【発明の詳細な説明】[Detailed description of the invention]
（産業上の利用分野）
この発明は育毛養毛等美髪料に関し、より詳し
くは通常の食用植物であるアシタバ
（AugelicaKeiskei Koidz）を利用し、その地下
部を必ず含有する全草部の抽出物を主成分とし、
副作用を排して極めて安全性が高いとともに皮膚
ことに頭皮機能の賦活による養毛、白髪防止、抗
脱毛等の効果の高い育毛等美髪料の提供にある。
（従来の技術及びその欠点）
一般に、人は成人後加齢するに従い老化現象が
亢進し、この老化現象に伴う疎毛、脱毛、白髪の
問題が特に男性にとつて大きな悩みとなついる。
一方、近年生活全般におけるストレスの充満、
特に仕事の高度化及び煩雑化に伴う勤労者の過労
と一方における美食（高カロリー、高糖質食）に
原因して老化開始年齢が低下してきており、それ
によつてますます上記疎毛、脱毛、白髪などの問
題も低年齢化してきている。
最近は、学童、学生ら未成年者においてすら早
くも老化現象と考えられる症状を呈する者が多
く、実際に文部省の調査では体力のピークは17才
を頂上として下降する現状である。
特に、学童、学生らに際立つて特異現象として
美食（高カロリー、高糖質食）と添加物を含む加
工食品の多摂に原因する体脂肪増に伴う皮膚頭髪
の脆弱化という症状がある。
即ち、頭髪の脱落昂進や白髪に悩む男性の急増
であり、特にその年齢層の低い方への拡大であ
る。
従来から育毛養毛等頭髪保全の問題を解決する
為種々の化粧料組成物が開発されているが、その
作用機序は、その殆どが頭髪の生え際の皮膚特に
毛根を刺激し、毛根部とその周辺の血流を促進し
頭皮への栄養補給をはかるもの、又は保湿剤配合
により頭皮の乾燥を防ぎ育毛養毛等美髪問題を解
決せんとこころみるものであつた。
又、物理的に頭皮をブラシ等でたたいて刺激す
るのも同じ様な目的によるもので、又他に細胞賦
活を期待し或いは頭皮の炎症の予防の為の薬剤や
生薬成分を配合するのが一般的な方法であるが何
れも確たる効果を期待しうるものに非ず、その為
従来の育毛料にはそれぞれの目的に沿うように総
括的に数種の成分が配合されている。
例えばエタノール、女性ホルモン、ビタミン
B6、ビタミンＥ、パントテン酸、トウガラシチ
ンキ、シヨウキヨウチンキ、センブリエキス、ヒ
ノキチオール、セフアランチン、感光素、オード
キニン等が通常３種類以上混合されている。
現在のところ、上記２方法の併用を超えるすぐ
れた育毛、養毛方法は存在しない。
ところが、これら薬剤や生薬成分にあつてはそ
の効力が外用として明らかなものが少なく、その
結果従来の市販のものの外用による育毛効果は、
大方において期待されている実を挙げていない。
又、これら前記の各種成分は育毛料としての厚
生省承許可を取得するために配合前例あるものと
して安易に反復利用されてきた傾向もある。
更に、これらの従来の育毛養毛等化粧料は、配
合成分が複数有ることにより皮膚刺激効果による
過敏反応が表れやすく人によつてはかぶれの問題
が生じたり、炎症を生じたり頭皮、頭髪が乾燥し
すぎたりして却つて逆効果である等の欠点がある
場合もあつた。
（解決手段）
ところで、この発明者は従来から食用植物の研
究をすすめその過程でアシタバ（Angelica
eiskei Koidz）の地下部を必ず含有する全草部を
15〜80℃の温湯で抽出した抽出物を必須成分とす
る育毛養毛等美髪料が単味であつても優れた育
毛、養毛等の美髪効果をもつことを見いだすと同
時に配合成分数が少ない為もあり頭部のかぶれや
損傷がすくなく、従つて従来の欠点が解消できる
ことを見いだし、この発明に到達したものであ
る。
（発明の構成）
この発明に於いて使用するアシタバ
（Angelica KeigkeiKoidz）とは、通常食用に提
供されるセリ科の多年草で主として伊豆大島、八
丈島において生育し普通その葉茎部が食される。
この発明に於いては、前記アシタバ
（AngelicaKeiskei Koidz）の地下部を必ず含有
する全草部を用いる。
この発明においてアシタバ（Angelica
KeiskeiKoidz）の使用部位としては根部等の地
下部位を必ず使用することにより効果が大きくな
り望ましいという実験的知得も存する。
この地下部を必ず含有する全草部をこの発明に
係る育毛養毛等美髪料の必須成分とするには以下
に記す抽出法でエキス或いはエキス粉末を得る。
尚、抽出方法は次の例に限定されるものでは無
い。
まず地下部を必ず含有する全草部をよく洗浄し
細切し、約10倍量の温湯（15〜80℃）を加え、恒
温状態で一夜静置し濾過し濾液を得る。
これをそのまま、又は約1/10量に減圧等の方法
で濃縮し、この発明の必須成分として供する。
この発明で温湯を用いて抽出する理由は、フロ
クマリン等の皮膚への安全性に問題のある光感作
アルレゲン物質が温湯を用いて抽出を行なえば抽
出されることがないからである。
また、この温湯の温度は15〜80℃がよく、より
好ましくは40〜50℃が望ましい。
この理由は、80℃を越える熱水抽出では低沸点
の有効性物質が気化蒸散して効果が小さくなるか
らである。
反対に15℃以下の温湯での抽出は、有効成分が
抽出されず所期効果が期待できないからである。
従つて、40〜50℃の温湯で抽出した場合が最も
効率よく確実に有効成分のみを抽出することがで
きる。
このようにして得た抽出液又はその濃縮液或い
はその乾燥粉末は、一定量のリノール酸を用い一
定時間に一定量の空気を吹き込み、一定の熱をか
け続けた時に生じるリノール酸の過酸化物を抑制
する効果を、日本薬局方 dl―α―トコフエロー
ル（ビタミンＥ）と比較した場合、たとえばアシ
タバ葉茎部注出液（ビタミンＥと等量を予めリノ
ール酸に混合した場合）のリノール酸過酸化物抑
制率は、ビタミンＥの数倍に達する。
この事実は脱毛、白髪等発生要因の一つである
頭皮皮脂過酸化に対し有効性をもつものと推論で
きるが、この発明者からの今後の課題でもある。
また、この発明では根部等の地下部位を必ず使
用することにより効果が大きくなるという実験的
知得を存する。
この理由に関し、この発明者らは現在鋭意検討
中で解明は今後の重要課題であるが、アシタバ
（Angelica、Keiskei Koidz）の地下部の含有成
分と地上部の含有成分はことなり、特に地下部に
は地上部には微量しか含まれないビオチン、ビタ
ミンB12等の成分が豊富に含まれており、これら
の作用或いはこれらの相互作用により効果を示す
ものと推定される。
この発明でアシタバ（Angelica Keiskei
Koidz）の葉茎を含む濃縮液或いはその乾燥粉末
又は抽出物のヘアトニツクへの添加量は１％水溶
液として換算して３〜10w／ｖ％とするのが望ま
しい。
その理由は、3w／ｖ％未満では充分この発明
の効果が奏せず、又逆に10w／ｖ％を越えて配合
してもその効果は10w／ｖ％配合物に比して大き
く効果が増大しないということに基づく。
また、この発明においてはアシタバ
（Angelica Keigkei Koidz）の養毛育毛効果を
増大させるために他にいずれか配合成分を混合し
てもよい。
この配合物としては、エタノール、女性ホルモ
ン、ビタミンB6、ビタミンＥ、パントテン酸、
トウガラシチンキ、シヨウキヨウチンキ、センブ
リエキス、ヒノキチオール、セフアランチン、感
光素、オードキニン等の通常育毛料に配合されて
いる成分全てが挙げられる。
この様な配合成分を混合してこの発明にかかる
育毛養毛等美髪料とするには、常法に準じて行え
ばよく最終形態としてはヘアトニツク、ヘアクリ
ーム、ヘアトリートメント、ヘアオイル等の任意
の形態を採用できる。
（効果）
以上詳述した如く、この発明はアシタバ
（Angelica Keiskei Koidz）の地下部を必ず含有
する全草部を15〜80℃の温湯で抽出した抽出物を
必須成分とする育毛養毛等美髪料であるから、こ
の成分単独或いはせいぜい他の一成分を混合する
だけで育毛養毛等美髪効果があるため、従来のよ
うに多成分混合系の育毛養毛美髪料と異なり頭皮
への副作用を防止しながら育毛養毛等効果を発揮
することができる美髪料である。
しかも、安全性に全く問題がないので、長期間
使用でき、期間が長ければより効果を得ることが
できる。
次に実施例及び試験例を記載することにより、
より一層この発明の効果を明確にする。
実施例及び比較例１・２・３
（実施例）
アシタバの全草部の乾燥物２Kgを調製し、この
乾燥物を粉砕し、この粉砕物に温湯（40〜50℃）
10リツトルを加え恒温状態で一夜抽出した。
その後、これを濾別し濾液を1/10に濃縮し、エ
キス減圧乾燥し、660gの緑色粉末が得られた。
この粉末を10％水溶液として用いて、次の処方
によりヘアトニツクを作り試験に供した。
エタノール 34.5％
香料 0.5％
精製水 62％
アシタバ抽出物水溶液 ３％
比較例 １
アシタバ乾燥物の粉砕物を100℃の熱水で抽出
した以外は実施例と同様にヘアトニツクを調製し
た。
比較例 ２
実施例にヘアトニツクの配合物中アシタバ抽出
物水溶液を、局方センブリ末10％水溶液とした以
外は実施例と同一組成のヘアトニツクを調製し
た。
比較例 ３
原料としてアシタバ（Angelica Keiskei
Koidz）の地上部（草茎部）のみの乾燥物２Kgを
用いた以外は実施例と同様にヘアトニツクを調製
した。
試験例 １
実施例で得たヘアトニツクを、脱毛で悩んでい
る22才から51才の男性30人を（第１群）、（第２
群）、（第３群）の三群各群10人にわけ、毎日入浴
洗髪後、乾いたタオルで頭髪を良く清拭させた
後、所要量頭髪に被用させた。
第１群は抜毛が多いもの。
第２群は部分的に頭髪のうすいも。
第３群は全体に頭髪のうすいもの。
３週間後の結果を、次の第１表に示す。
(Field of Industrial Application) This invention relates to hair care products such as hair growth and nourishment, and more specifically, it uses a common edible plant, Augelica Keiskei Koidz, and extracts the whole plant, which necessarily contains the underground part. The main component is
The object of the present invention is to provide a hair-growth and other beautifying agent that is extremely safe by eliminating side effects and is highly effective in hair growth, prevention of gray hair, anti-hair loss, etc. by activating skin, especially scalp functions. (Prior Art and Its Disadvantages) In general, as people age after reaching adulthood, the aging phenomenon accelerates, and the problems of sparse hair, hair loss, and gray hair that accompany this aging phenomenon become a major problem, especially for men. On the other hand, in recent years, life in general has become full of stress,
In particular, the age at which aging begins is decreasing due to overwork of workers as work becomes more sophisticated and complicated, and on the other hand, due to gourmet food (high-calorie, high-carbohydrate foods). , problems such as gray hair are also becoming younger. Recently, even minors such as school children and students are showing symptoms that are considered to be signs of aging, and in fact, according to a survey by the Ministry of Education, physical strength peaks at the age of 17 and then declines. In particular, a particularly peculiar phenomenon among schoolchildren and students is the weakening of the skin and hair caused by increased body fat caused by high consumption of gourmet foods (high calorie, high carbohydrate foods) and processed foods containing additives. In other words, the number of men suffering from hair loss and gray hair is rapidly increasing, especially among younger age groups. Various cosmetic compositions have been developed to solve hair preservation problems such as hair growth, but the mechanism of action of most of them is that they stimulate the skin at the hairline, especially the hair roots, and cause damage to the hair roots. The aim was to promote blood flow in the surrounding area and supply nutrients to the scalp, or to prevent dryness of the scalp by incorporating moisturizers and to solve hair beauty problems such as hair growth. In addition, physically hitting the scalp with a brush or the like to stimulate it has the same purpose, and it also uses drugs or herbal medicine ingredients that are expected to activate cells or prevent scalp inflammation. Although these are common methods, none of them can be expected to have a definite effect, so conventional hair growth products generally contain several types of ingredients to meet their respective purposes. For example, ethanol, female hormones, vitamins
B 6 , vitamin E, pantothenic acid, capsicum tincture, chili pepper tincture, Japanese cabbage extract, hinokitiol, cephalanthine, photosensitizer, ordokinin, etc. are usually mixed in three or more types. At present, there is no superior hair growth or hair cultivation method that exceeds the combination of the above two methods. However, the efficacy of these drugs and herbal medicine ingredients for external use is rarely clear, and as a result, the hair growth effect of conventional commercially available products when used externally is
For the most part, it has not produced the results expected. In addition, there is a tendency that these various ingredients mentioned above have been easily and repeatedly used in order to obtain approval from the Ministry of Health and Welfare as a hair growth agent, assuming that there is a precedent for their formulation. Furthermore, these conventional cosmetics for hair growth, etc., contain multiple ingredients, so they tend to cause hypersensitivity reactions due to skin irritation effects, which can cause rashes, inflammation, and damage to the scalp and hair in some people. In some cases, there were disadvantages such as excessive drying, which had the opposite effect. (Solution) By the way, this inventor has been researching edible plants for a long time, and in the process, he discovered Angelica
eiskei Koidz)
It was discovered that a hair-growth, hair-nourishing, and other hair-beautifying agent that contains an extract extracted with hot water at 15 to 80°C as an essential ingredient has excellent hair-growth, hair-nourishing, and other beautifying effects even when used alone. This invention was developed based on the discovery that because there are only a few, there is less chance of rash or damage to the head, and the drawbacks of the conventional methods can therefore be overcome. (Structure of the Invention) Angelica Keigkei Koidz used in this invention is a perennial plant of the Umbelliferae family that is usually provided as food, and grows mainly on Izu Oshima and Hachijo Island, and its leaves and stems are usually eaten. In this invention, the whole plant part of Angelica Keiskei Koidz, which always contains the underground part, is used. In this invention, Ashitaba (Angelica)
There is also experimental knowledge that it is preferable to always use underground parts such as the roots of KeiskeiKoidz (KeiskeiKoidz) to increase the effect. In order to use the whole plant part, which necessarily contains the underground part, as an essential component of the hair care product for hair growth and nourishment according to the present invention, an extract or extract powder is obtained by the extraction method described below. Note that the extraction method is not limited to the following example. First, thoroughly wash the whole plant, which always contains the underground part, and cut it into small pieces. Add about 10 times the amount of warm water (15 to 80°C), leave it at a constant temperature overnight, and filter it to obtain a filtrate. This is used as an essential component of the present invention either as it is or after being concentrated to about 1/10 volume by a method such as reduced pressure. The reason why hot water is used for extraction in this invention is that photosensitizing allergen substances, such as furocoumarins, which have a safety problem for the skin, will not be extracted if hot water is used for extraction. Further, the temperature of this hot water is preferably 15 to 80°C, more preferably 40 to 50°C. The reason for this is that hot water extraction at temperatures exceeding 80°C causes effective substances with low boiling points to vaporize and transpire, reducing the effectiveness. On the other hand, extraction with hot water below 15°C will not extract the active ingredients and the desired effect cannot be expected. Therefore, only the active ingredients can be extracted most efficiently and reliably when extracted with hot water at 40 to 50°C. The extract obtained in this way, its concentrated liquid, or its dry powder is a peroxide of linoleic acid that is produced when a certain amount of linoleic acid is used, a certain amount of air is blown in for a certain period of time, and a certain amount of heat is continued. When comparing the effect of inhibiting dl-α-tocopherol (vitamin E) in the Japanese Pharmacopoeia, for example, the effect of linoleic acid peroxide in the extract of the leaf stem of Ashitaba japonica (when an equal amount of vitamin E is mixed with linoleic acid in advance). The oxide inhibition rate is several times higher than that of vitamin E. This fact can be inferred to be effective against scalp sebum peroxidation, which is one of the causes of hair loss and gray hair, but this is also a future challenge for the inventor. Moreover, in this invention, it has been experimentally learned that the effect is enhanced by always using underground parts such as roots. The inventors are currently actively investigating the reason for this, and elucidating it will be an important future issue. However, the components contained in the underground part of Angelica (Keiskei Koidz) are different from those contained in the above-ground part, especially in the underground part. It is rich in components such as biotin and vitamin B12 , which are only contained in trace amounts in the above-ground parts, and it is presumed that the effect is due to the action or interaction of these. With this invention, Ashitaba (Angelica Keiskei)
It is desirable that the amount of the concentrated solution containing the leaves and stems of Koidz, or its dry powder or extract, added to the hair tonic is 3 to 10 w/v%, calculated as a 1% aqueous solution. The reason for this is that the effect of the present invention cannot be achieved sufficiently when the content is less than 3w/v%, and conversely, even when the content exceeds 10w/v%, the effect is greater than that of a 10w/v% blend. Based on the fact that it does not increase. Further, in the present invention, any other ingredients may be mixed in order to increase the hair growth effect of Angelica Keigkei Koidz. This formulation includes ethanol, female hormones, vitamin B6 , vitamin E, pantothenic acid,
All of the ingredients that are usually included in hair growth products such as capsicum tincture, chili pepper tincture, Jasperia japonica extract, hinokitiol, cephalantin, photosensitizer, and ordokinin can be mentioned. To prepare the hair growth and nourishing hair beauty product of the present invention by mixing such ingredients, it is sufficient to follow a conventional method, and the final form can be any hair tonic, hair cream, hair treatment, hair oil, etc. form can be adopted. (Effects) As detailed above, this invention provides hair growth, hair growth, and hair growth benefits using an extract obtained by extracting the whole plant of Angelica Keiskei Koidz (Angelica Keiskei Koidz), which always contains the underground part, with hot water at a temperature of 15 to 80°C. Since it is a hair ingredient, this ingredient alone or mixed with at most one other ingredient has hair growth and beautifying effects, so unlike conventional hair growth and nurturing hair beauty products that use a multi-ingredient mixture, it is effective for the scalp. It is a hair beauty product that can exert effects such as hair growth and nourishment while preventing the side effects of hair loss. Moreover, since there is no problem with safety, it can be used for a long period of time, and the longer the period, the more effective it can be. Next, by describing examples and test examples,
The effects of this invention will be made clearer. Examples and Comparative Examples 1, 2, and 3 (Example) Prepare 2 kg of dried whole plant part of Ashitaba, crush this dried substance, and add hot water (40 to 50℃) to this crushed substance.
Added 10 liters and extracted overnight at constant temperature. Thereafter, this was filtered, the filtrate was concentrated to 1/10, and the extract was dried under reduced pressure to obtain 660 g of green powder. Using this powder as a 10% aqueous solution, a hair tonic was prepared according to the following formulation and subjected to testing. Ethanol 34.5% Fragrance 0.5% Purified water 62% Acitabella extract aqueous solution 3% Comparative Example 1 A hair tonic was prepared in the same manner as in Example, except that the pulverized product of dried Acutella aspenica was extracted with hot water at 100°C. Comparative Example 2 A hair tonic having the same composition as in the example was prepared except that the aqueous solution of Acetabella extract in the formulation of the hair tonic in the example was replaced with a 10% aqueous solution of pharmacopoeia assemblage powder. Comparative Example 3 Angelica Keiskei was used as a raw material.
A hair tonic was prepared in the same manner as in the example except that 2 kg of dried aerial parts (plant stems) of C. nigra (Koidz) were used. Test Example 1 The hair tonic obtained in Example was administered to 30 men aged 22 to 51 who were suffering from hair loss (Group 1) and (Group 2).
After bathing and washing their hair every day, they thoroughly wiped their hair with a dry towel and applied the required amount to their hair. The first group has a lot of hair loss. The second group has thin hair in some areas. The third group has thin hair all over the head. The results after 3 weeks are shown in Table 1 below.
【表】
脱毛試験は、入浴時に洗髪しこの後乾燥したタ
オルで頭髪をこすりタオルに残つた髪の毛の数で
判断した。
尚、洗髪時期、洗髪方法、タオルで頭髪を拭く
回数も一定とした。
育毛、養毛については本人の自覚を問診で確認
し、著効という本人の自覚にたいしては第三者が
同時に頭部の産毛の生え状況を目視で確認して結
論した。
育毛、養毛についての有効中には本人の自覚の
みで第三者の確認をともなわないものも含む。
試験例 ２
25才から55才までのやや毛が薄い男性合計30人
を、実施例１施用群（第１群）、比較例１施用群
（第２群）、比較例２施用群（第３群）のそれぞれ
110人づつのグループに分け、試験例１と同様に
施用させて３ケ月後、及び６ケ月後に改善状態を
質問して、調べた。
結果をまとめて第２表及び第３表に示す。[Table] The hair removal test was judged by the number of hairs remaining on the towel after washing the hair during bathing and then rubbing the hair with a dry towel. In addition, the time of hair washing, the hair washing method, and the number of times the hair was wiped with a towel were also kept constant. The individual's awareness of hair growth and growth was confirmed through an interview, and the individual's awareness of the effectiveness was determined by a third party visually confirming the state of hair growth on the head at the same time. Effective information regarding hair growth and hair restoration includes those that are based solely on the person's awareness and do not involve confirmation by a third party. Test Example 2 A total of 30 men with slightly thin hair between the ages of 25 and 55 were treated with the Example 1 application group (Group 1), the Comparative Example 1 application group (Group 2), and the Comparative Example 2 application group (Group 3). group)
They were divided into groups of 110 people and asked questions about the improvement after 3 months and 6 months after applying the same method as in Test Example 1. The results are summarized in Tables 2 and 3.
【表】【table】
【表】
で効果確認が出来なくとも、本人が効果有
りと自覚したものを含む。
試験例 ３
25才から35才までのやや毛が薄い男性合計20人
を、実施例１施用群（第１群）、比較例３施用群
（第４群）のそれぞれ10人づつのグループに分け、
試験例１と同様に施用させて３ケ月後、及び６ケ
月後に改善状態を質問して、調べた。
結果をまとめて第４表に示す。[Table] Includes those that the person himself was aware of as having an effect, even if the effect could not be confirmed.
Test Example 3 A total of 20 men with slightly thin hair between the ages of 25 and 35 were divided into groups of 10 each: Example 1 application group (1st group) and Comparative Example 3 application group (4th group). ,
In the same manner as in Test Example 1, the improvement status was investigated by asking questions 3 months and 6 months after the application. The results are summarized in Table 4.
【表】【table】
【表】
で効果確認が出来なくとも、本人が効果有
りと自覚したものを含む。
叉、効果有とは第三者が外観状目視で効果が顕
著に確認できるものをまとめた。
以上の結果から判るように、この発明に係る育
毛養毛等美髪料は長期施用により、従来品に比べ
て効果が顕著になることが判るとともに副作用が
無く、有効に育毛養毛等美髪の効果を発揮できる
ことが明らかである。[Table] Includes those that the person himself was aware of as having an effect, even if the effect could not be confirmed.
Furthermore, "effective" refers to those whose effects can be clearly confirmed by a third party's visual inspection. As can be seen from the above results, the hair growth agent of the present invention is more effective than conventional products when used for a long period of time, has no side effects, and is effective for hair growth and hair growth. It is clear that this effect can be achieved.