JPH024706A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic cosmetic, containing a fatty acid, aliphatic alcohol having an odd number of carbon chain length or derivative thereof and plant extract, excellent in cell activating effects and remarkably improved in hair growth promoting action without adversely affecting human bodies. CONSTITUTION:A hair tonic cosmetic containing 0.1-30wt.% fatty acid having an odd number of carbon chain length (e.g., propionic or nonadecanoic acid) or a derivative thereof (e.g., ester, salt or amide) or an aliphatic alcohol having an odd number of carbon chain length (e.g., n-propyl alcohol) or a derivative thereof (e.g., ester or ether) and 0.1-10wt.% plant extract (e.g., licorice, ginseng, Japanese angelica root, garlic or Coptidis Rhizoma) having nutriment supplying effects. If the carbon number is odd, either of saturated and unsaturated substances may be used as the above-mentioned alcohol and fatty acid and plural double bonds may be contained therein.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a hair nourishing cosmetic that exhibits an excellent hair growth promoting effect.

(Prior Art) Hair tonics containing various medicinal ingredients that are expected to have hair growth and hair growth effects have been known, and are used for the prevention and treatment of alopecia. Examples of medicinal agents include vitamins such as vitamin E; amino acids such as serine and methionine; vasodilators such as acetyl colon derivatives; anti-inflammatory agents such as purple root extract; female hormones such as estradiol; cef-7 latin, etc. skin function enhancers; melanin synthesis catalysts such as copper pantothenate; and keratolytic agents such as cericylic acid.

Fatty acids with odd carbon chain lengths or their derivatives have been discovered as medicinal ingredients that have a hair-nourishing effect, and a hair-nourishing agent containing them as an active ingredient has been proposed (Japanese Patent Application Laid-Open No. 1983-1992).
-27809).

Furthermore, nutritional supplements containing various plant extracts as active ingredients have also been proposed (Japanese Patent Laid-open Nos. 59-88303 and 60-94).
907 etc.).

However, it cannot be said that any of these has sufficient effects as a hair nourishing agent.

(Problems to be Solved by the Invention) The present invention was made in view of the above circumstances, and an object of the present invention is to provide a hair nourishing cosmetic that exhibits an excellent hair growth promoting effect.

(Means for Solving the Problems) As a result of intensive research to achieve the above object, the present inventors have found that fatty acids with odd carbon chain lengths, which have an excellent cell activating effect, are extracted from plants. The present inventors have discovered that the addition of the above-mentioned hair growth products has an even more excellent effect on promoting hair growth, and have completed the present invention.

That is, the hair nourishing cosmetic of the present invention is characterized by containing a fatty acid or a derivative thereof having an odd number of carbon chain lengths, an aliphatic alcohol or a derivative thereof having an odd number of carbon chain lengths, and a plant extract. do.

The aliphatic alcohol which is the first essential component of the hair nourishing cosmetic of the present invention may be either saturated or unsaturated if the number of carbon atoms constituting the carbon chain is an odd number. or, if unsaturated, may contain multiple double bonds.

Further, the alcohol may be a lower alcohol or a higher alcohol, and may be any of primary, secondary, and tertiary alcohols.

Examples of preferred odd chain length aliphatic alcohols include n-propyl alcohol, n-amyl alcohol, n-heptyl alcohol, n-nonyl alcohol, n-undenyl alcohol, n-tridecyl alcohol, n-pentadecyl alcohol, n-heptadecyl alcohol, n-nonadecyl alcohol, n-raneicosyl alcohol,
Mention may be made of n-tridecyl alcohol and n-bentacocyl alcohol.

Further, derivatives of such odd chain length fatty acid alcohols can also be used in the hair nourishing cosmetic composition of the present invention. Typical derivatives are esters and ethers of odd chain length alcohols. Preferred esterified products include the above-mentioned odd-numbered chain length alcohols and aliphatic carboxylic acids (particularly those having 2 to 2 carbon atoms).
4 is preferred), organic acids such as succinic acid, citric acid, fumaric acid, lactic acid, pyruvic acid, malic acid, and oxaloacetic acid, and esters with inorganic acids such as phosphoric acid.

A preferred etherified product is the above-mentioned odd chain length alcohol;
Aliphatic alcohols (especially preferred are those with 2 to 24 carbon atoms); polyhydric alcohols such as glycerin, polyglycerin, ethylene glycol, propylene glycol, butanediol; glucose, ribose, galactose,
Includes etherified products with sugars such as arabinose, mannose, xylose, sorbitol, and mannitol.

Alternatively, the etherified product may contain two or more odd-numbered chain-length alcohol residues in one molecule, such as di- or tri-odd-numbered chain-length alkoxide of glycerin.

In addition, the odd-number chain length alcohol derivative used in the hair-growth cosmetic of the present invention need only contain the residue of the above-mentioned odd-number chain length alcohol, as long as it does not have an adverse effect on the human body. Therefore, the acid residues in the above-mentioned esterified products and the alcohol residues and sugar residues in the etherified products may be substituted with various substituents.

The other first essential component, fatty acids, can be either saturated or unsaturated, as long as the number of carbon atoms composing the chain is an odd number. May contain bonds. Further, the fatty acid may be a lower fatty acid or a higher fatty acid, and preferred ones include propionic acid, valeric acid, heptanoic acid, nonanoic acid, undecanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, heneicosanoic acid, tricosanoic acid, and Examples include pentacosanoic acid.

The hair nourishing cosmetic composition of the present invention can also use such derivatives of fatty acids with odd chain lengths. Preferred derivatives include esters, salts, and amides of odd chain length fatty acids. Examples of these include:

b) Monoglyceride represented by the general formula [1] or [II], [I] [II] CH20
CORCH2(OH) CH(OH) CHOCORCH,(OH
) CH2(OH) (However, R represents a straight-chain aliphatic group having an even carbon chain length.) Diglyceride represented by the following general formula [III] or [IV], [III] [rV] CR2(OH) CR20COR2 (However, at least one of R7 and R2 may represent a linear aliphatic group having an even carbon chain length, and the other may be a linear organic group having an odd carbon chain length. In this case, diglycerides of fatty acids with odd chain lengths are particularly preferred.

) c) Triglyceride represented by the following general formula [V], [V] CH20COR.

CHOCOR2 CH20COR3 (However, at least one of R1, R2, and R3 represents a linear aliphatic group having an even number of carbon chain lengths, and the others represent a linear H group having an odd number of carbon chain lengths. In this case, triglycerides of fatty acids with odd chain lengths are particularly preferred.) d) Fatty acid salts represented by the following general formula [VI], [VI] (RCOO) n M (However, R is a straight-chain aliphatic group with an even carbon chain length,
M represents a hydrogen atom, ammonia, an organic amine, or a metal atom, and n represents an integer corresponding to the valence of M. For example, R.C.
OOH, RCOONa.

RCOOK, RCOOL i, etc. ) E) Represents an ester represented by the following general formula [■], a [■ RCOOH4'' residue, or a sucrose residue. Typical examples of monohydric alcohols are methanol and ethanol.) To) The following general formula The primary amide represented by [■], [■] RCONR-R' (wherein, R represents a straight-chain aliphatic group having an even carbon chain length. R- and R' are hydrogen or Represents an organic group that is not given.) g) The following general formula [IX]
A second amide represented by [IX] RI C0NC0R2 (however, at least one of R1 and R2 is a straight-chain aliphatic group having an even carbon chain length, and the other one and R- are Any organic group may be used as long as it does not have an adverse effect on R-, and R- may be hydrogen. It is particularly preferable that both are straight-chain groups with an even chain length.) H) The third compound represented by the following general formula [X]
Amide, [X] R, C0NC0R2 0R3 (However, at least one of R1R2 and R3 is a straight-chain aliphatic group with an even number of carbon chain lengths, and the others do not have an adverse effect on the human body. (It is particularly preferable that all three of these groups are linear organic groups with an even number chain length.) J) Dibasic acid represented by the following general formula [XI] and its salts, [XI] MOOCRCOOM ((R represents a straight-chain aliphatic group having an odd carbon chain length, M is the same as above)) The following general formula [X [Xn] (represents a straight-chain organic group having a length of r1 (u and R is an even number of carbon atoms)) phospholipid represented by the general formula [XIII], [
XII[] [XIV] CH20COR1 CHOC0R2 CH20COR.

CHOCOR2 (However, R3 and R2 are chain organic groups, and at least one of them, particularly preferably both, represents a straight chain aliphatic group having an even carbon chain length. X is a choline residue , represents an ethanolamine residue, a serine residue, or an inositol residue. When using phatidylserine or inositol, it becomes phosphatidylinositol.) w) The following general formula [
phosph-7tidic acid represented by (represents a group) W) A sphingolipid represented by the following general formula [XV], [XV] (wherein R is a linear aliphatic group having an even number of carbon chain lengths,
X represents a sugar residue, a phosphate residue, or an amine base residue such as choline or ethanolamine. ) These odd-number chain length fatty acid derivatives need only contain the residues of the above-mentioned odd-number chain length fatty acids as long as they do not adversely affect the human body. Therefore, the portions other than the odd chain length fatty acid residues in the above derivative may be substituted with various substituents.

The total amount of fatty acids or derivatives thereof having an odd carbon chain length, or aliphatic alcohols or derivatives thereof having an odd carbon chain length in the hair nourishing cosmetic is not particularly limited, and is usually 0.1% by weight to 0.1% by weight. It is about 30% by weight.

The second essential ingredient of the hair-nourishing cosmetic composition of the present invention is a plant extract that has a nourishing effect. Preferred plants for obtaining extracts include licorice, chinensis, ginseng, trumpet,
Ryutan, Bellflower, Rauolphia, Uzu, Bushi,
Valerian root, Keihi, Auricularia japonica, Clove, Fennel, Sansho, Anmi, Kyonin, Gobaiko, Jacora,
Cephalanthine, yokuinin, aloe, japonica, chimpi, staghorn, garlic, kouka, aspergillus, nebula, chinensis, red bean gin, tanjin, burdock, chamomile, burdock, chamomile, stonewort, arnica, pine tree, tokoharu ivy, orchid mustard, kujin, japonica japonica, calamus Con, Japanese horseradish, rice moth, horse chestnut, Hamamelis, grape, Hypericum perforatum, Calendula perforatum, Japanese chinensis, cornflower, Japanese horsetail, horsetail,
Examples include hops, salvia, pomegranate, mallow, elderberry, nettle, rhubarb, and rhubarb. The blending amount of the plant extract is 0.3% to 30% by weight, preferably 0.1% to 10% by weight.

The hair nourishing cosmetic of the present invention may further include various commonly used auxiliary ingredients, such as esters, polyhydric alcohols,
Surfactants, oils and fats, etc. can be blended.

In addition, medicinal ingredients include vitamins, hormones, amino acids, vasodilators, anti-inflammatory agents, cell activators, keratolytic agents,
Known hair nourishing agents such as bactericides and transdermal absorption enhancers may be added at the same time.

(Effects) The hair nourishing cosmetic composition of the present invention has excellent cell activating effects, has no adverse effects on the human body, and has significantly improved hair growth promoting properties.

(Example) Examples and comparative examples of the present invention will be shown below to explain the present invention more specifically. Before explaining each example, the hair growth effect test method, skin moisture retention ability, and subcutaneous blood flow measurement test method adopted in each example will be explained.

[Hair growth effect test method] A group of 6 to 8 New Sealant White rabbits weighing 2.5 kg were removed from their backs, and only those in the resting phase were subjected to the experiment. Apply 0.2 ml of each test sample to the hair-removed back of the telogen, twice a week for 30 to 8
The product was sprayed for 0FI, and the number of sprays required for converting resting cut hairs to growing cut hairs was determined. In addition, the "promoted Fl number" used as an index of the hair-nourishing effect refers to how many times the conversion from resting cut hair to growing cut hair is promoted compared to spraying ethanol that does not contain the test substance. It shows. The hair nourishing effect is
Evaluation was made based on the criteria shown in Table 1 below.

Table 1 Evaluation criteria for hair growth effect [Skin moisture retention capacity and subcutaneous blood flow measurement test method] On the other hand, skin moisture retention capacity and subcutaneous blood flow 1111 were determined by applying 1 sample of each test sample to the forearm site of a normal human. Apply 4 times a day for 2 consecutive weeks/
11. Two hours after the final application, the intoxicated area was washed with soap, and one hour later, the normal skin conductivity (asual value) and blood flow value were determined. The conductivity value was used to evaluate skin moisture retention because it is proportional to the amount of moisture retained by the skin.

From each measured value, the increase rate when the asual value was set to 100 was determined and evaluated based on the criteria shown in Tables 2 and 3 below.

Table 2 Evaluation Criteria for Skin Moisture Retention Ability Table 3 Evaluation Criteria for Subcutaneous Blood Flow 18 types of test samples shown in Tables 4 and 5 below were prepared, and the characteristics of each were evaluated.

The results are shown in the same table.

From Tables 4 and 5, it can be seen that the test samples (Examples 1 to 15) containing predetermined amounts of two types of white active ingredients within the scope of the present invention all exhibit excellent properties in terms of cell activation. 7
=l L, test samples outside the scope of the present invention (Comparative Examples 1 to 3)
It can be seen that none of them exhibits excellent characteristics. That is, the test sample (Comparative Example 1.2) that does not contain fatty acids with odd carbon chain lengths or derivatives thereof or aliphatic alcohols with odd carbon chain lengths of 0 or derivatives thereof has a significant effect on hair growth, skin moisture retention, and subcutaneous blood. Test sample that did not exhibit superior properties in terms of flow rate and did not contain plant extracts (Comparative Example 3)
) did not show superior properties in terms of skin moisture retention and subcutaneous blood flow.

Next, a formulation example in which the hair nourishing cosmetic of the present invention is applied to an actual product will be shown. It has been confirmed that in each case, the excellent properties are lost. In addition, the weight of the IP position in the example of the do note is 9o.

Formulation example 1 (hair growth agent) Ingredients Pentadecanoic acid glyceride Cephalanthine POE (20) Hardened Castor sorbitan monostearate Safflower oil Biotin Succinic acid Acetic acid d, e-α-Tocopherol Fragrance 99.5% ethanol Treatment example 2 (Hair (tonic) Ingredients Isopropyl tridecanoate Menthol Benzyl nicotinate 6 Weight% 3,0 1.0 1.0 1,0 0,5 0,02 0,5 0.2 0.5 Balance weight 96 2, 0 1, 0 0.2 0.5 99, 5% Ethanol Purified water formulation example 3 (shampoo) Ingredients Sodium lauryl ether sulfate Sodium α-olefin sulfonate Cationized cellulose Pentadecanol Senega Purified water 70, 0 Remaining weight % 10, 0 10, 0 1, 0 2, 0 0, 5 Remainder Formulation Example 4 (Rinse) Ingredients Stearyltrimethylammonium chloride Distearyldimethylammonium chloride Cetostearyl alcohol Liquid paraffin n-heptadecanoic acid Senega Weight % 1.5 0.5 1 , 5 1 , 0 0.5 Purified water remainder Formulation example 5 (aerosol hair growth agent) (undiluted solution) Ingredients Ball amount % Tory〇-pentadecyl glyceryl ether 2.0 Yokuinin
1. Ol-menthol
0. 】citric acid
0.3 fragrance
0.5 ethanol 70.0 purified water
Remainder (diluted liquid for filling)

Claims (1)

[Claims] 1. A hair nourishing cosmetic containing a fatty acid or a derivative thereof having an odd carbon chain length, an aliphatic alcohol or a derivative thereof having an odd carbon chain length, and a plant extract.