JPH0297398A - 固相ペプチド合成におけるｐａｍ酵素の使用 - Google Patents

固相ペプチド合成におけるｐａｍ酵素の使用

Info

Publication number
JPH0297398A
JPH0297398A JP1187225A JP18722589A JPH0297398A JP H0297398 A JPH0297398 A JP H0297398A JP 1187225 A JP1187225 A JP 1187225A JP 18722589 A JP18722589 A JP 18722589A JP H0297398 A JPH0297398 A JP H0297398A
Authority
JP
Japan
Prior art keywords
peptide
gly
solid phase
enzyme
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1187225A
Other languages
English (en)
Japanese (ja)
Inventor
Castiglione Roberto De
ロベルト・デ・カスチグリオーネ
Luigia Gozzini
ルイージヤ・ゴツツイーニ
Carlo Visco
カルロ・ビスコ
Mauro Galantino
マウロ・ガランチノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of JPH0297398A publication Critical patent/JPH0297398A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP1187225A 1988-07-20 1989-07-19 固相ペプチド合成におけるｐａｍ酵素の使用 Pending JPH0297398A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8817265.5 1988-07-20
GB8817265A GB2220938B (en) 1988-07-20 1988-07-20 Use of pam enzyme in solid phase peptide synthesis

Publications (1)

Publication Number Publication Date
JPH0297398A true JPH0297398A (ja) 1990-04-09

Family

ID=10640781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1187225A Pending JPH0297398A (ja) 1988-07-20 1989-07-19 固相ペプチド合成におけるｐａｍ酵素の使用

Country Status (4)

Country Link
JP (1) JPH0297398A (it)
DE (1) DE3923583A1 (it)
GB (1) GB2220938B (it)
IT (1) IT1231149B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233978B (en) * 1989-07-17 1993-03-03 Erba Carlo Spa Cofactors for enzymatic amidation
GB9015369D0 (en) * 1990-07-12 1990-08-29 Erba Carlo Spa Amidated fibrinolytic enzymes and their precursors,and processes for their preparation
AU2014310555B2 (en) 2013-08-20 2018-01-18 Lek Pharmaceuticals D.D. Cell culture medium and process for controlling alpha-amidation and/or C-terminal amino acid cleavage of polypeptides

Also Published As

Publication number Publication date
DE3923583A1 (de) 1990-01-25
GB2220938A (en) 1990-01-24
GB2220938B (en) 1992-01-29
IT1231149B (it) 1991-11-19
IT8921210A0 (it) 1989-07-17
GB8817265D0 (en) 1988-08-24

Similar Documents

Publication Publication Date Title
US11518794B2 (en) Synthesis method for liraglutide with low racemate impurity
JP4405594B2 (ja) 改良型固相ペプチド合成及びかかる合成において利用するための試薬
EP0477885B1 (en) Parathyroid hormone derivatives
CN108148115A (zh) 一种环肽合成新方法及其在药物开发中的应用
CN106478805B (zh) 一种glp-1衍生物的制备方法
CN104177490B (zh) 片段缩合制备醋酸鲑鱼降钙素的方法
CN109575109A (zh) 片段缩合制备地加瑞克的方法
CN113121673B (zh) 一种固液结合法制备依降钙素的方法
CN110903352A (zh) 一种西曲瑞克的制备方法
EP0087066B1 (en) Process for purifying secretin
JPH0297398A (ja) 固相ペプチド合成におけるｐａｍ酵素の使用
WO1991007433A1 (en) Peptide and process for preparing cyclic peptide
US6448031B1 (en) Process for producing LH-RH derivatives
CN105367627A (zh) 一种特利加压素的制备方法
US5252705A (en) Peptide derivatives
EP0277561B1 (en) New arginine derivative, process for the preparation thereof and its use in peptide synthesis
JP2777193B2 (ja) ペプチドの製造方法
CN120554481B (zh) 一种司美格鲁肽中间体的混合物及司美格鲁肽制备方法
JPH06336496A (ja) 環状ヘキサペプチド及びその製造方法、並びに環状ペプチドの製造方法
CN110922452A (zh) 一种戈舍瑞林的合成方法
EP0662482A1 (en) Process for preparation of human glicentin
CN106928340A (zh) 一种利西拉来的制备方法
CN121652261A (zh) 一种阿巴帕肽的合成方法
AU3708697A (en) Process for producing lh-rh derivatives
WO1992015695A1 (en) Process for the c-terminal modification of peptides having a c_terminal penultimate proline residue