JPH0223967A - Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatite - Google Patents
Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatiteInfo
- Publication number
- JPH0223967A JPH0223967A JP63174812A JP17481288A JPH0223967A JP H0223967 A JPH0223967 A JP H0223967A JP 63174812 A JP63174812 A JP 63174812A JP 17481288 A JP17481288 A JP 17481288A JP H0223967 A JPH0223967 A JP H0223967A
- Authority
- JP
- Japan
- Prior art keywords
- tricalcium phosphate
- hydroxyapatite
- mixed
- acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 18
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 18
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 16
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 16
- 229940078499 tricalcium phosphate Drugs 0.000 title claims abstract description 16
- 229910000391 tricalcium phosphate Inorganic materials 0.000 title claims abstract description 16
- 235000019731 tricalcium phosphate Nutrition 0.000 title claims abstract description 16
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 13
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 239000002253 acid Substances 0.000 title claims abstract description 12
- 150000004676 glycans Chemical class 0.000 title claims abstract 5
- 210000000988 bone and bone Anatomy 0.000 title claims description 19
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000012620 biological material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract description 8
- 239000000843 powder Substances 0.000 abstract description 6
- 229920002307 Dextran Polymers 0.000 abstract description 4
- 239000012153 distilled water Substances 0.000 abstract description 4
- 239000007864 aqueous solution Substances 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 230000036571 hydration Effects 0.000 abstract description 3
- 238000006703 hydration reaction Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 230000002378 acidificating effect Effects 0.000 abstract description 2
- 239000003633 blood substitute Substances 0.000 abstract description 2
- 230000015271 coagulation Effects 0.000 abstract description 2
- 238000005345 coagulation Methods 0.000 abstract description 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 150000004804 polysaccharides Chemical class 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 239000002639 bone cement Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010067268 Post procedural infection Diseases 0.000 description 1
- 229920001284 acidic polysaccharide Polymers 0.000 description 1
- 150000004805 acidic polysaccharides Chemical class 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
（イ）産業上の利用分野
本発明のリン酸三カルシウムと酸と多糖類と水と水酸ア
パタイトを混合する事により硬化生成した材料は、医療
上利用される。すなわち、この材料を主に人工骨として
生体に移植し、骨の代用物として利用する。あるいは人
工材料（たとえば人工関節など）と骨とを接着させる骨
セメントとして利用する。DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The material hardened by mixing tricalcium phosphate, acid, polysaccharide, water and hydroxyapatite of the present invention is used medically. That is, this material is mainly transplanted into a living body as an artificial bone and used as a bone substitute. Alternatively, it can be used as bone cement to bond artificial materials (for example, artificial joints) and bone.
（ロ）従来の技術の欠点
従来の水酸アパタイトなどのセラミック材料による人工
骨は、焼成された物を生体に適合させていたが、これで
は形態付与が困難であり、また形成に時間がかかる。ま
た、粉末状あるいは顆粒状の水酸アパタイトなどを移植
した場合、生体内でこれらは散在してしまい希望する部
位に留まらないという欠点があった。また従来、人工関
節などを骨に接着する場合に用いられた骨セメントは−
１にＭＭＡレジンが用いられており、これは手術中のシ
ョックや術後感染などの生体為害性の指摘が多く、これ
に変わる良い材料が焦い、一方、リン酸三カルシウムは
従来より人工骨材料として利用されているがこれは速や
かに生体に吸収されてしまう欠点があった。また、特に
ａ型のリン酸三カルシウム粉末は酸性水溶液との混合、
あるいは水と混合後加熱によりリン酸へカルシウムある
いは水酸アパタイトへ転化し凝結硬化することが知られ
ているがこのリン酸三カルシウムの水和凝結のみの生成
物は脆弱で人工骨として利用するには不適当であった。(b) Disadvantages of conventional technology Conventional artificial bones made of ceramic materials such as hydroxyapatite were made by firing and making them compatible with living organisms, but this makes it difficult to give shape and takes time to form. . Furthermore, when powdered or granular hydroxyapatite is implanted, there is a drawback that it is scattered within the body and does not remain in the desired site. In addition, the bone cement traditionally used to bond artificial joints to bone is
1, MMA resin is used, and there are many indications that it is harmful to the body, such as shock during surgery and postoperative infection, and there is a need for a better material to replace it.On the other hand, tricalcium phosphate has been used for artificial bone. Although it is used as a material, it has the disadvantage that it is rapidly absorbed by living organisms. In particular, type A tricalcium phosphate powder can be mixed with an acidic aqueous solution,
Alternatively, it is known that by heating after mixing with water, phosphoric acid is converted into calcium or hydroxyapatite, which solidifies and hardens, but the product of only hydration and solidification of tricalcium phosphate is too fragile to be used as an artificial bone. was inappropriate.
（ハ）発明が解決しようとする問題点
本発明は上記の欠点を除くために発明されたものであり
、形態付与が容易で十分な強度を持ち。(c) Problems to be Solved by the Invention The present invention was invented to eliminate the above-mentioned drawbacks, and it is easy to form and has sufficient strength.
組織親和性に優れた材料であり１人工骨材料あるいは骨
セメントとして利用可能な材料である。It is a material with excellent tissue affinity and can be used as an artificial bone material or bone cement.
（ニ）問題点を解決するための手段と作用本発明は以前
私が出願した、特許ＷＡ ｒリン酸三カルシウムと酸と
多糖類と水を混合する事により硬化生成した人工骨ｊ
（特許出願番号６ｌ−２８８４９５）の発明に水酸アパ
タイトを加えたものである。すなわち１本発明の人工骨
の原材料は主にα型のリン酸三カルシウム粉末と酸と水
溶性多糖類と水と顆粒状水酸アパタイトである。これら
の適した混合比の混合により、ａ型リン酸三カルシウム
と酸と水による水和凝結を中心とした反応により材料は
硬化する。この場合、多ＩＩ類の存在が重要であり、多
糖類が存在することによりこの多糖類が骨格となり、凝
結物に十分な強度を与え１人工骨として使用に耐えつる
強度となる。また顆粒状あるいは粉末状の水酸アパタイ
トの添加は硬化した材料をより固くシ、吸収されにくく
するのに役立つ、この水酸アパタイトの混合比率は使用
目的に応じて加減し、また粒子の大きさも選択する。(d) Means and action for solving the problems The present invention is based on a patent I previously applied for: Artificial bone produced by hardening by mixing tricalcium phosphate, acid, polysaccharide, and water.
(Patent Application No. 6l-288495) to which hydroxyapatite is added. That is, the raw materials for the artificial bone of the present invention are mainly α-type tricalcium phosphate powder, acid, water-soluble polysaccharide, water, and granular hydroxyapatite. By mixing these at an appropriate mixing ratio, the material is hardened by a reaction centered on hydration and coagulation between the a-type tricalcium phosphate, acid, and water. In this case, the presence of polysaccharide II is important; the presence of the polysaccharide makes this polysaccharide a skeleton and provides sufficient strength to the aggregate, making it strong enough to withstand use as an artificial bone. Also, the addition of granular or powdered hydroxyapatite helps to make the hardened material harder and less likely to be absorbed.The mixing ratio of this hydroxyapatite can be adjusted depending on the purpose of use, and the size of the particles can also be adjusted. select.
本発明の混合物が硬化するまでに数秒から数分を要する
が、その硬化の過程で任意の形態に形成することが可能
である０本発明による人工骨は形態付与が容易で、手術
中に形成する事が可能であり、これは画期的な材料であ
る。この手術中の人工骨の形成により従来の方法に比し
て手術の簡素化と時間雉縮が可能となる。また、硬化し
た本材料は組Ｉｌ親和性に優れ人工骨として臨床応用す
るに十分なものと考えられる。Although it takes several seconds to several minutes for the mixture of the present invention to harden, it is possible to form it into any desired shape during the hardening process.The artificial bone according to the present invention can be easily shaped and formed during surgery. This is an innovative material. This formation of artificial bone during surgery makes it possible to simplify the surgery and shorten the time compared to conventional methods. Furthermore, the cured material has excellent affinity for group Il and is considered to be sufficient for clinical application as an artificial bone.
また１本発明の材料を人工関節などの人工生体材料と骨
との結合を目的として骨セメントとして利用した場合、
術中骨内で本材料を硬化させる事により人工生体材料と
骨との十分な接着性が得られるが、従来の物に比して組
織親和性に優れた材料となる。In addition, when the material of the present invention is used as a bone cement for the purpose of bonding an artificial biomaterial such as an artificial joint with bone,
By hardening this material within the bone during surgery, sufficient adhesion between the artificial biomaterial and the bone can be obtained, and the material has superior tissue affinity compared to conventional materials.
（ホ）実施例
実施例の一部を示すと、原材料は（ｌｅａ型リシリン酸
三カルシウム粉末２）酸として生体内で代謝される有機
酸の一つであるグリコール酸、（３）水溶性多糖類とし
ては、血液代用製剤として臨床上実際生体に応用されて
いるデキストラン、陣）蒸留水、（５）顆粒状あるいは
粉末状の水酸アパタイト、を用い以上（１）〜（５）の
５者を適した混合比で混合することにより材料は数分で
凝結硬化する。実際混合する場合、まず、（２）グリコ
ール酸と（４）蒸留水を混合し、これに（３）デキスト
ランを加える。これらの混合比は重哩比で （２）：
（３１： （４）＝６：２５：１４が望ましい、こ
の混合された酸性の多糖類の水溶液に（＋）ａ型リン酸
三カルシウム粉末を加えると水和凝結反応が起き混合物
は固い硬化物となる。この時（１）リン酸三カルシウム
と（５）水酸アパタイトを混合して反応させると水酸ア
パタイトが凝結硬化物内に混入され、硬化物がより固く
なり、また吸収されにくくなる。(e) Example To show a part of the example, the raw materials are (lea type tricalcium ricylate powder 2) glycolic acid, which is one of the organic acids that is metabolized in the living body as an acid, (3) water-soluble polyester. As sugars, dextran, which is clinically applied to living organisms as a blood substitute, (5) distilled water, and (5) granular or powdered hydroxyapatite are used. By mixing them in the appropriate ratio, the material will solidify and harden in a few minutes. When actually mixing, first, (2) glycolic acid and (4) distilled water are mixed, and (3) dextran is added to this. The mixing ratio of these is the weight ratio (2):
(31: (4) = 6:25:14 is desirable. When (+) type A tricalcium phosphate powder is added to this mixed aqueous solution of acidic polysaccharides, a hydration-condensation reaction occurs and the mixture becomes a hard hardened product. At this time, when (1) tricalcium phosphate and (5) hydroxyapatite are mixed and reacted, hydroxyapatite will be mixed into the solidified and cured product, making the cured product harder and difficult to absorb. .
本発明で使用する酸は他のいかなる酸でも構わないが、
為害件の無いもの特に生体内で代謝される有機酸などが
望ましい、また、多糖類もいかなるものでも構わない、
また各混合比も場合に応じた混合比を選択すればよい。The acid used in the present invention may be any other acid, but
Non-hazardous substances, especially organic acids that can be metabolized within the body, are preferable, and any polysaccharides are acceptable.
Further, each mixing ratio may be selected depending on the situation.
４、図の簡単な説明
第１図は本発明により生成した人工骨断面の予想模式拡
大図である。4. Brief Description of the Figures Figure 1 is a schematic enlarged view of a cross section of an artificial bone produced according to the present invention.
図面番号ｌは水酸アパタイト顆粒、２は多糖類３はリン
酸三カルシウムが水和凝結してリン酸へカルシウムある
いは水酸アパタイトに転化したものである。Drawing number 1 is hydroxyapatite granules, 2 is polysaccharide 3, and tricalcium phosphate is hydrated and condensed to convert into phosphoric acid or calcium or hydroxyapatite.
Claims (1)
（ハイドロキシアパタイト）を混合することにより、混
合物は凝結硬化する。この方法により硬化生成した材料
の人工骨あるいはその他の生体材料としての利用By mixing tricalcium phosphate, acid, polysaccharide, water, and hydroxyapatite, the mixture solidifies and hardens. Use of the material hardened by this method as artificial bone or other biomaterials
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63174812A JPH0223967A (en) | 1988-07-13 | 1988-07-13 | Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63174812A JPH0223967A (en) | 1988-07-13 | 1988-07-13 | Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0223967A true JPH0223967A (en) | 1990-01-26 |
Family
ID=15985099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63174812A Pending JPH0223967A (en) | 1988-07-13 | 1988-07-13 | Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatite |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0223967A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07102224B2 (en) * | 1990-10-26 | 1995-11-08 | サントル ナショナル ド ラ ルシェルシュ シアンティフィク（セ．エヌ．エル．エス．） | Biodegradable implantable material and method of making same |
-
1988
- 1988-07-13 JP JP63174812A patent/JPH0223967A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07102224B2 (en) * | 1990-10-26 | 1995-11-08 | サントル ナショナル ド ラ ルシェルシュ シアンティフィク（セ．エヌ．エル．エス．） | Biodegradable implantable material and method of making same |
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