplifies blood collection preparation and equipment management in terms of efficiency. Therefore, the vacuum blood collection tube used in such a vacuum blood collection system consists of a tubular container and a sealing rubber stopper that can be punctured. Thereafter, the other end is punctured into the rubber stopper to communicate with the inside of the sealed container, and the negative pressure inside the container causes white fluid to flow in and blood to be collected. Conventionally, such vacuum blood collection tubes have been made of glass tubular containers, which have no gas permeability and good transparency, and butyl rubber stoppers, which have low gas permeability and can be punctured. More have been used.
しかしながら、ガラス製管状容器は、保存または連撮中
、もしくは使用中に破損しやすく、また重いという欠点
があった。このため、軽量で透明な合成樹脂製管状容器
の使用について検討を行なったが、合成樹脂は大なり小
なりガス透過性があるので、長期間の保存中に周囲の雰
囲気ガス、例えば空気が密封された減圧採血管内に透過
してしまい、この結果、採血管内の圧力が−Ｌ昇して所
定の減圧採血ができないことがｔｌｆ明した。このため
、合成樹脂製減圧採血管を使用しようとすれば、減圧包
装容器内に保存する必要があった。しかるに、減圧口製
容器による保存は、包装容器が減圧容器であるために、
極めて高価であるうえに、密封および開缶に著しく手間
がかかるのでコスト高となるという欠点があった。However, glass tubular containers have the disadvantage that they are easily damaged during storage, continuous shooting, or use, and are heavy. For this reason, we considered using a lightweight and transparent tubular container made of synthetic resin, but since synthetic resin is more or less gas permeable, surrounding atmospheric gases, such as air, are sealed during long-term storage. It became clear that the blood was permeated into the reduced pressure blood collection tube, and as a result, the pressure inside the blood collection tube increased by -L, making it impossible to perform blood collection under the specified reduced pressure. For this reason, if synthetic resin vacuum blood collection tubes were to be used, they had to be stored in vacuum packaging containers. However, since the packaging container is a vacuum container, storage in a container made with a vacuum port is difficult.
In addition to being extremely expensive, sealing and opening the can requires considerable effort, resulting in high costs.
また、ブチルゴム製栓体のベースとなるポリマーはそれ
自身では製品として必要な物性を白”していないため、
硫黄、加硫促進剤等の助剤を添加する等複雑な工程を経
なければならないとともに、製造時に再生利用のできな
いパリ部分が多く、生産ロスも大きくなる等の欠点があ
った。よって熱可塑性エラストマーを含み再生が可能な
材質とすることができるが、この材質は栓体としてブチ
ルゴム製のものよりもガス透過性が大きいという欠点が
あった。In addition, the polymer that is the base of the butyl rubber stopper itself does not have the physical properties necessary for the product, so
In addition to having to go through complicated processes such as adding auxiliary agents such as sulfur and vulcanization accelerators, there are also drawbacks such as a large amount of waste that cannot be recycled during production, resulting in large production losses. Therefore, it is possible to use a material that includes a thermoplastic elastomer and is recyclable, but this material has a disadvantage in that it has higher gas permeability than a plug made of butyl rubber.
Ｉｌ、発明の目的
したがって、本発明の目的は、新規な合成樹脂製減圧採
血管を提供することにある。本発明の他の目的は、減圧
度の長期維持が可能な合成樹脂製減圧採血管を提供する
ことにある。1. OBJECT OF THE INVENTION Accordingly, an object of the present invention is to provide a novel vacuum blood collection tube made of synthetic resin. Another object of the present invention is to provide a vacuum blood collection tube made of synthetic resin that can maintain the degree of vacuum for a long period of time.
これらの諸口的は、一端が閉塞しかつ他端が開口した合
成樹脂製管状部材と、該開口端を密閉した穿刺可能な栓
部材とよりなり内部空間の空気が減圧されてなる採血管
と、該採血管を収納した密封′ｄ器とよりなり、該密閉
容器内が窒素ガス雰囲気に保たれてなる減圧採血管によ
り達成される。These blood collection tubes are composed of a synthetic resin tubular member with one end closed and the other end open, and a pierceable plug member with the open end sealed, and the air in the internal space is reduced in pressure. This is achieved by using a reduced pressure blood collection tube, which consists of a sealed container containing the blood collection tube, and the inside of the closed container is maintained in a nitrogen gas atmosphere.
■、°発明の詳細な説明 つぎに、図面を参照しながら本発明の詳細な説明する。■、°Detailed description of the invention Next, the present invention will be described in detail with reference to the drawings.
すなわち、第１図に示すように、本発明による減圧採血
管１は、一端が閉塞しかつ他端が開口した合成樹脂製管
状部材２と、該管状部）ＦＡ２の開口端３を密閉した穿
刺可能な栓部材４とよりなるもので、該減圧採血管１は
、第２図に示すように、密封容器１２内に収納されてい
る。しかして、前記減圧採血管１の内部空間５は、内部
空気が減圧状態に保たれている。That is, as shown in FIG. 1, the vacuum blood collection tube 1 according to the present invention includes a synthetic resin tubular member 2 with one end closed and the other end open, and a puncture tube with the open end 3 of the tubular portion FA2 sealed. The reduced pressure blood collection tube 1 is housed in a sealed container 12, as shown in FIG. Therefore, the internal air in the internal space 5 of the reduced pressure blood collection tube 1 is kept in a reduced pressure state.
この合成樹脂製管状部材２を構成する部材としては、で
きるだけガス透過性の低いもの、好ましくは窒素のガス
透過性がｌＸｌ０−１０ｅｕ＋３ （ＳＴＰ）ｃｍ／ｃ
ｍ２ ・ｓｅｅ−ｃｍＨｇ以下、特に好ましくは０．
１Ｘ１０ ″）ｃｍ” （ＳＴＰ） ｃｍ／ｃｍ２・
ｓｃｃ ＊ｃａＨｇ以下のもので、かつ透明性に優れ、
保形性ないし機械的強度の充分なものがよい。その代表
的なものとしては、−例を挙げると、例えばポリメチル
メタクリレート、ポリ塩化ビニリデン、ポリ塩化ビニル
、エチレン−ビニルアルコール共重合体。The material constituting this synthetic resin tubular member 2 is one that has as low a gas permeability as possible, preferably a nitrogen gas permeability of lXl0-10eu+3 (STP) cm/c.
m2·see-cmHg or less, particularly preferably 0.
1X10″)cm” (STP) cm/cm2・
scc *caHg or less, and has excellent transparency,
It is preferable that the material has sufficient shape retention and mechanical strength. Typical examples include polymethyl methacrylate, polyvinylidene chloride, polyvinyl chloride, and ethylene-vinyl alcohol copolymer.
ポリエチレンテレフタレート６．６−ナイロン。Polyethylene terephthalate 6.6-nylon.
６−ナイロン等があり、好ましくはポリメチルメタクリ
レート、エチレン−ビニルアルコール共重合体等であり
、最も好ましくはポリメチルメタクリレートである。栓
部材４を構成する月料としては、ブチルゴム以外に後述
するように使用時に採血針の穿刺が可能でかつ該採血公
１の穿刺により採血針と栓部材との間が緩まないだけの
充分な弾性を存し、さらに再生利用が可能でありしかも
前記管状部材を構成する合成樹脂と同様にガス透過性の
低いものが望ましい。その代表的なものとしては、例え
ば熱可塑性エラストマーとポリイソブチレンと部分架橋
ブチルゴムとの配合物等があり、好ましくは熱可塑性エ
ラストマーとポリイソブチレンと部分架橋ブチルゴムと
の配合物である。6-nylon, etc., preferably polymethyl methacrylate, ethylene-vinyl alcohol copolymer, etc., and most preferably polymethyl methacrylate. In addition to butyl rubber, the material constituting the plug member 4 is made of a material other than butyl rubber that is sufficient to allow the puncture of the blood collection needle during use and to prevent the gap between the blood collection needle and the plug member from loosening due to the puncture of the blood collection member 1. It is desirable to use a material that has elasticity, is recyclable, and has low gas permeability like the synthetic resin constituting the tubular member. Typical examples thereof include, for example, a blend of a thermoplastic elastomer, polyisobutylene, and partially crosslinked butyl rubber, and preferably a blend of a thermoplastic elastomer, polyisobutylene, and partially crosslinked butyl rubber.
該配合物における谷成分の組成は、熱可塑性エラス）・
マー１００重量部当りポリイソブチ１２１００〜２００
重量部、好ましくは１２０〜．１５０市量部であり、部
分架橋ブチルゴム１００〜２００市量部、＆ｒ４しくは
１２０〜１５０重量部である。The composition of the valley component in the blend is thermoplastic elastomer).
Polyisobutylene 12100-200 per 100 parts by weight
Parts by weight, preferably 120-. 150 parts by weight, and 100 to 200 parts by weight of partially crosslinked butyl rubber, or 120 to 150 parts by weight.
熱可塑性エラストマーとしては、エチレン−プロピレン
ゴム系、ポリエステルエラストマー ナイロンエラスト
マー系、スチレン−イソプレンブロック共重合体、スチ
レン−ブタジェンブロック共重合体、ポリブタジェン、
熱可塑性ポリウレタン、水素添加スチレン−ブタジェン
ブロック共重合体等がある。ポリイソブチレンは、分子
ｍ１５．０００〜２００，０００、好ましくはｇｏ、ｏ
ｏｏ〜１５００００のものである。部分架橋ブチルゴム
は、イソブチレンと少量（例えば０．３〜３．０モル％
）のイソプレンとを共重合させて得られるブチルゴムを
部分架橋してなるものである。Examples of thermoplastic elastomers include ethylene-propylene rubber, polyester elastomer, nylon elastomer, styrene-isoprene block copolymer, styrene-butadiene block copolymer, polybutadiene,
Examples include thermoplastic polyurethane, hydrogenated styrene-butadiene block copolymer, and the like. Polyisobutylene has molecules m15.000 to 200,000, preferably go, o
It is from oo to 150,000. Partially crosslinked butyl rubber contains isobutylene and a small amount (for example, 0.3 to 3.0 mol%).
) is obtained by partially crosslinking butyl rubber obtained by copolymerizing with isoprene.
本発明で使用される密封容器１２は、ガス遮断性のもの
でさえあれば特にその形状を限定されるものではないが
、−例を挙げると、例えば第２図に示すように周縁部に
フランジ部１３を−６する皿状容器本体１４の前記フラ
ンジ部１３にホットメルト
状謔体１５をヒートシールしてなるものがある。The shape of the sealed container 12 used in the present invention is not particularly limited as long as it is gas-barrier; however, for example, as shown in FIG. There is one in which a hot-melt cover 15 is heat-sealed to the flange part 13 of a dish-shaped container main body 14 with a section 13 of -6.
また、この他にブリスター包装容器でもよいことはもち
ろんである。In addition, it goes without saying that a blister packaging container may also be used.
このようなガス遮断性の高い材料としては、ガス透過性
が０．ｌＸ１０”’ｃｍ３（ＳＴＰ）Ｃｍ／ｅａｒ２ｓ
ｅｃ φｅｍＨｇ以下、好ましくは０．００１Ｘ １０
−’ Ｃｍ３（ＳＴＰ）ｃｍ／ｅａ＋２ ・ｓｅｅ −
ｅｍＨｇ以下のものであって、例えば二軸延伸ポリプロ
ピレンとエチレン−ビニルアルコール共重合体と二軸延
伸ポリプロピレンとのラミネート、エチレン−ビニルア
ルコール共重合体とポリエチレンとのラミネート。Such a material with high gas barrier properties has a gas permeability of 0. lX10'''cm3 (STP) Cm/ear2s
ec φemHg or less, preferably 0.001X 10
-' Cm3 (STP) cm/ea+2 ・see -
emHg or less, such as a laminate of biaxially oriented polypropylene, an ethylene-vinyl alcohol copolymer, and a biaxially oriented polypropylene, or a laminate of an ethylene-vinyl alcohol copolymer and polyethylene.
ポリ塩化ビニリデンとポリエチレンとのラミネート、ポ
リプロピレンとエチレン−ビニルアルコール共重合体と
ポリプロピレンとのラミネート等がある。これらのラミ
ネートの総合厚みは５０−１５００１ｔｍｓ好ましくは
ｔｏｏ − ｔｏｏｏμｌである。Examples include a laminate of polyvinylidene chloride and polyethylene, a laminate of polypropylene, an ethylene-vinyl alcohol copolymer, and polypropylene, and the like. The total thickness of these laminates is 50-15001 tms, preferably too-tooul.
しかして、該密封容器１２内は窒素ガス雰囲気下に保た
れている。該密封容器１１内を窒素ガス雰囲気下に保つ
には、窒素ガス雰囲気中で前記減圧採血管１を密封容器
１２内に収納してシールするか、あるいは第２図に示す
ように、大気中で収納作業を行なって脱酸素剤１１を同
時に収納することにより、この脱酸素剤１１の作用によ
り密封容器１２内の酸素を吸収除去して窒素ガス雰囲気
に保つことにより行なわれる。Therefore, the inside of the sealed container 12 is maintained under a nitrogen gas atmosphere. In order to maintain the inside of the sealed container 11 under a nitrogen gas atmosphere, the reduced pressure blood collection tube 1 is housed in the sealed container 12 and sealed in a nitrogen gas atmosphere, or as shown in FIG. By carrying out the storage operation and storing the oxygen absorber 11 at the same time, the action of the oxygen absorber 11 absorbs and removes the oxygen in the sealed container 12 and maintains a nitrogen gas atmosphere.
脱酸素剤としては種々のものがあるが、−例を挙げると
、例えば炭化鉄．鉄カルボニル、酸化第一鉄，水酸化第
一鉄およびケイ素鉄からなる？！Ｔから選ばれる少なく
とも１種の化合物とノ１０ゲン化金属（必要により水を
含む）とよりなる酸素吸収剤（特開昭５４−３７０８８
ｔシ）、金属粉を１１０ゲン化金属で被覆してなる酸素
吸収剤（特開昭５４−３５１８９号）等がある。There are various oxygen scavengers, including iron carbide. Consisting of iron carbonyl, ferrous oxide, ferrous hydroxide and iron silicon? ! An oxygen absorbent comprising at least one compound selected from T and a metal oxide (containing water if necessary) (Japanese Patent Application Laid-Open No. 54-37088
There are also oxygen absorbers made by coating metal powder with metal 110 (Japanese Patent Application Laid-open No. 35189/1989).
このような採血管１および脱酸素剤１１を包装容器１２
に収納する場合には、両者を１１１１状容器本体１４に
収納し、ついでホットメルト
介して蓋体１５をフランジ部１３に当接し、ヒートシー
ルすることにより密封する。Such a blood collection tube 1 and oxygen absorber 11 are placed in a packaging container 12.
When storing both containers in the 1111-shaped container body 14, the lid body 15 is then brought into contact with the flange portion 13 via hot melt and sealed by heat sealing.
本発明による減圧採血管内の減圧度は、所定の血液が管
内に流入するに必要にしてかつ充分な負圧となるだけの
ものであればよい。例えば内容積１２７７１１１の採血
管の場合、血液を１０７７１ Ｑ採取しようとする場合
には７６Ｘ （ ２／ １２） ｅｍＨｇのガス圧とな
るように減圧すればよい。なお、前記減圧採血管内には
、必要により予め抗凝血剤を収納しておいてもよいこと
はもちろんである。The degree of vacuum in the vacuum blood collection tube according to the present invention may be as long as it is necessary and sufficient for the predetermined blood to flow into the tube. For example, in the case of a blood collection tube with an internal volume of 1277111, if 10771Q of blood is to be collected, the pressure may be reduced to a gas pressure of 76X (2/12) emHg. It goes without saying that an anticoagulant may be stored in the vacuum blood collection tube in advance, if necessary.
■．具体的作用
以Ｉ−のごとき構成を有する減圧採血管は、つぎのよう
にして使用される。すなわち、第２図に示す密封包装容
器１２から五体１５を剥離して所定の減圧度に減圧した
減圧採血管１を取出し、第３図に示すように一端が閉塞
しかつ他端が開口し、該閉塞端部６のねじ穴７に採血針
８を螺着した採血管ホルダー９内に前記開口部から嵌挿
する。この採血針８は、例えば血管刺通部８ａと栓穿刺
部８ｂとよりなり、該栓穿刺部８ｂには合成樹脂製のル
アーアダプター１０で包装されている。ついで、採血針
８の血省゛刺通部８ｂを血管、例えば静脈に刺通し、さ
らに減圧採血管１を採血管ホルダー９の閉塞端部６へ抑
圧挿入すると、採血管８の栓穿刺部８ａがルアーアダプ
ター１０および栓部材４を穿刺してその先端部が採血管
１の内部空間５に達するので、血管と該内部空間５とが
連通し、該内部空間５内の負圧により血管内の１１１１
液は減圧度に相当するだけ採血管１の内部空間５内に流
入する。ついで、採血針８の血管刺通部８ａを血管より
外すことにより採血が終了する。■． DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The reduced pressure blood collection tube having the configuration shown in I- is used in the following manner. That is, the body 15 is peeled off from the sealed packaging container 12 shown in FIG. 2, and the vacuum blood collection tube 1, which has been reduced to a predetermined degree of vacuum, is taken out, and one end is closed and the other end is opened, as shown in FIG. The blood collection needle 8 is inserted into the blood collection tube holder 9 screwed into the screw hole 7 of the closed end 6 through the opening. This blood collection needle 8 is composed of, for example, a blood vessel piercing part 8a and a plug puncturing part 8b, and the plug puncturing part 8b is wrapped with a luer adapter 10 made of synthetic resin. Next, when the blood sampling needle 8b of the blood sampling needle 8 is pierced into a blood vessel, for example, a vein, and the reduced pressure blood sampling tube 1 is inserted under pressure into the closed end 6 of the blood sampling tube holder 9, the stopper piercing portion 8a of the blood sampling tube 8 is inserted. The luer adapter 10 and plug member 4 are punctured so that their tips reach the internal space 5 of the blood collection tube 1, so that the blood vessel and the internal space 5 communicate with each other, and the negative pressure within the internal space 5 causes the 1111 inside the blood vessel to
The liquid flows into the internal space 5 of the blood collection tube 1 in an amount corresponding to the degree of vacuum. Then, blood collection is completed by removing the blood vessel piercing portion 8a of the blood collection needle 8 from the blood vessel.
つぎに、実施例を挙げて本発明をさらに詳細に説明する
。Next, the present invention will be explained in more detail by giving examples.
実施例 １
第１図に示すように、一端が閉塞しかつ他端が開口した
肉厚１ｍｍ＋の管状容器２をポリメチルメタクリレ−１
・で作った。一方、熱可塑性エラストマー （ １．２
−ポリブタジェン） ２５ｍｆｆｉ部、ポリイソブチレ
ン（分子ｆｆｌ １００．０００） ３５重量部および
部分架橋ブチルゴム２５重量部、流動パラフィン１５重
量部よりなる配合物で栓部材を作り、前記管状容器２の
開口端３に密栓し、該管状容器２内の空気の減圧度、（
管内圧）を１５０ｍｏ＋Ｈｇに保った。このようにして
得られた減圧採血管１を、窒素ガス雰囲気中で第２図に
示すように包装容器１２に収納したのち、蓋体１５をホ
ットメルト接着剤を介してフランジ部１３においてヒー
トシールした。このときのポリメチルメタクリレートに
対する酸素の透過係数は、窒素の透過係数の約５倍であ
った。Example 1 As shown in FIG. 1, a tubular container 2 with a wall thickness of 1 mm+, which was closed at one end and opened at the other end, was placed in polymethyl methacrylate 1.
・Made with. On the other hand, thermoplastic elastomer (1.2
- Polybutadiene) 25 mffi parts, polyisobutylene (molecular ffl 100.000) 35 parts by weight, partially crosslinked butyl rubber 25 parts by weight, liquid paraffin 15 parts by weight to make a plug member, and plug it into the open end 3 of the tubular container 2. The degree of decompression of the air inside the tubular container 2, (
The tube internal pressure) was maintained at 150 mo+Hg. The vacuum blood collection tube 1 obtained in this manner is housed in a packaging container 12 in a nitrogen gas atmosphere as shown in FIG. did. The permeability coefficient of oxygen to polymethyl methacrylate at this time was about 5 times the permeability coefficient of nitrogen.
このようにして作成された減圧採血管１について包装容
器１２を大気中に放置後の採血量の経時変化を試験した
ところ、第１表の結果が得られた。When the vacuum blood collection tube 1 thus prepared was tested for changes over time in the amount of blood collected after the packaging container 12 was left in the atmosphere, the results shown in Table 1 were obtained.
なお、」−記栓体をブチルゴム製のものとした場合も同
様な結果が得られた。Similar results were obtained when the plug was made of butyl rubber.
実施例２
実施例１と同様な方法において、脱酸素剤１１としてエ
ージレス（商品名：三菱瓦斯化学（株）製）を減圧採血
管１とともに密封包装容器に収納した以外は同様にして
密封した。このようにして作成された減圧採血管１につ
いて採血量の経時変化を試験したところ、第１表の結果
が得られた。Example 2 In the same manner as in Example 1, except that Ageless (trade name: manufactured by Mitsubishi Gas Chemical Co., Ltd.) as the oxygen absorber 11 was housed together with the vacuum blood collection tube 1 in a sealed packaging container, the container was sealed. When the vacuum blood collection tube 1 thus prepared was tested for changes over time in the amount of blood collected, the results shown in Table 1 were obtained.
比較例 ｌ
実施例６の方法において、密封容器に窒素ガスの代りに
空気を封入した以外は同様な方法を行なったところ、第
１表の結果が得られた。Comparative Example 1 The same method as in Example 6 was carried out except that air was filled in the sealed container instead of nitrogen gas, and the results shown in Table 1 were obtained.
第１表
実施例１ １０．０ ９．２ ８．４ ７．６実
施例２ １０．０ ９．３ ８．６ ８．０比較
Ｆ１１ １０．０ ８．８ ７．７ ６．７■１
発明の具体的効果
以Ｉ−述べたように、本発明は、一端が閉塞しかつ他端
が開口した管状部材と、該開口端を密閉した穿刺可能な
栓部材とよりなり内部空間の空気が減圧されてなる採血
管と、該採血管を収納した密封容器とよりなり、該密封
容器内が窒素ガス雰囲気に保たれてなる減圧採血管であ
るから、酸素ガスの透過係数の方が窒素ガスの透過係数
よりも約５倍量にも大きいので、包装容器内の減圧採血
管外から採血管内への窒素ガスの侵入よりも、採血管内
から採血管外への酸素（空気）の侵出の方が大きいので
、減圧採血管内の減圧度は長期間にわたって維持される
。Table 1 Example 1 10.0 9.2 8.4 7.6 Example 2 10.0 9.3 8.6 8.0 Comparison F11 10.0 8.8 7.7 6.7■1
Specific Effects of the Invention - As described above, the present invention comprises a tubular member with one end closed and the other end open, and a punctuable plug member with the open end sealed, so that the air in the internal space can be removed. A vacuum blood collection tube consists of a blood collection tube under reduced pressure and a sealed container that houses the blood collection tube, and the inside of the sealed container is kept in a nitrogen gas atmosphere, so the permeability coefficient of oxygen gas is higher than that of nitrogen gas. The permeability coefficient is approximately 5 times larger than the permeability coefficient of Since the pressure is larger, the degree of vacuum in the vacuum blood collection tube is maintained for a long period of time.
また、包装容器内に脱酸素剤を収納しておけば、採血管
の収納時に包装容器内を窒素雰囲気にしておかなくても
、保存時に包装容器内の酸素ガスは脱酸素剤に吸着除去
されて包装容器内が窒素ガス雰囲気となるだけでなく、
採血管内の酸素も管外へ侵出したのちに脱酸素剤に吸収
除去されるので、この点からも減圧採血管は長期間にわ
たって減圧度を維持できるのである。In addition, if an oxygen absorber is stored in the packaging container, the oxygen gas in the packaging container will be adsorbed and removed by the oxygen absorber during storage, without having to create a nitrogen atmosphere inside the packaging container when storing blood collection tubes. This not only creates a nitrogen gas atmosphere inside the packaging container, but also
Oxygen in the blood collection tube is also absorbed and removed by the oxygen scavenger after leaking out of the tube, so from this point of view as well, the reduced pressure blood collection tube can maintain a reduced pressure level for a long period of time.
第１図は本発明による減圧採血管の一例を示す断面図で
あり、また第２図は減圧採血管を密封容器に収納した状
態を示す斜視図であり、また、第３〜４図は減圧採血管
の使用状態を示す断面図である。
１・・・減圧採血管、２・・・管状容器、３・・・開目
端、４・・・栓部祠、 ５・・・内部空間、１１・・
・脱酸素剤、１２・・・密封容器。FIG. 1 is a sectional view showing an example of a reduced pressure blood collection tube according to the present invention, FIG. 2 is a perspective view showing the reduced pressure blood collection tube housed in a sealed container, and FIGS. FIG. 2 is a cross-sectional view showing how the blood collection tube is used. DESCRIPTION OF SYMBOLS 1... Decompression blood collection tube, 2... Tubular container, 3... Open end, 4... Stopper shrine, 5... Internal space, 11...
・Oxygen absorber, 12... sealed container.
Claims (1)
、該開口端を密閉した穿刺可能な栓部材とよりなり内部
空間の空気が減圧されてなる採血管と、該採血管を収納
した密封容器とよりなり、該密封容器内が窒素ガス雰囲
気に保たれてなる減圧採血管。A blood collection tube comprising a synthetic resin tubular member with one end closed and the other end open, and a punctureable stopper member with the open end sealed, and the air in the internal space is reduced in pressure, and the blood collection tube is housed. A vacuum blood collection tube consisting of a sealed container, the inside of which is maintained in a nitrogen gas atmosphere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1338379A JPH02189131A (en) | 1989-12-28 | 1989-12-28 | Pressure reducing blood collecting tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1338379A JPH02189131A (en) | 1989-12-28 | 1989-12-28 | Pressure reducing blood collecting tube |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57176231A Division JPS5967934A (en) | 1982-10-08 | 1982-10-08 | Vacuum blood sampling tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02189131A true JPH02189131A (en) | 1990-07-25 |
| JPH0347853B2 JPH0347853B2 (en) | 1991-07-22 |
Family
ID=18317599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1338379A Granted JPH02189131A (en) | 1989-12-28 | 1989-12-28 | Pressure reducing blood collecting tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02189131A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005304790A (en) * | 2004-04-21 | 2005-11-04 | Techno Medica Co Ltd | Blood collection kit |
-
1989
- 1989-12-28 JP JP1338379A patent/JPH02189131A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005304790A (en) * | 2004-04-21 | 2005-11-04 | Techno Medica Co Ltd | Blood collection kit |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0347853B2 (en) | 1991-07-22 |
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