JPH022852B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a novel hair growth promoting hair nourishment, which is safe and does not cause skin irritation. Conventionally, various compounds and extracts of crude drugs have been used to promote hair growth, but few of them have shown significant effects, and those that have some effect have been found to be effective enough to cause dermatitis. Although there were drawbacks such as strong irritation and difficulty in continuous use, the inventors of the present invention obtained the present invention without such drawbacks as a result of various experimental studies. The present invention is based on the structural formula Cinnamon alcohol denoted by. However, R ₁ is a cinnamic alcohol ester represented by an alkyl group, such as a monocarboxylic acid ester of cinnamic alcohol such as cinnamyl stearate, or a dicarboxylic acid ester of cinnamic alcohol such as (mono-di)cinnamyl adipic acid ester. . Cinnamic acid indicated by. However, R ₂ is a triterpene residue, a steroid residue, or a cinnamic acid ester represented by an alcohol, such as a cyclic alcohol ester of cinnamic acid such as cinnamic acid-β-sitosterol ester, or a cinnamic acid ester such as cinnamic acid cholesterol ester. aliphatic alcohol. It contains at least one of the following. The content of one or more of cinnamic alcohol, cinnamic alcohol esters, cinnamic acid, and cinnamic acid esters contained as active ingredients in the hair growth promoting hair nourishment according to the present invention is 0.1 to 5.0% by weight, preferably 0.5%. ~2.0% by weight, and examples of cinnamic alcohol esters include those obtained by completing esterification by using monocarboxylic acid and dicarboxylic acid chloride with pyridine as a catalyst and adding cinnamic alcohol; For example, it is obtained by completing esterification using cinnamic acid chloride, using pyridine as a catalyst, and adding a cyclic alcohol and an aliphatic alcohol. The hair growth-promoting hair tonic containing one or more of cinnamic alcohol, cinnamic alcohol ester, cinnamic acid, and cinnamic acid ester, which is applied to the present invention, is used by the method of measuring hair growth in mice as shown in Table 1 below. That is, in either Test Method 1 or the method for measuring hair growth density in mice shown in Table 2, that is Test Method 2, remarkable effects were shown compared to other hair growth promoting and hair nourishing substances. There is. This is the result of cinnamic alcohol, cinnamic alcohol esters, cinnamic acid, and a mixture of two or more of cinnamic acid esters stimulating the hair roots, increasing blood circulation in the hair roots, and improving metabolism. Brief explanation of test method 1 Using 7-week-old DDY mice, one group was divided into 10
2.0cm x 2.0cm on the back of each group.
Create two areas with the size of the hair removed, and apply 0.5 to 2.0 g of the specimen to one area, and apply ethanol to the other area. On the 13th and 18th day after application, the hair that has grown is pulled out from each area and the length of the hair is measured. (The number of hairs measured was 10.) Brief explanation of test method 2 Using 7-week-old DDY mice, one group was divided into 10 hairs.
Make 3 groups of 2.0cm x 2.0cm on their backs.
Apply 0.2 to 5.0 g of the sample to the area where the hair has been removed, and on the 7th, 9th, and 13th day, measure the density of hair growth in the area using a colorimeter to control the whiteness increase. Compare with.

【table】

[Table] Concentrations of each material applied in Tables 1 and 2: Vitamin E: 2%, Menthol: 2%, Estradiol: 2%, Ferulic acid: 2%, Cinnamon alcohol: 2%, Cinnamon alcohol stearate: 2%, cinnamic acid: 2%, cinnamic acid β-sitosterol ester: 2%, and ethanol concentration: 95%. Next, an example of a clinical trial is shown. A 2% by weight ethanol solution of cinnamon alcohol was used as a sample. Three times a day (1 After applying 3 to 5 g of hair at a time, women developed short hair growth at the hair loss site after about 3 months, and black terminal hair appeared after 6 months. In men, short hairs appear on the bald area on the top of the head after 3 months, turning into brown-black terminal hair after 6 months, and short hairs appear on the bald area on the side of the head after 3 months, and short white hairs appear on the side of the head after 3 months. It became soft hair. No skin damage was observed after continuous application for 6 months. A prescription example is shown next. The blending ratio is in parts by weight. Example 1 Cinnamon alcohol 2.0 Menthol 0.5 95% ethanol 60.0 Purified water 37.8 Manufacturing method Dissolve cinnamon alcohol and menthol in 95% ethanol, then add purified water to manufacture. Example 2 Hair cream Cinnamon alcohol (stearate ester) 2.0 Vaseline 7.0 Beeswax 8.0 Crystrol 37.0 Emulsifier 5.5 Purified water 40.5 Manufacturing method Cinnamon alcohol, petrolatum, beeswax, Crystol, and emulsifier are mixed and dissolved at 80℃, and then at 80℃
Gradually add purified water to the oil phase to make it creamy. Example 3 Ointment Cinnamic acid (β-sitosterol ester) 2.0 IPM 10.0 Setanol 2.0 Paraffin wax 6.0 Microcrystalline wax 10.0 Emulsifier 11.0 Distilled water 59.0 Manufacturing method Cinnamic acid, IPM, Setanol, Paraffin wax,
Microcrystalline wax and emulsifier are melted by heating to 80℃ to make them homogeneous, add separately heated distilled water, and continue stirring occasionally until cooled and solidified.

Claims (1)

[Claims] 1. A hair growth-promoting hair tonic containing at least one selected from cinnamic alcohol, cinnamic alcohol esters, cinnamic acid, and cinnamic acid esters.