JPH02232053A - Production of coated ampoule - Google Patents

Abstract

PURPOSE:To solve the problems, such as wounding of the fingers, etc., at the time of cutting a cutting part and intrusion of the fine powder of glass into an internal liquid, by applying a UV curing type resin compsn. to at least the cutting part of the glass ampoule, then irradiating the coated surface with UV rays to cure the resin. CONSTITUTION:A glass tube 3 is mounted to an aperture 2 of the easy-to-cut ampoule 1 subjected to an inspection. The rotation of the glass tube is transmitted as it is to the ampoule. The UV curing type resin compsn. is applied on the cutting part 4 while the glass tube 3 is rotated by a motor 6. The resin is thereafter irradiated with UV rays and is thereby cured. The ampoule coated with the resin film 5 in the cutting part is thus obtd.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a method for manufacturing an ampoule coated at least around the cut portion for filling an injection preparation or other ampoule preparation.

[Conventional technology]

Recently, percutaneous infections caused by accidental punctures with blood-contaminated needles have been considered the main cause of medical accidents involving medical workers, but infections from wounds caused by injuries during ampoule cutting are also considered to be a major cause. .

It is even said that with conventional ampoules, a considerable number of medical professionals have experienced injury to their fingers when cutting the ampoules.

There was also the problem that fine glass powder was mixed into the injection when the ampoule was cut.

JP-A-63-138987 proposes an ampoule that is covered with a heat-shrinkable film and then heated to shrink the film so that the ampoule is brought into close contact with the ampoule, but the method for covering the ampoule with the film is complicated. Therefore, there was a need for a method to cover the cut part of the ampoule with a simpler process. [Problems to be Solved by the Invention] The present invention solves the problems of injuring fingers, etc. when cutting the cut portion of a glass ampoule containing an injection preparation, etc., and the problem of glass fine powder getting mixed into the content liquid. The purpose is to provide a method to solve this problem. Furthermore, it is an object of the present invention to provide a method with good workability for achieving the above object.

[Means of problem solving]

The present invention is characterized in that after an ultraviolet curable resin composition is applied to at least the cut portion of a glass ampoule, the applied surface is irradiated with ultraviolet rays to be cured.

The ultraviolet curable resin composition used in the present invention may be any resin composition that cures upon irradiation with ultraviolet rays, and includes, for example, acrylic, polyene-polythiol, unsaturated polyester, and epoxy resin compositions. These compositions only need to contain as basic components a component that is cured by ultraviolet rays and a photoinitiator, and various other additives may be added.

The ampoule used in the present invention does not have a particular shape, and is preferably an easy-cut ampoule, a tungsten-cut ampoule, a one-point ampoule, or the like. The coating thickness is about 5 μm to 1000 μm, preferably 10 μm to 700 μm. If it is thinner than 5 μm, the effect of the resin coating will be insufficient and there is a possibility of injury. Moreover, if it is thicker than 1000 μm, cuttability will be impaired. The composition of the present invention only needs to be applied to at least the area to be cut to a predetermined thickness, and may or may not be applied to other areas.

The viscosity of the ultraviolet curable resin composition is not particularly limited;
0 cps to 100,000 cps, preferably 100 cps
s ~70,000 cps. If the viscosity is lower than 50 cps, a dripping phenomenon will occur, resulting in uneven application, resulting in 100,000 cps.
If it is higher, the coating operation becomes difficult.

When applying the composition of the present invention to a glass ampoule,
It can be applied by hand using a brush or dispenser, or by automatic equipment. In some cases, the ampoule may be immersed.

There are no particular restrictions on the ultraviolet light source, and examples include high-pressure mercury lamps, metal halide lamps, etc.
The amount of irradiation is appropriately determined depending on the type and blending ratio of the ultraviolet curable resin composition used.

[Effect]

In the present invention, since the cut portion of the glass ampoule is coated with an ultraviolet curable resin, it hardens while adhering closely to the glass surface, improving adhesion to the glass. In addition, the ultraviolet curable resin coating is highly elastic, and when the glass breaks, it covers the broken surface in an umbrella-like manner, so it has the advantage that even if your fingers touch the broken surface, you will not be injured.

Furthermore, since a fluidized ultraviolet curable resin composition is used, workability is good when applying to the force section 7 of the ampoule. Thereafter, simply by irradiating with ultraviolet rays, the cured coating adheres to the glass surface, making it possible to industrially easily manufacture safe coated ampoules.

〔effect〕

When using the ampoule manufactured by the method of the present invention, there is no risk of injury when breaking the bulge with one's fingers. Further, since the glass fine powder generated when opening the ampoule adheres to the cured coating, it is possible to prevent the glass fine powder from being mixed into the contents, and furthermore, it is possible to prevent damage during transportation.

〔Example〕

FIG. 1 shows a sectional view of an embodiment of the present invention. ■ is an easy-cut ampoule that has been inspected, and a glass tube 3 is attached to the opening 2. The rotation of the glass tube is directly transmitted to the ampoule. The ultraviolet curable resin composition was applied to the cant portion 4 while the glass tube 3 was rotated by the motor 6. The coating was applied using a brush to a thickness of approximately 150.t+m. Then, apply ultraviolet rays for 1 minute (approximately 5,000
mJ/co! ) The ampoule was irradiated and cured to produce an ampoule whose cant portion was covered with a resin coating 5.

Five types of ultraviolet curable resin compositions were used, each of which had the ingredients listed in Table 1 as its main ingredients. In addition, all resin amounts were shown in parts by weight.

All of the resulting coatings adhered tightly to the cut surfaces of the ampoules, and when cut, they were cut with almost the same resistance as uncoated ampoules, and even the fine glass powder did not fly off, eliminating anything that could cause injury.

[Margin below] [Brief explanation of the drawing]

The drawings show embodiments of the invention, and FIG. 1 is a cross-sectional view of an ampoule. In the drawings, reference numeral 1 indicates an easy-cut ampoule, 2 an opening, 3 a glass rod, 4 a cut portion, 5 an ultraviolet curable resin composition, and 6 a motor. Patent applicant Denka Pharmaceutical Co., Ltd. Denki Kagaku Kogyo Co., Ltd. Agent Patent attorney Sadako Suzuki

Claims (1)

[Claims] 1. A method for producing a coated ampoule, which comprises applying an ultraviolet curable resin composition to at least the cut portion of a glass ampoule, and then irradiating the applied surface with ultraviolet rays to cure it.