JPH031874A - Blood pump integrated type oxygenator - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an oxygenator in which a fluid-driven diaphragm blood pump is integrally attached to a membrane oxygenator.

[Prior art] Conventional general membrane oxygenators consist of ■an oxygenator that performs gas exchange, ■a heat exchanger that warms the blood to an appropriate temperature, and ■a blood storage tank, which can be adjusted depending on the purpose or necessity. However, there are types that do not have either (1) and (2) above, or one of them. When such an artificial lung is actually used, it is connected to a pump system including a blood pump through a long tube.

Further, Japanese Patent Publication No. 57-4346 discloses a detachable artificial heart-lung device in which a sack-type artificial lung is housed in a hard case. According to this artificial heart-lung machine, a sack-type artificial lung is contracted and expanded by air drive, and the artificial lung itself is used as a blood pump.

[Problems to be solved by the invention] However, in the conventional membrane oxygenator that has been generally used, the oxygenator and pump device are connected by a tube, so the entire device and blood circuit are large. This made treatment at the patient's bedside difficult and required a long tube to lead blood from the patient to an artificial lung, pump, etc. In addition, as the extracorporeal circulation amount and circulation time of blood increases, the blood is cooled by the atmosphere, so a heat exchanger for heating must also be provided, and the blood filling volume needs to be at least 400 to 500 Ili. becomes. On the other hand, when providing respiratory support to infants and children, it is often necessary to perform the procedure quickly, and there is no time to prepare blood for transfusion, and blood transfusions are also reluctant. Bloodless extracorporeal circulation, in which the blood circuit of the artificial lung is quickly filled with physiological saline or the like and the extracorporeal circulation begins, is preferred. However, as mentioned above, when the amount of blood filled is large, the amount of blood in the body of infants and children is 200 to 100%.
00cc (calculated as 8% of body weight), there is a problem that bloodless extracorporeal circulation is almost impossible.

In addition, in the artificial lung disclosed in Japanese Patent Publication No. 57-4346, since the soft artificial lung is repeatedly contracted and expanded by air, the artificial lung itself deteriorates when used for a long time, and a large amount of blood flows into the artificial lung. There is a risk of a dangerous situation where air gets mixed in.

The present invention has been made in view of the problems of the prior art as described above, and its purpose is to integrate a membrane oxygenator and a liquid-driven diaphragm blood pump into a compact, small blood pump with a small amount of blood filling. The goal is to provide artificial lungs.

[Means for Solving the Problems] According to the present invention, the object is to provide a blood pump integrated oxygenator consisting of a membrane oxygenator and a blood pump integrally attached to its blood supply section. The blood pump is a diaphragm pump driven by liquid, and
This can be achieved by a blood pump-integrated artificial joint characterized in that the artificial lung and the blood pump are connected by a flow path provided with an artificial valve.

In addition, in the artificial lung of the present invention, it is also possible to connect the artificial lung and the blood pump by a flow path made of a soft tube instead of the flow path provided with the artificial valve.

[Function] In the present invention, a liquid-driven diaphragm blood pump is integrally attached to a membrane oxygenator, and the two are connected by a flow path equipped with an artificial valve or a wave path made of a soft tube.

By introducing a driving fluid into the driving side chamber of a diaphragm type blood pump and operating the diaphragm, blood introduced into one blood side chamber is passed through a flow path equipped with an artificial valve or a flow path made of a soft tube. In this case, the diaphragm type blood pump uses liquid as the driving fluid, so it is incompressible, and the operating amount of the driving fluid is accurately transmitted to the diaphragm.

The artificial valve has the function of keeping blood flowing in a constant direction, and the soft tube has a clamp that opens and closes to allow blood to flow in a fixed direction, preventing blood from flowing backwards. ing.

[Examples] The present invention will be further explained below with reference to illustrated examples, but the present invention is not limited to these examples.

FIG. 1 shows an embodiment of the artificial lung of the present invention, which is of a type in which the artificial lung and a blood pump are connected through a flow path provided with an artificial valve.

In FIG. 1, an artificial lung 1 consists of a blood pump section 1 and a lung section 2.
A circulation chamber 9 is charged with blood that is circulated by the operation of the pump. The lung part 2 is mainly composed of a porous hollow fiber membrane 12 disposed between an inner cylinder lO and an outer cylinder 11, and the blood flowing outside the porous hollow fiber membrane 12 and the porous hollow fiber membrane 12
Gas exchange is carried out by contacting the #element gas flowing through the hollow portion of the hollow fiber membrane 12 via the hollow fiber membrane 12.

Here, 13 is an oxygen gas inlet, 14 is an exchange gas outlet 0.
15 indicates a blood outlet.

The diaphragm 3 of the blood pump part l supplies the driving fluid (
(Physiological saline solution) It is operated by taking physiological saline in and out from the inlet/outlet lower (see arrows in the figure), and when the physiological saline solution is led out from the drive chamber 8 via the drive fluid inlet/outlet lower, blood is transferred from the blood supply port 6 to the circulation chamber. 9, and when physiological saline is introduced into the drive chamber 8 from the drive fluid inlet/output lower, blood is caused to flow into the lung section 2 through the connecting pipe 5.

The artificial valve 4 is provided at the outlet of the drive chamber 8 and connected to the connecting pipe 5. The artificial valve 4 opens when blood flows from the pump section 1 to the lung section 2. It closes when blood enters the pump section 1, and has the function of keeping the flow direction of blood constant.

The material of the diaphragm 3 of the blood pump 1 used here is not particularly limited, and for example, silicone rubber or synthetic resin can be used.

FIG. 2 shows another embodiment of the artificial lung of the present invention, in which the artificial lung and a blood pump are connected through a flow path made of a soft tube.

In the embodiment shown in FIG. 2, a soft tube 16 connects the circulation chamber 9 of the pump section 1 to the lung section 2, and the soft tube 16 is connected to a solenoid-type, motor-type or air-driven clamp (not shown). By performing the operation of closing or opening the valve (2), it plays the same role as the artificial valve shown in Figure 1, allowing blood to flow in a fixed direction (that is, toward the lungs).

Here, the material of the soft tube is not particularly limited in type, and for example, silicone resin or vinyl chloride resin can be used.

In addition, the porous hollow fiber membrane 12 disposed between the inner cylinder 1O and the outer cylinder 11 may be a polyolefin resin such as polypropylene or polyethylene, a fluororesin such as polyvinylidene fluoride or ethylenetetrafluoroethylene copolymer, Alternatively, hydrophobic resins such as silicone resins are preferably used. Also.

Even when using a material other than a hydrophobic resin, it is also possible to use a material whose contact surface with blood is treated with a silicone resin or the like to make it hydrophobic. A porous hollow fiber membrane has a large number of micropores in its peripheral wall, and gas exchange takes place there. The average pore diameter of micropores is generally 0.0
1 to lpm is preferred. Furthermore, the porosity of the porous hollow fiber membrane is generally preferably about 20 to 80%. Further, it is usually sufficient for the membrane area of the porous hollow fiber membrane to be 3 m2 or less.

This eliminates the need for a heat exchanger.

(4) Respiratory support ECM especially for infants and children
O(Extra-Corpareal Me＋＊bra
ne Oxygenation), ECL A
(Extra-Corporeal Lung As5
ist), E CCOz R (Extra-Corpo
This is useful for real (:02 Removal), etc.

[Effects of the Invention] As explained above, since the artificial lung of the present invention integrates a diaphragm blood pump, it can achieve the following effects.

(1) The blood circuit can be simplified, and the blood filling volume can be reduced to approximately 10
The amount can be reduced to 0mM or less, and bloodless extracorporeal circulation using physiological saline is recommended.

(2) Due to miniaturization, bedside treatment is possible; it is only necessary to draw out a blood circuit of tens to several tens of C from the patient, and treatment can be performed with a low amount of blood filling.

(3) Reduced extracorporeal circulating blood volume and shortened circulation time, which reduces blood cooling and warms the blood.

[Brief explanation of the drawing]

FIG. 1 shows an embodiment of the artificial lung of the present invention, (a
) is a schematic plan view, and (b) is a schematic vertical cross-sectional view. FIG. 2 is a schematic vertical cross-sectional view showing another embodiment of the artificial lung of the present invention. DESCRIPTION OF SYMBOLS 1--Artificial lung, l...Blood pump part, 2...Lung part, 3...Diaphragm, 4...Artificial valve, 5...Connecting pipe, 6...Blood inlet, 7 ...Driver fluid inlet/outlet, 8.
... Drive chamber, 9... Circulation chamber, lO... Inner cylinder, 11.
...Outer cylinder, 12--Porous hollow fiber membrane, 13--Oxygen gas inlet, 14--Exchange gas outlet, 15-'Blood outlet, 16--Soft tube.

Claims (2)

[Claims] (1) A blood pump integrated oxygenator consisting of a membrane oxygenator and a blood pump integrally attached to the blood pump, the blood pump being a diaphragm pump driven by liquid; An artificial lung integrated with a blood pump, characterized in that the artificial lung and the blood pump are connected by a flow path provided with an artificial valve. (2) The blood pump integrated artificial lung according to claim 1, wherein the artificial lung and the blood pump are connected by a flow path made of a soft tube instead of a flow path provided with an artificial valve.