JPH02287152A - Biochemical analyzing device - Google Patents

Abstract

PURPOSE:To eliminate the need for the heaters in a temp. control chamber, to prevent danger and to reduce electric power consumption by disposing heaters to the lower members and upper members of an incubator and heating both end parts to the temp. higher than in a central part to uniformly maintain the internal temp. CONSTITUTION:The heaters 32d to 32g are vertically provided near both ends in the lateral direction of the downward pendent parts on both sides of the channel of the lower member 32 of the incubator 30 and further, temp. sensors 32h, 32i are provided. Heater currents are so controlled that the sensors register the specified temp. The heaters 31a to 31c and a temp. sensor 31d are provided laterally in the upper member 31 of the incubator 30 and the heater currents are so controlled that the sensor registers the specified temp. The heaters 32d to 32g are provided at both ends of the member 32 in such a manner to compen sate the difference in the outflow of the heat between the central part and both end parts. The need for the heaters to maintain the temp. in the temp. control chamber constant is eliminated in this way, by which the danger is prevented and the electric power consumption is reduced.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention relates to a chemical analysis slide containing a reagent that causes a change in optical density through a chemical reaction with a predetermined biochemical substance contained in a sample liquid such as blood or urine. The present invention relates to a biochemical analyzer that determines the concentration of a predetermined biochemical substance in a sample liquid by spotting the sample liquid on a slide and measuring the optical density of the chemical analysis slide.

(Prior Art) Analyzing specific chemical components in a sample liquid qualitatively or quantitatively is a commonly performed operation in various industrial fields. In particular, quantitative analysis of chemical components or formed components in biological body fluids such as blood and urine is extremely important in the field of clinical biochemistry.

In recent years, dry-type chemical analysis slides have been developed that can quantitatively analyze specific chemical components or formed components contained in a sample solution by simply applying small droplets of the sample solution (Tokuko Sho). No. 53-21877 (US 399
2158), JP-A No. 55-184356 (US
4292272) etc.) have been put into practical use.

Using this chemical analysis slide, it is possible to analyze sample liquids more easily and quickly than the conventional wet analysis method, so it is especially useful for medical institutions and research institutions that need to analyze a large number of sample liquids. This is preferable in some places.

To perform quantitative analysis of chemical components in a sample solution using such a chemical analysis slide, the sample solution is spotted on the chemical analysis slide and then kept in an incubator for a predetermined period of time. A color reaction (pigment formation reaction) is caused by maintaining the temperature at constant temperature (incubation), and then measurement irradiation light containing a wavelength pre-selected by the combination of the predetermined biochemical substance in the sample solution and the reagent contained in the chemical analysis slide is applied. is irradiated onto this chemical analysis slide to measure its optical density, and from this optical density, a calibration curve representing the correspondence between the predetermined optical density and the substance concentration of a predetermined biochemical substance is used to calculate the sample solution. A biochemical analyzer configured to determine the substance concentration of a predetermined biochemical substance in the biochemical substance is used.

In this biochemical analyzer, as an incubator for keeping chemical analysis slides at constant temperature, it is necessary to keep a large number of chemical analysis slides at constant temperature at the same time. The direction in which these many storage rooms are lined up (
Hereinafter, this may be referred to as a "predetermined direction." ) may be used.

On the other hand, if the internal temperature of the incubator changes, the rate of progress of the color reaction between the reagent on the chemical analysis slide and the sample solution will change drastically, and the final concentration of the substance determined will include a fairly large error. Therefore, it is necessary to control the internal temperature of the incubator quite strictly, such as controlling the internal temperature to always maintain it at 37.0° C.±0.2° C., for example.

However, if the incubator extends in a predetermined direction as described above, it is very difficult to maintain a uniform internal temperature. At the same time, the incubator itself was placed inside a temperature-controlled chamber, and the temperature inside this temperature-controlled chamber was further controlled (e.g., 33°C).
(See Publication No. 42451). By using this dual temperature control method, the incubator is not directly affected by changes in outside temperature, etc., and the temperature inside the incubator can be stably controlled.

(Problem to be Solved by the Invention) However, when the above-mentioned double temperature control method is adopted, the internal volume of the incubator is quite large because the entire incubator is placed inside the temperature control chamber, and therefore the temperature within the temperature control chamber is maintained at a predetermined temperature (
For example, in order to maintain the temperature at 33℃, it is necessary to install a fairly large heater such as 70W, and in order to maintain the temperature inside the temperature-controlled room at 33℃, the temperature of the heater itself must be 70℃~
The temperature rises to 80℃. For this reason, if a chemical analysis slide, for example, were dropped near the heater, there was a risk that an accident would occur, such as the chemical analysis slide being considerably deformed. There was also the risk that one's hands would come into contact with the heater in order to pick up the chemical analysis slides and other small items. Further, even if such a risk can be prevented by, for example, devising a cover or the like, there is a problem in that the power consumption of the device is large.

In view of the above-mentioned circumstances, the present invention eliminates the double temperature control system accompanied by the above-mentioned problems, and maintains the inside of an incubator extending in a predetermined direction at a uniform predetermined temperature, thereby reducing the above-mentioned risks and power consumption. The purpose is to provide a biochemical analyzer.

(Means for Solving the Problems) The biochemical analyzer of the present invention detects a predetermined biochemical substance in the sample liquid by measuring the optical density of a chemical analysis slide on which the sample liquid is spotted on the reagent layer. A biochemical analyzer that determines the concentration of a substance includes a lower member having a number of storage chambers arranged in a row in which a number of chemical analysis slides are stored one by one in the upper part, and an upper member that covers the number of storage chambers from above. The present invention is characterized in that it has an incubator having a member, and is configured so that the temperature inside the incubator is made uniform by heating both ends of the incubator rather than the center.

(Function) The incubator moves in a specified direction (the direction in which many storage chambers are lined up)
If it extends for a long time, the temperature at both ends tends to be lower than that at the center.

In the biochemical analyzer of the present invention, both ends of the incubator are heated more than the center, so the temperature difference between the center and both ends is eliminated, and the incubator does not need to be placed in a temperature-controlled room. The internal temperature of the incubator can be maintained uniformly, so there is no need for a heater to maintain a constant temperature inside the temperature-controlled room, and dangers caused by the heater can be prevented.
Power consumption is reduced and the structure of the device can be simplified.

(Embodiments) Hereinafter, preferred embodiments of the present invention will be described based on the drawings.

FIG. 1 is a perspective view showing the appearance of a chemical analysis apparatus according to an embodiment of the present invention.

An incubator, slide transport means, slide insertion means, etc. are arranged inside the main body 10 and covered with a cover 11. The outside of this biochemical analyzer includes a display section 13 for displaying measurement data, etc., a delivery port 12 for sending out a sheet on which the displayed data is printed out, and operation keys 14 for operating this display, etc.
is provided.

Furthermore, a slide guide 15a for holding unused chemical analysis slides is formed in the slide special section 15 on the right side, and a plurality of unused chemical analysis slides are usually held in a stacked manner on this slide guide 15a. . Note that a cartridge storing and holding a plurality of stacked chemical analysis slides may be attached to this slide guide 15a. A spotting means 20 for spotting a predetermined sample liquid onto the reagent layer of the chemical analysis slide is disposed on the back side of the slide special section 15. The spotting means 20 includes a spotting arm 21 that projects forward and rotates up and down around its rear end, and a spotting pipette 22 that extends downward from the front end of the spotting arm 21.
and an operation button 2 for vertically moving the spotting arm 21 and aspirating and spotting the sample liquid into the spotting pipette 22.
It consists of 3. When spotting is performed using this spotting means 20, by operating the operation button 23, the spotting arm 21 is rotated upward to lift the spotting pipette 22, and the sample liquid in the container is transferred to the spotting pipette 22. A predetermined amount of sample liquid is drawn into the spotting pipette 22 by contacting the tip, and then the spotting arm 21 is rotated downward again to remove the reagent layer of the chemical analysis slide from the spotting pipette 22 below. Spot a predetermined amount of sample solution on top.

FIG. 2 is a plan view showing the main parts of the biochemical analyzer shown in FIG. 1 with the cover removed, and FIG. 3 is a plan view showing the main parts of the biochemical analyzer shown in FIG.
FIG. 1 is a sectional view taken along line 1; The internal structure of this biochemical analyzer will be explained below with reference to both figures.

Inside this biochemical analyzer, there is an incubator 30 for maintaining a constant temperature of the chemical analysis slide 1 onto which a sample liquid is applied by the above-mentioned spotting means 20, and a coloring degree ( A measuring means 40 for measuring the optical reflection density) is arranged, and a chemical analysis slide 1
A slide transfer means 81 (not shown in FIG. 2; see FIG. 6 described later) transports the chemical analysis slide 1 from the slide special equipment section 15 to the slide supply section 26, and a storage chamber 33 of the incubator 30 to transfer the chemical analysis slide 1 from the slide supply section 26 to the slide supply section 26. slide transport means 50 for transporting the slide to the position and slide insertion means 70 for inserting the transported chemical analysis slide 1 into the storage chamber 33 of the incubator 30 (not shown in FIG. 2).
have. In addition to the above means, battery 1
B, a printed wiring board 17 for a control circuit, a light source 18a for the measuring means 40, a magnetic disk drive mechanism 18b, etc. are arranged, but detailed explanation thereof will be omitted. Also,
In the following description, the direction indicated by arrow F will be referred to as the front, the direction indicated by arrow R will be referred to as rear, and the right and left sides in FIG. 2 will be referred to as right and left, respectively.

The incubator 30 is arranged to extend in the left-right direction, and has a plurality of storage chambers 33, 33. ...33 are formed side by side in the left and right direction. These storage rooms 33.3
3, . . . 33 each have an inlet opening and an outlet opening, the inlet openings are formed side by side at the rear of the storage chamber 33, and the outlet openings are formed at the front of the storage chamber 33 side by side from side to side. . Chemical analysis slide 1 goes from the entrance opening to storage room 3
3, the chemical analysis slide 1 is configured to be inserted into the slide 1 and ejected from the exit opening;
is a defect box 80 installed on the front side of the incubator 30
will be disposed of within The storage chamber 33 also includes a lower member 3z on which the chemical analysis slide 1 is placed, and an upper member 3 that presses down the chemical analysis slide 1 placed on the lower member 32 from above.
1, and the chemical analysis slide is kept at a constant temperature by both members 31 and 32.

The lower member 32 has a slide sliding surface 32a that is flush with the floor surface of the multiple storage chambers 33 and extends behind the entrance opening and toward the slide supply section 2B. As described later,
The chemical analysis slide 1 is transported by sliding on this slide sliding surface 32a and is stored in the storage chamber 33. Also,
The lower member 32 has a long groove 32b extending in the left-right direction, into which a measuring head 41 of a measuring means 40 for measuring the optical reflection density of a chemical analysis slide stored in the storage chamber 33 is inserted. Opening 3 for measuring optical reflection density by measuring head 41 in the lower part of storage chamber 33
It has 2c.

The measurement head 41 has a holding base 42 that holds it.
A wire 44 fixed to the holding table 42 is connected to a drive motor 45.
By being pulled by the guide rods 43a, 4
3b to move left and right within the long groove 32b,
The optical reflection density of the chemical analysis slide 1 stored in the storage chamber 83 is measured. The measurement head 41 also moves below the two density reference plates 2a, 2b and measures the optical reflection density of these density reference plates 2a, 2b for calibration. Furthermore, this a+ constant head 41 also moves below the transfer chamber 19, and the chemical analysis slide 1, which is waiting in the slide special equipment section 15, is delivered to the slide supply section-26 by a slide transfer means 81 (FIG. 6), which will be described later. During the transfer, the optical reflection density (fog) of the chemical analysis slide 1 is determined to be 11N. In addition, chemical analysis slide 1 is slide special part 15.
A barcode reader 25 is provided at the lower part of the transfer route from the slide to the slide supply section 2B, and when the chemical analysis slide 1 passes there, the chemical information written on the mount of the chemical analysis slide 1 is displayed. A bar code indicating the type of reagent, lot number, etc. on the analysis slide 1 is read.

A slide conveying means 50 is provided behind the incubator 30 and the measuring means 40. The slide conveying means 50 includes a conveying section 51 that holds and conveys the chemical analysis slide 1 in a state where the chemical analysis slide 1 is placed on the slide sliding surface 32a. Slide the chemical analysis slide 1 on the sliding surface 32
It is transported to the rear position of the entrance opening of the storage chamber 33 while sliding on the upper surface of the storage chamber 33. The conveyance section 51 includes a holding table 5 that holds the conveyance section 51.
2 is guided by guide rods 53a and 53b and moves left and right on the slide surface 32a as a wire 54 fixed to the holding base 52 is pulled by a pulse motor 58 as a drive motor.

FIG. 4 is a front view of the incubator showing the arrangement of heaters for maintaining constant temperature inside the incubator.

The arrangement of the heaters in the incubator will be explained using FIGS. 2, 3, and 4.

Heaters 32d, 3Ze:32L32g are arranged vertically near both ends in the left-right direction of a portion of the lower member 32 of the incubator 30 that hangs downward across the groove 32b (see FIG. 3). A temperature sensor 32h is arranged further to the left of the heater 32d (further to the left end of the incubator 30), and the currents of the left heaters 32d and 32e are controlled so that the temperature sensor 32h always indicates a constant temperature.

A temperature sensor 32i is arranged further to the right of the heater 32 (further to the right end of the incubator 30),
The currents of the right heaters 321' and 32g are controlled so that the temperature sensor 32i always indicates a constant temperature.

Three heaters 3 are installed in the upper member 31 of the incubator 30.
1a, 31b, and 31c are arranged horizontally. Further, a temperature sensor 31d is arranged to the left of the heater 31a.

These heaters 31a, 31b, and 31c are for heating the incubator 30 almost uniformly from above.
Therefore, these three heaters 31a, 31b, 3
Instead of 1e, one heater with a large area may be arranged over the entire surface. The currents flowing through these shutters 31a, 31b, and 3Lc are controlled so that the temperature sensor 31d always indicates a constant temperature.

FIG. 5 shows that after a predetermined period of time has elapsed after cutting off the current to all heaters while keeping the incubator 30 at a constant temperature.
FIG. 3 is a diagram showing an example of the temperature distribution in the left and right direction inside the incubator.

The temperature at both left and right ends of the incubator 30 is lower than that at the center. In this way, the heat flows out from the ends more intensely, so the lower member 32 is equipped with heaters 3 at both ends.
2d to 321 are arranged to compensate for the difference in heat outflow between the center and both ends, thereby maintaining the inside of the incubator 30 at a uniform temperature.

FIG. 6 shows chemical analysis slides 1 stacked and waiting in the slide special equipment section 15 one by one at the slide supply section 2.
6 is a diagram showing slide transfer means 81 for transferring up to 6. Here, it is expressed that the chemical analysis slide 1 is transferred from upstream to downstream, and the slide special equipment section 15 side is called the upstream side, and the slide supply section 2B side is called the downstream side.

The slide transfer means 81 includes a main body block 82, a transfer arm 84 rotatably supported by the main body block 82 via a pin 83, and a permanent magnet 85 fixed to the main body block 82. The main body block 82 is driven by a drive means (not shown) to the transfer means special equipment section 8 located on the most upstream side.
The chemical analysis slide 1 is reciprocated along the transfer path 3 in the vicinity of the transfer path 3 along which the chemical analysis slide 1 is transferred between the slide supply section 26 located at the most downstream side. The transfer arm 84 is at a transfer position where the front end 84a protrudes into the transfer path 3, as shown in the transfer means special mechanism section 87 and the slide supply section 26, and at a transfer position where the front end 84a protrudes into the transfer path 3, as shown in the slide special mechanism section 15. pin 8
3 from the transfer position to the downstream side, the transfer path 3 is rotated between the retracted position and the retracted position.

Permanent magnet 85 is for holding transfer arm 84 in the transfer position. In addition, the transfer means special unit 87 has a pin 8.
6 is provided. This pin 8B is connected to the main body block 8
2 moves from the slide supply section 2B to the transfer means special section 87 via the slide special section 15, and just before it stops, the rear end portion 84 of the transfer arm 84 is in the retracted position.
b to rotate the transfer arm 84 from the retracted position to the transfer position.

When the main body block 82 moves from the transfer means special mechanism part 87 to the slide special mechanism part 15 to the slide supply part 26, the transfer arm 84 in the transfer position moves to the slide special mechanism part 1.
The slide supply unit 26 pushes out the lowest chemical analysis slide among the chemical analysis slides 1 stacked on the slide 5.
Transfer to.

Further, when the main body block 82 is moved from the slide supply section 26 to the moving means special device section 87 via the slide special device section 15, the transfer arm 84 in the transfer position is attached to the slide special device section 15 as shown by the dashed line. As such, it comes into contact with the chemical analysis slide 1 in the slide special section 15 and retreats to the retracted position against the force of the permanent magnet 85, and then returns to the retracted position from the retracted position by contacting the pin 86.

The chemical analysis slides 1 stacked in the slide special equipment section 15 in this way are sequentially transferred one by one to the slide supply section 2B, and then moved to the slide supply section 26 and waiting at the transfer section 51 of the slide transfer means 50. The uke is passed on. As described above, the slide conveying means 50 slides the chemical analysis slide 1 passed onto the slide sliding surface 32a shown in FIGS. Transfer to a position behind the inlet opening.

FIG. 7A is a plan view of the conveying section 51 of the slide conveying means 50, and FIG. 7B is a cross-sectional view taken along the line -■ in FIG. 7A.

The transport section 51 is equipped with a slide clamping piece 55 that clamps the chemical analysis slide 1, an ejection lever 56 that is movable back and forth, and an insertion lever 57 that is also movable back and forth. . The slide clamping piece 55 is received so as to rest on the slide sliding surface 32a as shown in FIG. 7B, and the slide holding piece 55 is held so as to ride on the slide sliding surface 32a. The analysis slide 1 is placed and held on the slide sliding surface 32a. Also, the front of this slide clamping piece 55 (No. 7A)
7B) is open so that the chemical analysis slide 1 can be inserted into the slide holding piece 55 and taken out from the slide holding piece 55. A slide insertion means 70 extending left and right is arranged at the upper part of this conveyance section 51, and when this slide insertion means 70 moves forward (to the left in FIGS. 7A and 7B), its tip 70a When moving backward, the insertion lever 57 is pushed forward with the rear end 70b. As described above, the insertion lever 57 is provided so as to be freely movable back and forth, and this transport section 51 holds the chemical analysis slide 1 between the slide holding pieces 55 and inserts it into the incubator 3.
After moving to the rear position of the entrance opening of each storage chamber 33 of 0, when the slide insertion means 70 moves forward, it is pushed by the slide insertion means 70 and the slide sliding surface 32
It moves forward while sliding on a, and by its tip 57a,
The chemical analysis slide 1 held by the slide holding pieces 55 is pushed forward and inserted into the storage chamber 33 from the entrance opening of the storage chamber 33. Along with this insertion, the chemical analysis slide 1 that was already stored in the storage chamber 33 is pushed by the front end of the newly inserted chemical analysis slide 1 and is ejected from the exit opening and placed in the epidemiology box 80. Will be scrapped. As the insertion means 70 moves backward, the insertion lever 57 is moved as shown in FIG.
Move backward to the original position shown in Figure B. However, if this continues, the final chemical analysis slide 1 will not be ejected. Therefore, an ejection lever 5 is provided in the conveying section 5I that extends to the same position as the front end of the chemical analysis slide 1 held by the slide holding pieces 55.
6 is provided, and this ejection lever 56 is connected to the storage chamber 33.
The conveyance section 51 is moved so as to be located opposite the entrance opening of the storage chamber 53, and in this state the slide insertion means 70 moves forward.At this time, the ejection lever 56 moves forward instead of the insertion lever 57 described above, and the storage chamber 53 It comes into contact with the rear end of the chemical analysis slide 1 housed in the chamber and pushes the chemical analysis slide 1 out of the exit opening. The ejection lever 56 is connected to the insertion lever 57.
As in the case of , it retreats as the slide insertion means 70 retreats.

As described above, the slide transport means 81 in the slide supply unit 26 supplies the chemical analysis slide 1 to the slide transport means 50 (see FIG. 6), and the slide transport means 50 supplies the chemical analysis slide 1 to the storage chamber 53. The transportation to the rear position of the opening and the insertion of the chemical analysis slide 1 into the storage chamber 33 by the slide insertion means 70 are both performed with the chemical analysis slide 1 placed on the slide sliding surface 32a.

FIG. 8A is a rear view of the slide conveyance means 50 seen from the rear.

The slide conveying means 50 includes the slide clamping piece 55 described above.
a conveying section 5 comprising an ejection lever 5B and an insertion lever 57;
1. Holding stand 52 that holds this conveyance unit 51; Holding stand 52
Guide rods 53a, 53 that guide the left and right movement of the
b, a pulse motor 58 provided on one end of the left and right sides of the incubator 30, a drive pulley 59 attached to the shaft 58a of the pulse motor 58, an idle pulley 60 provided on the other end of the left and right sides of the incubator 30, and an intermediate portion is fixed to the holding stand 52 and both ends thereof are fixed to the driving pulley 59, and is provided with a wire 54 connecting the holding stand 52, the driving pulley 59, and the idle pulley 60.

FIG. 8B is an enlarged plan view showing the vicinity of the drive pulley 59.

The wire 54 is wound so that the vicinity where it is fixed to the drive pulley 59 is aligned with the drive pulley 59 so that the holding table 52 can move left and right along the incubator 30 .

The idler pulley 60 is pulled to the left as shown in FIG. 8A by a spring 61, thereby preventing the wire 54 from loosening.

Although the slide conveying means 50 has the above-described configuration, it is assumed that, in very rare cases, it may stop operating normally while the chemical analysis slide 1 is being conveyed.

FIG. 9A and FIG. 9B are explanatory diagrams showing a typical example of the case where the device does not operate normally.

As shown in FIG. 9A, the chemical analysis slide 1, which has been held by the slide holding pieces 52 and transported to a position facing the entrance opening of the storage chamber 33, is incompletely placed inside the storage chamber 33 due to some abnormal cause. It is assumed that the transport unit 51 is inserted and starts moving in the direction of arrow B in that state. If such a situation occurs, the chemical analysis slide 1 will be caught between the slide holding piece 52 and the partition wall 33a of the storage chamber 33, and the pulse motor 58 will lose synchronization in this state.

When such a situation occurs in very rare cases, the operator removes the stuck chemical analysis slide 1 and restarts the measurement. However, when the lock state is reached, the wire 54 may end up overlapping the wire wound around the drive pulley 59, as shown in FIG. 9B. When such a situation occurs, since the position control of the transport unit 51 is performed by the number of pulses input to the pulse motor 58, an error occurs in the moving distance of the holding table 52 with respect to the number of rotations of the pulse motor, which is the cause. After removing the chemical analysis slide 1 and restarting the ΔIll determination, even when the transport unit 51 clamps the chemical analysis slide 1 on the slide clamping piece 52 and comes to the rear of the artificial opening of the storage chamber 33, it is slightly shifted from the entrance opening. This results in a situation where the chemical analysis slide 1 is not stored in the storage chamber 33 again.

Therefore, the wire 54 has the maximum traction force T, o (see FIG. 9A) exerted by the pulse motor 58 on the wire 54.
The relationship between the tension Te of the wire 54 due to the spring 61 is expressed as T
The force of the spring force or the current input to the pulse motor 58 is set so that o<Te.

By setting To<Te in this way, even if a locked state as shown in FIG. 9A occurs, the wire 54 will not run over as shown in FIG. 9B, and the chemical that caused the problem will be avoided. By removing analysis slide 1, the system operates normally thereafter.

Incidentally, the moving mechanism of the 1111J fixed means 40 (see FIG. 3) is also constructed almost in the same way as the moving mechanism of the slide conveying means 50.

(Effects of the Invention) As explained in detail above, in the biochemical analyzer of the present invention, both ends of the incubator are heated more than the center, so there is no need to adopt a dual temperature control method. The internal temperature of the incubator can be kept uniform at a predetermined temperature, danger can be prevented, power consumption can be reduced, and the structure of the device can be simplified.

[Brief explanation of the drawing]

1 is a perspective view showing the external appearance of a biochemical analyzer according to an embodiment of the present invention; FIG. 2 is a plan view showing the main parts of the biochemical analyzer shown in FIG. 1 with the cover removed; Figure 3 is a sectional view taken along arrow 1-1 in Figure 2, Figure 4 is a front view of the incubator showing the arrangement of heaters, and Figure 5 is a predetermined time elapsed after the heater inside the incubator was stopped. A diagram showing an example of the subsequent internal temperature distribution, FIG. 6 is a diagram showing the slide transfer means, and FIG. 7A is a diagram showing an example of the internal temperature distribution.
FIG. 7B is a sectional view taken along the line ■-■ in FIG. 7A; FIG. 8A is a rear view of the slide conveyance means; FIG. 8B is a
The enlarged plan view of the vicinity of the drive pulley, FIG. 9A, and FIG. 9B are diagrams showing a typical example of the case where the slide conveying means does not operate normally. 1...Chemical analysis slide 10...Main body 15...
Slide special unit 15a...Slide guide 20.
... Spotting means 25 ... Barcode reader 2
6...Slide supply unit 30...Incubator 31-...Upper member 31a, 31b, 31c
・-・Heater 31d...Temperature sensor 32...
・Lower member 32a...Slide sliding surface 32b...
Long groove 32c...openings 32d, 32e, 32f, 32g - heaters 32h, 3
21...Temperature sensor 33...Storage chamber 40...a
lljll settings 41...Measuring head 42...
・Holding bases 43a, 43b...Guide rod 44...Wire 50...Slide conveyance means 51...Transportation section 52...Holding base 5
3a, 53b...Guide rod 54...Wire 56...Ejection lever 58...Pulse motor 80...Disposal box 82...Main block 84...Transfer arm 87...Transfer means Special equipment section 55...Slide clamping piece 57...Insertion lever 70...Slide insertion means 81...Slide transfer means 83...Bin 85...Permanent magnet 86...Bin diagram Figure 7A Figure 78

Claims (1)

[Scope of Claims] A biochemical analyzer that determines the concentration of a predetermined biochemical substance in a sample solution by measuring the optical density of a chemical analysis slide on which a sample solution is spotted on a reagent layer, comprising: an incubator comprising a lower member having a plurality of storage chambers arranged in a row for storing a plurality of chemical analysis slides one by one, and an upper member that covers the plurality of storage chambers from above; 1. A biochemical analyzer characterized in that the temperature distribution inside the incubator is made uniform by heating both ends of the incubator more than the end portions of the incubator.