JPH0245408A - Skin-beautifying cosmetic - Google Patents

Abstract

PURPOSE:To provide a skin-beautifying cosmetic containing kojic acids and ascorbic acids, exhibiting excellent skin-beautifying and whitening effect compared with the separate use of the component by synergistic effect, effective in improving light-stability of kojic acid and having anti-suntan effect. CONSTITUTION:The objective cosmetic contains at least one kind of components selected from (A) a cosmetic compounded with kojic acid [5-oxy-2-oxymethyl-gamma- pyrone (C6H6O4)] or a kojic acid salt known as a component having bleaching and skin-whitening effect and (B) an ascorbic acid derivative such as ascorbic acid, ascorbic acid salt, ascorbic acid stearic acid ester, etc. The composition is further compounded with oils and fats, surfactant, perfumery, humectant, vitamins, etc., and used in the form of cream, milky lotion, face lotion, pack, sun-care, etc. The amounts of kojic acids and ascorbic acid are 0.002-14wt.% and 0.01-15wt.% based on the whole cosmetic, respectively.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention provides a method for combining kojic acid and ascorbic acid by blending ascorbic acid, an ascorbate salt, or an ascorbic acid derivative into a cosmetic product containing kojic acid or a kojate salt. This invention relates to a skin-lightening cosmetic that can enhance the skin-whitening effect through the synergistic effect of the following.

[Prior Art] Kojic acid is conventionally known as a component that has a bleaching and skin-whitening effect.
Added to packs, milky lotions, lotions, etc.
The effect has been achieved (Japanese Patent Publication No. 32-8100, Japanese Patent Application Laid-Open No. 53-3538, etc.).

Furthermore, ascorbic acid or ascorbate 1 ascorbic acid derivatives have been known for a long time as ingredients that have a skin-lightening effect. (What is your tendency? Vitamin, Volume 28, 50
1, 1963) [Problem to be Solved by the Invention J When kojic acid or kojic acid salts are blended into cosmetics, a skin whitening effect can be seen and it is effective in preventing spots and freckles.

However, using kojic acid or kojic acid salt alone has a weak skin-whitening effect, and even if the cream is applied daily, it takes more than a month for the effect to appear.

Like kojic acid, ascorbic acid, ascorbate salts, and ascorbic acid derivatives have a skin-lightening effect, but their skin-lightening effect is weaker than that of kojic acid, and there has been a desire for something with an even stronger skin-lightening effect.

As a result of intensive research to develop cosmetics with further superior skin whitening effects, the present inventors have discovered that ascorbic acid, ascorbate, or ascorbic acid derivatives are blended into cosmetic products containing kojic acid or kojic acid salts. The inventors have discovered that the synergistic effect of kojic acid and ascorbic acid can provide even higher skin whitening effects, and have completed the present invention.

That is, the present invention relates to a fair-skinned cosmetic containing kojic acid or a kojic acid salt and at least one selected from ascorbic acid, ascorbate and ascorbic acid derivatives.

The present invention will be explained in detail below.

Kojic acid applied to the present invention has a chemical name of 5-oxy-
2-year-old pheasant methyl-γ-pyrone (C@H@04) is obtained mainly by extraction or recrystallization from the fermentation liquid of microorganisms such as Aspergillus, but of course it can also be obtained by synthetic methods. It is also possible to use the

In the present invention, not only kojic acid but also kojic acid salts can be used.

Ascorbic acid, ascorbate, and ascorbic acid derivatives used in the present invention may be In, L-form, or racemic. As the ascorbate, sodium ascorbate and potassium ascorbate are generally used. However, ascorbic acid derivatives are not particularly specified as long as they have a reducing effect and have a skin-lightening effect.Ascorbic acid derivatives include fat-soluble ascorbic acid balmitic acid ester, ascorbic acid stearic acid ester, and ascorbic acid 2 As a stable derivative of .6 palmitate and ascorbic acid, magnesium ascorbic acid-3-phosphate, which has the OH group at the 3-position phosphoric acid esterified, is generally used, but it has a reducing effect and has been observed to have a fairing effect. There is no specific requirement as long as it is possible.

Next, the fairing cosmetics provided by the present invention include creams, milky lotions, lotions, powders, makeup bags, lip colors, and under makeup.

There are many things such as sun care.

The above-mentioned kojic acid, kojic acid salts and ascorbic acid, ascorbate salts, and ascorbic acid derivatives may be used in any combination;
It may be one type and one type, one type and many types, many types and one type, or many types and many types.The amounts of kojic acid and ascorbic acid to be blended are arbitrarily selected depending on the properties of the cosmetic. However, the amount of kojic acid or kojic acid salt is usually 0.002 to 14% by weight, preferably 0.002 to 14% by weight based on the total weight of the cosmetic.
．． The amount of ascorbic acid, ascorbate, and ascorbic acid derivatives is generally 0.0% by weight.
It ranges from 1 to 15% by weight, preferably from 0.3 to 5.0% by weight. When kojic acid, kojic acid salts, ascorbic acid, ascorbate salts, and ascorbic acid derivatives are blended within such specific ranges, a greater skin whitening effect can be obtained than when each is used alone.

In addition to general ingredients, the fair skin cosmetics according to the present invention include:
Additives commonly used in cosmetics, such as oils and fats, surfactants, antioxidants, fragrances, pigments, alcohols, preservatives, sunscreens, water, heat insulating agents, vitamins, etc., can be added. can.

[Example 1] The present invention will be illustrated below with reference to Examples, but the present invention is not limited to these Examples.

Example 1 (Cream) - Stearic acid 1.0% by weight - Stearyl alcohol 6.0 - Hydrogenated lanolin 5.0 - Octyldodecyl alcohol 10.0 - Propylene glycol
5.0 ・Kojic acid 0.5 ・Ascorbic acid stearate ester ・Purified water ・Fragrance ・Preservative Example 2 (emulsion) ・Stearic acid ・Cetanol ・Vaseline Liquid paraffin ・Polyoxyethylene monooleate ester triethanolamine polyethylene Glycol Sodium Kojinate Ascorbic Acid Purified Water Fragrance Example 3 (Lotion) ・95% Ethanol 1.0 65.5 Appropriate amount 2.5% by weight 1.5 5.0 1O90 10.0% by weight ・Glycerin/Propylene glycol・Polyoxyethylene hydrogenated castor oil ・Citric acid ・Sodium citrate ・Kojic acid ・Sodium ascorbate ・Purified water ・Fragrance example 4 (bag) ・Vinyl acetate resin emulsion ・Polyvinyl alcohol ・Olive oil ・Glycerin ・Zinc white ・Kaolin ・Ethanol/Kojic acid/Magnesium ascorbic acid phosphate 0.5/Purified water/Fragrance 45.5 Adequacy test 1 Kojic acid of the present invention. A synergistic effect test on the melanin suppressing effect of sodium ascorbate was conducted.

Sample A: Water B: Means 0.5mMfmmol/g. Same below) Kojic acid C: 0.5mM Sodium ascorbate D: 1. Om
M sodium ascorbate E: 0.5mM kojic acid +
0.5mM sodium ascorbate F: 0.5mM kojic acid +1. Add 1IR of Om&l sodium ascorbate L-tyrosine solution (0.3mg/m), 1° of Matsukulupein's buffer (pH 6,8) and 0.9J of the above sample, and place in a spectrophotometer [Hitachi U-3200]. It was kept at 37° C. and stirred in a spectrophotometer for 15 minutes.

While stirring at 37°C, add O,l-tyrosinase solution (0.2mg/'+nf) and take a time scan at 475nm to detect the red doperchrome (
The relationship between the amount of melanin pigment (precursor of melanin pigment) produced and time was determined. The results are shown in FIG.

Compared to sample A (water), samples B-H exhibited a melanin-suppressing effect. Sample B (0.5 mM kojic acid) had a stronger melanin suppressing effect than Sample C (0.5++ tl sodium ascorbate). Sample B linearly suppressed doper chromium formation. Samples C and D had a smaller suppressive effect than sample B, but the doper chromium production reaction stopped midway.

Comparing samples B and C with sample E, sample E is different from samples B and C.
It was found that doper chromium was suppressed more than any other method.For example, when looking at the time until doper chromium formation
Sample B took 5 minutes and sample CO took 10 minutes.

Similarly, when Samples B, D and Sample F were compared, the synergistic effect could be more clearly recognized. The time required for doper chrome formation was 85 minutes for sample and 2 minutes for sample D, while sample F took 15 minutes. Also.

Sample F not only had a strong doper chromium production suppressing effect, but also stopped the doper chromium production reaction at a lower position than sample F.

From the above, by mixing kojic acid and sodium ascorbate, the formation of doperchrome was suppressed more strongly than when each was used alone. Therefore, it can be seen that each of these products has superior whitening, three-skin whitening, and zero sun protection effects compared to each of them alone.

Exam 2 A skin whitening effect test of the cream was conducted.

Forty women were divided into four groups, A, B, C, and D, each with 10 women.

From Group A Example 1, tudic acid. A cream without ascorbic acid stearate was used and applied to the face daily for 60 days.

Group B A cream from Example 1 except ascorbic acid stearate was used and applied to the face every day for 60 days.

Group C A cream from Example 1 except for the kojic acid was applied to the face every day for 60 days.

Group D The cream of Example 1 was applied to the face daily for 60 days.

Thereafter, a sensory evaluation test was conducted using the method shown in Table 1.

Table 1 As shown in Table 2, the fair skin cosmetics according to the present invention are A, B
, Group C, the results are higher than all the scores. It combines the effects of both groups B and C, and was particularly effective on skin firmness and dark spots.

Table 2 Test 3 Kojic acid has the drawback that it is chemically unstable, and when exposed to light, it decomposes and becomes colored, resulting in a weakened whitening effect. However, the following tests revealed that the present invention, in addition to the skin-lightening effect, also makes kojic acid chemically stable.

The lotion obtained by removing sodium ascorbate from the lotion of Group A Example 3 was placed in a transparent bottle and exposed to direct sunlight for 3 days.

Group B The lotion of Example 3 was placed in a transparent bottle and exposed to direct sunlight for 3 days.

Coloring lotion due to light using a spectrophotometer, 450
It was measured by absorbance at nm. The results are shown in Table 3.

Table 3 As shown in Table 3, sodium ascorbate allows
It can be seen that kojic acid becomes chemically stable against light.

In other words, it has been found that the present invention not only enhances the skin whitening effect due to the synergistic effect, but also has the effect of stabilizing kojic acid against light.

[Brief explanation of the drawing]

FIG. 1 shows test results regarding the melanin suppressing effects of kojic acid and sodium ascorbate. Patent applicant f1401 Kansai Paint Co., Ltd. Figure 1 Measurement (亦)

Claims (1)

[Claims] 1. A fair-skinned cosmetic containing kojic acid or a kojic acid salt and at least one selected from ascorbic acid, ascorbate and ascorbic acid derivatives.